Industry
CLEF: Clinically-Guided Contrastive Learning for Electrocardiogram Foundation Models
Shu, Yuxuan, Charlton, Peter H., Kawsar, Fahim, Hernesniemi, Jussi, Malekzadeh, Mohammad
The electrocardiogram (ECG) is a key diagnostic tool in cardiovascular health. Single-lead ECG recording is integrated into both clinical-grade and consumer wearables. While self-supervised pretraining of foundation models on unlabeled ECGs improves diagnostic performance, existing approaches do not incorporate domain knowledge from clinical metadata. We introduce a novel contrastive learning approach that utilizes an established clinical risk score to adaptively weight negative pairs: clinically-guided contrastive learning. It aligns the similarities of ECG embeddings with clinically meaningful differences between subjects, with an explicit mechanism to handle missing metadata. On 12-lead ECGs from 161K patients in the MIMIC-IV dataset, we pretrain single-lead ECG foundation models at three scales, collectively called CLEF, using only routinely collected metadata without requiring per-sample ECG annotations. We evaluate CLEF on 18 clinical classification and regression tasks across 7 held-out datasets, and benchmark against 5 foundation model baselines and 3 self-supervised algorithms. When pretrained on 12-lead ECG data and tested on lead-I data, CLEF outperforms self-supervised foundation model baselines: the medium-sized CLEF achieves average AUROC improvements of at least 2.6% in classification and average reductions in MAEs of at least 3.2% in regression. Comparing with existing self-supervised learning algorithms, CLEF improves the average AUROC by at least 1.8%. Moreover, when pretrained only on lead-I data for classification tasks, CLEF performs comparably to the state-of-the-art ECGFounder, which was trained in a supervised manner. Overall, CLEF enables more accurate and scalable single-lead ECG analysis, advancing remote health monitoring. Code and pretrained CLEF models are available at: github.com/Nokia-Bell-Labs/ecg-foundation-model.
SplatSuRe: Selective Super-Resolution for Multi-view Consistent 3D Gaussian Splatting
Asthana, Pranav, Hanson, Alex, Tu, Allen, Goldstein, Tom, Zwicker, Matthias, Varshney, Amitabh
3D Gaussian Splatting (3DGS) enables high-quality novel view synthesis, motivating interest in generating higher-resolution renders than those available during training. A natural strategy is to apply super-resolution (SR) to low-resolution (LR) input views, but independently enhancing each image introduces multi-view inconsistencies, leading to blurry renders. Prior methods attempt to mitigate these inconsistencies through learned neural components, temporally consistent video priors, or joint optimization on LR and SR views, but all uniformly apply SR across every image. In contrast, our key insight is that close-up LR views may contain high-frequency information for regions also captured in more distant views, and that we can use the camera pose relative to scene geometry to inform where to add SR content. Building from this insight, we propose SplatSuRe, a method that selectively applies SR content only in undersampled regions lacking high-frequency supervision, yielding sharper and more consistent results. Across Tanks & Temples, Deep Blending and Mip-NeRF 360, our approach surpasses baselines in both fidelity and perceptual quality. Notably, our gains are most significant in localized foreground regions where higher detail is desired.
Factor(T,U): Factored Cognition Strengthens Monitoring of Untrusted AI
Sandoval, Aaron, Rushing, Cody
The field of AI Control seeks to develop robust control protocols, deployment safeguards for untrusted AI which may be intentionally subversive. However, existing protocols that rely on weaker monitors to detect unsafe behavior often fail on complex tasks beyond the monitor's comprehension. We develop control protocols based on factored cognition, in which a trusted model decomposes a task, an untrusted model solves each resultant child task in isolation, and the results are reassembled into a full solution. These protocols may improve safety by several means, such as by simplifying the context for monitors, or by obscuring vulnerabilities in the environment. We implement our protocols in the APPS coding setting and red team them against backdoor attempts from an adversarial GPT-4.1 Nano. We find that: (i) Adding factored cognition to a trusted monitoring protocol can boost safety from 41% to 63%; (ii) Safety improves because monitor performance improves; (iii) Factored cognition makes it no harder for capable LLMs to write backdoors in APPS. While our protocols show low usefulness in APPS, they hold promise for more complex tasks.
