Large language models have shown promise in various domains, including healthcare. In this study, we conduct a comprehensive evaluation of LLMs in the context of mental health tasks using social media data. We explore the zero-shot (ZS) and few-shot (FS) capabilities of various LLMs, including GPT-4, Llama 3, Gemini, and others, on tasks such as binary disorder detection, disorder severity evaluation, and psychiatric knowledge assessment. Our evaluation involved 33 models testing 9 main prompt templates across the tasks. Key findings revealed that models like GPT-4 and Llama 3 exhibited superior performance in binary disorder detection, with accuracies reaching up to 85% on certain datasets. Moreover, prompt engineering played a crucial role in enhancing model performance. Notably, the Mixtral 8x22b model showed an improvement of over 20%, while Gemma 7b experienced a similar boost in performance. In the task of disorder severity evaluation, we observed that FS learning significantly improved the model's accuracy, highlighting the importance of contextual examples in complex assessments. Notably, the Phi-3-mini model exhibited a substantial increase in performance, with balanced accuracy improving by over 6.80% and mean average error dropping by nearly 1.3 when moving from ZS to FS learning. In the psychiatric knowledge task, recent models generally outperformed older, larger counterparts, with the Llama 3.1 405b achieving an accuracy of 91.2%. Despite promising results, our analysis identified several challenges, including variability in performance across datasets and the need for careful prompt engineering. Furthermore, the ethical guards imposed by many LLM providers hamper the ability to accurately evaluate their performance, due to tendency to not respond to potentially sensitive queries.

This involves taking multiple images to detect an object more than once within a short enough time for the detections to be linked. The actual linkage of detection can include decision trees or the connection of several detections together within similar co-moving velocities (Kubica et al., 2005; Masci et al., 2019). Multiple detection linking algorithms can link the detections of both point-source, asteroidal detections and those that are extended, as for comets. Even for comets, whose detections have a large, extended appearance, multiple detections can be linked as for point sources if the measurement of the comet's position relative to the moving frame of the object is consistent from detection to detection (Denneau et al., 2013). However, in some survey imaging pipelines, extended objects, defined as having a width more expansive than the measured width for known point sources, can be flagged as potential outliers and removed from further processing (Duev et al., 2019).

The exponential growth in computational power and accessibility has transformed the complexity and scale of bioinformatics research, necessitating standardized documentation for transparency, reproducibility, and regulatory compliance. The IEEE BioCompute Object (BCO) standard addresses this need but faces adoption challenges due to the overhead of creating compliant documentation, especially for legacy research. This paper presents a novel approach to automate the creation of BCOs from scientific papers using Retrieval-Augmented Generation (RAG) and Large Language Models (LLMs). We describe the development of the BCO assistant tool that leverages RAG to extract relevant information from source papers and associated code repositories, addressing key challenges such as LLM hallucination and long-context understanding. The implementation incorporates optimized retrieval processes, including a two-pass retrieval with re-ranking, and employs carefully engineered prompts for each BCO domain. We discuss the tool's architecture, extensibility, and evaluation methods, including automated and manual assessment approaches. The BCO assistant demonstrates the potential to significantly reduce the time and effort required for retroactive documentation of bioinformatics research while maintaining compliance with the standard. This approach opens avenues for AI-assisted scientific documentation and knowledge extraction from publications thereby enhancing scientific reproducibility. The BCO assistant tool and documentation is available at https://biocompute-objects.github.io/bco-rag/.

Multi-modal generative AI has received increasing attention in both academia and industry. Particularly, two dominant families of techniques are: i) The multi-modal large language model (MLLM) such as GPT-4V, which shows impressive ability for multi-modal understanding; ii) The diffusion model such as Sora, which exhibits remarkable multi-modal powers, especially with respect to visual generation. As such, one natural question arises: Is it possible to have a unified model for both understanding and generation? To answer this question, in this paper, we first provide a detailed review of both MLLM and diffusion models, including their probabilistic modeling procedure, multi-modal architecture design, and advanced applications to image/video large language models as well as text-to-image/video generation. Then, we discuss the two important questions on the unified model: i) whether the unified model should adopt the auto-regressive or diffusion probabilistic modeling, and ii) whether the model should utilize a dense architecture or the Mixture of Experts(MoE) architectures to better support generation and understanding, two objectives. We further provide several possible strategies for building a unified model and analyze their potential advantages and disadvantages. We also summarize existing large-scale multi-modal datasets for better model pretraining in the future. To conclude the paper, we present several challenging future directions, which we believe can contribute to the ongoing advancement of multi-modal generative AI.

Large language models (LLMs) augmented with external data have demonstrated remarkable capabilities in completing real-world tasks. Techniques for integrating external data into LLMs, such as Retrieval-Augmented Generation (RAG) and fine-tuning, are gaining increasing attention and widespread application. Nonetheless, the effective deployment of data-augmented LLMs across various specialized fields presents substantial challenges. These challenges encompass a wide range of issues, from retrieving relevant data and accurately interpreting user intent to fully harnessing the reasoning capabilities of LLMs for complex tasks. We believe that there is no one-size-fits-all solution for data-augmented LLM applications. In practice, underperformance often arises from a failure to correctly identify the core focus of a task or because the task inherently requires a blend of multiple capabilities that must be disentangled for better resolution. In this survey, we propose a RAG task categorization method, classifying user queries into four levels based on the type of external data required and primary focus of the task: explicit fact queries, implicit fact queries, interpretable rationale queries, and hidden rationale queries. We define these levels of queries, provide relevant datasets, and summarize the key challenges and most effective techniques for addressing these challenges. Finally, we discuss three main forms of integrating external data into LLMs: context, small model, and fine-tuning, highlighting their respective strengths, limitations, and the types of problems they are suited to solve. This work aims to help readers thoroughly understand and decompose the data requirements and key bottlenecks in building LLM applications, offering solutions to the different challenges and serving as a guide to systematically developing such applications.

