Finding new ways to treat the novel coronavirus and its ever-changing variants has been a challenge for researchers, especially when the traditional drug development and discovery process can take years. A Michigan State University researcher and his team are taking a hi-tech approach to determine whether drugs already on the market can pull double duty in treating new COVID variants. "The COVID-19 virus is a challenge because it continues to evolve," said Bin Chen, an associate professor in the College of Human Medicine. "By using artificial intelligence and really large data sets, we can repurpose old drugs for new uses." Chen built an international team of researchers with expertise on topics ranging from biology to computer science to tackle this challenge.

The vast majority of FDA-approved medical devices enabled by artificial intelligence or machine learning are concentrated in radiology and cardiovascular care, according to an analysis by Rock Health. Rock Health used data from FDA clearances and approvals from 1997 to 2021 to determine where these devices are used the most. Here are the AI/machine-learning enabled devices by therapeutic area, the Oct. 8 report found:

An exoskeleton "boot" that allows people to walk 9% faster with 17% less effort has been developed by scientists. This robotic footwear comes with a motor that works with calf muscles to give the wearer an extra push with every step, researchers from Stanford University in the US said. The team said its work, which is published in the journal Nature, could help people with mobility impairments "move throughout the world as they like". Patrick Slade, who worked on the exoskeleton as a PhD student at the Stanford Biomechatronics Laboratory and is the first author on the study, told the PA news agency: "There are a number of clinical populations we hope to help including older adults, people with muscle weakness from a variety of conditions like stroke, and specific injury recoveries for things like achilles tendon strain. "We are starting to perform studies to explore the benefits of using our device with older adults.

To understand the potential of intelligent confirmatory tools, the U.S. Nuclear Regulatory Committee (NRC) initiated a future-focused research project to assess the regulatory viability of machine learning (ML) and artificial intelligence (AI)-driven Digital Twins (DTs) for nuclear power applications. Advanced accident tolerant fuel (ATF) is one of the priority focus areas of the U.S. Department of Energy (DOE). A DT framework can offer game-changing yet practical and informed solutions to the complex problem of qualifying advanced ATFs. Considering the regulatory standpoint of the modeling and simulation (M&S) aspect of DT, uncertainty quantification and sensitivity analysis are paramount to the DT framework's success in terms of multi-criteria and risk-informed decision-making. This chapter introduces the ML-based uncertainty quantification and sensitivity analysis methods while exhibiting actual applications to the finite element-based nuclear fuel performance code BISON.

Recent years have witnessed the rise of misinformation campaigns that spread specific narratives on social media to manipulate public opinions on different areas, such as politics and healthcare. Consequently, an effective and efficient automatic methodology to estimate the influence of the misinformation on user beliefs and activities is needed. However, existing works on misinformation impact estimation either rely on small-scale psychological experiments or can only discover the correlation between user behaviour and misinformation. To address these issues, in this paper, we build up a causal framework that model the causal effect of misinformation from the perspective of temporal point process. To adapt the large-scale data, we design an efficient yet precise way to estimate the Individual Treatment Effect (ITE) via neural temporal point process and gaussian mixture models. Extensive experiments on synthetic dataset verify the effectiveness and efficiency of our model. We further apply our model on a real-world dataset of social media posts and engagements about COVID-19 vaccines. The experimental results indicate that our model recognized identifiable causal effect of misinformation that hurts people's subjective emotions toward the vaccines.

We present a novel technique for hierarchical super resolution (SR) with neural networks (NNs), which upscales volumetric data represented with an octree data structure to a high-resolution uniform grid with minimal seam artifacts on octree node boundaries. Our method uses existing state-of-the-art SR models and adds flexibility to upscale input data with varying levels of detail across the domain, instead of only uniform grid data that are supported in previous approaches. The key is to use a hierarchy of SR NNs, each trained to perform 2x SR between two levels of detail, with a hierarchical SR algorithm that minimizes seam artifacts by starting from the coarsest level of detail and working up. We show that our hierarchical approach outperforms baseline interpolation and hierarchical upscaling methods, and demonstrate the usefulness of our proposed approach across three use cases including data reduction using hierarchical downsampling+SR instead of uniform downsampling+SR, computation savings for hierarchical finite-time Lyapunov exponent field calculation, and super-resolving low-resolution simulation results for a high-resolution approximation visualization.

