To enable robots to develop human-like fine manipulation, it is essential to understand how mechanical compliance, multi-modal sensing, and purposeful interaction jointly shape tactile perception. In this study, we use a dedicated modular e-Skin with tunable mechanical compliance and multi-modal sensing (normal, shear forces and vibrations) to systematically investigate how sensing embodiment and interaction strategies influence robotic perception of objects. Leveraging a curated set of soft wave objects with controlled viscoelastic and surface properties, we explore a rich set of palpation primitives-pressing, precession, sliding that vary indentation depth, frequency, and directionality. In addition, we propose the latent filter, an unsupervised, action-conditioned deep state-space model of the sophisticated interaction dynamics and infer causal mechanical properties into a structured latent space. This provides generalizable and in-depth interpretable representation of how embodiment and interaction determine and influence perception. Our investigation demonstrates that multi-modal sensing outperforms uni-modal sensing. It highlights a nuanced interaction between the environment and mechanical properties of e-Skin, which should be examined alongside the interaction by incorporating temporal dynamics.

Teleoperation of beyond-human-scale robotic manipulators (BHSRMs) presents unique challenges that differ fundamentally from conventional human-scale systems. As these platforms gain relevance in industrial domains such as construction, mining, and disaster response, immersive interfaces must be rethought to support scalable, safe, and effective human-robot collaboration. This paper investigates the control, cognitive, and interface-level challenges of immersive teleoperation in BHSRMs, with a focus on ensuring operator safety, minimizing sensorimotor mismatch, and enhancing the sense of embodiment. We analyze design trade-offs in haptic and visual feedback systems, supported by early experimental comparisons of exoskeleton- and joystick-based control setups. Finally, we outline key research directions for developing new evaluation tools, scaling strategies, and human-centered safety models tailored to large-scale robotic telepresence.

Despite the significant advancements in Large Language Models (LLMs), catastrophic forgetting remains a substantial challenge, where models lose previously acquired knowledge upon learning new information. Continual learning (CL) strategies have emerged as a potential solution to this problem, with replay-based techniques demonstrating superior performance in preserving learned knowledge. In this context, we introduce Gauss-Tin, a novel approach that integrates the replay strategy with a Gaussian mixture model to enhance the quality of sample selection during training, supplemented by instructional guidance to facilitate the generation of past learning. This method aims to improve LLMs' retention capabilities by strategically reinforcing important past learnings while accommodating new information. Our experimental results indicate a promising 6\% improvement in retention metrics over traditional methods, suggesting that Gauss-Tin is an effective strategy for mitigating catastrophic forgetting in LLMs. This study underscores the potential of hybrid models in enhancing the robustness and adaptability of LLMs in dynamic learning environments.

One of the key challenges to predict odor from molecular structure is unarguably our limited understanding of the odor space and the complexity of the underlying structure-odor relationships. Here, we show that the predictive performance of machine learning models for structure-based odor predictions can be improved using both, an expert and a data-driven odor taxonomy. The expert taxonomy is based on semantic and perceptual similarities, while the data-driven taxonomy is based on clustering co-occurrence patterns of odor descriptors directly from the prepared dataset. Both taxonomies improve the predictions of different machine learning models and outperform random groupings of descriptors that do not reflect existing relations between odor descriptors. We assess the quality of both taxonomies through their predictive performance across different odor classes and perform an in-depth error analysis highlighting the complexity of odor-structure relationships and identifying potential inconsistencies within the taxonomies by showcasing pear odorants used in perfumery. The data-driven taxonomy allows us to critically evaluate our expert taxonomy and better understand the molecular odor space. Both taxonomies as well as a full dataset are made available to the community, providing a stepping stone for a future community-driven exploration of the molecular basis of smell. In addition, we provide a detailed multi-layer expert taxonomy including a total of 777 different descriptors from the Pyrfume repository.

The GLUE benchmark consists of 8 (originally 9) tasks [Wang et al., 2018]. Hypothesis: "It has a buffet." CoLA (Corpus of Linguistic Acceptability) [8,551 train, 1,063 test] [Warstadt et al., 2019] is a "The higher the stakes, the lower his expectations are." The task is to classify the sentiment as either positive or negative [Socher et al., 2013]. Note that we excluded finetuning on the 9th GLUE task WNLI (Winograd NLI) [Levesque et al., We used the hyperparameters in Table S1 for finetuning all BERT and RapidBERT models.

Large language models (LLMs) are increasingly being applied to black-box optimization tasks, from program synthesis to molecule design. Prior work typically leverages in-context learning to iteratively guide the model towards better solutions. Such methods, however, often struggle to balance exploration of new solution spaces with exploitation of high-reward ones. Recently, test-time training (TTT) with synthetic data has shown promise in improving solution quality. However, the need for hand-crafted training data tailored to each task limits feasibility and scalability across domains. To address this problem, we introduce MiGrATe-a method for online TTT that uses GRPO as a search algorithm to adapt LLMs at inference without requiring external training data. MiGrATe operates via a mixed-policy group construction procedure that combines on-policy sampling with two off-policy data selection techniques: greedy sampling, which selects top-performing past completions, and neighborhood sampling (NS), which generates completions structurally similar to high-reward ones. Together, these components bias the policy gradient towards exploitation of promising regions in solution space, while preserving exploration through on-policy sampling. We evaluate MiGrATe on three challenging domains-word search, molecule optimization, and hypothesis+program induction on the Abstraction and Reasoning Corpus (ARC)-and find that it consistently outperforms both inference-only and TTT baselines, demonstrating the potential of online TTT as a solution for complex search tasks without external supervision.

