The use of narratives as a means of fusing information from knowledge graphs (KGs) into a coherent line of argumentation has been the subject of recent investigation. Narratives are especially useful in event-centric knowledge graphs in that they provide a means to connect different real-world events and categorize them by well-known narrations. However, specifically for controversial events, a problem in information fusion arises, namely, multiple viewpoints regarding the validity of certain event aspects, e.g., regarding the role a participant takes in an event, may exist. Expressing those viewpoints in KGs is challenging because disputed information provided by different viewpoints may introduce inconsistencies. Hence, most KGs only feature a single view on the contained information, hampering the effectiveness of narrative information access. This paper is an extension of our original work and introduces attributions, i.e., parameterized predicates that allow for the representation of facts that are only valid in a specific viewpoint. For this, we develop a conceptual model that allows for the representation of viewpoint-dependent information. As an extension, we enhance the model by a conception of viewpoint-compatibility. Based on this, we deepen our original deliberations on the model's effects on information fusion and provide additional grounding in the literature.

Molecular optimization is a crucial yet complex and time-intensive process that often acts as a bottleneck for drug development. Traditional methods rely heavily on trial and error, making multi-objective optimization both time-consuming and resource-intensive. Current AI-based methods have shown limited success in handling multi-objective optimization tasks, hampering their practical utilization. To address this challenge, we present MultiMol, a collaborative large language model (LLM) system designed to guide multi-objective molecular optimization. MultiMol comprises two agents, including a data-driven worker agent and a literature-guided research agent. The data-driven worker agent is a large language model being fine-tuned to learn how to generate optimized molecules considering multiple objectives, while the literature-guided research agent is responsible for searching task-related literature to find useful prior knowledge that facilitates identifying the most promising optimized candidates. In evaluations across six multi-objective optimization tasks, MultiMol significantly outperforms existing methods, achieving a 82.30% success rate, in sharp contrast to the 27.50% success rate of current strongest methods. To further validate its practical impact, we tested MultiMol on two real-world challenges. First, we enhanced the selectivity of Xanthine Amine Congener (XAC), a promiscuous ligand that binds both A1R and A2AR, successfully biasing it towards A1R. Second, we improved the bioavailability of Saquinavir, an HIV-1 protease inhibitor with known bioavailability limitations. Overall, these results indicate that MultiMol represents a highly promising approach for multi-objective molecular optimization, holding great potential to accelerate the drug development process and contribute to the advancement of pharmaceutical research.

How capable are large language models (LLMs) in the domain of taxation? Although numerous studies have explored the legal domain in general, research dedicated to taxation remain scarce. Moreover, the datasets used in these studies are either simplified, failing to reflect the real-world complexities, or unavailable as open source. To address this gap, we introduce PLAT, a new benchmark designed to assess the ability of LLMs to predict the legitimacy of additional tax penalties. PLAT is constructed to evaluate LLMs' understanding of tax law, particularly in cases where resolving the issue requires more than just applying related statutes. Our experiments with six LLMs reveal that their baseline capabilities are limited, especially when dealing with conflicting issues that demand a comprehensive understanding. However, we found that enabling retrieval, self-reasoning, and discussion among multiple agents with specific role assignments, this limitation can be mitigated.

While advances in deep learning in the last years have led to impressive performance in many domains, such models are not always reliable, particularly when it comes to generalizing to new environments or adversarial attacks. To improve on that, numerous methods have been developed in the field of explainable artificial intelligence (xAI) [5] to provide insights into model behavior and facilitate actionable modifications. However, the majority of methods focus on explaining model predictions, which can help understand misclassifications but do not explicitly address predictive uncertainty(See Figure 1). Understanding uncertainty is crucial for detecting potential model weaknesses, particularly in dynamic environments. Since uncertainty quantification is useful in various applications, including active learning [20], classification with rejects [17], adversarial example detection [26], and reinforcement learning [24], a significant body of work aims to improve the quantification of predictive uncertainty using Bayesian deep learning (BDL) and approximations thereof [15,9,14]. In contrast, the literature on understanding the sources of uncertainty for a given model via explanations is limited, focusing on methods for feature attribution [28,27] (see section 2.4 for more related

Circulating tumor cells (CTCs) are crucial biomarkers in liquid biopsy, offering a noninvasive tool for cancer patient management. However, their identification remains particularly challenging due to their limited number and heterogeneity. Labeling samples for contrast limits the generalization of fluorescence-based methods across different hospital datasets. Analyzing single-cell images enables detailed assessment of cell morphology, subcellular structures, and phenotypic variations, often hidden in clustered images. Developing a method based on bright-field single-cell analysis could overcome these limitations. CTCs can be isolated using an unbiased workflow combining Parsortix technology, which selects cells based on size and deformability, with DEPArray technology, enabling precise visualization and selection of single cells. Traditionally, DEPArray-acquired digital images are manually analyzed, making the process time-consuming and prone to variability. In this study, we present a Deep Learning-based classification pipeline designed to distinguish CTCs from leukocytes in blood samples, aimed to enhance diagnostic accuracy and optimize clinical workflows. Our approach employs images from the bright-field channel acquired through DEPArray technology leveraging a ResNet-based CNN. To improve model generalization, we applied three types of data augmentation techniques and incorporated fluorescence (DAPI) channel images into the training phase, allowing the network to learn additional CTC-specific features. Notably, only bright-field images have been used for testing, ensuring the model's ability to identify CTCs without relying on fluorescence markers. The proposed model achieved an F1-score of 0.798, demonstrating its capability to distinguish CTCs from leukocytes. These findings highlight the potential of DL in refining CTC analysis and advancing liquid biopsy applications.

