Language detoxification involves removing toxicity from offensive language. While a neutral-toxic paired dataset provides a straightforward approach for training detoxification models, creating such datasets presents several challenges: i) the need for human annotation to build paired data, and ii) the rapid evolution of offensive terms, rendering static datasets quickly outdated. To tackle these challenges, we introduce an automated paired data generation pipeline, called K/DA. This pipeline is designed to generate offensive language with implicit offensiveness and trend-aligned slang, making the resulting dataset suitable for detoxification model training. We demonstrate that the dataset generated by K/DA exhibits high pair consistency and greater implicit offensiveness compared to existing Korean datasets, and also demonstrates applicability to other languages. Furthermore, it enables effective training of a high-performing detoxification model with simple instruction fine-tuning.

Generating high-fidelity and biologically plausible synthetic single-cell RNA sequencing (scRNA-seq) data, especially with conditional control, is challenging due to its high dimensionality, sparsity, and complex biological variations. Existing generative models often struggle to capture these unique characteristics and ensure robustness to structural noise in cellular networks. We introduce LapDDPM, a novel conditional Graph Diffusion Probabilistic Model for robust and high-fidelity scRNA-seq generation. LapDDPM uniquely integrates graph-based representations with a score-based diffusion model, enhanced by a novel spectral adversarial perturbation mechanism on graph edge weights. Our contributions are threefold: we leverage Laplacian Positional Encodings (LPEs) to enrich the latent space with crucial cellular relationship information; we develop a conditional score-based diffusion model for effective learning and generation from complex scRNA-seq distributions; and we employ a unique spectral adversarial training scheme on graph edge weights, boosting robustness against structural variations. Extensive experiments on diverse scRNA-seq datasets demonstrate LapDDPM's superior performance, achieving high fidelity and generating biologically-plausible, cell-type-specific samples. LapDDPM sets a new benchmark for conditional scRNA-seq data generation, offering a robust tool for various downstream biological applications.

This work demonstrates electronic logbook (eLog) systems leveraging modern AI-driven information retrieval capabilities at the accelerator facilities of Fermilab, Jefferson Lab, Lawrence Berkeley National Laboratory (LBNL), SLAC National Accelerator Laboratory. We evaluate contemporary tools and methodologies for information retrieval with Retrieval Augmented Generation (RAGs), focusing on operational insights and integration with existing accelerator control systems. The study addresses challenges and proposes solutions for state-of-the-art eLog analysis through practical implementations, demonstrating applications and limitations. We present a framework for enhancing accelerator facility operations through improved information accessibility and knowledge management, which could potentially lead to more efficient operations.

Optimization is widely used for decision making across various domains, valued for its ability to improve efficiency. However, poor implementation practices can lead to unintended consequences, particularly in socioeconomic contexts where externalities (costs or benefits to third parties outside the optimization process) are significant. To propose solutions, it is crucial to first characterize involved stakeholders, their goals, and the types of subpar practices causing unforeseen outcomes. This task is complex because affected stakeholders often fall outside the direct focus of optimization processes. Also, incorporating these externalities into optimization requires going beyond traditional economic frameworks, which often focus on describing externalities but fail to address their normative implications or interconnected nature, and feedback loops. This paper suggests a framework that combines systems thinking with the economic concept of externalities to tackle these challenges. This approach aims to characterize what went wrong, who was affected, and how (or where) to include them in the optimization process. Economic externalities, along with their established quantification methods, assist in identifying "who was affected and how" through stakeholder characterization. Meanwhile, systems thinking (an analytical approach to comprehending relationships in complex systems) provides a holistic, normative perspective. Systems thinking contributes to an understanding of interconnections among externalities, feedback loops, and determining "when" to incorporate them in the optimization. Together, these approaches create a comprehensive framework for addressing optimization's unintended consequences, balancing descriptive accuracy with normative objectives. Using this, we examine three common types of subpar practices: ignorance, error, and prioritization of short-term goals.

Hate speech detection across contemporary social media presents unique challenges due to linguistic diversity and the informal nature of online discourse. These challenges are further amplified in settings involving code-mixing, transliteration, and culturally nuanced expressions. While fine-tuned transformer models, such as BERT, have become standard for this task, we argue that recent large language models (LLMs) not only surpass them but also redefine the landscape of hate speech detection more broadly. To support this claim, we introduce IndoHateMix, a diverse, high-quality dataset capturing Hindi-English code-mixing and transliteration in the Indian context, providing a realistic benchmark to evaluate model robustness in complex multilingual scenarios where existing NLP methods often struggle. Our extensive experiments show that cutting-edge LLMs (such as LLaMA-3.1) consistently outperform task-specific BERT-based models, even when fine-tuned on significantly less data. With their superior generalization and adaptability, LLMs offer a transformative approach to mitigating online hate in diverse environments. This raises the question of whether future works should prioritize developing specialized models or focus on curating richer and more varied datasets to further enhance the effectiveness of LLMs.

Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current analysis methods often struggle with noisy data, limited scalability, and inadequate modelling of complex cellular relationships. We present SemanticST, a biologically informed, graph-based deep learning framework that models diverse cellular contexts through multi-semantic graph construction. SemanticST builds multiple context-specific graphs capturing spatial proximity, gene expression similarity, and tissue domain structure, and learns disentangled embeddings for each. These are fused using an attention-inspired strategy to yield a unified, biologically meaningful representation. A community-aware min-cut loss improves robustness over contrastive learning, particularly in sparse ST data. SemanticST supports mini-batch training, making it the first graph neural network scalable to large-scale datasets such as Xenium (500,000 cells). Benchmarking across four platforms (Visium, Slide-seq, Stereo-seq, Xenium) and multiple human and mouse tissues shows consistent 20 percentage gains in ARI, NMI, and trajectory fidelity over DeepST, GraphST, and IRIS. In re-analysis of breast cancer Xenium data, SemanticST revealed rare and clinically significant niches, including triple receptor-positive clusters, spatially distinct DCIS-to-IDC transition zones, and FOXC2 tumour-associated myoepithelial cells, suggesting non-canonical EMT programs with stem-like features. SemanticST thus provides a scalable, interpretable, and biologically grounded framework for spatial transcriptomics analysis, enabling robust discovery across tissue types and diseases, and paving the way for spatially resolved tissue atlases and next-generation precision medicine.

Detecting AI-generated text is a difficult problem to begin with; detecting AI-generated text on social media is made even more difficult due to the short text length and informal, idiosyncratic language of the internet. It is nonetheless important to tackle this problem, as social media represents a significant attack vector in online influence campaigns, which may be bolstered through the use of mass-produced AI-generated posts supporting (or opposing) particular policies, decisions, or events. We approach this problem with the mindset and resources of a reasonably sophisticated threat actor, and create a dataset of 505,159 AI-generated social media posts from a combination of open-source, closed-source, and fine-tuned LLMs, covering 11 different controversial topics. We show that while the posts can be detected under typical research assumptions about knowledge of and access to the generating models, under the more realistic assumption that an attacker will not release their fine-tuned model to the public, detectability drops dramatically. This result is confirmed with a human study. Ablation experiments highlight the vulnerability of various detection algorithms to fine-tuned LLMs. This result has implications across all detection domains, since fine-tuning is a generally applicable and realistic LLM use case.

A common problem in LLM evaluation is how to choose a subset of metrics from a full suite of possible metrics. Subset selection is usually done for efficiency or interpretability reasons, and the goal is often to select a ``representative'' subset of metrics. However, ``representative'' is rarely clearly defined. In this work, we use ideas from social choice theory to formalize two notions of representation for the selection of a subset of evaluation metrics. We first introduce positional representation, which guarantees every alternative is sufficiently represented at every position cutoff. We then introduce positional proportionality, which guarantees no alternative is proportionally over- or under-represented by more than a small error at any position. We prove upper and lower bounds on the smallest number of metrics needed to guarantee either of these properties in the worst case. We also study a generalized form of each property that allows for additional input on groups of metrics that must be represented. Finally, we tie theory to practice through real-world case studies on both LLM evaluation and hospital quality evaluation.

Foundation models hold significant promise in healthcare, given their capacity to extract meaningful representations independent of downstream tasks. This property has enabled state-of-the-art performance across several clinical applications trained on structured electronic health record (EHR) data, even in settings with limited labeled data, a prevalent challenge in healthcare. However, there is little consensus on these models' potential for clinical utility due to the lack of desiderata of comprehensive and meaningful tasks and sufficiently diverse evaluations to characterize the benefit over conventional supervised learning. To address this gap, we propose a suite of clinically meaningful tasks spanning patient outcomes, early prediction of acute and chronic conditions, including desiderata for robust evaluations. We evaluate state-of-the-art foundation models on EHR data consisting of 5 million patients from Columbia University Irving Medical Center (CUMC), a large urban academic medical center in New York City, across 14 clinically relevant tasks. We measure overall accuracy, calibration, and subpopulation performance to surface tradeoffs based on the choice of pre-training, tokenization, and data representation strategies. Our study aims to advance the empirical evaluation of structured EHR foundation models and guide the development of future healthcare foundation models.

Large Language Models (LLMs) have emerged as a powerful approach for driving offensive penetration-testing tooling. Due to the opaque nature of LLMs, empirical methods are typically used to analyze their efficacy. The quality of this analysis is highly dependent on the chosen testbed, captured metrics and analysis methods employed. This paper analyzes the methodology and benchmarking practices used for evaluating Large Language Model (LLM)-driven attacks, focusing on offensive uses of LLMs in cybersecurity. We review 19 research papers detailing 18 prototypes and their respective testbeds. We detail our findings and provide actionable recommendations for future research, emphasizing the importance of extending existing testbeds, creating baselines, and including comprehensive metrics and qualitative analysis. We also note the distinction between security research and practice, suggesting that CTF-based challenges may not fully represent real-world penetration testing scenarios.