Organic reaction, the foundation of modern chemical industry, is crucial for new material development and drug discovery. However, deciphering reaction mechanisms and modeling multi-molecular relationships remain formidable challenges due to the complexity of molecular dynamics. While several state-of-the-art models like Uni-Mol2 have revolutionized single-molecular representation learning, their extension to multi-molecular systems, where chemical reactions inherently occur, has been underexplored. This paper introduces Uni-Mol3, a novel deep learning framework that employs a hierarchical pipeline for multi-molecular reaction modeling. At its core, Uni-Mol3 adopts a multi-scale molecular tokenizer (Mol-Tokenizer) that encodes 3D structures of molecules and other features into discrete tokens, creating a 3D-aware molecular language. The framework innovatively combines two pre-training stages: molecular pre-training to learn the molecular grammars and reaction pre-training to capture fundamental reaction principles, forming a progressive learning paradigm from single- to multi-molecular systems. With prompt-aware downstream fine-tuning, Uni-Mol3 demonstrates exceptional performance in diverse organic reaction tasks and supports multi-task prediction with strong generalizability. Experimental results across 10 datasets spanning 4 downstream tasks show that Uni-Mol3 outperforms existing methods, validating its effectiveness in modeling complex organic reactions. This work not only ushers in an alternative paradigm for multi-molecular computational modeling but also charts a course for intelligent organic reaction by bridging molecular representation with reaction mechanism understanding.

The ability to engineer complex three-dimensional shapes from planar sheets with precise, programmable control underpins emerging technologies in soft robotics, reconfigurable devices, and functional materials. Here, we present a reduced-order numerical and experimental framework for a bilayer system consisting of a stimuli-responsive thermoplastic sheet (Shrinky Dink) bonded to a kirigami-patterned, inert plastic layer. Upon uniform heating, the active layer contracts while the patterned layer constrains in-plane stretch but allows out-of-plane bending, yielding programmable 3D morphologies from simple planar precursors. Our approach enables efficient computational design and scalable manufacturing of 3D forms with a single-layer reduced model that captures the coupled mechanics of stretching and bending. Unlike traditional bilayer modeling, our framework collapses the multilayer composite into a single layer of nodes and elements, reducing the degrees of freedom and enabling simulation on a 2D geometry. This is achieved by introducing a novel energy formulation that captures the coupling between in-plane stretch mismatch and out-of-plane bending - extending beyond simple isotropic linear elastic models. Experimentally, we establish a fully planar, repeatable fabrication protocol using a stimuli-responsive thermoplastic and a laser-cut inert plastic layer. The programmed strain mismatch drives an array of 3D morphologies, such as bowls, canoes, and flower petals, all verified by both simulation and physical prototypes.

Hyperspectral imaging (HSI) is an advanced sensing modality that simultaneously captures spatial and spectral information, enabling non-invasive, label-free analysis of material, chemical, and biological properties. This Primer presents a comprehensive overview of HSI, from the underlying physical principles and sensor architectures to key steps in data acquisition, calibration, and correction. We summarize common data structures and highlight classical and modern analysis methods, including dimensionality reduction, classification, spectral unmixing, and AI-driven techniques such as deep learning. Representative applications across Earth observation, precision agriculture, biomedicine, industrial inspection, cultural heritage, and security are also discussed, emphasizing HSI's ability to uncover sub-visual features for advanced monitoring, diagnostics, and decision-making. Persistent challenges, such as hardware trade-offs, acquisition variability, and the complexity of high-dimensional data, are examined alongside emerging solutions, including computational imaging, physics-informed modeling, cross-modal fusion, and self-supervised learning. Best practices for dataset sharing, reproducibility, and metadata documentation are further highlighted to support transparency and reuse. Looking ahead, we explore future directions toward scalable, real-time, and embedded HSI systems, driven by sensor miniaturization, self-supervised learning, and foundation models. As HSI evolves into a general-purpose, cross-disciplinary platform, it holds promise for transformative applications in science, technology, and society.

Large language model (LLM)-based multi-agent systems (MASs) are a recent but rapidly evolving technology with the potential to transform chemical engineering by decomposing complex workflows into teams of collaborative agents with specialized knowledge and tools. This review surveys the state-of-the-art of MAS within chemical engineering. While early studies demonstrate promising results, scientific challenges remain, including the design of tailored architectures, integration of heterogeneous data modalities, development of foundation models with domain-specific modalities, and strategies for ensuring transparency, safety, and environmental impact. As a young but fast-moving field, MASs offer exciting opportunities to rethink chemical engineering workflows.