Takeda's psoriasis pill developed with AI assistance succeeds in trials Psoriasis is a chronic autoimmune disorder that causes rashes marked by itchy, scaly rashes and afflicts more than 125 million people worldwide. Takeda Pharmaceutical announced that its oral psoriasis drug zasocitinib proved safe and effective in late-stage trials, marking a milestone in its effort to treat the incurable skin condition and offset looming revenue pressure. Patients with moderate-to-severe plaque psoriasis who took the once-daily pill showed significantly clearer skin compared with those on placebo or the existing therapy apremilast, the company said in a statement Thursday. Takeda plans to submit data to the U.S. Food and Drug Administration and other regulators beginning in fiscal year 2026. If approved, zasocitinib would join the small but growing oral psoriasis treatments -- long a market dominated by ointments and injectable antibody therapies -- and stand out as one of the first drugs discovered with the help of artificial intelligence.

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Knee osteoarthritis (KOA) affects more than 600 million individuals globally and is associated with significant pain, functional impairment, and disability. While personalized multidisciplinary interventions have the potential to slow disease progression and enhance quality of life, they typically require substantial medical resources and expertise, making them difficult to implement in resource-limited settings. To address this challenge, we developed KOM, a multi-agent system designed to automate KOA evaluation, risk prediction, and treatment prescription. This system assists clinicians in performing essential tasks across the KOA care pathway and supports the generation of tailored management plans based on individual patient profiles, disease status, risk factors, and contraindications. In benchmark experiments, KOM demonstrated superior performance compared to several general-purpose large language models in imaging analysis and prescription generation. A randomized three-arm simulation study further revealed that collaboration between KOM and clinicians reduced total diagnostic and planning time by 38.5% and resulted in improved treatment quality compared to each approach used independently. These findings indicate that KOM could help facilitate automated KOA management and, when integrated into clinical workflows, has the potential to enhance care efficiency. The modular architecture of KOM may also offer valuable insights for developing AI-assisted management systems for other chronic conditions.

Abstract--T cell receptor (TCR) repertoires encode critical immunological signatures for autoimmune diseases, yet their clinical application remains limited by sequence sparsity and low witness rates. We developed EAMil, a multi-instance deep learning framework that leverages TCR sequencing data to diagnose systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) with exceptional accuracy. By integrating Prime-Seq feature extraction with ESMonehot encoding and enhanced gate attention mechanisms, our model achieved state-of-the-art performance with AUCs of 98.95% for SLE and 97.76% for RA. EAMIL successfully identified disease-associated genes with over 90% concordance with established differential analyses and effectively distinguished disease-specific TCR genes. The model demonstrated robustness in classifying multiple disease categories, utilizing the SLEDAI score to stratify SLE patients by disease severity as well as to diagnose the site of damage in SLE patients, and effectively controlling for confounding factors such as age and gender . This interpretable framework for immune receptor analysis provides new insights for autoimmune disease detection and classification with broad potential clinical applications across immune-mediated conditions.

Realizing personalized medicine at scale calls for methods that distill insights from longitudinal patient journeys, which can be viewed as a sequence of medical events. Foundation models pretrained on large-scale medical event data represent a promising direction for scaling real-world evidence generation and generalizing to diverse downstream tasks. Using Epic Cosmos, a dataset with medical events from de-identified longitudinal health records for 16.3 billion encounters over 300 million unique patient records from 310 health systems, we introduce the Curiosity models, a family of decoder-only transformer models pretrained on 118 million patients representing 115 billion discrete medical events (151 billion tokens). We present the largest scaling-law study of medical event data, establishing a methodology for pretraining and revealing power-law scaling relationships for compute, tokens, and model size. Consequently, we pretrained a series of compute-optimal models with up to 1 billion parameters. Conditioned on a patient's real-world history, Curiosity autoregressively predicts the next medical event to simulate patient health timelines. We studied 78 real-world tasks, including diagnosis prediction, disease prognosis, and healthcare operations. Remarkably for a foundation model with generic pretraining and simulation-based inference, Curiosity generally outperformed or matched task-specific supervised models on these tasks, without requiring task-specific fine-tuning or few-shot examples. Curiosity's predictive power consistently improves as the model and pretraining scale. Our results show that Curiosity, a generative medical event foundation model, can effectively capture complex clinical dynamics, providing an extensible and generalizable framework to support clinical decision-making, streamline healthcare operations, and improve patient outcomes.

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented generation (RAG) has been widely adopted to address these limitations by supplementing model outputs with retrieved evidence. However, whether RAG reliably achieves these goals remains unclear. Here, we present the most comprehensive expert evaluation of RAG in medicine to date. Eighteen medical experts contributed a total of 80,502 annotations, assessing 800 model outputs generated by GPT-4o and Llama-3.1-8B across 200 real-world patient and USMLE-style queries. We systematically decomposed the RAG pipeline into three components: (i) evidence retrieval (relevance of retrieved passages), (ii) evidence selection (accuracy of evidence usage), and (iii) response generation (factuality and completeness of outputs). Contrary to expectation, standard RAG often degraded performance: only 22% of top-16 passages were relevant, evidence selection remained weak (precision 41-43%, recall 27-49%), and factuality and completeness dropped by up to 6% and 5%, respectively, compared with non-RAG variants. Retrieval and evidence selection remain key failure points for the model, contributing to the overall performance drop. We further show that simple yet effective strategies, including evidence filtering and query reformulation, substantially mitigate these issues, improving performance on MedMCQA and MedXpertQA by up to 12% and 8.2%, respectively. These findings call for re-examining RAG's role in medicine and highlight the importance of stage-aware evaluation and deliberate system design for reliable medical LLM applications.

