No political deepfake has alarmed the world's disinformation experts more than the doctored audio message of U.S. President Joe Biden that began circulating over the weekend. In the phone message, a voice edited to sound like Biden urged voters in New Hampshire not to cast their ballots in Tuesday's Democratic primary. "Save your vote for the November election," the phone message went.

A new front opened in Russia's war on Ukraine that highlights the vulnerability of oil exports from the nation's western ports, after reports of drone attacks against facilities on the Baltic coast. Last week, the first ever Ukrainian drone reached Russia's Leningrad region, approximately 1,000 kilometers (620 miles) from the border. The aircraft was downed over the privately-owned Petersburg Oil Terminal without causing damage, according to Russian authorities. A second drone attack on Sunday, which an official with knowledge of the matter said was organized by Ukraine's secret services, was more disruptive. It caused a fire that shut down a Novatek PJSC gas-condensate plant in port of Ust-Luga that supplied fuel to the Russian army, they stated with the condition of anonymity.

This paper presents Climinator, a novel AI-based tool designed to automate the fact-checking of climate change claims. Utilizing an array of Large Language Models (LLMs) informed by authoritative sources like the IPCC reports and peer-reviewed scientific literature, Climinator employs an innovative Mediator-Advocate framework. This design allows Climinator to effectively synthesize varying scientific perspectives, leading to robust, evidence-based evaluations. Our model demonstrates remarkable accuracy when testing claims collected from Climate Feedback and Skeptical Science. Notably, when integrating an advocate with a climate science denial perspective in our framework, Climinator's iterative debate process reliably converges towards scientific consensus, underscoring its adeptness at reconciling diverse viewpoints into science-based, factual conclusions. While our research is subject to certain limitations and necessitates careful interpretation, our approach holds significant potential. We hope to stimulate further research and encourage exploring its applicability in other contexts, including political fact-checking and legal domains.

Most traditional AI safety research has approached AI models as machines and centered on algorithm-focused attacks developed by security experts. As large language models (LLMs) become increasingly common and competent, non-expert users can also impose risks during daily interactions. This paper introduces a new perspective to jailbreak LLMs as human-like communicators, to explore this overlooked intersection between everyday language interaction and AI safety. Specifically, we study how to persuade LLMs to jailbreak them. First, we propose a persuasion taxonomy derived from decades of social science research. Then, we apply the taxonomy to automatically generate interpretable persuasive adversarial prompts (PAP) to jailbreak LLMs. Results show that persuasion significantly increases the jailbreak performance across all risk categories: PAP consistently achieves an attack success rate of over $92\%$ on Llama 2-7b Chat, GPT-3.5, and GPT-4 in $10$ trials, surpassing recent algorithm-focused attacks. On the defense side, we explore various mechanisms against PAP and, found a significant gap in existing defenses, and advocate for more fundamental mitigation for highly interactive LLMs

However, these texts do not provide any guidelines that specify and detail the relationship between AI standards and fundamental rights, its meaning or implication. This chapter aims to clarify this critical regulatory blind spot. The main issue tackled is whether the adoption of AI harmonised standards, based on the future AI Act, should take into account fundamental rights. In our view, the response is yes. The high risks posed by certain AI systems relate in particular to infringements of fundamental rights. Therefore, mitigating such risks involves fundamental rights considerations and this is what future harmonised standards should reflect. At the same time, valid criticisms of the European standardisation process have to be addressed. Finally, the practical incorporation of fundamental rights considerations in the ongoing European standardisation of AI systems is discussed.

Non-significant randomized control trials can hide subgroups of good responders to experimental drugs, thus hindering subsequent development. Identifying such heterogeneous treatment effects is key for precision medicine and many post-hoc analysis methods have been developed for that purpose. While several benchmarks have been carried out to identify the strengths and weaknesses of these methods, notably for binary and continuous endpoints, similar systematic empirical evaluation of subgroup analysis for time-to-event endpoints are lacking. This work aims to fill this gap by evaluating several subgroup analysis algorithms in the context of time-to-event outcomes, by means of three different research questions: Is there heterogeneity? What are the biomarkers responsible for such heterogeneity? Who are the good responders to treatment? In this context, we propose a new synthetic and semi-synthetic data generation process that allows one to explore a wide range of heterogeneity scenarios with precise control on the level of heterogeneity. We provide an open source Python package, available on Github, containing our generation process and our comprehensive benchmark framework. We hope this package will be useful to the research community for future investigations of heterogeneity of treatment effects and subgroup analysis methods benchmarking.

Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate relevant, accurate, helpful, and unharmful responses to lab test-related questions asked by patients and to identify potential issues that can be mitigated with augmentation approaches. We first collected lab test results related question and answer data from Yahoo! Answers and selected 53 QA pairs for this study. Using the LangChain framework and ChatGPT web portal, we generated responses to the 53 questions from four LLMs including GPT-4, Meta LLaMA 2, MedAlpaca, and ORCA_mini. We first assessed the similarity of their answers using standard QA similarity-based evaluation metrics including ROUGE, BLEU, METEOR, BERTScore. We also utilized an LLM-based evaluator to judge whether a target model has higher quality in terms of relevance, correctness, helpfulness, and safety than the baseline model. Finally, we performed a manual evaluation with medical experts for all the responses to seven selected questions on the same four aspects. The results of Win Rate and medical expert evaluation both showed that GPT-4's responses achieved better scores than all the other LLM responses and human responses on all four aspects (relevance, correctness, helpfulness, and safety). However, LLM responses occasionally also suffer from a lack of interpretation in one's medical context, incorrect statements, and lack of references. We find that compared to other three LLMs and human answer from the Q&A website, GPT-4's responses are more accurate, helpful, relevant, and safer. However, there are cases which GPT-4 responses are inaccurate and not individualized. We identified a number of ways to improve the quality of LLM responses.

Organizations including companies, nonprofits, governments, and academic institutions are increasingly developing, deploying, and utilizing artificial intelligence (AI) tools. Responsible AI (RAI) governance approaches at organizations have emerged as important mechanisms to address potential AI risks and harms. In this work, we interviewed 17 technical contributors across organization types (Academic, Government, Industry, Nonprofit) and sectors (Finance, Health, Tech, Other) about their experiences with internal RAI governance. Our findings illuminated the variety of organizational definitions of RAI and accompanying internal governance approaches. We summarized the first detailed findings on algorithm review boards (ARBs) and similar review committees in practice, including their membership, scope, and measures of success. We confirmed known robust model governance in finance sectors and revealed extensive algorithm and AI governance with ARB-like review boards in health sectors. Our findings contradict the idea that Institutional Review Boards alone are sufficient for algorithm governance and posit that ARBs are among the more impactful internal RAI governance approaches. Our results suggest that integration with existing internal regulatory approaches and leadership buy-in are among the most important attributes for success and that financial tensions are the greatest challenge to effective organizational RAI. We make a variety of suggestions for how organizational partners can learn from these findings when building their own internal RAI frameworks. We outline future directions for developing and measuring effectiveness of ARBs and other internal RAI governance approaches.

Topological data analysis (TDA) is gaining prominence across a wide spectrum of machine learning tasks that spans from manifold learning to graph classification. A pivotal technique within TDA is persistent homology (PH), which furnishes an exclusive topological imprint of data by tracing the evolution of latent structures as a scale parameter changes. Present PH tools are confined to analyzing data through a single filter parameter. However, many scenarios necessitate the consideration of multiple relevant parameters to attain finer insights into the data. We address this issue by introducing the Effective Multidimensional Persistence (EMP) framework. This framework empowers the exploration of data by simultaneously varying multiple scale parameters. The framework integrates descriptor functions into the analysis process, yielding a highly expressive data summary. It seamlessly integrates established single PH summaries into multidimensional counterparts like EMP Landscapes, Silhouettes, Images, and Surfaces. These summaries represent data's multidimensional aspects as matrices and arrays, aligning effectively with diverse ML models. We provide theoretical guarantees and stability proofs for EMP summaries. We demonstrate EMP's utility in graph classification tasks, showing its effectiveness. Results reveal that EMP enhances various single PH descriptors, outperforming cutting-edge methods on multiple benchmark datasets.

A species' genetic code or genome encodes valuable evolutionary, biological, and phylogenetic information that aids in species recognition, taxonomic classification, and understanding genetic predispositions like drug resistance and virulence. However, the vast number of potential species poses significant challenges in developing a general-purpose whole genome classification tool. Traditional bioinformatics tools have made notable progress but lack scalability and are computationally expensive. Machine learning-based frameworks show promise but must address the issue of large classification vocabularies with long-tail distributions. In this study, we propose addressing this problem through zero-shot learning using TEPI, Taxonomy-aware Embedding and Pseudo-Imaging. We represent each genome as pseudo-images and map them to a taxonomy-aware embedding space for reasoning and classification. This embedding space captures compositional and phylogenetic relationships of species, enabling predictions in extensive search spaces. We evaluate TEPI using two rigorous zero-shot settings and demonstrate its generalization capabilities qualitatively on curated, large-scale, publicly sourced data.