Inference attacks have been widely studied and offer a systematic risk assessment of ML services; however, their implementation and the attack parameters for optimal estimation are challenging for non-experts. The emergence of advanced large language models presents a promising yet largely unexplored opportunity to develop autonomous agents as inference attack experts, helping address this challenge. In this paper, we propose AttackPilot, an autonomous agent capable of independently conducting inference attacks without human intervention. We evaluate it on 20 target services. The evaluation shows that our agent, using GPT-4o, achieves a 100.0% task completion rate and near-expert attack performance, with an average token cost of only $0.627 per run. The agent can also be powered by many other representative LLMs and can adaptively optimize its strategy under service constraints. We further perform trace analysis, demonstrating that design choices, such as a multi-agent framework and task-specific action spaces, effectively mitigate errors such as bad plans, inability to follow instructions, task context loss, and hallucinations. We anticipate that such agents could empower non-expert ML service providers, auditors, or regulators to systematically assess the risks of ML services without requiring deep domain expertise.

Accurate diagnosis of spitzoid tumors (ST) is critical to ensure a favorable prognosis and to avoid both under- and over-treatment. Epigenetic data, particularly DNA methylation, provide a valuable source of information for this task. However, prior studies assume complete data, an unrealistic setting as methylation profiles frequently contain missing entries due to limited coverage and experimental artifacts. Our work challenges these favorable scenarios and introduces ReMAC, an extension of ReMasker designed to tackle classification tasks on high-dimensional data under complete and incomplete regimes. Evaluation on real clinical data demonstrates that ReMAC achieves strong and robust performance compared to competing classification methods in the stratification of ST. Code is available: https://github.com/roshni-mahtani/ReMAC.

Abstract-- Detecting driver drowsiness reliably is crucial for enhancing road safety and supporting advanced driver assistance systems (ADAS). We introduce the Eyelid Angle (ELA), a novel, reproducible metric of eye openness derived from 3D facial landmarks. Unlike conventional binary eye state estimators or 2D measures, such as the Eye Aspect Ratio (EAR), the ELA provides a stable geometric description of eyelid motion that is robust to variations in camera angle. Using the ELA, we design a blink detection framework that extracts temporal characteristics, including the closing, closed, and reopening durations, which are shown to correlate with drowsiness levels. T o address the scarcity and risk of collecting natural drowsiness data, we further leverage ELA signals to animate rigged avatars in Blender 3D, enabling the creation of realistic synthetic datasets with controllable noise, camera viewpoints, and blink dynamics. Experimental results in public driver monitoring datasets demonstrate that the ELA offers lower variance under viewpoint changes compared to EAR and achieves accurate blink detection. At the same time, synthetic augmentation expands the diversity of training data for drowsiness recognition. Our findings highlight the ELA as both a reliable biometric measure and a powerful tool for generating scalable datasets in driver state monitoring. URL: The link with the code will be made publicly available upon acceptance.

Traditional vision-based material perception methods often experience substantial performance degradation under visually impaired conditions, thereby motivating the shift toward non-visual multimodal material perception. Despite this, existing approaches frequently perform naive fusion of multimodal inputs, overlooking key challenges such as modality-specific noise, missing modalities common in real-world scenarios, and the dynamically varying importance of each modality depending on the task. These limitations lead to suboptimal performance across several benchmark tasks. In this paper, we propose a robust multimodal fusion framework, TouchFormer. Specifically, we employ a Modality-Adaptive Gating (MAG) mechanism and intra- and inter-modality attention mechanisms to adaptively integrate cross-modal features, enhancing model robustness. Additionally, we introduce a Cross-Instance Embedding Regularization(CER) strategy, which significantly improves classification accuracy in fine-grained subcategory material recognition tasks. Experimental results demonstrate that, compared to existing non-visual methods, the proposed TouchFormer framework achieves classification accuracy improvements of 2.48% and 6.83% on SSMC and USMC tasks, respectively. Furthermore, real-world robotic experiments validate TouchFormer's effectiveness in enabling robots to better perceive and interpret their environment, paving the way for its deployment in safety-critical applications such as emergency response and industrial automation. The code and datasets will be open-source, and the videos are available in the supplementary materials.

