'Alien-cortical' mice: Can human brain cells grow inside animals? Share'Alien-cortical' mice: Can human brain cells grow inside animals? on social media In a laboratory in California, in the United States, mice are scurrying around their cages, as mice do. But inside their brains are millions of working human neurons. Researchers at Stanford University have implanted lab-grown human cells into mice genetically engineered to lack parts of their brains, including the cerebral cortex, the outer region that plays a major role in perception, movement, decision-making and attention. Putting human brain tissue inside an animal sounds like something out of Mary Shelley's Frankenstein, but how "human" are these mice, really?

A 24-year-old runner in the New York City Marathon collapsed and died just two miles from the finish line, despite being in perfect health, perfect shape, her father has said. Rachel Apa, from Lewisberry, Pennsylvania, was running on Sunday with the Parkinson's Foundation Champions to raise money and honor her grandfather who had the disease, she said in a fundraising page. It was Apa's first marathon, though she was an athlete and had trained for months, father Steve Apa told the New York Times. She died from rhabdomyolysis, a rare condition where muscles break down and poison the bloodstream, which can be brought on by overexertion, her father said. Near mile marker 24, Apa collapsed in Central Park and a bystander performed CPR before race medical staff arrived, race organiser New York Road Runners told the BBC's US partner CBS News.

Did the World Just Gain Hundreds of Millions of Alzheimer's Patients? A new definition of Alzheimer's includes people without symptoms. Experts are fiercely divided over whether that makes sense--and whether the new drugs really help. Many have heralded a golden age of Alzheimer's research, excited by the promise of new amyloid-targeting antibodies. Yet a large meta-study of such antibodies concluded that they probably result in "little to no difference" in the decline of memory and of cognitive ability. This July, some ten thousand people descended on London for the Alzheimer's Association International Conference. Another three thousand of us joined virtually. I'm an anthropologist, accustomed to conferences where croissants at coffee breaks count as a luxury. This one opened with six trumpeters dressed as Buckingham Palace guards, followed by dancers who discoed, vogued, and high-kicked through the history of British pop. After the first day's sessions, participants dispersed to parties; at one, singers in sequins belted out covers while someone played an illuminated, transparent violin. One night, the London Eye was lit purple to honor the people in attendance. The mood matched the spectacle. Joanne Pike, the Alzheimer's Association's president and C.E.O., announced that recent advances had brought the campaign against the disease to a "pivotal moment." Maria Carrillo, its chief science officer, hailed a groundswell of progress. That optimism followed decades of disappointment. Between 1974 and 2020, the U.S. government spent roughly twenty billion dollars on Alzheimer's research without seeing the approval of a single treatment designed to act on the disease's underlying biology, let alone stop or reverse its course. Today, Alzheimer's afflicts roughly one in nine Americans over sixty-five and, along with related dementias, has been estimated to cost the economy about three-quarters of a trillion dollars a year. In surveys, it ranks with cancer as the disease people fear most. It typically starts by robbing patients of recent memories--conversations they just had, where they put important objects--before corroding the basic functions of adult independence, from paying bills to managing medications. Eventually, it leaves patients unable to speak, move, swallow, or recognize close relatives.

You're viewing the US edition You can switch to the UK, AU or IE homepage at any time using this menu. The unspeakable materials stashed in Thomas Markle's storage unit that change everything. The other royals can't ignore this scandal any longer: MAUREEN CALLAHAN The Alexander brothers' secret lives behind bars: Bizarre group rituals, famous new friends and prison alliances... as family source reveals terrifying next fear after gruesome attack Inside the mysterious rise of midlife epilepsy: A growing number of adults are developing seizures later in life - now experts believe they know why... A little-known type of dementia leaves patients like Bruce Willis unrecognizable to their loved ones. These are the signs you have the gene... and why scientists believe one family holds the key to eradicating the disease Fears for Miley Cyrus: Friends reveal her battle for sobriety, 'power struggle' with fiancé who gave her the ick... and the tragic timing of Dolly Parton's death as she seeks help How, at the age of 53, after losing four stone on weight-loss jab'microdosing', I have become something of man magnet - and am finally getting the male attention I am so starved of by my husband Why are so many celebs dying of pancreatic cancer?

