Teams of researchers across 18 institutes spread over 11 countries have worked together to assess the utility of AlphaFold2 (AF2) predictions in the analysis of distinctive structural elements, the impact of missense variants, the prediction of function and ligand binding sites, the modeling of interactions, and the modeling of experimental structural data. A significant biological macromolecule involved in every cellular activity is the protein. It is crucial for interaction, protein function, and how missense mutations (point mutations where a single nucleotide change results in a codon that codes for a different amino acid) can affect a protein's functionality. The primary structure of amino acids, through protein folding, forms a three-dimensional tertiary or quaternary structure. Although the experimental methods for figuring out protein structures have advanced tremendously, most of the protein universe remained unidentified.

This course takes you from understanding the fundamentals of a machine learning project. Learners will understand and implement supervised learning techniques on real case studies to analyze business case scenarios where decision trees, k-nearest neighbours and support vector machines are optimally used. Learners will also gain skills to contrast the practical consequences of different data preparation steps and describe common production issues in applied ML. To be successful, you should have at least beginner-level background in Python programming (e.g., be able to read and code trace existing code, be comfortable with conditionals, loops, variables, lists, dictionaries and arrays). You should have a basic understanding of linear algebra (vector notation) and statistics (probability distributions and mean/median/mode).

The recent success of large language models for text generation poses a severe threat to academic integrity, as plagiarists can generate realistic paraphrases indistinguishable from original work. However, the role of large autoregressive transformers in generating machine-paraphrased plagiarism and their detection is still developing in the literature. This work explores T5 and GPT-3 for machine-paraphrase generation on scientific articles from arXiv, student theses, and Wikipedia. We evaluate the detection performance of six automated solutions and one commercial plagiarism detection software and perform a human study with 105 participants regarding their detection performance and the quality of generated examples. Our results suggest that large models can rewrite text humans have difficulty identifying as machine-paraphrased (53% mean acc.). Human experts rate the quality of paraphrases generated by GPT-3 as high as original texts (clarity 4.0/5, fluency 4.2/5, coherence 3.8/5). The best-performing detection model (GPT-3) achieves a 66% F1-score in detecting paraphrases.

Offline goal-conditioned reinforcement learning (GCRL) promises general-purpose skill learning in the form of reaching diverse goals from purely offline datasets. We propose $\textbf{Go}$al-conditioned $f$-$\textbf{A}$dvantage $\textbf{R}$egression (GoFAR), a novel regression-based offline GCRL algorithm derived from a state-occupancy matching perspective; the key intuition is that the goal-reaching task can be formulated as a state-occupancy matching problem between a dynamics-abiding imitator agent and an expert agent that directly teleports to the goal. In contrast to prior approaches, GoFAR does not require any hindsight relabeling and enjoys uninterleaved optimization for its value and policy networks. These distinct features confer GoFAR with much better offline performance and stability as well as statistical performance guarantee that is unattainable for prior methods. Furthermore, we demonstrate that GoFAR's training objectives can be re-purposed to learn an agent-independent goal-conditioned planner from purely offline source-domain data, which enables zero-shot transfer to new target domains. Through extensive experiments, we validate GoFAR's effectiveness in various problem settings and tasks, significantly outperforming prior state-of-art. Notably, on a real robotic dexterous manipulation task, while no other method makes meaningful progress, GoFAR acquires complex manipulation behavior that successfully accomplishes diverse goals.

Labeling a module defective or non-defective is an expensive task. Hence, there are often limits on how much-labeled data is available for training. Semi-supervised classifiers use far fewer labels for training models, but there are numerous semi-supervised methods, including self-labeling, co-training, maximal-margin, and graph-based methods, to name a few. Only a handful of these methods have been tested in SE for (e.g.) predicting defects and even that, those tests have been on just a handful of projects. This paper takes a wide range of 55 semi-supervised learners and applies these to over 714 projects. We find that semi-supervised "co-training methods" work significantly better than other approaches. However, co-training needs to be used with caution since the specific choice of co-training methods needs to be carefully selected based on a user's specific goals. Also, we warn that a commonly-used co-training method ("multi-view"-- where different learners get different sets of columns) does not improve predictions (while adding too much to the run time costs 11 hours vs. 1.8 hours). Those cautions stated, we find using these "co-trainers," we can label just 2.5% of data, then make predictions that are competitive to those using 100% of the data. It is an open question worthy of future work to test if these reductions can be seen in other areas of software analytics. All the codes used and datasets analyzed during the current study are available in the https://GitHub.com/Suvodeep90/Semi_Supervised_Methods.

Despite being responsible for state-of-the-art results in several computer vision and natural language processing tasks, neural networks have faced harsh criticism due to some of their current shortcomings. One of them is that neural networks are correlation machines prone to model biases within the data instead of focusing on actual useful causal relationships. This problem is particularly serious in application domains affected by aspects such as race, gender, and age. To prevent models from incurring on unfair decision-making, the AI community has concentrated efforts in correcting algorithmic biases, giving rise to the research area now widely known as fairness in AI. In this survey paper, we provide an in-depth overview of the main debiasing methods for fairness-aware neural networks in the context of vision and language research. We propose a novel taxonomy to better organize the literature on debiasing methods for fairness, and we discuss the current challenges, trends, and important future work directions for the interested researcher and practitioner.

State-of-the-art deep-learning-based approaches to Natural Language Processing (NLP) are credited with various capabilities that involve reasoning with natural language texts. In this paper we carry out a large-scale empirical study investigating the detection of formally valid inferences in controlled fragments of natural language for which the satisfiability problem becomes increasingly complex. We find that, while transformer-based language models perform surprisingly well in these scenarios, a deeper analysis re-veals that they appear to overfit to superficial patterns in the data rather than acquiring the logical principles governing the reasoning in these fragments.

In order to deal with variant-length long videos, prior works extract multi-modal features and fuse them to predict students' engagement intensity. In this paper, we present a new end-to-end method Class Attention in Video Transformer (CavT), which involves a single vector to process class embedding and to uniformly perform end-to-end learning on variant-length long videos and fixed-length short videos. Furthermore, to address the lack of sufficient samples, we propose a binary-order representatives sampling method (BorS) to add multiple video sequences of each video to augment the training set. BorS+CavT not only achieves the state-of-the-art MSE (0.0495) on the EmotiW-EP dataset, but also obtains the state-of-the-art MSE (0.0377) on the DAiSEE dataset. The code and models have been made publicly available at https://github.com/mountainai/cavt.

In this first course of the AI Product Management Specialization offered by Duke University's Pratt School of Engineering, you will build a foundational understanding of what machine learning is, how it works and when and why it is applied. To successfully manage an AI team or product and work collaboratively with data scientists, software engineers, and customers you need to understand the basics of machine learning technology. This course provides a non-coding introduction to machine learning, with focus on the process of developing models, ML model evaluation and interpretation, and the intuition behind common ML and deep learning algorithms. The course will conclude with a hands-on project in which you will have a chance to train and optimize a machine learning model on a simple real-world problem.

Learn what Data Analysts, Data Scientists, and Machine Learning engineers do. Industry experts teach you key job-relevant skills through 25 in-class real-world projects and case studies. Get familiar with how data science projects are managed and delivered in different industries. Participate in Hackathon to test and prove your skills. Imagine how you would feel when you have the skills to analyze complex business data, thereby empowering you to make accurate sales predictions or identify promising growth opportunities for your organization.