The increasing frequency and sophistication of cybersecurity vulnerabilities in software systems underscore the urgent need for robust and effective methods of vulnerability assessment. However, existing approaches often rely on highly technical and abstract frameworks, which hinders understanding and increases the likelihood of exploitation, resulting in severe cyberattacks. Given the growing adoption of Large Language Models (LLMs) across diverse domains, this paper explores their potential application in cybersecurity, specifically for enhancing the assessment of software vulnerabilities. We propose ChatNVD, an LLM-based cybersecurity vulnerability assessment tool leveraging the National Vulnerability Database (NVD) to provide context-rich insights and streamline vulnerability analysis for cybersecurity professionals, developers, and non-technical users. We develop three variants of ChatNVD, utilizing three prominent LLMs: GPT-4o mini by OpenAI, Llama 3 by Meta, and Gemini 1.5 Pro by Google. To evaluate their efficacy, we conduct a comparative analysis of these models using a comprehensive questionnaire comprising common security vulnerability questions, assessing their accuracy in identifying and analyzing software vulnerabilities. This study provides valuable insights into the potential of LLMs to address critical challenges in understanding and mitigation of software vulnerabilities.

Multimodal AI has the potential to significantly enhance document-understanding tasks, such as processing receipts, understanding workflows, extracting data from documents, and summarizing reports. Code generation tasks that require long-structured outputs can also be enhanced by multimodality. Despite this, their use in commercial applications is often limited due to limited access to training data and restrictive licensing, which hinders open access. To address these limitations, we introduce BigDocs-7.5M, a high-quality, open-access dataset comprising 7.5 million multimodal documents across 30 tasks. We use an efficient data curation process to ensure our data is high-quality and license-permissive. Our process emphasizes accountability, responsibility, and transparency through filtering rules, traceable metadata, and careful content analysis. Additionally, we introduce BigDocs-Bench, a benchmark suite with 10 novel tasks where we create datasets that reflect real-world use cases involving reasoning over Graphical User Interfaces (GUI) and code generation from images. Our experiments show that training with BigDocs-Bench improves average performance up to 25.8% over closed-source GPT-4o in document reasoning and structured output tasks such as Screenshot2HTML or Image2Latex generation. Finally, human evaluations showed a preference for outputs from models trained on BigDocs over GPT-4o. This suggests that BigDocs can help both academics and the open-source community utilize and improve AI tools to enhance multimodal capabilities and document reasoning. The project is hosted at https://bigdocs.github.io .

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and spatial omics data remains challenging. First, single-cell sequencing data are high-dimensional and sparse, often contaminated by noise and uncertainty, obscuring the underlying biological signals. Second, these data often encompass multiple modalities, including gene expression, epigenetic modifications, and spatial locations. Integrating these diverse data modalities is crucial for enhancing prediction accuracy and biological interpretability. Third, while the scale of single-cell sequencing has expanded to millions of cells, high-quality annotated datasets are still limited. Fourth, the complex correlations of biological tissues make it difficult to accurately reconstruct cellular states and spatial contexts. Traditional feature engineering-based analysis methods struggle to deal with the various challenges presented by intricate biological networks. Deep learning has emerged as a powerful tool capable of handling high-dimensional complex data and automatically identifying meaningful patterns, offering significant promise in addressing these challenges. This review systematically analyzes these challenges and discusses related deep learning approaches. Moreover, we have curated 21 datasets from 9 benchmarks, encompassing 58 computational methods, and evaluated their performance on the respective modeling tasks. Finally, we highlight three areas for future development from a technical, dataset, and application perspective. This work will serve as a valuable resource for understanding how deep learning can be effectively utilized in single-cell and spatial transcriptomics analyses, while inspiring novel approaches to address emerging challenges.

Federated Learning (FL) marks a transformative approach to distributed model training by combining locally optimized models from various clients into a unified global model. While FL preserves data privacy by eliminating centralized storage, it encounters significant challenges such as performance degradation, slower convergence, and reduced robustness of the global model due to the heterogeneity in client data distributions. Among the various forms of data heterogeneity, label skew emerges as a particularly formidable and prevalent issue, especially in domains such as image classification. To address these challenges, we begin with comprehensive experiments to pinpoint the underlying issues in the FL training process. Based on our findings, we then introduce an innovative dual-strategy approach designed to effectively resolve these issues. First, we introduce an adaptive loss function for client-side training, meticulously crafted to preserve previously acquired knowledge while maintaining an optimal equilibrium between local optimization and global model coherence. Secondly, we develop a dynamic aggregation strategy for aggregating client models at the server. This approach adapts to each client's unique learning patterns, effectively addressing the challenges of diverse data across the network. Our comprehensive evaluation, conducted across three diverse real-world datasets, coupled with theoretical convergence guarantees, demonstrates the superior efficacy of our method compared to several established state-of-the-art approaches.