Mental health disorders, particularly cognitive disorders defined by deficits in cognitive abilities, are described in detail in the DSM-5, which includes definitions and examples of signs and symptoms. A simplified, machine-actionable representation was developed to assess the similarity and separability of these disorders, but it is not suited for the most complex cases. Generating or applying a full binary matrix for similarity calculations is infeasible due to the vast number of symptom combinations. This research develops an alternative representation that links the narrative form of the DSM-5 with the binary matrix representation and enables automated generation of valid symptom combinations. Using a strict pre-defined format of lists, sets, and numbers with slight variations, complex diagnostic pathways involving numerous symptom combinations can be represented. This format, called the symptom profile generator (or simply generator), provides a readable, adaptable, and comprehensive alternative to a binary matrix while enabling easy generation of symptom combinations (profiles). Cognitive disorders, which typically involve multiple diagnostic criteria with several symptoms, can thus be expressed as lists of generators. Representing several psychotic disorders in generator form and generating all symptom combinations showed that matrix representations of complex disorders become too large to manage. The MPCS (maximum pairwise cosine similarity) algorithm cannot handle matrices of this size, prompting the development of a profile reduction method using targeted generator manipulation to find specific MPCS values between disorders. The generators allow easier creation of binary representations for large matrices and make it possible to calculate specific MPCS cases between complex disorders through conditional generators.

Organic photovoltaic (OPV) materials offer a promising path toward sustainable energy generation, but their development is limited by the difficulty of identifying high performance donor and acceptor pairs with strong power conversion efficiencies (PCEs). Existing design strategies typically focus on either the donor or the acceptor alone, rather than using a unified approach capable of modeling both components. In this work, we introduce a dual machine learning framework for OPV discovery that combines predictive modeling with generative molecular design. We present the Organic Photovoltaic Donor Acceptor Dataset (OPV2D), the largest curated dataset of its kind, containing 2000 experimentally characterized donor acceptor pairs. Using this dataset, we develop the Organic Photovoltaic Classifier (OPVC) to predict whether a material exhibits OPV behavior, and a hierarchical graph neural network that incorporates multi task learning and donor acceptor interaction modeling. This framework includes the Molecular Orbital Energy Estimator (MOE2) for predicting HOMO and LUMO energy levels, and the Photovoltaic Performance Predictor (P3) for estimating PCE. In addition, we introduce the Material Generative Pretrained Transformer (MatGPT) to produce synthetically accessible organic semiconductors, guided by a reinforcement learning strategy with three objective policy optimization. By linking molecular representation learning with performance prediction, our framework advances data driven discovery of high performance OPV materials.

The rapid advancement of generators (e.g., StyleGAN, Midjourney, DALL-E) has produced highly realistic synthetic images, posing significant challenges to digital media authenticity. These generators are typically based on a few core architectural families, primarily Generative Adversarial Networks (GANs) and Diffusion Models (DMs). A critical vulnerability in current forensics is the failure of detectors to achieve cross-generator generalization, especially when crossing architectural boundaries (e.g., from GANs to DMs). We hypothesize that this gap stems from fundamental differences in the artifacts produced by these \textbf{distinct architectures}. In this work, we provide a theoretical analysis explaining how the distinct optimization objectives of the GAN and DM architectures lead to different manifold coverage behaviors. We demonstrate that GANs permit partial coverage, often leading to boundary artifacts, while DMs enforce complete coverage, resulting in over-smoothing patterns. Motivated by this analysis, we propose the \textbf{Tri}archy \textbf{Detect}or (TriDetect), a semi-supervised approach that enhances binary classification by discovering latent architectural patterns within the "fake" class. TriDetect employs balanced cluster assignment via the Sinkhorn-Knopp algorithm and a cross-view consistency mechanism, encouraging the model to learn fundamental architectural distincts. We evaluate our approach on two standard benchmarks and three in-the-wild datasets against 13 baselines to demonstrate its generalization capability to unseen generators.