How Market Volatility Shapes Algorithmic Collusion: A Comparative Analysis of Learning-Based Pricing Algorithms
Sravon, Aheer, Ibrahim, Md., Mazumder, Devdyuti, Aziz, Ridwan Al
The rapid diffusion of autonomous pricing algorithms has reshaped competitive dynamics in digital marketplaces, raising important economic and policy questions about their potential for collusive behavior. A substantial body of research demonstrates that reinforcement-learning (RL) agents can autonomously coordinate on supracompetitive outcomes even in the absence of explicit communication. Foundational contributions--including the work in [1]--show that algorithmic agents may systematically learn tacitly collusive strategies across multiple market structures, with Q-learning in particular generating prices above competitive levels in Logit, Hotelling, and linear demand environments. These concerns are reinforced by seminal work such as [2], which demonstrates that simple Q-learning agents reliably sustain collusion through structured punishment and reward cycles in repeated pricing games, as well as by [3], who document how algorithmic systems may generate sudden price spikes in response to high-impact, low-probability events (HILP), unintentionally coordinating on elevated prices. The study of [4] establishes a robust empirical and computational foundation demonstrating that pricing algorithms may autonomously learn to collude. A complementary line of research focuses specifically on Q-learning's capacity to learn collusive equilibria, as documented in papers [2], [5], and [6]. These findings are consistent with the theoretical properties of Q-learning established by [7], who show that the algorithm incrementally learns long-run discounted value-maximizing strategies in sequential decision problems. More recent studies further reveal that deep reinforcement-learning (deep RL) algorithms--including DDQN and SAC--may also display collusive tendencies. For instance, [8] documents that modern RL systems can coordinate on higher-than-competitive prices under a variety of market configurations.
Cross-View Topology-Aware Graph Representation Learning
Korkmaz, Ahmet Sami, Coskunuzer, Selim, Uddin, Md Joshem
Graph classification has gained significant attention due to its applications in chemistry, social networks, and bioinformatics. While Graph Neural Networks (GNNs) effectively capture local structural patterns, they often overlook global topological features that are critical for robust representation learning. In this work, we propose GraphTCL, a dual-view contrastive learning framework that integrates structural em-beddings from GNNs with topological embeddings derived from persistent homology. By aligning these complementary views through a cross-view contrastive loss, our method enhances representation quality and improves classification performance. Extensive experiments on benchmark datasets, including TU and OGB molecular graphs, demonstrate that GraphTCL consistently outperforms state-of-the-art baselines. This study highlights the importance of topology-aware contrastive learning for advancing graph representation methods.
Opening the Black Box: Nowcasting Singapore's GDP Growth and its Explainability
Timely assessment of current conditions is essential especially for small, open economies such as Singapore, where external shocks transmit rapidly to domestic activity. We develop a real-time nowcasting framework for quarterly GDP growth using a high-dimensional panel of approximately 70 indicators, encompassing economic and financial indicators over 1990Q1-2023Q2. The analysis covers penalized regressions, dimensionality-reduction methods, ensemble learning algorithms, and neural architectures, benchmarked against a Random Walk, an AR(3), and a Dynamic Factor Model. The pipeline preserves temporal ordering through an expanding-window walk-forward design with Bayesian hyperparameter optimization, and uses moving block-bootstrap procedures both to construct prediction intervals and to obtain confidence bands for feature-importance measures. It adopts model-specific and XAI-based explainability tools. A Model Confidence Set procedure identifies statistically superior learners, which are then combined through simple, weighted, and exponentially weighted schemes; the resulting time-varying weights provide an interpretable representation of model contributions. Predictive ability is assessed via Giacomini-White tests. Empirical results show that penalized regressions, dimensionality-reduction models, and GRU networks consistently outperform all benchmarks, with RMSFE reductions of roughly 40-60%; aggregation delivers further gains. Feature-attribution methods highlight industrial production, external trade, and labor-market indicators as dominant drivers of Singapore's short-run growth dynamics.
Comparing Baseline and Day-1 Diffusion MRI Using Multimodal Deep Embeddings for Stroke Outcome Prediction
Raeisadigh, Sina, Tan, Myles Joshua Toledo, Müller, Henning, Hedjoudje, Abderrahmane
This study compares baseline (J0) and 24-hour (J1) diffusion magnetic resonance imaging (MRI) for predicting three-month functional outcomes after acute ischemic stroke (AIS). Seventy-four AIS patients with paired apparent diffusion coefficient (ADC) scans and clinical data were analyzed. Three-dimensional ResNet-50 embeddings were fused with structured clinical variables, reduced via principal component analysis (<=12 components), and classified using linear support vector machines with eight-fold stratified group cross-validation. J1 multimodal models achieved the highest predictive performance (AUC = 0.923 +/- 0.085), outperforming J0-based configurations (AUC <= 0.86). Incorporating lesion-volume features further improved model stability and interpretability. These findings demonstrate that early post-treatment diffusion MRI provides superior prognostic value to pre-treatment imaging and that combining MRI, clinical, and lesion-volume features produces a robust and interpretable framework for predicting three-month functional outcomes in AIS patients.
