Time series forecasting underpins vital decision-making across various sectors, yet raw predictions from sophisticated models often harbor systematic errors and biases. We examine the Forecast-Then-Optimize (FTO) framework, pioneering its systematic synopsis. Unlike conventional Predict-Then-Optimize (PTO) methods, FTO explicitly refines forecasts through optimization techniques such as ensemble methods, meta-learners, and uncertainty adjustments. Furthermore, deep learning and large language models have established superiority over traditional parametric forecasting models for most enterprise applications. This paper surveys significant advancements from 2016 to 2025, analyzing mainstream deep learning FTO architectures. Focusing on real-world applications in operations management, we demonstrate FTO's crucial role in enhancing predictive accuracy, robustness, and decision efficacy. Our study establishes foundational guidelines for future forecasting methodologies, bridging theory and operational practicality.

With the growing prominence of antibody - based therapeutics, antibody engineering has gained increasing attention as a critical area of research and development. Recent progress in transformer - based protein large language models (LLMs) has demonstrated prom ising applications in protein sequence design and structural prediction. Moreover, the availability of large - scale antibody datasets such as the Observed Antibody Space (OAS) database has opened new avenues for the development of LLMs specialized for proce ssing antibody sequences . Among these, RoBERTa has demonstrated improved performance relative to BERT, while maintaining a smaller parameter count (125M) compared to the BERT - based protein model, ProtBERT (420M). This reduced model size enables more efficient deployment in antibody - related application s . However, despite the numerous advantages of the RoBERTa architecture, antibody - specific foundational models built upon it have remained inaccessible to the research community. In this study, we introduce Ab - RoBERTa, a RoBERTa - based antibody - specific LLM, which is publicly available at https://huggingface.co/mogam - ai/Ab - RoBERTa . This resource is intended to support a wide range of antibody - related research applications including paratope prediction or humanness assessment .

Machine Translation (MT) tools are widely used today, often in contexts where professional translators are not present. Despite progress in MT technology, a gap persists between system development and real-world usage, particularly for non-expert users who may struggle to assess translation reliability. This paper advocates for a human-centered approach to MT, emphasizing the alignment of system design with diverse communicative goals and contexts of use. We survey the literature in Translation Studies and Human-Computer Interaction to recontextualize MT evaluation and design to address the diverse real-world scenarios in which MT is used today.

The long horizon forecasting (LHF) problem has come up in the time series literature for over the last 35 years or so. This review covers aspects of LHF in this period and how deep learning has incorporated variants of trend, seasonality, fourier and wavelet transforms, misspecification bias reduction and bandpass filters while contributing using convolutions, residual connections, sparsity reduction, strided convolutions, attention masks, SSMs, normalization methods, low-rank approximations and gating mechanisms. We highlight time series decomposition techniques, input data preprocessing and dataset windowing schemes that improve performance. Multi-layer perceptron models, recurrent neural network hybrids, self-attention models that improve and/or address the performances of the LHF problem are described, with an emphasis on the feature space construction. Ablation studies are conducted over the ETTm2 dataset in the multivariate and univariate high useful load (HUFL) forecasting contexts, evaluated over the last 4 months of the dataset. The heatmaps of MSE averages per time step over test set series in the horizon show that there is a steady increase in the error proportionate to its length except with xLSTM and Triformer models and motivate LHF as an error propagation problem. The trained models are available here: https://bit.ly/LHFModelZoo

While contrastive multi-view clustering has achieved remarkable success, it implicitly assumes balanced class distribution. However, real-world multi-view data primarily exhibits class imbalance distribution. Consequently, existing methods suffer performance degradation due to their inability to perceive and model such imbalance. To address this challenge, we present the first systematic study of imbalanced multi-view clustering, focusing on two fundamental problems: i. perceiving class imbalance distribution, and ii. mitigating representation degradation of minority samples. We propose PROTOCOL, a novel PaRtial Optimal TranspOrt-enhanced COntrastive Learning framework for imbalanced multi-view clustering. First, for class imbalance perception, we map multi-view features into a consensus space and reformulate the imbalanced clustering as a partial optimal transport (POT) problem, augmented with progressive mass constraints and weighted KL divergence for class distributions. Second, we develop a POT-enhanced class-rebalanced contrastive learning at both feature and class levels, incorporating logit adjustment and class-sensitive learning to enhance minority sample representations. Extensive experiments demonstrate that PROTOCOL significantly improves clustering performance on imbalanced multi-view data, filling a critical research gap in this field.

