In the coming decade, artificially intelligent agents with the ability to plan and execute complex tasks over long time horizons with little direct oversight from humans may be deployed across the economy. This chapter surveys recent developments and highlights open questions for economists around how AI agents might interact with humans and with each other, shape markets and organizations, and what institutions might be required for well-functioning markets.

The making of knowledge engines in natural language processing has been shaped by two seemingly distinct paradigms: one grounded in structure, the other driven by massively available unstructured data. The structured paradigm leverages predefined symbolic interactions, such as knowledge graphs, as priors and designs models to capture them. In contrast, the unstructured paradigm centers on scaling transformer architectures with increasingly vast data and model sizes, as seen in modern large language models. Despite their divergence, this thesis seeks to establish conceptual connections bridging these paradigms. Two complementary forces, structure and destructure, emerge across both paradigms: structure organizes seen symbolic interactions, while destructure, through periodic embedding resets, improves model plasticity and generalization to unseen scenarios. These connections form a new recipe for developing general knowledge engines that can support transparent, controllable, and adaptable intelligent systems.

As early detection of breast cancer strongly favors successful therapeutic outcomes, there is major commercial interest in optimizing breast cancer screening. However, current risk prediction models achieve modest performance and do not incorporate digital breast tomosynthesis (DBT) imaging, which was FDA-approved for breast cancer screening in 2011. To address this unmet need, we present a deep learning (DL)-based framework capable of forecasting an individual patient's 5-year breast cancer risk directly from screening DBT. Using an unparalleled dataset of 161,753 DBT examinations from 50,590 patients, we trained a risk predictor based on features extracted using the Meta AI DINOv2 image encoder, combined with a cumulative hazard layer, to assess a patient's likelihood of developing breast cancer over five years. On a held-out test set, our best-performing model achieved an AUROC of 0.80 on predictions within 5 years. These findings reveal the high potential of DBT-based DL approaches to complement traditional risk assessment tools, and serve as a promising basis for additional investigation to validate and enhance our work.

The training of topic models for a multilingual environment is a challenging task, requiring the use of sophisticated algorithms, topic-aligned corpora, and manual evaluation. These difficulties are further exacerbated when the developer lacks knowledge of the target language or is working in an environment with limited data, where only small or unusable multilingual corpora are available. Considering these challenges, we introduce Topic Model Translation (TMT), a novel, robust and transparent technique designed to transfer topic models (e.g., Latent Dirichlet Allocation (LDA) based topic models) from one language to another, without the need for metadata, embeddings, or aligned corpora. TMT enables the reuse of topic models across languages, making it especially suitable for scenarios where large corpora in the target language are unavailable or manual translation is infeasible. Furthermore, we evaluate TMT extensively using both quantitative and qualitative methods, demonstrating that it produces semantically coherent and consistent topic translations.

Learning with physical systems is an emerging paradigm that seeks to harness the intrinsic nonlinear dynamics of physical substrates for learning. The impetus for a paradigm shift in how hardware is used for computational intelligence stems largely from the unsustainability of artificial neural network software implemented on conventional transistor-based hardware. This Perspective highlights one promising approach using physical networks comprised of resistive memory nanoscale components with dynamically reconfigurable, self-organising electrical circuitry. Experimental advances have revealed the non-trivial interactions within these Self-Organising Memristive Networks (SOMNs), offering insights into their collective nonlinear and adaptive dynamics, and how these properties can be harnessed for learning using different hardware implementations. Theoretical approaches, including mean-field theory, graph theory, and concepts from disordered systems, reveal deeper insights into the dynamics of SOMNs, especially during transitions between different conductance states where criticality and other dynamical phase transitions emerge in both experiments and models. Furthermore, parallels between adaptive dynamics in SOMNs and plasticity in biological neuronal networks suggest the potential for realising energy-efficient, brain-like continual learning. SOMNs thus offer a promising route toward embedded edge intelligence, unlocking real-time decision-making for autonomous systems, dynamic sensing, and personalised healthcare, by enabling embedded learning in resource-constrained environments. The overarching aim of this Perspective is to show how the convergence of nanotechnology, statistical physics, complex systems, and self-organising principles offers a unique opportunity to advance a new generation of physical intelligence technologies.

Cybersecurity defense involves interactions between adversarial parties (namely defenders and hackers), making multi-agent reinforcement learning (MARL) an ideal approach for modeling and learning strategies for these scenarios. This paper addresses one of the key challenges to MARL, the complexity of simultaneous training of agents in nontrivial environments, and presents a novel policy-based Nash Q-learning to directly converge onto a steady equilibrium. We demonstrate the successful implementation of this algorithm in a notable complex cyber defense simulation treated as a two-player zero-sum Markov game setting. We propose the Nash Q-Network, which aims to learn Nash-optimal strategies that translate to robust defenses in cybersecurity settings. Our approach incorporates aspects of proximal policy optimization (PPO), deep Q-network (DQN), and the Nash-Q algorithm, addressing common challenges like non-stationarity and instability in multi-agent learning. The training process employs distributed data collection and carefully designed neural architectures for both agents and critics.

