Social media memes are a challenging domain for hate detection because they intertwine visual and textual cues into culturally nuanced messages. To tackle these challenges, we introduce TRACE, a hierarchical multimodal framework that leverages visually grounded context augmentation, along with a novel caption-scoring network to emphasize hate-relevant content, and parameter-efficient fine-tuning of CLIP's text encoder. Our experiments demonstrate that selectively fine-tuning deeper text encoder layers significantly enhances performance compared to simpler projection-layer fine-tuning methods. Specifically, our framework achieves state-of-the-art accuracy (0.807) and F1-score (0.806) on the widely-used Hateful Memes dataset, matching the performance of considerably larger models while maintaining efficiency. Moreover, it achieves superior generalization on the MultiOFF offensive meme dataset (F1-score 0.673), highlighting robustness across meme categories. Additional analyses confirm that robust visual grounding and nuanced text representations significantly reduce errors caused by benign confounders. We publicly release our code to facilitate future research.

Progress in image generation raises significant public security concerns. We argue that fake image detection should not operate as a "black box". Instead, an ideal approach must ensure both strong generalization and transparency. Recent progress in Multi-modal Large Language Models (MLLMs) offers new opportunities for reasoning-based AI-generated image detection. In this work, we evaluate the capabilities of MLLMs in comparison to traditional detection methods and human evaluators, highlighting their strengths and limitations. Furthermore, we design six distinct prompts and propose a framework that integrates these prompts to develop a more robust, explainable, and reasoning-driven detection system. The code is available at https://github.com/Gennadiyev/mllm-defake.

Scientific discovery increasingly depends on efficient experimental optimization to navigate vast design spaces under time and resource constraints. Traditional approaches often require extensive domain expertise and feature engineering. While large language models, with their vast scientific knowledge, circumvent the feature engineering limitations, they lack the calibrated uncertainty estimates required for high-stakes decision making. Hence, current optimization methods force a choice between domain knowledge and reliability, with no principled approach that affords both. In this work, we show that training language models through the uncertainty-aware objectives of traditional optimization methods enables their use as reliable optimizers guided by natural language. By teaching LLMs from experimental outcomes under uncertainty, we transform their overconfidence from a fundamental limitation into a precise calibration mechanism. Applied to Buchwald-Hartwig reactions, a cornerstone of pharmaceutical synthesis, our method nearly doubles the discovery rate of high-yielding reaction conditions, from 24% to 43% in 50 experimental iterations starting from 10 unsuccessful conditions. Across 19 diverse optimization problems spanning organic synthesis, materials science and catalysis, process chemistry, and molecular design, our approach ranks first on average, establishing a new paradigm for reliable, uncertainty-guided optimization with LLMs. Our approach can accelerate discovery by lowering the barrier to using powerful optimization methods, replacing the need for domain-specific feature engineering with more accessible natural language interfaces. These findings highlight that ensuring reliability through principled uncertainty quantification is critical for realizing the full potential of AI-guided experimentation.

Disease diagnosis is a central pillar of modern healthcare, enabling early detection and timely intervention for acute conditions while guiding lifestyle adjustments and medication regimens to prevent or slow chronic disease. Self-reports preserve clinically salient signals that templated electronic health record (EHR) documentation often attenuates or omits, especially subtle but consequential details. To operationalize this shift, we introduce MIMIC-SR-ICD11, a large English diagnostic dataset built from EHR discharge notes and natively aligned to WHO ICD-11 terminology. We further present LL-Rank, a likelihood-based re-ranking framework that computes a length-normalized joint likelihood of each label given the clinical report context and subtracts the corresponding report-free prior likelihood for that label. Across seven model backbones, LL-Rank consistently outperforms a strong generation-plus-mapping baseline (GenMap). Ablation experiments show that LL-Rank's gains primarily stem from its PMI-based scoring, which isolates semantic compatibility from label frequency bias.

Predicting the effect of amino acid mutations on enzyme thermodynamic stability (DDG) is fundamental to protein engineering and drug design. While recent deep learning approaches have shown promise, they often process sequence and structure information independently, failing to capture the intricate coupling between local structural geometry and global sequential patterns. We present DGTN (Diffused Graph-Transformer Network), a novel architecture that co-learns graph neural network (GNN) weights for structural priors and transformer attention through a diffusion mechanism. Our key innovation is a bidirectional diffusion process where: (1) GNN-derived structural embeddings guide transformer attention via learnable diffusion kernels, and (2) transformer representations refine GNN message passing through attention-modulated graph updates. We provide rigorous mathematical analysis showing this co-learning scheme achieves provably better approximation bounds than independent processing. On ProTherm and SKEMPI benchmarks, DGTN achieves state-of-the-art performance (Pearson Rho = 0.87, RMSE = 1.21 kcal/mol), with 6.2% improvement over best baselines. Ablation studies confirm the diffusion mechanism contributes 4.8 points to correlation. Our theoretical analysis proves the diffused attention converges to optimal structure-sequence coupling, with convergence rate O(1/sqrt(T) ) where T is diffusion steps. This work establishes a principled framework for integrating heterogeneous protein representations through learnable diffusion.

