Data-driven acceleration of scientific computing workflows has been a high-profile aim of machine learning (ML) for science, with numerical simulation of transient partial differential equations (PDEs) being one of the main applications. The focus thus far has been on methods that require classical simulations to train, which when combined with the data-hungriness and optimization challenges of neural networks has caused difficulties in demonstrating a convincing advantage against strong classical baselines. We consider an alternative paradigm in which the learner uses a classical solver's own data to accelerate it, enabling a one-shot speedup of the simulation. Concretely, since transient PDEs often require solving a sequence of related linear systems, the feedback from repeated calls to a linear solver such as preconditioned conjugate gradient (PCG) can be used by a bandit algorithm to online-learn an adaptive sequence of solver configurations (e.g. preconditioners). The method we develop, PCGBandit, is implemented directly on top of the popular open source software OpenFOAM, which we use to show its effectiveness on a set of fluid and magnetohydrodynamics (MHD) problems.

The absolute dominance of Artificial Intelligence (AI) introduces unprecedented societal harms and risks. Existing AI risk assessment models focus on internal compliance, often neglecting diverse stakeholder perspectives and real-world consequences. We propose a paradigm shift to a human-centric, harm-severity adaptive approach grounded in empirical incident data. We present AI Harmonics, which includes a novel AI harm assessment metric (AIH) that leverages ordinal severity data to capture relative impact without requiring precise numerical estimates. AI Harmonics combines a robust, generalized methodology with a data-driven, stakeholder-aware framework for exploring and prioritizing AI harms. Experiments on annotated incident data confirm that political and physical harms exhibit the highest concentration and thus warrant urgent mitigation: political harms erode public trust, while physical harms pose serious, even life-threatening risks, underscoring the real-world relevance of our approach. Finally, we demonstrate that AI Harmonics consistently identifies uneven harm distributions, enabling policymakers and organizations to target their mitigation efforts effectively.

Large Language Models (LLMs) have significantly advanced the development of Legal Artificial Intelligence (Legal AI) in recent years, enhancing the efficiency and accuracy of legal tasks. To advance research and applications of LLM-based approaches in legal domain, this paper provides a comprehensive review of 16 legal LLMs series and 47 LLM-based frameworks for legal tasks, and also gather 15 benchmarks and 29 datasets to evaluate different legal capabilities. Additionally, we analyse the challenges and discuss future directions for LLM-based approaches in the legal domain. We hope this paper provides a systematic introduction for beginners and encourages future research in this field. Resources are available at https://github.com/ZhitianHou/LLMs4LegalAI.

Population health management programs for Medicaid populations coordinate longitudinal outreach and services (e.g., benefits navigation, behavioral health, social needs support, and clinical scheduling) and must be safe, fair, and auditable. We present a Hybrid Adaptive Conformal Offline Reinforcement Learning (HACO) framework that separates risk calibration from preference optimization to generate conservative action recommendations at scale. In our setting, each step involves choosing among common coordination actions (e.g., which member to contact, by which modality, and whether to route to a specialized service) while controlling the near-term risk of adverse utilization events (e.g., unplanned emergency department visits or hospitalizations). Using a de-identified operational dataset from Waymark comprising 2.77 million sequential decisions across 168,126 patients, HACO (i) trains a lightweight risk model for adverse events, (ii) derives a conformal threshold to mask unsafe actions at a target risk level, and (iii) learns a preference policy on the resulting safe subset. We evaluate policies with a version-agnostic fitted Q evaluation (FQE) on stratified subsets and audit subgroup performance across age, sex, and race. HACO achieves strong risk discrimination (AUC ~0.81) with a calibrated threshold ( τ ~0.038 at α = 0.10), while maintaining high safe coverage. Subgroup analyses reveal systematic differences in estimated value across demographics, underscoring the importance of fairness auditing. Our results show that conformal risk gating integrates cleanly with offline RL to deliver conservative, auditable decision support for population health management teams.

Background: Investigational New Drug (IND) application preparation is time-intensive and expertise-dependent, slowing early clinical development. Objective: To evaluate whether a large language model (LLM) platform (AutoIND) can reduce first-draft composition time while maintaining document quality in regulatory submissions. Methods: Drafting times for IND nonclinical written summaries (eCTD modules 2.6.2, 2.6.4, 2.6.6) generated by AutoIND were directly recorded. For comparison, manual drafting times for IND summaries previously cleared by the U.S. FDA were estimated from the experience of regulatory writers ($\geq$6 years) and used as industry-standard benchmarks. Quality was assessed by a blinded regulatory writing assessor using seven pre-specified categories: correctness, completeness, conciseness, consistency, clarity, redundancy, and emphasis. Each sub-criterion was scored 0-3 and normalized to a percentage. A critical regulatory error was defined as any misrepresentation or omission likely to alter regulatory interpretation (e.g., incorrect NOAEL, omission of mandatory GLP dose-formulation analysis). Results: AutoIND reduced initial drafting time by $\sim$97% (from $\sim$100 h to 3.7 h for 18,870 pages/61 reports in IND-1; and to 2.6 h for 11,425 pages/58 reports in IND-2). Quality scores were 69.6\% and 77.9\% for IND-1 and IND-2. No critical regulatory errors were detected, but deficiencies in emphasis, conciseness, and clarity were noted. Conclusions: AutoIND can dramatically accelerate IND drafting, but expert regulatory writers remain essential to mature outputs to submission-ready quality. Systematic deficiencies identified provide a roadmap for targeted model improvements.

