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Adaptive-TMLE for the Average Treatment Effect based on Randomized Controlled Trial Augmented with Real-World Data
van der Laan, Mark, Qiu, Sky, van der Laan, Lars
We consider the problem of estimating the average treatment effect (ATE) when both randomized control trial (RCT) data and real-world data (RWD) are available. We decompose the ATE estimand as the difference between a pooled-ATE estimand that integrates RCT and RWD and a bias estimand that captures the conditional effect of RCT enrollment on the outcome. We introduce an adaptive targeted minimum loss-based estimation (A-TMLE) framework to estimate them. We prove that the A-TMLE estimator is root-n-consistent and asymptotically normal. Moreover, in finite sample, it achieves the super-efficiency one would obtain had one known the oracle model for the conditional effect of the RCT enrollment on the outcome. Consequently, the smaller the working model of the bias induced by the RWD is, the greater our estimator's efficiency, while our estimator will always be at least as efficient as an efficient estimator that uses the RCT data only. A-TMLE outperforms existing methods in simulations by having smaller mean-squared-error and 95% confidence intervals. A-TMLE could help utilize RWD to improve the efficiency of randomized trial results without biasing the estimates of intervention effects. This approach could allow for smaller, faster trials, decreasing the time until patients can receive effective treatments.
Making deepfake images is increasingly easy โ controlling their use is proving all but impossible
"Very creepy," was April's first thought when she saw her face on a generative AI website. April is one half of the Maddison twins. She and her sister Amelia make content for OnlyFans, Instagram and other platforms, but they also existed as a custom generative AI model โ made without their consent. "It was really weird to see our faces, but not really our faces," she says. Deepfakes โ the creation of realistic but false imagery, video and audio using artificial intelligence โ is on the political agenda after the federal government announced last week it would introduce legislation to ban the creation and sharing of deepfake pornography as part of measures to combat violence against women.
Microsoft Deploys Generative AI for US Spies
Law enforcement in the United States, United Kingdom, and Australia this week named a Russian national as the person behind LockBitSupp, the pseudonym of the leader of the LockBit ransomware gang that the US says is responsible for extracting 500 million from its victims. Dmitry Yuryevich Khoroshev has been sanctioned and charged with 26 criminal counts in the US, which combined could result in a prison sentence of 185 years. That is, if he's ever arrested and successfully prosecuted--an extremely rare event for suspects who live in Russia. Elsewhere in the world of cybercrime, WIRED's Andy Greenberg interviewed a representative of Cyber Army of Russia, a group of hackers who have targeted water utilities in the US and Europe and are said to have ties to the notorious Russian military hacking unit known as Sandworm. The responses from Cyber Army of Russia were littered with pro-Kremlin talking points--and some curious admissions.
Top secret Iranian drone site used by IRGC, terror proxies exposed by opposition group
IDF Special Operations veteran Aaron Cohen and executive director of The Lawfare Project Brooke Goldstein react to Israel's'limited' retaliatory strike on Iran on'Hannity.' The People's Mojahedin Organization of Iran (MEK), an exiled Iranian resistance group, provided a report to Fox News Digital presenting evidence of a top-secret unmanned aerial vehicle (UAV) site in the Islamic Republic of Iran, north of Qom City in the Ganjine region. According to the report, members of the Islamic Revolutionary Guard Corps (IRGC) are trained to use "all kinds of drones" at the base, including the Mohajer series, manufactured by Qods Aviation Industry. Employees of Qods Aviation Industry also reportedly use the site to train small groups of Iranian proxy operatives of Hezbollah, as well as members of Iranian proxy groups from Syria, Yemen and Iraq, to use the Mohajer-4 drone platform. The National Council of Resistance of Iran (NCRI), based on information from the MEK, told Fox News Digital that the site is a proving ground for Mohajer-4, Mohajer-6, and Mohajer-10 drones.
Deciphering public attention to geoengineering and climate issues using machine learning and dynamic analysis
Debnath, Ramit, Zhang, Pengyu, Qin, Tianzhu, Alvarez, R. Michael, Fitzgerald, Shaun D.
As the conversation around using geoengineering to combat climate change intensifies, it is imperative to engage the public and deeply understand their perspectives on geoengineering research, development, and potential deployment. Through a comprehensive data-driven investigation, this paper explores the types of news that captivate public interest in geoengineering. We delved into 30,773 English-language news articles from the BBC and the New York Times, combined with Google Trends data spanning 2018 to 2022, to explore how public interest in geoengineering fluctuates in response to news coverage of broader climate issues. Using BERT-based topic modeling, sentiment analysis, and time-series regression models, we found that positive sentiment in energy-related news serves as a good predictor of heightened public interest in geoengineering, a trend that persists over time. Our findings suggest that public engagement with geoengineering and climate action is not uniform, with some topics being more potent in shaping interest over time, such as climate news related to energy, disasters, and politics. Understanding these patterns is crucial for scientists, policymakers, and educators aiming to craft effective strategies for engaging with the public and fostering dialogue around emerging climate technologies.
A Robust Governance for the AI Act: AI Office, AI Board, Scientific Panel, and National Authorities
Novelli, Claudio, Hacker, Philipp, Morley, Jessica, Trondal, Jarle, Floridi, Luciano
Regulation is nothing without enforcement. This particularly holds for the dynamic field of emerging technologies. Hence, this article has two ambitions. First, it explains how the EU s new Artificial Intelligence Act (AIA) will be implemented and enforced by various institutional bodies, thus clarifying the governance framework of the AIA. Second, it proposes a normative model of governance, providing recommendations to ensure uniform and coordinated execution of the AIA and the fulfilment of the legislation. Taken together, the article explores how the AIA may be implemented by national and EU institutional bodies, encompassing longstanding bodies, such as the European Commission, and those newly established under the AIA, such as the AI Office. It investigates their roles across supranational and national levels, emphasizing how EU regulations influence institutional structures and operations. These regulations may not only directly dictate the structural design of institutions but also indirectly request administrative capacities needed to enforce the AIA.