In the past decades, machine learning with Empirical Risk Minimization (ERM) has demonstrated great capability in learning and exploiting the statistical patterns from data, or even surpassing humans. Despite the success, ERM avoids the modeling of causality the way of understanding and handling changes, which is fundamental to human intelligence. When deploying models beyond the training environment, distribution shifts are everywhere. For example, an autopilot system often needs to deal with new weather conditions that have not been seen during training, An Al-aided drug discovery system needs to predict the biochemical properties of molecules with respect to new viruses such as COVID-19. It renders the problem of Out-of-Distribution (OOD) generalization challenging to conventional machine learning. In this thesis, we investigate how to incorporate and realize the causality for broader tasks in modern machine learning. In particular, we exploit the invariance implied by the principle of independent causal mechanisms (ICM), that is, the causal mechanisms generating the effects from causes do not inform or influence each other. Therefore, the conditional distribution between the target variable given its causes is invariant under distribution shifts. With the causal invariance principle, we first instantiate it to graphs -- a general data structure ubiquitous in many real-world industry and scientific applications, such as financial networks and molecules. Then, we shall see how learning the causality benefits many of the desirable properties of modern machine learning, in terms of (i) OOD generalization capability; (ii) interpretability; and (iii) robustness to adversarial attacks. Realizing the causality in machine learning, on the other hand, raises a dilemma for optimization in conventional machine learning, as it often contradicts the objective of ERM...

Preference-based Reinforcement Learning (PbRL) entails a variety of approaches for aligning models with human intent to alleviate the burden of reward engineering. However, most previous PbRL work has not investigated the robustness to labeler errors, inevitable with labelers who are non-experts or operate under time constraints. Additionally, PbRL algorithms often target very specific settings (e.g. pairwise ranked preferences or purely offline learning). We introduce Similarity as Reward Alignment (SARA), a simple contrastive framework that is both resilient to noisy labels and adaptable to diverse feedback formats and training paradigms. SARA learns a latent representation of preferred samples and computes rewards as similarities to the learned latent. We demonstrate strong performance compared to baselines on continuous control offline RL benchmarks. We further demonstrate SARA's versatility in applications such as trajectory filtering for downstream tasks, cross-task preference transfer, and reward shaping in online learning.

The explosive growth of scientific publications has created an urgent need for automated methods that facilitate knowledge synthesis and hypothesis generation. Literature-based discovery (LBD) addresses this challenge by uncovering previously unknown associations between disparate domains. This article surveys recent methodological advances in LBD, focusing on developments from 2000 to the present. We review progress in three key areas: knowledge graph construction, deep learning approaches, and the integration of pre-trained and large language models (LLMs). While LBD has made notable progress, several fundamental challenges remain unresolved, particularly concerning scalability, reliance on structured data, and the need for extensive manual curation. By examining ongoing advances and outlining promising future directions, this survey underscores the transformative role of LLMs in enhancing LBD and aims to support researchers and practitioners in harnessing these technologies to accelerate scientific innovation.

Social robots are increasingly being explored as tools to support emotional wellbeing, particularly in non-clinical settings. Drawing on a range of empirical studies and practical deployments, this paper outlines six key insights that highlight both the opportunities and challenges in using robots to promote mental wellbeing. These include (1) the lack of a single, objective measure of wellbeing, (2) the fact that robots don't need to act as companions to be effective, (3) the growing potential of virtual interactions, (4) the importance of involving clinicians in the design process, (5) the difference between one-off and long-term interactions, and (6) the idea that adaptation and personalization are not always necessary for positive outcomes. Rather than positioning robots as replacements for human therapists, we argue that they are best understood as supportive tools that must be designed with care, grounded in evidence, and shaped by ethical and psychological considerations. Our aim is to inform future research and guide responsible, effective use of robots in mental health and wellbeing contexts.

This paper comprehensively surveys research trends in imitation learning for contact-rich robotic tasks. Contact-rich tasks, which require complex physical interactions with the environment, represent a central challenge in robotics due to their nonlinear dynamics and sensitivity to small positional deviations. The paper examines demonstration collection methodologies, including teaching methods and sensory modalities crucial for capturing subtle interaction dynamics. We then analyze imitation learning approaches, highlighting their applications to contact-rich manipulation. Recent advances in multimodal learning and foundation models have significantly enhanced performance in complex contact tasks across industrial, household, and healthcare domains. Through systematic organization of current research and identification of challenges, this survey provides a foundation for future advancements in contact-rich robotic manipulation.