Overview
Breaking and Fixing Defenses Against Control-Flow Hijacking in Multi-Agent Systems
Jha, Rishi, Triedman, Harold, Wagle, Justin, Shmatikov, Vitaly
Control-flow hijacking attacks manipulate orchestration mechanisms in multi-agent systems into performing unsafe actions that compromise the system and exfiltrate sensitive information. Recently proposed defenses, such as LlamaFirewall, rely on alignment checks of inter-agent communications to ensure that all agent invocations are "related to" and "likely to further" the original objective. We start by demonstrating control-flow hijacking attacks that evade these defenses even if alignment checks are performed by advanced LLMs. We argue that the safety and functionality objectives of multi-agent systems fundamentally conflict with each other. This conflict is exacerbated by the brittle definitions of "alignment" and the checkers' incomplete visibility into the execution context. LLM-based "agents" equipped with tools for querying APIs, searching the Web, and executing code promise to automate many digital tasks. Popular frameworks like AutoGen (Microsoft, 2025), OpenManus (OpenManus, 2025), CrewAI (CrewAI, 2025), and MetaGPT (MetaGPT, 2025) enable design and deployment of multi-agent systems (MAS). The key principle in MAS is delegation. Given a relatively complex task (e.g., "organize an offsite given team members' calendars, managers' private messages, and Web data about attractions and weather"), MAS can plan how to solve it, delegate sub-tasks to specialized agents, evaluate their responses, and adaptively re-plan if necessary. Delegation splits fulfilling a task into chunks that are (a) hidden within individual agents (e.g., how to access a website or read a file), and (b) joined into the overall plan by an orchestrator who does not observe the execution of sub-tasks, only their results as reported by other agents. Critically, there is no single vantage point in the system where the entire context is visible. This exposes them to indirect prompt injection, or IPI (Greshake et al., 2023), i.e., malicious instructions in the content they ingest (Constantin, 2025; Karliner, 2025; Ravia, 2025; Abu, 2025). Aligning individual agents to resist IPI is not enough. Triedman et al. (2025) demonstrated control-flow hijacking (CFH) attacks that exploit confused-deputy vulnerabilities (Hardy, 1988) in otherwise aligned agents. CFH attacks masquerade as legitimate errors (e.g., failure to parse a file), along with seemingly helpful instructions on how to fix the issue and continue with the user's task. MAS orchestrators receive these instructions from a trusted agent to which they delegated an essential sub-task and rely on them to re-plan the execution and invoke unsafe agents as (indirectly) requested by the attacker.
Market-Driven Subset Selection for Budgeted Training
Jha, Ashish, Leplat, Valentin, Phan, AH
Training large language models on massive datasets is computationally expensive, yet empirical evidence suggests that substantial portions of training examples contribute minimally to final performance. Data subset selection addresses this inefficiency by identifying small, high-utility subsets under resource constraints. However, example utility is inherently multi-faceted, encompassing uncertainty, distributional rarity, and diversity signals that are heterogeneous and typically combined through ad hoc weighted sums lacking theoretical grounding. We propose a market-based framework that treats each training example as a tradeable contract and employs the Logarithmic Market Scoring Rule to aggregate multiple utility signals into coherent prices. Heterogeneous signals act as traders, a single liquidity parameter controls concentration versus smoothing, and topic-wise normalization ensures calibrated aggregation. Token budgets are handled explicitly through a price-per-token decision rule with an interpretable length-bias parameter. We establish theoretical connections to maximum-entropy aggregation and provide utility recovery guarantees under noisy but monotone signals. On GSM8K mathematical reasoning under strict 60k-token budgets, our selector achieves parity with strong single-signal baselines while exhibiting lower variance and incurring less than 0.1 GPU-hour overhead. On AGNews classification at 5-25\% retention rates, the market formulation delivers competitive accuracy with improved stability. Our framework unifies multi-signal data curation under fixed computational budgets for prompt-level reasoning and classification tasks.
A Scoping Review of Machine Learning Applications in Power System Protection and Disturbance Management
Oelhaf, Julian, Kordowich, Georg, Pashaei, Mehran, Bergler, Christian, Maier, Andreas, Jäger, Johann, Bayer, Siming
The integration of renewable and distributed energy resources reshapes modern power systems, challenging conventional protection schemes. This scoping review synthesizes recent literature on machine learning (ML) applications in power system protection and disturbance management, following the PRISMA for Scoping Reviews framework. Based on over 100 publications, three key objectives are addressed: (i) assessing the scope of ML research in protection tasks; (ii) evaluating ML performance across diverse operational scenarios; and (iii) identifying methods suitable for evolving grid conditions. ML models often demonstrate high accuracy on simulated datasets; however, their performance under real-world conditions remains insufficiently validated. The existing literature is fragmented, with inconsistencies in methodological rigor, dataset quality, and evaluation metrics. This lack of standardization hampers the comparability of results and limits the generalizability of findings. To address these challenges, this review introduces a ML-oriented taxonomy for protection tasks, resolves key terminological inconsistencies, and advocates for standardized reporting practices. It further provides guidelines for comprehensive dataset documentation, methodological transparency, and consistent evaluation protocols, aiming to improve reproducibility and enhance the practical relevance of research outcomes. Critical gaps remain, including the scarcity of real-world validation, insufficient robustness testing, and limited consideration of deployment feasibility. Future research should prioritize public benchmark datasets, realistic validation methods, and advanced ML architectures. These steps are essential to move ML-based protection from theoretical promise to practical deployment in increasingly dynamic and decentralized power systems.
