A targeted learning (TL) framework is developed to estimate the difference in the restricted mean survival time (RMST) for a clinical trial with time-to-event outcomes. The approach starts by defining the target estimand as the RMST difference between investigational and control treatments. Next, an efficient estimation method is introduced: a targeted minimum loss estimator (TMLE) utilizing pseudo-observations. Moreover, a version of the copy reference (CR) approach is developed to perform a sensitivity analysis for right-censoring. The proposed TL framework is demonstrated using a real data application.

Machine learning systems appear stochastic but are deterministically random, as seeded pseudorandom number generators produce identical realisations across repeated executions. Standard evaluation practice typically treats runs across alternatives as independent and does not exploit shared sources of randomness. This paper analyses the statistical structure of comparative evaluation under shared random seeds. Under this design, competing systems are evaluated using identical seeds, inducing matched stochastic realisations and yielding strict variance reduction whenever outcomes are positively correlated at the seed level. We demonstrate these effects using an extended learning-based multi-agent economic simulator, where paired evaluation exposes systematic differences in aggregate and distributional outcomes that remain statistically inconclusive under independent evaluation at fixed budgets.

Predicting Parkinson's Disease (PD) progression is crucial, and voice biomarkers offer a non-invasive method for tracking symptom severity (UPDRS scores) through telemonitoring. Analyzing this longitudinal data is challenging due to within-subject correlations and complex, nonlinear patient-specific progression patterns. This study benchmarks LMMs against two advanced hybrid approaches: the Generalized Neural Network Mixed Model (GNMM) (Mandel 2021), which embeds a neural network within a GLMM structure, and the Neural Mixed Effects (NME) model (Wortwein 2023), allowing nonlinear subject-specific parameters throughout the network. Using the Oxford Parkinson's telemonitoring voice dataset, we evaluate these models' performance in predicting Total UPDRS to offer practical guidance for PD research and clinical applications.

Elon Musk has suggested he could buy Ryanair and called for its chief executive to be fired amid a deepening spat between the pair. The budget airline on Tuesday branded the Tesla chief executive an idiot, and used the extraordinary row to promote its January sale. Musk and Ryanair boss Michael O'Leary have been trading insults over the past week after O'Leary rejected the idea of using Musk's Starlink technology to provide wi-fi on flights. The two are among the world's most outspoken business chiefs, with Musk the world's richest man with an estimated net worth of $769bn (£573bn), and O'Leary running Europe's busiest airline. A statement on Ryanair's X account on Tuesday evening said: Perhaps Musk needs a break?? Ryanair is launching a Great Idiots seat sale especially for Elon and any other idiots on'X'.

DIY Tech Hacks How to really spot AI-generated images, with Google's help Breakthroughs, discoveries, and DIY tips sent six days a week. It's harder than ever to tell AI-generated images from real photographs and illustrations produced by flesh-and-blood human beings. And in recent years, the fakery produced by AI models has become a lot more realistic and a lot more convincing. However, that doesn't mean it's impossible to spot AI pictures: There are still signs to watch out for, checks you can make, and tools you can use to distinguish the genuine from the synthetic. As is the case with AI-generated video, you don't have to give up just yet.

Scientists discover how a vitamin A byproduct may weaken immune responses against cancer, potentially explaining why some immunotherapies fail in patients.

'Veronika' Is the First Cow Known to Use a Tool This is the first recorded instance of a bovine using tools from her environment to relieve an itch--leaving scientists astonished. Justice for cartoonist Gary Larson: A team of scientists has observed, for the first time, a cow using a tool in a flexible manner. The ingenuity of "Veronika," as the animal is called, shows that cattle possess enough intelligence to manipulate elements of their environment and solve challenges they would otherwise be unable to overcome. Veronika is a pet cow in Austria. Nor was she trained to do tricks; on the contrary, for the past 10 years she has developed the ability to find branches in the grass, choose one, hold it with her mouth, and scratch herself with it to relieve skin irritation. Until now, only chimpanzees had convincingly demonstrated the ability to employ tools to improve their living conditions.

Stirling Distillery has two years to figure it out. Breakthroughs, discoveries, and DIY tips sent six days a week. Scotland's smallest whisky distillery also hopes to be one of the most innovative in time for its first batch's debut. But with only around two years until Sterling Distillery's inaugural liquor matures, it remains to be seen if the company can ditch traditional glass bottles for a material associated more with cheap beer than fine whisky--aluminum. Any serious distillery uses glass bottles for the good stuff.

The Industry I Offered to Take Less Money to Get Hired. In a rough hiring market, a growing number of younger, female job seekers have begun "lowballing" their salary expectations. I know this because I did it myself. If it feels impossible to get hired in today's job market, it's because it is. Greenhouse, a hiring software firm, estimates that when someone applies for a job, they now have a 0.4 percent chance of being hired--meaning you have a better chance of getting into Harvard than securing employment.

When you purchase through links in our articles, we may earn a small commission. Most floodlight cams need hardwired power, limiting your installation options. This battery-powered model can go anywhere, and it has a solar panel, too! Single floodlight isn't as bright as you get with hardwired models Despite a couple of minor bugs, this low-cost, battery-powered floodlight camera knocks it out of the park in most respects. The "Kit" in TP-Link Tapo C615F Kit refers to the inclusion of a solar panel that comes with this full-featured security camera/floodlight combo to keep its battery charged.