Catastrophe Insurance: An Adaptive Robust Optimization Approach
Bertsimas, Dimitris, Zeng, Cynthia
The escalating frequency and severity of natural disasters, exacerbated by climate change, underscore the critical role of insurance in facilitating recovery and promoting investments in risk reduction. This work introduces a novel Adaptive Robust Optimization (ARO) framework tailored for the calculation of catastrophe insurance premiums, with a case study applied to the United States National Flood Insurance Program (NFIP). To the best of our knowledge, it is the first time an ARO approach has been applied to for disaster insurance pricing. Our methodology is designed to protect against both historical and emerging risks, the latter predicted by machine learning models, thus directly incorporating amplified risks induced by climate change. Using the US flood insurance data as a case study, optimization models demonstrate effectiveness in covering losses and produce surpluses, with a smooth balance transition through parameter fine-tuning. Among tested optimization models, results show ARO models with conservative parameter values achieving low number of insolvent states with the least insurance premium charged. Overall, optimization frameworks offer versatility and generalizability, making it adaptable to a variety of natural disaster scenarios, such as wildfires, droughts, etc. This work not only advances the field of insurance premium modeling but also serves as a vital tool for policymakers and stakeholders in building resilience to the growing risks of natural catastrophes.
Automating Thematic Analysis: How LLMs Analyse Controversial Topics
Khan, Awais Hameed, Kegalle, Hiruni, D'Silva, Rhea, Watt, Ned, Whelan-Shamy, Daniel, Ghahremanlou, Lida, Magee, Liam
Large Language Models (LLMs) are promising analytical tools. They can augment human epistemic, cognitive and reasoning abilities, and support'sensemaking' - making sense of a complex environment or subject - by analysing large volumes of data with a sensitivity to context and nuance absent in earlier text processing systems. This paper presents a pilot experiment that explores how LLMs can support thematic analysis of controversial topics. We compare how human researchers and two LLMs (GPT-4 and Llama 2) categorise excerpts from media coverage of the controversial Australian Robodebt scandal. Our findings highlight intriguing overlaps and variances in thematic categorisation between human and machine agents, and suggest where LLMs can be effective in supporting forms of discourse and thematic analysis. We argue LLMs should be used to augment - and not replace - human interpretation, and we add further methodological insights and reflections to existing research on the application of automation to qualitative research methods. We also introduce a novel card-based design toolkit, for both researchers and practitioners to further interrogate LLMs as analytical tools.
Length-Aware Multi-Kernel Transformer for Long Document Classification
Han, Guangzeng, Tsao, Jack, Huang, Xiaolei
Lengthy documents pose a unique challenge to neural language models due to substantial memory consumption. While existing state-of-the-art (SOTA) models segment long texts into equal-length snippets (e.g., 128 tokens per snippet) or deploy sparse attention networks, these methods have new challenges of context fragmentation and generalizability due to sentence boundaries and varying text lengths. For example, our empirical analysis has shown that SOTA models consistently overfit one set of lengthy documents (e.g., 2000 tokens) while performing worse on texts with other lengths (e.g., 1000 or 4000). In this study, we propose a Length-Aware Multi-Kernel Transformer (LAMKIT) to address the new challenges for the long document classification. LAMKIT encodes lengthy documents by diverse transformer-based kernels for bridging context boundaries and vectorizes text length by the kernels to promote model robustness over varying document lengths. Experiments on five standard benchmarks from health and law domains show LAMKIT outperforms SOTA models up to an absolute 10.9% improvement. We conduct extensive ablation analyses to examine model robustness and effectiveness over varying document lengths.
Editing Knowledge Representation of Language Model via Rephrased Prefix Prompts
Cai, Yuchen, Cao, Ding, Guo, Rongxi, Wen, Yaqin, Liu, Guiquan, Chen, Enhong
Neural language models (LMs) have been extensively trained on vast corpora to store factual knowledge about various aspects of the world described in texts. Current technologies typically employ knowledge editing methods or specific prompts to modify LM outputs. However, existing knowledge editing methods are costly and inefficient, struggling to produce appropriate text. Additionally, prompt engineering is opaque and requires significant effort to find suitable prompts. To address these issues, we introduce a new method called PSPEM (Prefix Soft Prompt Editing Method), that can be used for a lifetime with just one training. It resolves the inefficiencies and generalizability issues in knowledge editing methods and overcomes the opacity of prompt engineering by automatically seeking optimal soft prompts. Specifically, PSPEM utilizes a prompt encoder and an encoding converter to refine key information in prompts and uses prompt alignment techniques to guide model generation, ensuring text consistency and adherence to the intended structure and content, thereby maintaining an optimal balance between efficiency and accuracy. We have validated the effectiveness of PSPEM through knowledge editing and attribute inserting. On the COUNTERFACT dataset, PSPEM achieved nearly 100\% editing accuracy and demonstrated the highest level of fluency. We further analyzed the similarities between PSPEM and original prompts and their impact on the model's internals. The results indicate that PSPEM can serve as an alternative to original prompts, supporting the model in effective editing.