As artificial intelligence (AI) systems become ubiquitous in professional contexts, there is an urgent need to equip workers, often with backgrounds outside of STEM, with the skills to use these tools effectively as well as responsibly, that is, to be AI literate. However, prevailing definitions and therefore assessments of AI literacy often emphasize foundational technical knowledge, such as programming, mathematics, and statistics, over practical knowledge such as interpreting model outputs, selecting tools, or identifying ethical concerns. This leaves a noticeable gap in assessing someone's AI literacy for real-world job use. We propose a work-task-oriented assessment model for AI literacy which is grounded in the competencies required for effective use of AI tools in professional settings. We describe the development of a novel AI literacy assessment instrument, and accompanying formative assessments, in the context of a US Navy robotics training program. The program included training in robotics and AI literacy, as well as a competition with practical tasks and a multiple choice scenario task meant to simulate use of AI in a job setting. We found that, as a measure of applied AI literacy, the competition's scenario task outperformed the tests we adopted from past research or developed ourselves. We argue that when training people for AI-related work, educators should consider evaluating them with instruments that emphasize highly contextualized practical skills rather than abstract technical knowledge, especially when preparing workers without technical backgrounds for AI-integrated roles.

Graph network-based simulators (GNS) have demonstrated strong potential for learning particle-based physics (such as fluids, deformable solids, and granular flows) while generalizing to unseen geometries due to their inherent inductive biases. However, existing models are typically trained for a single material type and fail to generalize across distinct constitutive behaviors, limiting their applicability in real-world engineering settings. Using granular flows as a running example, we propose a parameter-efficient conditioning mechanism that makes the GNS model adaptive to material parameters. We identify that sensitivity to material properties is concentrated in the early message-passing (MP) layers, a finding we link to the local nature of constitutive models (e.g., Mohr-Coulomb) and their effects on information propagation. We empirically validate this by showing that fine-tuning only the first few (1-5) of 10 MP layers of a pretrained model achieves comparable test performance as compared to fine-tuning the entire network. Building on this insight, we propose a parameter-efficient Feature-wise Linear Modulation (FiLM) conditioning mechanism designed to specifically target these early layers. This approach produces accurate long-term rollouts on unseen, interpolated, or moderately extrapolated values (e.g., up to 2.5 degrees for friction angle and 0.25 kPa for cohesion) when trained exclusively on as few as 12 short simulation trajectories from new materials, representing a 5-fold data reduction compared to a baseline multi-task learning method. Finally, we validate the model's utility by applying it to an inverse problem, successfully identifying unknown cohesion parameters from trajectory data. This approach enables the use of GNS in inverse design and closed-loop control tasks where material properties are treated as design variables.

Adaptive control seeks to design controllers that adapt to uncertain or unknown system dynamics. Rooted in early work on self-tuning regulators for flight and aerospace applications [ Astr om and Wittenmark, 1973, Astr om, 1983], it remains central to modern control. Among its formulations, the linear quadratic regulator (LQR) serves as a canonical benchmark due to its tractability and theoretical appeal. Extensive research over the last five or so years has established non-asymptotic performance guarantees for adaptive LQR through regret analysis [Abbasi-Yadkori and Szepesv ari, 2011, Dean et al., 2018, Cohen et al., 2019, Simchowitz and Foster, 2020, Hazan et al., 2020, Ziemann and Sandberg, 2022], proving that in the single-system setting the optimal expected regret scales as O( dT), with d = d

As artificial intelligence (AI) increasingly shapes decision-making across domains, there is a growing need to support AI literacy among learners beyond computer science. However, many current approaches rely on programming-heavy tools or abstract lecture-based content, limiting accessibility for non-STEM audiences. This paper presents findings from a study of AI User, a modular, web-based curriculum that teaches core AI concepts through interactive, no-code projects grounded in real-world scenarios. The curriculum includes eight projects; this study focuses on instructor feedback on Projects 5-8, which address applied topics such as natural language processing, computer vision, decision support, and responsible AI. Fifteen community college instructors participated in structured focus groups, completing the projects as learners and providing feedback through individual reflection and group discussion. Using thematic analysis, we examined how instructors evaluated the design, instructional value, and classroom applicability of these experiential activities. Findings highlight instructors' appreciation for exploratory tasks, role-based simulations, and real-world relevance, while also surfacing design trade-offs around cognitive load, guidance, and adaptability for diverse learners. This work extends prior research on AI literacy by centering instructor perspectives on teaching complex AI topics without code. It offers actionable insights for designing inclusive, experiential AI learning resources that scale across disciplines and learner backgrounds.

Natural flyers use soft wings to seamlessly enable a wide range of flight behaviours, including agile manoeuvres, squeezing through narrow passageways, and withstanding collisions. In contrast, conventional quadrotor designs rely on rigid frames that support agile flight but inherently limit collision resilience and squeezability, thereby constraining flight capabilities in cluttered environments. Inspired by the anisotropic stiffness and distributed mass-energy structures observed in biological organisms, we introduce FlexiQuad, a soft-frame quadrotor design approach that limits this trade-off. We demonstrate a 405-gram FlexiQuad prototype, three orders of magnitude more compliant than conventional quadrotors, yet capable of acrobatic manoeuvres with peak speeds above 80 km/h and linear and angular accelerations exceeding 3 g and 300 rad/s$^2$, respectively. Analysis demonstrates it can replicate accelerations of rigid counterparts up to a thrust-to-weight ratio of 8. Simultaneously, FlexiQuad exhibits fourfold higher collision resilience, surviving frontal impacts at 5 m/s without damage and reducing destabilising forces in glancing collisions by a factor of 39. Its frame can fully compress, enabling flight through gaps as narrow as 70% of its nominal width. Our analysis identifies an optimal structural softness range, from 0.006 to 0.77 N/mm, comparable to that of natural flyers' wings, whereby agility, squeezability, and collision resilience are jointly achieved for FlexiQuad models from 20 to 3000 grams. FlexiQuad expands hovering drone capabilities in complex environments, enabling robust physical interactions without compromising flight performance.