Predictive machine learning models are widely used in customer relationship management (CRM) to forecast customer behaviors and support decision-making. However, the dynamic nature of customer behaviors often results in significant distribution shifts between training data and serving data, leading to performance degradation in predictive models. Domain generalization, which aims to train models that can generalize to unseen environments without prior knowledge of their distributions, has become a critical area of research. In this work, we propose a novel domain generalization method tailored to handle complex distribution shifts, encompassing both covariate and concept shifts. Our method builds upon the Distributionally Robust Optimization framework, optimizing model performance over a set of hypothetical worst-case distributions rather than relying solely on the training data. Through simulation experiments, we demonstrate the working mechanism of the proposed method. We also conduct experiments on a real-world customer churn dataset, and validate its effectiveness in both temporal and spatial generalization settings. Finally, we discuss the broader implications of our method for advancing Information Systems (IS) design research, particularly in building robust predictive models for dynamic managerial environments.

Current approaches to emotion detection often overlook the inherent subjectivity of affective experiences, instead relying on aggregated labels that mask individual variations in emotional responses. We introduce iNews, a novel large-scale dataset explicitly capturing subjective affective responses to news headlines. Our dataset comprises annotations from 291 demographically diverse UK participants across 2,899 multimodal Facebook news posts from major UK outlets, with an average of 5.18 annotators per sample. For each post, annotators provide multifaceted labels including valence, arousal, dominance, discrete emotions, content relevance judgments, sharing likelihood, and modality importance ratings (text, image, or both). Furthermore, we collect comprehensive annotator persona information covering demographics, personality, media trust, and consumption patterns, which explain 15.2% of annotation variance - higher than existing NLP datasets. Incorporating this information yields a 7% accuracy gain in zero-shot prediction and remains beneficial even with 32-shot. iNews will enhance research in LLM personalization, subjectivity, affective computing, and individual-level behavior simulation.

Analyzing large volumes of case law to uncover evolving legal principles, across multiple cases, on a given topic is a demanding task for legal professionals. Structured topical reports provide an effective solution by summarizing key issues, principles, and judgments, enabling comprehensive legal analysis on a particular topic. While prior works have advanced query-based individual case summarization, none have extended to automatically generating multi-case structured reports. To address this, we introduce LexGenie, an automated LLM-based pipeline designed to create structured reports using the entire body of case law on user-specified topics within the European Court of Human Rights jurisdiction. LexGenie retrieves, clusters, and organizes relevant passages by topic to generate a structured outline and cohesive content for each section. Expert evaluation confirms LexGenie's utility in producing structured reports that enhance efficient, scalable legal analysis.

We present a transformer model, named DeepHalo, to predict the occurrence of halo coronal mass ejections (CMEs). Our model takes as input an active region (AR) and a profile, where the profile contains a time series of data samples in the AR that are collected 24 hours before the beginning of a day, and predicts whether the AR would produce a halo CME during that day. Each data sample contains physical parameters, or features, derived from photospheric vector magnetic field data taken by the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory (SDO). We survey and match CME events in the Space Weather Database Of Notification, Knowledge, Information (DONKI) and Large Angle and Spectrometric Coronagraph (LASCO) CME Catalog, and compile a list of CMEs including halo CMEs and non-halo CMEs associated with ARs in the period between November 2010 and August 2023. We use the information gathered above to build the labels (positive versus negative) of the data samples and profiles at hand, where the labels are needed for machine learning. Experimental results show that DeepHalo with a true skill statistics (TSS) score of 0.907 outperforms a closely related long short-term memory network with a TSS score of 0.821. To our knowledge, this is the first time that the transformer model has been used for halo CME prediction.

In Australia, post-contact language varieties, including creoles and local varieties of international languages, emerged as a result of forced contact between Indigenous communities and English speakers. These contact varieties are widely used, yet are poorly supported by language technologies. This gap presents barriers to participation in civil and economic society for Indigenous communities using these varieties, and reproduces minoritisation of contemporary Indigenous sociolinguistic identities. This paper concerns three questions regarding this context. First, can speech technologies support speakers of Australian Aboriginal English, a local indigenised variety of English? Second, what risks are inherent in such a project? Third, what technology development practices are appropriate for this context, and how can researchers integrate meaningful community participation in order to mitigate risks? We argue that opportunities do exist -- as well as risks -- and demonstrate this through a case study exploring design practices in a real-world project aiming to improve speech technologies for Australian Aboriginal English. We discuss how we integrated culturally appropriate and participatory processes throughout the project. We call for increased support for languages used by Indigenous communities, including contact varieties, which provide practical economic and socio-cultural benefits, provided that participatory and culturally safe practices are enacted.