"When we talk about cloud without compromise what we're talking about is that when people think about'I need the flexibility of the cloud' - it's the ability to create applications and run them in a cloud environment that's far more flexible," explained Matthew Finnie, CTO of Interoute, in this SYS-CON.tv With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend 21st Cloud Expo, October 31 - November 2, 2017, at the Santa Clara Convention Center, CA, and June 12-14, 2018, at the Javits Center in New York City, NY, and learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation. Every Global 2000 enterprise in the world is now integrating cloud computing in some form into its IT development and operations. Midsize and small businesses are also migrating to the cloud in increasing numbers. Companies are each developing their unique mix of cloud technologies and services, forming multi-cloud and hybrid cloud architectures and deployments across all major industries.

Binary, or one-bit, representations of data arise naturally in many applications, and are appealing in both hardware implementations and algorithm design. In this work, we study the problem of data classification from binary data and propose a framework with low computation and resource costs. We illustrate the utility of the proposed approach through stylized and realistic numerical experiments, and provide a theoretical analysis for a simple case. We hope that our framework and analysis will serve as a foundation for studying similar types of approaches.

Extracting meaningful knowledge from large and nonlinearly-connected data structures is of primary importance for efficiently utilizing data. Big data problems (e.g. 1 GB/s) often contain superpositions of multiple distinct processes, sources, or latent factors. Estimating or inferring the component distributions or statistical factors is called the mixture problem. Methods for solving mixture problems are known as mixture models [Everitt, 1996], and in machine learning they are used to define Bayes classifiers [Bishop, 2006]. Mixture models are a widely applicable pattern recognition and dimensionality reduction approach for extracting meaningful content from large and complex datasets. Only finite mixture models are described here, although countably or uncountably infinite numbers of mixture components are also possible [McAuliffe et al., 2006]. In terms of dimensionality reduction methods, Laplacian mixture models provide global and nonhierarchical analyses of massive datasets using scalable algorithms.

Independent Component Analysis (ICA) is a dimensionality reduction technique that can boost efficiency of machine learning models that deal with probability density functions, e.g. Bayesian neural networks. Algorithms that implement adaptive ICA converge slower than their nonadaptive counterparts, however, they are capable of tracking changes in underlying distributions of input features. This intrinsically slow convergence of adaptive methods combined with existing hardware implementations that operate at very low clock frequencies necessitate fundamental improvements in both algorithm and hardware design. This paper presents an algorithm that allows efficient hardware implementation of ICA. Compared to previous work, our FPGA implementation of adaptive ICA improves clock frequency by at least one order of magnitude and throughput by at least two orders of magnitude. Our proposed algorithm is not limited to ICA and can be used in various machine learning problems that use stochastic gradient descent optimization.

Traditionally, kernel learning methods requires positive definitiveness on the kernel, which is too strict and excludes many sophisticated similarities, that are indefinite, in multimedia area. To utilize those indefinite kernels, indefinite learning methods are of great interests. This paper aims at the extension of the logistic regression from positive semi-definite kernels to indefinite kernels. The model, called indefinite kernel logistic regression (IKLR), keeps consistency to the regular KLR in formulation but it essentially becomes non-convex. Thanks to the positive decomposition of an indefinite matrix, IKLR can be transformed into a difference of two convex models, which follows the use of concave-convex procedure. Moreover, we employ an inexact solving scheme to speed up the sub-problem and develop a concave-inexact-convex procedure (CCICP) algorithm with theoretical convergence analysis. Systematical experiments on multi-modal datasets demonstrate the superiority of the proposed IKLR method over kernel logistic regression with positive definite kernels and other state-of-the-art indefinite learning based algorithms.

This project was motivated by a dialysis study in northern Taiwan. Dialysis patients, after shunt implantation, may experience two types ("acute" or "non-acute") of shunt thrombosis, both of which may recur. We formulate the problem under the framework of recurrent events data in the presence of competing risks. In particular we focus on marginal inference for the gap time variable of specific type. The functions of interest are the cumulative incidence function and cause-specific hazard function. The major challenge of nonparametric inference is the problem of induced dependent censoring. We apply the technique of inverse probability of censoring weighting (IPCW) to adjust for the selection bias. Besides point estimation, we apply the bootstrap re-sampling method for further inference. Large sample properties of the proposed estimators are derived. Simulations are performed to examine the finite-sample performances of the proposed methods. Finally we apply the proposed methodology to analyze the dialysis data.

The regret bound of an optimization algorithms is one of the basic criteria for evaluating the performance of the given algorithm. By inspecting the differences between the regret bounds of traditional algorithms and adaptive one, we provide a guide for choosing an optimizer with respect to the given data set and the loss function. For analysis, we assume that the loss function is convex and its gradient is Lipschitz continuous.

We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational Autoencoder (Dr.VAE), learn latent representation of the underlying gene states before and after drug application that depend on: (i) drug-induced biological change of each gene and (ii) overall treatment response outcome. Our VAE-based models outperform the current published benchmarks in the field by anywhere from 3 to 11% AUROC and 2 to 30% AUPR. In addition, we found that better reconstruction accuracy does not necessarily lead to improvement in classification accuracy and that jointly trained models perform better than models that minimize reconstruction error independently.

We present a new method for estimating multivariate, second-order stationary Gaussian Random Field (GRF) models based on the Sparse Precision matrix Selection (SPS) algorithm, proposed by Davanloo et al. (2015) for estimating scalar GRF models. Theoretical convergence rates for the estimated between-response covariance matrix and for the estimated parameters of the underlying spatial correlation function are established. Numerical tests using simulated and real datasets validate our theoretical findings. Data segmentation is used to handle large data sets.

Multiple hypothesis testing is a core problem in statistical inference and arises in almost every scientific field. Given a set of null hypotheses $\mathcal{H}(n) = (H_1,\dotsc, H_n)$, Benjamini and Hochberg introduced the false discovery rate (FDR), which is the expected proportion of false positives among rejected null hypotheses, and proposed a testing procedure that controls FDR below a pre-assigned significance level. Nowadays FDR is the criterion of choice for large scale multiple hypothesis testing. In this paper we consider the problem of controlling FDR in an "online manner". Concretely, we consider an ordered --possibly infinite-- sequence of null hypotheses $\mathcal{H} = (H_1,H_2,H_3,\dots )$ where, at each step $i$, the statistician must decide whether to reject hypothesis $H_i$ having access only to the previous decisions. This model was introduced by Foster and Stine. We study a class of "generalized alpha-investing" procedures and prove that any rule in this class controls online FDR, provided $p$-values corresponding to true nulls are independent from the other $p$-values. (Earlier work only established mFDR control.) Next, we obtain conditions under which generalized alpha-investing controls FDR in the presence of general $p$-values dependencies. Finally, we develop a modified set of procedures that also allow to control the false discovery exceedance (the tail of the proportion of false discoveries). Numerical simulations and analytical results indicate that online procedures do not incur a large loss in statistical power with respect to offline approaches, such as Benjamini-Hochberg.