In vision-language modeling, critic models are typically trained to evaluate outputs -- assigning scalar scores or pairwise preferences -- rather than to generate responses. This separation from policy models, which produce the responses, is so entrenched that critics are rarely considered for direct policy use. In this work, we challenge this convention. We propose to reorganize preference-labeled critic datasets into verifiable training signals and perform reinforcement learning directly on a base generative model, producing LLaVA-Critic-R1, a multimodal critic trained to optimize preference judgments while retaining full generation ability. Surprisingly, LLaVA-Critic-R1 emerges not only as a top-performing critic but also as a competitive policy model -- matching or surpassing specialized reasoning VLMs trained with in-domain data across 26 visual reasoning and understanding benchmarks, with an average gain of +5.7% over its base model (Qwen-2.5-VL-7B). Extending this approach to existing strong reasoning VLMs yields LLaVA-Critic-R1+, which further advances policy performance without sacrificing critic quality, achieving a SoTA performance of 71.9 on MMMU at the 7B scale. Finally, we show that the enhanced critic ability benefits inference: applying self-critique at test time yields an average +13.8% improvement on five representative reasoning tasks without additional training. Our results reveal that RL training on critic data can produce a unified model excelling at both evaluation and generation, offering a simple path toward scalable, self-improving multimodal systems.

We investigate the efficacy of Large Language Models (LLMs) in detecting implicit and explicit hate speech, examining whether models with minimal safety alignment (uncensored) might provide more objective classification capabilities compared to their heavily-aligned (censored) counterparts. While uncensored models theoretically offer a less constrained perspective free from moral guardrails that could bias classification decisions, our results reveal a surprising trade-off: censored models significantly outperform their uncensored counterparts in both accuracy and robustness, achieving 78.7% versus 64.1% strict accuracy. However, this enhanced performance comes with its own limitation -- the safety alignment acts as a strong ideological anchor, making censored models resistant to persona-based influence, while uncensored models prove highly malleable to ideological framing. Furthermore, we identify critical failures across all models in understanding nuanced language such as irony. We also find alarming fairness disparities in performance across different targeted groups and systemic overconfidence that renders self-reported certainty unreliable. These findings challenge the notion of LLMs as objective arbiters and highlight the need for more sophisticated auditing frameworks that account for fairness, calibration, and ideological consistency.

In this paper, we propose an evolutionary Multi-objective Optimization for Replica-Exchange-based Physics-informed Operator learning Network, which is a novel operator learning network to efficiently solve parametric partial differential equations. In forward and inverse settings, this operator learning network only admits minimum requirement of noisy observational data. While physics-informed neural networks and operator learning approaches such as Deep Operator Networks and Fourier Neural Operators offer promising alternatives to traditional numerical solvers, they struggle with balancing operator and physics losses, maintaining robustness under noisy or sparse data, and providing uncertainty quantification. The proposed framework addresses these limitations by integrating: (i) evolutionary multi-objective optimization to adaptively balance operator and physics-based losses in the Pareto front; (ii) replica exchange stochastic gradient Langevin dynamics to improve global parameter-space exploration and accelerate convergence; and (iii) built-in Bayesian uncertainty quantification from stochastic sampling. The proposed operator learning method is tested numerically on several different problems including one-dimensional Burgers equation and the time-fractional mixed diffusion-wave equation. The results indicate that our framework consistently outperforms the general operator learning methods in accuracy, noise robustness, and the ability to quantify uncertainty.

Regional weather forecasting is a critical problem for localized climate adaptation, disaster mitigation, and sustainable development. While machine learning has shown impressive progress in global weather forecasting, regional forecasting remains comparatively underexplored. Existing efforts often use different datasets and experimental setups, limiting fair comparison and reproducibility. We introduce IndiaWeatherBench, a comprehensive benchmark for data-driven regional weather forecasting focused on the Indian subcontinent. IndiaWeatherBench provides a curated dataset built from high-resolution regional reanalysis products, along with a suite of deterministic and probabilistic metrics to facilitate consistent training and evaluation. To establish strong baselines, we implement and evaluate a range of models across diverse architectures, including UNets, Transformers, and Graph-based networks, as well as different boundary conditioning strategies and training objectives. While focused on India, IndiaWeatherBench is easily extensible to other geographic regions. We open-source all raw and preprocessed datasets, model implementations, and evaluation pipelines to promote accessibility and future development. We hope IndiaWeatherBench will serve as a foundation for advancing regional weather forecasting research. Code is available at https://github.com/tung-nd/IndiaWeatherBench.