The era of Large Language Models (LLMs) presents a new opportunity for interpretability--agentic interpretability: a multi-turn conversation with an LLM wherein the LLM proactively assists human understanding by developing and leveraging a mental model of the user, which in turn enables humans to develop better mental models of the LLM. Such conversation is a new capability that traditional `inspective' interpretability methods (opening the black-box) do not use. Having a language model that aims to teach and explain--beyond just knowing how to talk--is similar to a teacher whose goal is to teach well, understanding that their success will be measured by the student's comprehension. While agentic interpretability may trade off completeness for interactivity, making it less suitable for high-stakes safety situations with potentially deceptive models, it leverages a cooperative model to discover potentially superhuman concepts that can improve humans' mental model of machines. Agentic interpretability introduces challenges, particularly in evaluation, due to what we call `human-entangled-in-the-loop' nature (humans responses are integral part of the algorithm), making the design and evaluation difficult. We discuss possible solutions and proxy goals. As LLMs approach human parity in many tasks, agentic interpretability's promise is to help humans learn the potentially superhuman concepts of the LLMs, rather than see us fall increasingly far from understanding them.

Tariff exemptions are fundamental to attracting Foreign Direct Investment (FDI) into the manufacturing sector, though the associated administrative processes present areas for optimization for both investing entities and the national tax authority. This paper proposes a conceptual framework to empower tax administration by leveraging a synergistic integration of Optical Character Recognition (OCR) and Large Language Model (LLM) technologies. The proposed system is designed to first utilize OCR for intelligent digitization, precisely extracting data from diverse application documents and key regulatory texts such as tariff orders. Subsequently, the LLM would enhance the capabilities of administrative officers by automating the critical and time-intensive task of verifying submitted HS Tariff Codes for machinery, equipment, and raw materials against official exemption lists. By enhancing the speed and precision of these initial assessments, this AI-driven approach systematically reduces potential for non-alignment and non-optimized exemption utilization, thereby streamlining the investment journey for FDI companies. For the national administration, the benefits include a significant boost in operational capacity, reduced administrative load, and a strengthened control environment, ultimately improving the ease of doing business and solidifying the nation's appeal as a premier destination for high-value manufacturing FDI.

Cybersecurity organizations are adapting to GenAI integration through modified frameworks and hybrid operational processes, with success influenced by existing security maturity, regulatory requirements, and investments in human capital and infrastructure. This qualitative research employs systematic document analysis and comparative case study methodology to examine how cybersecurity organizations adapt their threat modeling frameworks and operational processes to address generative artificial intelligence integration. Through examination of 25 studies from 2022 to 2025, the research documents substantial transformation in organizational approaches to threat modeling, moving from traditional signature-based systems toward frameworks incorporating artificial intelligence capabilities. The research identifies three primary adaptation patterns: Large Language Model integration for security applications, GenAI frameworks for risk detection and response automation, and AI/ML integration for threat hunting. Organizations with mature security infrastructures, particularly in finance and critical infrastructure sectors, demonstrate higher readiness through structured governance approaches, dedicated AI teams, and robust incident response processes. Organizations achieve successful GenAI integration when they maintain appropriate human oversight of automated systems, address data quality concerns and explainability requirements, and establish governance frameworks tailored to their specific sectors. Organizations encounter ongoing difficulties with privacy protection, bias reduction, personnel training, and defending against adversarial attacks. This work advances understanding of how organizations adopt innovative technologies in high-stakes environments and offers actionable insights for cybersecurity professionals implementing GenAI systems.

Scholar Inbox is a new open-access platform designed to address the challenges researchers face in staying current with the rapidly expanding volume of scientific literature. We provide personalized recommendations, continuous updates from open-access archives (arXiv, bioRxiv, etc.), visual paper summaries, semantic search, and a range of tools to streamline research workflows and promote open research access. The platform's personalized recommendation system is trained on user ratings, ensuring that recommendations are tailored to individual researchers' interests. To further enhance the user experience, Scholar Inbox also offers a map of science that provides an overview of research across domains, enabling users to easily explore specific topics. We use this map to address the cold start problem common in recommender systems, as well as an active learning strategy that iteratively prompts users to rate a selection of papers, allowing the system to learn user preferences quickly. We evaluate the quality of our recommendation system on a novel dataset of 800k user ratings, which we make publicly available, as well as via an extensive user study. https://www.scholar-inbox.com/

In cancer therapeutics, protein-metal binding mechanisms critically govern the pharmacokinetics and targeting efficacy of drugs, thereby fundamentally shaping the rational design of anticancer metallodrugs. While conventional laboratory methods used to study such mechanisms are often costly, low throughput, and limited in capturing dynamic biological processes, machine learning (ML) has emerged as a promising alternative. Despite increasing efforts to develop protein-metal binding datasets and ML algorithms, the application of ML in tumor protein-metal binding remains limited. Key challenges include a shortage of high-quality, tumor-specific datasets, insufficient consideration of multiple data modalities, and the complexity of interpreting results due to the ''black box'' nature of complex ML models. This paper summarizes recent progress and ongoing challenges in using ML to predict tumor protein-metal binding, focusing on data, modeling, and interpretability. We present multimodal protein-metal binding datasets and outline strategies for acquiring, curating, and preprocessing them for training ML models. Moreover, we explore the complementary value provided by different data modalities and examine methods for their integration. We also review approaches for improving model interpretability to support more trustworthy decisions in cancer research. Finally, we offer our perspective on research opportunities and propose strategies to address the scarcity of tumor protein data and the limited number of predictive models for tumor protein-metal binding. We also highlight two promising directions for effective metal-based drug design: integrating protein-protein interaction data to provide structural insights into metal-binding events and predicting structural changes in tumor proteins after metal binding.