Abstract--Large language models (LLMs) exhibit exceptional performance but pose substantial privacy risks due to training data memorization, particularly within healthcare contexts involving imperfect or privacy-sensitive patient information. We present a hierarchical dual-strategy framework for selective knowledge unlearning that precisely removes specialized knowledge while preserving fundamental medical competencies. Our approach synergistically integrates geometric-constrained gradient updates to selectively modulate target parameters with concept-aware token-level interventions that distinguish between preservation-critical and unlearning-targeted tokens via a unified four-level medical concept hierarchy. Comprehensive evaluations on the MedMCQA (surgical) and MHQA (anxiety, depression, trauma) datasets demonstrate superior performance, achieving an 82.7% forgetting rate and 88.5% knowledge preservation. Notably, our framework maintains robust privacy guarantees while requiring modification of only 0.1% of parameters, addressing critical needs for regulatory compliance, auditability, and ethical standards in clinical research. Large language models (LLMs) have transformed healthcare informatics, demonstrating remarkable capabilities in medical question-answering and clinical decision support. However, their deployment faces significant challenges when dealing with imperfect medical data, which is characteristically incomplete, insufficiently labelled, imbalanced, or contains annotation noise [4].

PeriodNet: Boosting the Potential of Attention Mechanism for Time Series Forecasting Bowen Zhao, Huanlai Xing, Zhiwen Xiao, Jincheng Peng, Li Feng, Xinhan Wang, Rong Qu, Hui Li The proposed PeriodNet hybridizes a period attention mechanism, an iterative grouping mechanism, and a period diffuser architecture to achieve accurate multivariate time series forecasting. The period attention mechanism captures temporal similarities among adjacent periods to improve time series modeling. The period diffuser architecture leverages multi-scale period features extracted by the encoder to enhance the accuracy and efficiency of time series forecasting. Abstract The attention mechanism has demonstrated remarkable potential in sequence modeling, exemplified by its successful application in natural language processing with models such as Bidirectional Encoder Representations from Transformers (BERT) and Generative Pre-trained Transformer (GPT). Despite these advancements, its utilization in time series forecasting (TSF) has yet to meet expectations. Exploring a better network structure for attention in TSF holds immense significance across various domains. In this paper, we present PeriodNet with a brand new structure to forecast univari-ate and multivariate time series. PeriodNet incorporates period attention and sparse period attention mechanism for analyzing adjacent periods. It enhances the mining of local characteristics, periodic patterns, and global dependencies. For efficient cross-variable modeling, we introduce an iterative grouping mechanism which can directly reduce the cross-variable redundancy. To fully leverage the extracted features on the encoder side, we redesign the entire architecture of the vanilla Transformer and propose a period diffuser for precise multi-period prediction. Through comprehensive experiments conducted on eight datasets, we demonstrate that PeriodNet outperforms six state-of-the-art models in both univariate and multivariate TSF scenarios in terms of mean square error and mean absolute error.

Open-world machine learning is an emerging technique in artificial intelligence, where conventional machine learning models often follow closed-world assumptions, which can hinder their ability to retain previously learned knowledge for future tasks. However, automated intelligence systems must learn about novel classes and previously known tasks. The proposed model offers novel learning classes in an open and continuous learning environment. It consists of two different but connected tasks. First, it discovers unknown classes in the data and creates novel classes; next, it learns how to perform class incrementally for each new class. Together, they enable continual learning, allowing the system to expand its understanding of the data and improve over time. The proposed model also outperformed existing approaches in open-world learning. Furthermore, it demonstrated strong performance in continuous learning, achieving a highest average accuracy of 82.54% over four iterations and a minimum accuracy of 65.87%.