Pressure ulcers (PUs) are a serious and prevalent healthcare concern. Accurate classification of PU severity (Stages I-IV) is essential for proper treatment but remains challenging due to subtle visual distinctions and subjective interpretation, leading to variability among clinicians. Prior AI-based approaches using Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) achieved promising accuracy but offered limited interpretability. We present FT-ARM (Fine-Tuned Agentic Reflection Multimodal model), a fine-tuned multimodal large language model (MLLM) with an agentic self-reflection mechanism for pressure ulcer severity classification. Inspired by clinician-style diagnostic reassessment, FT-ARM iteratively refines its predictions by reasoning over visual features and encoded clinical knowledge from text, enhancing both accuracy and consistency. On the publicly available Pressure Injury Image Dataset (PIID), FT-ARM, fine-tuned from LLaMA 3.2 90B, achieved 85% accuracy in classifying PU stages I-IV, surpassing prior CNN-based models by +4%. Unlike earlier CNN/ViT studies that relied solely on offline evaluations, FT-ARM is designed and tested for live inference, reflecting real-time deployment conditions. Furthermore, it produces clinically grounded natural-language explanations, improving interpretability and trust. By integrating fine-tuning and reflective reasoning across multimodal inputs, FT-ARM advances the reliability, transparency, and clinical applicability of automated wound assessment systems, addressing the critical need for consistent and explainable PU staging to support improved patient care.

Storytelling is a powerful form of communication and may provide insights into factors contributing to gaps in healthcare outcomes. To determine whether Large Language Models (LLMs) can identify potential underlying factors and avenues for intervention, we performed topic-aware hierarchical summarization of narratives from African American (AA) storytellers. Fifty transcribed stories of AA experiences were used to identify topics in their experience using the Latent Dirichlet Allocation (LDA) technique. Stories about a given topic were summarized using an open-source LLM-based hierarchical summarization approach. Topic summaries were generated by summarizing across story summaries for each story that addressed a given topic. Generated topic summaries were rated for fabrication, accuracy, comprehensiveness, and usefulness by the GPT4 model, and the model's reliability was validated against the original story summaries by two domain experts. 26 topics were identified in the fifty AA stories. The GPT4 ratings suggest that topic summaries were free from fabrication, highly accurate, comprehensive, and useful. The reliability of GPT ratings compared to expert assessments showed moderate to high agreement. Our approach identified AA experience-relevant topics such as health behaviors, interactions with medical team members, caregiving and symptom management, among others. Such insights could help researchers identify potential factors and interventions by learning from unstructured narratives in an efficient manner-leveraging the communicative power of storytelling. The use of LDA and LLMs to identify and summarize the experience of AA individuals suggests a variety of possible avenues for health research and possible clinical improvements to support patients and caregivers, thereby ultimately improving health outcomes.

This study presents AmarDoctor, a multilingual voice-interactive digital health app designed to provide comprehensive patient triage and AI-driven clinical decision support for Bengali speakers, a population largely underserved in access to digital healthcare. AmarDoctor adopts a data-driven approach to strengthen primary care delivery and enable personalized health management. While platforms such as AdaHealth, WebMD, Symptomate, and K-Health have become popular in recent years, they mainly serve European demographics and languages. AmarDoctor addresses this gap with a dual-interface system for both patients and healthcare providers, supporting three major Bengali dialects. At its core, the patient module uses an adaptive questioning algorithm to assess symptoms and guide users toward the appropriate specialist. To overcome digital literacy barriers, it integrates a voice-interactive AI assistant that navigates users through the app services. Complementing this, the clinician-facing interface incorporates AI-powered decision support that enhances workflow efficiency by generating structured provisional diagnoses and treatment recommendations. These outputs inform key services such as e-prescriptions, video consultations, and medical record management. To validate clinical accuracy, the system was evaluated against a gold-standard set of 185 clinical vignettes developed by experienced physicians. Effectiveness was further assessed by comparing AmarDoctor performance with five independent physicians using the same vignette set. Results showed AmarDoctor achieved a top-1 diagnostic precision of 81.08 percent (versus physicians average of 50.27 percent) and a top specialty recommendation precision of 91.35 percent (versus physicians average of 62.6 percent).

Bone health studies are crucial in medical practice for the early detection and treatment of Osteopenia and Osteoporosis. Clinicians usually make a diagnosis based on densitometry (DEXA scans) and other patient history. The applications of AI in this field are an ongoing research. Most of the successful methods for this task include Deep Learning models that rely on vision alone (DEXA / X-ray imagery) geared towards high prediction accuracy, where ex-plainability is disregarded and largely based on the post hoc assessment of input contributions. W e propose ProtoMedX, a multi-modal model that uses both DEXA scans of the lumbar spine and patient records. ProtoMedX's prototype-based architecture is explainable by design, crucial for medical applications, especially in the context of the upcoming EU AI Act, as it allows explicit analysis of the model's decisions, especially the ones that are incorrect. ProtoMedX demonstrates state-of-the-art performance in bone health classification while also providing explanations that can be visually understood by clinicians. Using our dataset of 4,160 real NHS patients, the proposed ProtoMedX achieves 87.58% accuracy in vision-only tasks and 89.8% in its multi-modal variant, both approaches surpassing existing published methods.