From Betti Numbers to Persistence Diagrams: A Hybrid Quantum Algorithm for Topological Data Analysis
Persistence diagrams serve as a core tool in topological data analysis, playing a crucial role in pathological monitoring, drug discovery, and materials design. However, existing quantum topological algorithms, such as the LGZ algorithm, can only efficiently compute summary statistics like Betti numbers, failing to provide persistence diagram information that tracks the lifecycle of individual topological features, severely limiting their practical value. This paper proposes a novel quantum-classical hybrid algorithm that achieves, for the first time, the leap from "quantum computation of Betti numbers" to "quantum acquisition of practical persistence diagrams." The algorithm leverages the LGZ quantum algorithm as an efficient feature extractor, mining the harmonic form eigenvectors of the combinatorial Laplacian as well as Betti numbers, constructing specialized topological kernel functions to train a quantum support vector machine (QSVM), and learning the mapping from quantum topological features to persistence diagrams. The core contributions of this algorithm are: (1) elevating quantum topological computation from statistical summaries to pattern recognition, greatly expanding its application value; (2) obtaining more practical topological information in the form of persistence diagrams for real-world applications while maintaining the exponential speedup advantage of quantum computation; (3) proposing a novel hybrid paradigm of "classical precision guiding quantum efficiency." This method provides a feasible pathway for the practical implementation of quantum topological data analysis.
Robust Geospatial Coordination of Multi-Agent Communications Networks Under Attrition
Kent, Jonathan S., Stefani, Eliana, Plancher, Brian K.
Fast, efficient, robust communication during wildfire and other emergency responses is critical. One way to achieve this is by coordinating swarms of autonomous aerial vehicles carrying communications equipment to form an ad-hoc network connecting emergency response personnel to both each other and central command. However, operating in such extreme environments may lead to individual networking agents being damaged or rendered inoperable, which could bring down the network and interrupt communications. To overcome this challenge and enable multi-agent UAV networking in difficult environments, this paper introduces and formalizes the problem of Robust Task Networking Under Attrition (RTNUA), which extends connectivity maintenance in multi-robot systems to explicitly address proactive redundancy and attrition recovery. We introduce Physics-Informed Robust Employment of Multi-Agent Networks ($Φ$IREMAN), a topological algorithm leveraging physics-inspired potential fields to solve this problem. Through simulation across 25 problem configurations, $Φ$IREMAN consistently outperforms the DCCRS baseline, and on large-scale problems with up to 100 tasks and 500 drones, maintains $>99.9\%$ task uptime despite substantial attrition, demonstrating both effectiveness and scalability.
FDRMFL:Multi-modal Federated Feature Extraction Model Based on Information Maximization and Contrastive Learning
This study focuses on the feature extraction problem in multi-modal data regression. To address three core challenges in real-world scenarios: limited and non-IID data, effective extraction and fusion of multi-modal information, and susceptibility to catastrophic forgetting in model learning, a task-driven supervised multi-modal federated feature extraction method is proposed. The method integrates multi-modal information extraction and contrastive learning mechanisms, and can adapt to different neural network structures as the latent mapping functions for data of each modality. It supports each client to independently learn low-dimensional representations of multi-modal data, and can flexibly control the degree of retention of effective information about the response variable in the predictive variables within the low-dimensional features through parameter tuning. The multi-constraint learning framework constructed by the method guarantees regression accuracy using Mean Squared Error loss. Through the synergistic effect of mutual information preservation constraint, symmetric Kullback-Leibler divergence constraint, and inter-model contrastive constraint, it achieves the retention of task-related information, the extraction, fusion, and alignment of multi-modal features, and the mitigation of representation drift and catastrophic forgetting in non-IID scenarios, respectively. This ensures that the feature extraction process always centers on improving the performance of downstream regression tasks. Experimental results from simulations and real-world data analysis demonstrate that the proposed method achieves more significant performance improvement on downstream regression tasks compared with classical feature extraction techniques.