You're viewing the US edition You can switch to the UK, AU or IE homepage at any time using this menu. Election guru Nate Silver makes his final midterm elections prediction... giving the GOP a glimmer of hope: Live updates Daily Mail finds child pornography in Thomas Markle's Mexico storage unit: Explicit images and pedophilia magazines uncovered as we report him to the FBI How Jordon Hudson, 25, quietly amassed multi-million real estate empire while hooking up with the sports legend, 74 before'ditching him for new man' Female teacher, 36, is jailed for just five years after she admitted giving birth to 13-year-old student's child After a week from hell, enter'Meghan of the Manor' (in a Kate lookalike wardrobe). So is this proof she really IS in Britain to stay? That's what friends are telling ALISON BOSHOFF... but she desperately needs the help of one VERY connected woman The British student who sparked outrage in France by mocking shopkeeper victims of Paris riots on TV chat show ...

A biotech startup let an agent choose a gene therapy and successfully inject the treatment, offering a startling glimpse of the future of research labs. If you give an AI agent a robotic arm, an injector, and a live mouse, it might just perform brain surgery. Biotech founder Gabriel Ocana Santero recently did that using an agent to successfully carry out a brain injection procedure on a living mouse. Though it required some extra steps, it offers a glimpse into how AI could eventually become an active participant in laboratory research . Santero posted about the experiment on social media and tells WIRED he was interested in exploring what happens when AI agents are given direct access to lab equipment, rather than simply being asked to design experiments or analyze results.

In the 1960s, an odd experiment showed planarian worms could transfer memories by consuming each other. It was a sensational finding--that is, until the worms stopped learning. It was the dead of winter in Boston. The surface of the Charles River was frozen solid. But Zachary Kelso braved the biting cold to finally put to rest a mystery that has haunted neuroscience labs for over half a century. To do that, Kelso, a research assistant in the Harvard lab of the neuroscientist Sam Gershman, needed some worms . Specifically, planarians: arrow-headed flatworms, which are among the simplest creatures to possess a brain and a nervous system with bilateral symmetry like ours. Normally, labs order these widely used model organisms from biological supply companies.

You're viewing the US edition You can switch to the UK, AU or IE homepage at any time using this menu. The'real' Dan Sullivan erupts at'secret scheme to trick' voters in his Alaska Senate race as Trump blasts alleged Democrat gambit as'voter fraud at the highest level' Terrified neighbors of the iconic Hollywood Sign say they are living in fear... and they blame bungling Karen Bass and her ultra-woke rival There's already'tension' between Tom Brady and his new flame Candice Swanepoel, as friends make brutal'hookup' admission... and girl-on-girl Victoria's Secret feud erupts I know first-hand why MGK is giving Dakota Johnson the'best sex of her life'. Alexander brothers assaulted in prison: As rapist siblings are each jailed for 30 years, LUKE KENTON's devastating front-row account of day that sealed their fate - and moment the courtroom laughed in their faces Nicole Kidman is unrecognizable on her new Vogue cover. As a former fashion editor, I know the grotesque truth... and what the industry won't ever tell you: LIZ JONES Everyone says Trump and MAGA are doomed. But Obama's appalling new low and his cabal of Democrat idiots have just tipped this election on its head: MAUREEN CALLAHAN Donald Trump says Norway is a's***hole'.

Gift Ideas For Everyone On Your List Mashable's Best: E-readers, robovacs, laptops, earbuds, smart home and more Look Up Mashable @Home In My Bag Safety Net Versus Trending Now Say More Creator Playbook Mashable Selects Getting Technical with Mashable All Series The lawsuit says the chatbot helped her hide the plan from her doctors in the weeks before she died. Chance Townsend is the General Assignments Editor at Mashable, covering tech, video games, dating apps, digital culture, and whatever else comes his way. He has a Master's in Journalism from the University of North Texas and is a proud orange cat father. His writing has also appeared in PC Mag and . The parents of a 31-year-old Seattle woman are suing OpenAI, alleging the company's AI chatbot led to her death, according to a new report from .

You're viewing the US edition You can switch to the UK, AU or IE homepage at any time using this menu. Jaw-dropping new photos reveal most detailed look yet at Taylor Swift's wedding: Inside the reception... her scrapped carousel plans... and how they hid elaborate planning for months Trump labels Norway'a sh*thouse country' after he was overlooked for Nobel Peace Prize again America's military bases prepare for 90-day doomsday scenario Leaked Pentagon group chat reveals vulgar nickname for Trump-pick Army chief: Read texts laying bare ugly new war at very top of Pete Hegseth's department Tiny New York village home to just 2,600 people declared the'nicest place in America' RICHARD KAY: What insiders told me about whether Royals will reach out to Meghan and Harry. It's an opportunity to reconcile but there are risks - and the Palace is scrambling Bryan Kohberger's'passionate' prison calls amid shocking new bid for freedom... inside killer's state of mind and his chilling optimism to ...