We propose self-adaptive training -- a unified training algorithm that dynamically calibrates and enhances training processes by model predictions without incurring an extra computational cost -- to advance both supervised and self-supervised learning of deep neural networks. We analyze the training dynamics of deep networks on training data that are corrupted by, e.g., random noise and adversarial examples. Our analysis shows that model predictions are able to magnify useful underlying information in data and this phenomenon occurs broadly even in the absence of any label information, highlighting that model predictions could substantially benefit the training processes: self-adaptive training improves the generalization of deep networks under noise and enhances the self-supervised representation learning. The analysis also sheds light on understanding deep learning, e.g., a potential explanation of the recently-discovered double-descent phenomenon in empirical risk minimization and the collapsing issue of the state-of-the-art self-supervised learning algorithms. Experiments on the CIFAR, STL, and ImageNet datasets verify the effectiveness of our approach in three applications: classification with label noise, selective classification, and linear evaluation. To facilitate future research, the code has been made publicly available at https://github.com/LayneH/self-adaptive-training.

5G and beyond mobile networks will support heterogeneous use cases at an unprecedented scale, thus demanding automated control and optimization of network functionalities customized to the needs of individual users. Such fine-grained control of the Radio Access Network (RAN) is not possible with the current cellular architecture. To fill this gap, the Open RAN paradigm and its specification introduce an open architecture with abstractions that enable closed-loop control and provide data-driven, and intelligent optimization of the RAN at the user level. This is obtained through custom RAN control applications (i.e., xApps) deployed on near-real-time RAN Intelligent Controller (near-RT RIC) at the edge of the network. Despite these premises, as of today the research community lacks a sandbox to build data-driven xApps, and create large-scale datasets for effective AI training. In this paper, we address this by introducing ns-O-RAN, a software framework that integrates a real-world, production-grade near-RT RIC with a 3GPP-based simulated environment on ns-3, enabling the development of xApps and automated large-scale data collection and testing of Deep Reinforcement Learning-driven control policies for the optimization at the user-level. In addition, we propose the first user-specific O-RAN Traffic Steering (TS) intelligent handover framework. It uses Random Ensemble Mixture, combined with a state-of-the-art Convolutional Neural Network architecture, to optimally assign a serving base station to each user in the network. Our TS xApp, trained with more than 40 million data points collected by ns-O-RAN, runs on the near-RT RIC and controls its base stations. We evaluate the performance on a large-scale deployment, showing that the xApp-based handover improves throughput and spectral efficiency by an average of 50% over traditional handover heuristics, with less mobility overhead.

Several benchmarks have been built with heavy investment in resources to track our progress in NLP. Thousands of papers published in response to those benchmarks have competed to top leaderboards, with models often surpassing human performance. However, recent studies have shown that models triumph over several popular benchmarks just by overfitting on spurious biases, without truly learning the desired task. Despite this finding, benchmarking, while trying to tackle bias, still relies on workarounds, which do not fully utilize the resources invested in benchmark creation, due to the discarding of low quality data, and cover limited sets of bias. A potential solution to these issues -- a metric quantifying quality -- remains underexplored. Inspired by successful quality indices in several domains such as power, food, and water, we take the first step towards a metric by identifying certain language properties that can represent various possible interactions leading to biases in a benchmark. We look for bias related parameters which can potentially help pave our way towards the metric. We survey existing works and identify parameters capturing various properties of bias, their origins, types and impact on performance, generalization, and robustness. Our analysis spans over datasets and a hierarchy of tasks ranging from NLI to Summarization, ensuring that our parameters are generic and are not overfitted towards a specific task or dataset. We also develop certain parameters in this process.

Latest advances in Super-Resolution (SR) have been tested with general purpose images such as faces, landscapes and objects, mainly unused for the task of super-resolving Earth Observation (EO) images. In this research paper, we benchmark state-of-the-art SR algorithms for distinct EO datasets using both Full-Reference and No-Reference Image Quality Assessment (IQA) metrics. We also propose a novel Quality Metric Regression Network (QMRNet) that is able to predict quality (as a No-Reference metric) by training on any property of the image (i.e. its resolution, its distortions...) and also able to optimize SR algorithms for a specific metric objective. This work is part of the implementation of the framework IQUAFLOW which has been developed for evaluating image quality, detection and classification of objects as well as image compression in EO use cases. We integrated our experimentation and tested our QMRNet algorithm on predicting features like blur, sharpness, snr, rer and ground sampling distance (GSD) and obtain validation medRs below 1.0 (out of N=50) and recall rates above 95\%. Overall benchmark shows promising results for LIIF, CAR and MSRN and also the potential use of QMRNet as Loss for optimizing SR predictions. Due to its simplicity, QMRNet could also be used for other use cases and image domains, as its architecture and data processing is fully scalable.