In mental health counseling, condensing dialogues into concise and relevant summaries (aka counseling notes) holds pivotal significance. Large Language Models (LLMs) exhibit remarkable capabilities in various generative tasks; however, their adaptation to domain-specific intricacies remains challenging, especially within mental health contexts. Unlike standard LLMs, mental health experts first plan to apply domain knowledge in writing summaries. Our work enhances LLMs' ability by introducing a novel planning engine to orchestrate structuring knowledge alignment. To achieve high-order planning, we divide knowledge encapsulation into two major phases: (i) holding dialogue structure and (ii) incorporating domain-specific knowledge. We employ a planning engine on Llama-2, resulting in a novel framework, PIECE. Our proposed system employs knowledge filtering-cum-scaffolding to encapsulate domain knowledge. Additionally, PIECE leverages sheaf convolution learning to enhance its understanding of the dialogue's structural nuances. We compare PIECE with 14 baseline methods and observe a significant improvement across ROUGE and Bleurt scores. Further, expert evaluation and analyses validate the generation quality to be effective, sometimes even surpassing the gold standard. We further benchmark PIECE with other LLMs and report improvement, including Llama-2 (+2.72%), Mistral (+2.04%), and Zephyr (+1.59%), to justify the generalizability of the planning engine.

The integration of Artificial Intelligence (AI) and the Internet of Medical Things (IoMT) in healthcare, through Machine Learning (ML) and Deep Learning (DL) techniques, has advanced the prediction and diagnosis of chronic diseases. AI-driven models such as XGBoost, Random Forest, CNNs, and LSTM RNNs have achieved over 98\% accuracy in predicting heart disease, chronic kidney disease (CKD), Alzheimer's disease, and lung cancer, using datasets from platforms like Kaggle, UCI, private institutions, and real-time IoMT sources. However, challenges persist due to variations in data quality, patient demographics, and formats from different hospitals and research sources. The incorporation of IoMT data, which is vast and heterogeneous, adds complexities in ensuring interoperability and security to protect patient privacy. AI models often struggle with overfitting, performing well in controlled environments but less effectively in real-world clinical settings. Moreover, multi-morbidity scenarios especially for rare diseases like dementia, stroke, and cancers remain insufficiently addressed. Future research should focus on data standardization and advanced preprocessing techniques to improve data quality and interoperability. Transfer learning and ensemble methods are crucial for improving model generalizability across clinical settings. Additionally, the exploration of disease interactions and the development of predictive models for chronic illness intersections is needed. Creating standardized frameworks and open-source tools for integrating federated learning, blockchain, and differential privacy into IoMT systems will also ensure robust data privacy and security.

Regarding software engineering (SE) tasks, Large language models (LLMs) have the capability of zero-shot learning, which does not require training or fine-tuning, unlike pre-trained models (PTMs). However, LLMs are primarily designed for natural language output, and cannot directly produce intermediate embeddings from source code. They also face some challenges, for example, the restricted context length may prevent them from handling larger inputs, limiting their applicability to many SE tasks; while hallucinations may occur when LLMs are applied to complex downstream tasks. Motivated by the above facts, we propose zsLLMCode, a novel approach that generates functional code embeddings using LLMs. Our approach utilizes LLMs to convert source code into concise summaries through zero-shot learning, which is then transformed into functional code embeddings using specialized embedding models. This unsupervised approach eliminates the need for training and addresses the issue of hallucinations encountered with LLMs. To the best of our knowledge, this is the first approach that combines LLMs and embedding models to generate code embeddings. We conducted experiments to evaluate the performance of our approach. The results demonstrate the effectiveness and superiority of our approach over state-of-the-art unsupervised methods.

Despite advancements in perception and planning for autonomous vehicles (AVs), validating their performance remains a significant challenge. The deployment of planning algorithms in real-world environments is often ineffective due to discrepancies between simulations and real traffic conditions. Evaluating AVs planning algorithms in simulation typically involves replaying driving logs from recorded real-world traffic. However, agents replayed from offline data are not reactive, lack the ability to respond to arbitrary AV behavior, and cannot behave in an adversarial manner to test certain properties of the driving policy. Therefore, simulation with realistic and potentially adversarial agents represents a critical task for AV planning software validation. In this work, we aim to review current research efforts in the field of adversarial and reactive traffic agents, with a particular focus on the application of classical and adversarial learning-based techniques. The objective of this work is to categorize existing approaches based on the proposed scenario controllability, defined by the number of reactive or adversarial agents. Moreover, we examine existing traffic simulations with respect to their employed default traffic agents and potential extensions, collate datasets that provide initial driving data, and collect relevant evaluation metrics.

The rapid evolution of Multimodal Large Language Models (MLLMs) has brought substantial advancements in artificial intelligence, significantly enhancing the capability to understand and generate multimodal content. While prior studies have largely concentrated on model architectures and training methodologies, a thorough analysis of the benchmarks used for evaluating these models remains underexplored. This survey addresses this gap by systematically reviewing 211 benchmarks that assess MLLMs across four core domains: understanding, reasoning, generation, and application. We provide a detailed analysis of task designs, evaluation metrics, and dataset constructions, across diverse modalities. We hope that this survey will contribute to the ongoing advancement of MLLM research by offering a comprehensive overview of benchmarking practices and identifying promising directions for future work. An associated GitHub repository collecting the latest papers is available.