Doctor's husband'was watching X-rated videos in his house while daughter, 2, died in roasting car outside' Florida's housing market is flashing a warning for the rest of the US Now scientists redefine'obese' - and they've made up to 60% more people'fat' Bella Hadid's health battle takes dark turn: Loved ones reveal hellish new details about'missing' model... as ominous texts emerge America's saddest lost soul can no longer SPEAK and spends days hitting herself'after years of unspeakable abuse by gangs of men' Shocking moment brazen gunman opens fire at Michigan businessman's Land Rover in daylight attack'You will DIE if you do not remove your breasts', doctors screamed at me. I refused and tried a new experimental therapy instead... now I'm cancer-free The world's most powerful passport revealed - as UK and USA both drop to record lows Police say they have FOUND woman seen in viral'kidnapping' video and reveal what happened to her after harrowing footage emerged Will Trump's Gaza peace deal fail? Policy expert MARK DUBOWITZ breaks down all the forces at play... and how the president can actually pull this off America's most renowned'prophet' makes startling prediction about alien'mothership' Kim Kardashian says she wasn't'emotionally or financially safe' during'toxic' marriage to Kanye West as she claims rapper hasn't contacted their children for MONTHS and has destroyed her dating life Astonishing interactive map lays bare where MILLIONS of homes will be submerged by water within a few years... are YOU at risk? Outrageous reason LA County CEO was awarded $2m payout for'hurt feelings' that'll see her take months off taxpayer-funded $570,000-a-year job Ugly divorce war between Mitt Romney's wealthy brother and estranged wife before she was found dead Full horrors of torture suffered by Noa Argamani's commando boyfriend are revealed - including how 6ft 5in hostage was beaten and kept chained in 6ft cell for a year after he tried to escape from Hamas Mother, 52, and daughter, 21, die after eating'poisoned birthday cake delivered by relative who owed them money' in Brazil Astonishing interactive map lays bare where MILLIONS of homes will be submerged by water within a few years... are YOU at risk? Millions of buildings and even more Americans could be at risk of sinking underwater by the end of the century. Researchers from McGill University in Canada warned rising sea levels, resulting from continued greenhouse gas emissions, threaten to wipe out coastal cities worldwide. Sea level rise measures the ocean's surface height over time.

Microsoft, JP MorganChase, and a tech company consortium that includes Alphabet, Meta, Shopify, and Stripe have all recently struck multimillion-dollar deals to pay paper mill owners to capture at least hundreds of thousands of tons of this greenhouse gas by installing carbon scrubbing equipment in their facilities. The captured carbon dioxide will then be piped down into saline aquifers more than a mile underground, where it should be sequestered permanently. Big Tech is suddenly betting big on this form of carbon removal, known as bioenergy with carbon capture and storage, or BECCS. But experts have raised a number of concerns. Like many new nuclear startups, Kairos promises a path to reliable, 24/7 decarbonized power. Unlike most, it already has prototypes under construction and permits for several reactors.

The LED lights reduced entanglements by 63 percent, according to a new study. Breakthroughs, discoveries, and DIY tips sent every weekday. For fishers working the inky dark night, it can be difficult to keep endangered or unwanted animals out of their nets. While lighted nets can reduce the bycatch of sharks and sea turtles, their batteries are short lived, expensive to replace, and not always easy to dispose of. The lights themselves are also heavy, can make the nets sag, and not easy for fishers to work with.

AI agents are moving from pilots to enterprise scale, but trust and governance remain the linchpins of success, says Cloudera's Manasi Vartak, Forrester's Mike Gualtieri, and AWS' Eddie Kim. Artificial intelligence has always promised speed, efficiency, and new ways of solving problems. But what's changed in the past few years is how quickly those promises are becoming reality. From oil and gas to retail, logistics to law, AI is no longer confined to pilot projects or speculative labs. It is being deployed in critical workflows, reducing processes that once took hours to just minutes, and freeing up employees to focus on higher-value work. "Business process automation has been around a long while.

The 2025 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2025) will be held from 19-25 October in Hangzhou, China. The programme includes plenary and keynote talks, workshops, tutorials, forums, competitions, and a debate. There are three plenary talks on the programme this year, with one per day on Tuesday 21, Wednesday 22, and Thursday 23 October. On Wednesday, a debate will be held on the following topic: The participants will be: XingXing Wang (Unitree Robotics), Jun-Oh Ho (Samsung and Rainbow Robotics), Hong Qiao (Chinese Academy of Sciences), Andra Keay, (Silicon Valley Robotics), Yu Sun (EiC, IEEE Trans on Automation Science and Engineering), Tamim Asfour (Professor of Humanoid Robotics, Karlsruhe Institute of Technology), Ken Goldberg (UC Berkeley, Moderator). There are three tutorials planned, taking place on Monday 20 and Friday 24 October.