Intelligent autonomous agents hold much potential for the domain of cyber security. However, due to many state-of-the-art approaches relying on uninterpretable black-box models, there is growing demand for methods that offer stakeholders clear and actionable insights into their latent beliefs and motivations. To address this, we evaluate Theory of Mind (ToM) approaches for Autonomous Cyber Operations. Upon learning a robust prior, ToM models can predict an agent's goals, behaviours, and contextual beliefs given only a handful of past behaviour observations. In this paper, we introduce a novel Graph Neural Network (GNN)-based ToM architecture tailored for cyber-defence, Graph-In, Graph-Out (GIGO)-ToM, which can accurately predict both the targets and attack trajectories of adversarial cyber agents over arbitrary computer network topologies. To evaluate the latter, we propose a novel extension of the Wasserstein distance for measuring the similarity of graph-based probability distributions. Whereas the standard Wasserstein distance lacks a fixed reference scale, we introduce a graph-theoretic normalization factor that enables a standardized comparison between networks of different sizes. We furnish this metric, which we term the Network Transport Distance (NTD), with a weighting function that emphasizes predictions according to custom node features, allowing network operators to explore arbitrary strategic considerations. Benchmarked against a Graph-In, Dense-Out (GIDO)-ToM architecture in an abstract cyber-defence environment, our empirical evaluations show that GIGO-ToM can accurately predict the goals and behaviours of various unseen cyber-attacking agents across a range of network topologies, as well as learn embeddings that can effectively characterize their policies.

As the strength of Large Language Models (LLMs) has grown over recent years, so too has interest in their use as the underlying models for autonomous agents. Although LLMs demonstrate emergent abilities and broad expertise across natural language domains, their inherent unpredictability makes the implementation of LLM agents challenging, resulting in a gap between related research and the real-world implementation of such systems. To bridge this gap, this paper frames actionable insights and considerations from the research community in the context of established application paradigms to enable the construction and facilitate the informed deployment of robust LLM agents. Namely, we position relevant research findings into four broad categories--Planning, Memory, Tools, and Control Flow--based on common practices in application-focused literature and highlight practical considerations to make when designing agentic LLMs for real-world applications, such as handling stochasticity and managing resources efficiently. While we do not conduct empirical evaluations, we do provide the necessary background for discussing critical aspects of agentic LLM designs, both in academia and industry.

Recent advances in deep learning and natural language generation have significantly improved image captioning, enabling automated, human-like descriptions for visual content. In this work, we apply these captioning techniques to generate clinician-like interpretations of ECG data. This study leverages existing ECG datasets accompanied by free-text reports authored by healthcare professionals (HCPs) as training data. These reports, while often inconsistent, provide a valuable foundation for automated learning. We introduce an encoder-decoder-based method that uses these reports to train models to generate detailed descriptions of ECG episodes. This represents a significant advancement in ECG analysis automation, with potential applications in zero-shot classification and automated clinical decision support. The model is tested on various datasets, including both 1- and 12-lead ECGs. It significantly outperforms the state-of-the-art reference model by Qiu et al., achieving a METEOR score of 55.53% compared to 24.51% achieved by the reference model. Furthermore, several key design choices are discussed, providing a comprehensive overview of current challenges and innovations in this domain. The source codes for this research are publicly available in our Git repository https://git.zib.de/ableich/ecg-comment-generation-public

The rapid development of Artificial Intelligence (AI) has led to the creation of powerful text generation models, such as large language models (LLMs), which are widely used for diverse applications. However, concerns surrounding AI-generated content, including issues of originality, bias, misinformation, and accountability, have become increasingly prominent. This paper offers a comprehensive overview of AI text generators (AITGs), focusing on their evolution, capabilities, and ethical implications. This paper also introduces Retrieval-Augmented Generation (RAG), a recent approach that improves the contextual relevance and accuracy of text generation by integrating dynamic information retrieval. RAG addresses key limitations of traditional models, including their reliance on static knowledge and potential inaccuracies in handling real-world data. Additionally, the paper reviews detection tools that help differentiate AI-generated text from human-written content and discusses the ethical challenges these technologies pose. The paper explores future directions for improving detection accuracy, supporting ethical AI development, and increasing accessibility. The paper contributes to a more responsible and reliable use of AI in content creation through these discussions.

Game-theoretic scenarios have become pivotal in evaluating the social intelligence of Large Language Model (LLM)-based social agents. While numerous studies have explored these agents in such settings, there is a lack of a comprehensive survey summarizing the current progress. To address this gap, we systematically review existing research on LLM-based social agents within game-theoretic scenarios. Our survey organizes the findings into three core components: Game Framework, Social Agent, and Evaluation Protocol. The game framework encompasses diverse game scenarios, ranging from choice-focusing to communication-focusing games. The social agent part explores agents' preferences, beliefs, and reasoning abilities. The evaluation protocol covers both game-agnostic and game-specific metrics for assessing agent performance. By reflecting on the current research and identifying future research directions, this survey provides insights to advance the development and evaluation of social agents in game-theoretic scenarios.

The rapid advancement of deep learning has resulted in substantial advancements in AI-driven applications; however, the "black box" characteristic of these models frequently constrains their interpretability, transparency, and reliability. Explainable artificial intelligence (XAI) seeks to elucidate AI decision-making processes, guaranteeing that explanations faithfully represent the model's rationale and correspond with human comprehension. Despite comprehensive research in XAI, a significant gap persists in standardized procedures for assessing the efficacy and transparency of XAI techniques across many real-world applications. This study presents a unified XAI evaluation framework incorporating extensive quantitative and qualitative criteria to systematically evaluate the correctness, interpretability, robustness, fairness, and completeness of explanations generated by AI models. The framework prioritizes user-centric and domain-specific adaptations, hence improving the usability and reliability of AI models in essential domains. To address deficiencies in existing evaluation processes, we suggest defined benchmarks and a systematic evaluation pipeline that includes data loading, explanation development, and thorough method assessment. The suggested framework's relevance and variety are evidenced by case studies in healthcare, finance, agriculture, and autonomous systems. These provide a solid basis for the equitable and dependable assessment of XAI methodologies. This paradigm enhances XAI research by offering a systematic, flexible, and pragmatic method to guarantee transparency and accountability in AI systems across many real-world contexts.