The rapid integration of Large Language Models (LLMs) into various domains raises concerns about societal inequalities and information bias. This study examines biases in LLMs related to background, gender, and age, with a focus on their impact on decision-making and summarization tasks. Additionally, the research examines the cross-lingual propagation of these biases and evaluates the effectiveness of prompt-instructed mitigation strategies. Using an adapted version of the dataset by Tamkin et al. (2023) translated into Dutch, we created 151,200 unique prompts for the decision task and 176,400 for the summarisation task. Various demographic variables, instructions, salience levels, and languages were tested on GPT-3.5 and GPT-4o. Our analysis revealed that both models were significantly biased during decision-making, favouring female gender, younger ages, and certain backgrounds such as the African-American background. In contrast, the summarisation task showed minimal evidence of bias, though significant age-related differences emerged for GPT-3.5 in English. Cross-lingual analysis showed that bias patterns were broadly similar between English and Dutch, though notable differences were observed across specific demographic categories. The newly proposed mitigation instructions, while unable to eliminate biases completely, demonstrated potential in reducing them. The most effective instruction achieved a 27\% mean reduction in the gap between the most and least favorable demographics. Notably, contrary to GPT-3.5, GPT-4o displayed reduced biases for all prompts in English, indicating the specific potential for prompt-based mitigation within newer models. This research underscores the importance of cautious adoption of LLMs and context-specific bias testing, highlighting the need for continued development of effective mitigation strategies to ensure responsible deployment of AI.

Technology opportunities are critical information that serve as a foundation for advancements in technology, industry, and innovation. This paper proposes a framework based on the temporal relationships between technologies to identify emerging technology opportunities. The proposed framework begins by extracting text from a patent dataset, followed by mapping text-based topics to discover inter-technology relationships. Technology opportunities are then identified by tracking changes in these topics over time. To enhance efficiency, the framework leverages a large language model to extract topics and employs a prompt for a chat-based language model to support the discovery of technology opportunities. The framework was evaluated using an artificial intelligence patent dataset provided by the United States Patent and Trademark Office. The experimental results suggest that artificial intelligence technology is evolving into forms that facilitate everyday accessibility. This approach demonstrates the potential of the proposed framework to identify future technology opportunities.

We study whether language models (LMs) exhibit future- versus present-oriented preferences in intertemporal choice and whether those preferences can be systematically manipulated. Using adapted human experimental protocols, we evaluate multiple LMs on time-tradeoff tasks and benchmark them against a sample of human decision makers. We introduce an operational metric, the Manipulability of Time Orientation (MTO), defined as the change in an LM's revealed time preference between future- and present-oriented prompts. In our tests, reasoning-focused models (e.g., DeepSeek-Reasoner and grok-3-mini) choose later options under future-oriented prompts but only partially personalize decisions across identities or geographies. Moreover, models that correctly reason about time orientation internalize a future orientation for themselves as AI decision makers. We discuss design implications for AI assistants that should align with heterogeneous, long-horizon goals and outline a research agenda on personalized contextual calibration and socially aware deployment.

Large Language Models (LLMs) alignment methods have been credited with the commercial success of products like ChatGPT, given their role in steering LLMs towards user-friendly outputs. However, current alignment techniques predominantly mirror the normative preferences of a narrow reference group, effectively imposing their values on a wide user base. Drawing on theories of the power/knowledge nexus, this work argues that current alignment practices centralise control over knowledge production and governance within already influential institutions. To counter this, we propose decentralising alignment through three characteristics: context, pluralism, and participation. Furthermore, this paper demonstrates the critical importance of delineating the context-of-use when shaping alignment practices by grounding each of these features in concrete use cases. This work makes the following contributions: (1) highlighting the role of context, pluralism, and participation in decentralising alignment; (2) providing concrete examples to illustrate these strategies; and (3) demonstrating the nuanced requirements associated with applying alignment across different contexts of use.

Large Language Models (LLMs) are being increasingly used as a building block in data systems to process large text datasets. To do so, LLM model providers offer multiple LLMs with different sizes, spanning various cost-quality trade-offs when processing text at scale. Top-of-the-line LLMs (e.g., GPT-4o, Claude Sonnet) operate with high accuracy but are prohibitively expensive when processing many records. To avoid high costs, more affordable but lower quality LLMs (e.g., GPT-4o-mini, Claude Haiku) can be used to process records, but we need to ensure that the overall accuracy does not deviate substantially from that of the top-of-the-line LLMs. The model cascade framework provides a blueprint to manage this trade-off, by using the confidence of LLMs in their output (e.g., log-probabilities) to decide on which records to use the affordable LLM. However, existing solutions following this framework provide only marginal cost savings and weak theoretical guarantees because of poor estimation of the quality of the affordable LLM's outputs. We present BARGAIN, a method that judiciously uses affordable LLMs in data processing to significantly reduce cost while providing strong theoretical guarantees on the solution quality. BARGAIN employs a novel adaptive sampling strategy and statistical estimation procedure that uses data and task characteristics and builds on recent statistical tools to make accurate estimations with tight theoretical guarantees. Variants of BARGAIN can support guarantees on accuracy, precision, or recall of the output. Experimental results across 8 real-world datasets show that BARGAIN reduces cost, on average, by up to 86% more than state-of-the-art, while providing stronger theoretical guarantees on accuracy of output, with similar gains when guaranteeing a desired level of precision or recall.