Nonlinear and delayed effects of covariates often render time series forecasting challenging. To this end, we propose a novel forecasting framework based on ridge regression with signature features calculated on sliding windows. These features capture complex temporal dynamics without relying on learned or hand-crafted representations. Focusing on the discrete-time setting, we establish theoretical guarantees, namely universality of approximation and stationarity of signatures. We introduce an efficient sequential algorithm for computing signatures on sliding windows. The method is evaluated on both synthetic and real electricity demand data. Results show that signature features effectively encode temporal and nonlinear dependencies, yielding accurate forecasts competitive with those based on expert knowledge.

Diffusion-based samplers learn to sample complex, high-dimensional distributions using energies or log densities alone, without training data. Yet, they remain impractical for molecular sampling because they are often slower than molecular dynamics and miss thermodynamically relevant modes. Inspired by enhanced sampling, we encourage exploration by introducing a sequential bias along bespoke, information-rich, low-dimensional projections of atomic coordinates known as collective variables (CVs). We introduce a repulsive potential centered on the CVs from recent samples, which pushes future samples towards novel CV regions and effectively increases the temperature in the projected space. Our resulting method improves efficiency, mode discovery, enables the estimation of free energy differences, and retains independent sampling from the approximate Boltzmann distribution via reweighting by the bias. On standard peptide conformational sampling benchmarks, the method recovers diverse conformational states and accurate free energy profiles. We are the first to demonstrate reactive sampling using a diffusion-based sampler, capturing bond breaking and formation with universal interatomic potentials at near-first-principles accuracy. The approach resolves reactive energy landscapes at a fraction of the wall-clock time of standard sampling methods, advancing diffusion-based sampling towards practical use in molecular sciences.

As sixth generation (6G) wireless networks evolve, accurate signal-to-interference-noise ratio (SINR) maps are becoming increasingly critical for effective resource management and optimization. However, acquiring such maps at high resolution is often cost-prohibitive, creating a severe data scarcity challenge. This necessitates machine learning (ML) approaches capable of robustly reconstructing the full map from extremely sparse measurements. To address this, we introduce a novel reconstruction framework based on Group Equivariant Non-Expansive Operators (GENEOs). Unlike data-hungry ML models, GENEOs are low-complexity operators that embed domain-specific geometric priors, such as translation invariance, directly into their structure. This provides a strong inductive bias, enabling effective reconstruction from very few samples. Our key insight is that for network management, preserving the topological structure of the SINR map, such as the geometry of coverage holes and interference patterns, is often more critical than minimizing pixel-wise error. We validate our approach on realistic ray-tracing-based urban scenarios, evaluating performance with both traditional statistical metrics (mean squared error (MSE)) and, crucially, a topological metric (1-Wasserstein distance). Results show that while maintaining competitive MSE, our method dramatically outperforms established ML baselines in topological fidelity. This demonstrates the practical advantage of GENEOs for creating structurally accurate SINR maps that are more reliable for downstream network optimization tasks.

Reaction mechanism search tools have demonstrated the ability to provide insights into likely products and rate-limiting steps of reacting systems. However, reactions involving several concerted bond changes - as can be found in many key steps of natural product synthesis - can complicate the search process. To mitigate these complications, we present a mechanism search strategy particularly suited to help expedite exploration of an exemplary family of such complex reactions, cyclizations. We provide a cost-effective strategy for identifying relevant elementary reaction steps by combining graph-based enumeration schemes and machine learning techniques for intermediate filtering. Key to this approach is our use of a neural network potential (NNP), AIMNet2-rxn, for computational evaluation of each candidate reaction pathway. In this article, we evaluate the NNP's ability to estimate activation energies, demonstrate the correct anticipation of stereoselectivity, and recapitulate complex enabling steps in natural product synthesis.

Artificial intelligence (AI) has recently seen transformative breakthroughs in the life sciences, expanding possibilities for researchers to interpret biological information at an unprecedented capacity, with novel applications and advances being made almost daily. In order to maximise return on the growing investments in AI-based life science research and accelerate this progress, it has become urgent to address the exacerbation of long-standing research challenges arising from the rapid adoption of AI methods. We review the increased erosion of trust in AI research outputs, driven by the issues of poor reusability and reproducibility, and highlight their consequent impact on environmental sustainability. Furthermore, we discuss the fragmented components of the AI ecosystem and lack of guiding pathways to best support Open and Sustainable AI (OSAI) model development. In response, this perspective introduces a practical set of OSAI recommendations directly mapped to over 300 components of the AI ecosystem and provides guiding implementation pathways. Our work connects researchers with relevant AI resources, facilitating the implementation of sustainable, reusable and reproducible AI. Built upon life science community consensus and aligned to existing efforts, the outputs of this perspective are designed to aid the future development of policy and additional structured pathways for guiding AI implementation.