We propose Polyra Swarms, a novel machine-learning approach that approximates shapes instead of functions. Our method enables general-purpose learning with very low bias. In particular, we show that depending on the task, Polyra Swarms can be preferable compared to neural networks, especially for tasks like anomaly detection. We further introduce an automated abstraction mechanism that simplifies the complexity of a Polyra Swarm significantly, enhancing both their generalization and transparency. Since Polyra Swarms operate on fundamentally different principles than neural networks, they open up new research directions with distinct strengths and limitations.

Artificial intelligence (AI), propelled by advancements in machine learning, has made significant strides in solving complex tasks. However, the current neural network-based paradigm, while effective, is heavily constrained by inherent limitations, primarily a lack of structural organization and a progression of learning that displays undesirable properties. As AI research progresses without a unifying framework, it either tries to patch weaknesses heuristically or draws loosely from biological mechanisms without strong theoretical foundations. Meanwhile, the recent paradigm shift in evolutionary understanding -- driven primarily by evolutionary developmental biology (EDB) -- has been largely overlooked in AI literature, despite a striking analogy between the Modern Synthesis and contemporary machine learning, evident in their shared assumptions, approaches, and limitations upon careful analysis. Consequently, the principles of adaptation from EDB that reshaped our understanding of the evolutionary process can also form the foundation of a unifying conceptual framework for the next design philosophy in AI, going beyond mere inspiration and grounded firmly in biology's first principles. This article provides a detailed overview of the analogy between the Modern Synthesis and modern machine learning, and outlines the core principles of a new AI design paradigm based on insights from EDB. To exemplify our analysis, we also present two learning system designs grounded in specific developmental principles -- regulatory connections, somatic variation and selection, and weak linkage -- that resolve multiple major limitations of contemporary machine learning in an organic manner, while also providing deeper insights into the role of these mechanisms in biological evolution.

The advent of autonomous agents is transforming interactions with Graphical User Interfaces (GUIs) by employing natural language as a powerful intermediary. Despite the predominance of Supervised Fine-Tuning (SFT) methods in current GUI agents for achieving spatial localization, these methods face substantial challenges due to their limited capacity to accurately perceive positional data. Existing strategies, such as reinforcement learning, often fail to assess positional accuracy effectively, thereby restricting their utility. In response, we introduce Location Preference Optimization (LPO), a novel approach that leverages locational data to optimize interaction preferences. LPO uses information entropy to predict interaction positions by focusing on zones rich in information. Besides, it further introduces a dynamic location reward function based on physical distance, reflecting the varying importance of interaction positions. Supported by Group Relative Preference Optimization (GRPO), LPO facilitates an extensive exploration of GUI environments and significantly enhances interaction precision. Comprehensive experiments demonstrate LPO's superior performance, achieving SOTA results across both offline benchmarks and real-world online evaluations. Our code will be made publicly available soon, at https://github.com/AIDC-AI/LPO.

Time series analysis is pivotal in domains like financial forecasting and biomedical monitoring, yet traditional methods are constrained by limited nonlinear feature representation and long-term dependency capture. The emergence of Large Language Models (LLMs) offers transformative potential by leveraging their cross-modal knowledge integration and inherent attention mechanisms for time series analysis. However, the development of general-purpose LLMs for time series from scratch is still hindered by data diversity, annotation scarcity, and computational requirements. This paper presents a systematic review of pre-trained LLM-driven time series analysis, focusing on enabling techniques, potential applications, and open challenges. First, it establishes an evolutionary roadmap of AI-driven time series analysis, from the early machine learning era, through the emerging LLM-driven paradigm, to the development of native temporal foundation models. Second, it organizes and systematizes the technical landscape of LLM-driven time series analysis from a workflow perspective, covering LLMs' input, optimization, and lightweight stages. Finally, it critically examines novel real-world applications and highlights key open challenges that can guide future research and innovation. The work not only provides valuable insights into current advances but also outlines promising directions for future development. It serves as a foundational reference for both academic and industrial researchers, paving the way for the development of more efficient, generalizable, and interpretable systems of LLM-driven time series analysis.

Post-training quantization (PTQ) has stood out as a cost-effective and promising model compression paradigm in recent years, as it avoids computationally intensive model retraining. Nevertheless, current PTQ methods for Vision Transformers (ViTs) still suffer from significant accuracy degradation, especially under low-bit quantization. To address these shortcomings, we analyze the prevailing Hessian-guided quantization loss, and uncover certain limitations of conventional Hessian approximations. By following the block-wise reconstruction framework, we propose a novel PTQ method for ViTs, dubbed FIMA-Q. Specifically, we firstly establish the connection between KL divergence and FIM, which enables fast computation of the quantization loss during reconstruction. We further propose an efficient FIM approximation method, namely DPLR-FIM, by employing the diagonal plus low-rank principle, and formulate the ultimate quantization loss. Our extensive experiments, conducted across various vision tasks with representative ViT-based architectures on public datasets, demonstrate that our method substantially promotes the accuracy compared to the state-of-the-art approaches, especially in the case of low-bit quantization. The source code is available at https://github.com/ShiheWang/FIMA-Q.