From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery
Wei, Jiaqi, Yang, Yuejin, Zhang, Xiang, Chen, Yuhan, Zhuang, Xiang, Gao, Zhangyang, Zhou, Dongzhan, Wang, Guangshuai, Gao, Zhiqiang, Cao, Juntai, Qiu, Zijie, Hu, Ming, Ma, Chenglong, Tang, Shixiang, He, Junjun, Song, Chunfeng, He, Xuming, Zhang, Qiang, You, Chenyu, Zheng, Shuangjia, Ding, Ning, Ouyang, Wanli, Dong, Nanqing, Cheng, Yu, Sun, Siqi, Bai, Lei, Zhou, Bowen
Artificial intelligence (AI) is reshaping scientific discovery, evolving from specialized computational tools into autonomous research partners. We position Agentic Science as a pivotal stage within the broader AI for Science paradigm, where AI systems progress from partial assistance to full scientific agency. Enabled by large language models (LLMs), multimodal systems, and integrated research platforms, agentic AI shows capabilities in hypothesis generation, experimental design, execution, analysis, and iterative refinement -- behaviors once regarded as uniquely human. This survey provides a domain-oriented review of autonomous scientific discovery across life sciences, chemistry, materials science, and physics. We unify three previously fragmented perspectives -- process-oriented, autonomy-oriented, and mechanism-oriented -- through a comprehensive framework that connects foundational capabilities, core processes, and domain-specific realizations. Building on this framework, we (i) trace the evolution of AI for Science, (ii) identify five core capabilities underpinning scientific agency, (iii) model discovery as a dynamic four-stage workflow, (iv) review applications across the above domains, and (v) synthesize key challenges and future opportunities. This work establishes a domain-oriented synthesis of autonomous scientific discovery and positions Agentic Science as a structured paradigm for advancing AI-driven research.
Towards Explainable Deep Clustering for Time Series Data
Schlegel, Udo, Tavares, Gabriel Marques, Seidl, Thomas
Deep clustering uncovers hidden patterns and groups in complex time series data, yet its opaque decision-making limits use in safety-critical settings. This survey offers a structured overview of explainable deep clustering for time series, collecting current methods and their real-world applications. We thoroughly discuss and compare peer-reviewed and preprint papers through application domains across healthcare, finance, IoT, and climate science. Our analysis reveals that most work relies on autoencoder and attention architectures, with limited support for streaming, irregularly sampled, or privacy-preserved series, and interpretability is still primarily treated as an add-on. To push the field forward, we outline six research opportunities: (1) combining complex networks with built-in interpretability; (2) setting up clear, faithfulness-focused evaluation metrics for unsupervised explanations; (3) building explainers that adapt to live data streams; (4) crafting explanations tailored to specific domains; (5) adding human-in-the-loop methods that refine clusters and explanations together; and (6) improving our understanding of how time series clustering models work internally. By making interpretability a primary design goal rather than an afterthought, we propose the groundwork for the next generation of trustworthy deep clustering time series analytics.
Neural Network Reprogrammability: A Unified Theme on Model Reprogramming, Prompt Tuning, and Prompt Instruction
Ye, Zesheng, Cai, Chengyi, Dong, Ruijiang, Qi, Jianzhong, Feng, Lei, Chen, Pin-Yu, Liu, Feng
As large-scale pre-trained foundation models continue to expand in size and capability, efficiently adapting them to specific downstream tasks has become increasingly critical. Despite substantial progress, existing adaptation approaches have evolved largely in isolation, without a clear understanding of their interrelationships. This survey introduces neural network reprogrammability as a unifying framework that bridges mainstream model adaptation techniques--model reprogramming, prompt tuning, and prompt instruction--previously fragmented research areas yet converges on a shared principle: repurposing a pre-trained model by manipulating information at the interfaces while keeping the model parameters frozen. These methods exploit neural networks' sensitivity to manipulation on different interfaces, be it through perturbing inputs, inserting tokens into intermediate layers, or providing task-specific examples in context, to redirect model behaviors towards desired outcomes. We then present a taxonomy that categorizes such information manipulation-based adaptation approaches across four key dimensions: manipulation format (fixed or learnable), location (interfaces where manipulations occur), operator (how they are applied), and output alignment requirement (post-processing needed to align outputs with downstream tasks). Notably, this framework applies consistently across data modalities, independent of specific model architectures. Moreover, viewing established techniques like in-context learning and chain-of-thought prompting through this lens reveals both their theoretical connections and practical distinctions. We further analyze remaining technical challenges and ethical considerations, positioning neural network reprogrammability as a fundamental paradigm for efficient model adaptation. We lastly identify promising research directions emerging from this integrative viewpoint.
Automated Video-EEG Analysis in Epilepsy Studies: Advances and Challenges
Zuev, Valerii A., Salmagambetova, Elena G., Djakov, Stepan N., Utkin, Lev V.
Epilepsy is typically diagnosed through electroencephalography (EEG) and long-term video-EEG (vEEG) monitoring. The manual analysis of vEEG recordings is time-consuming, necessitating automated tools for seizure detection. Recent advancements in machine learning have shown promise in real-time seizure detection and prediction using EEG and video data. However, diversity of seizure symptoms, markup ambiguities, and limited availability of multimodal datasets hinder progress. This paper reviews the latest developments in automated video-EEG analysis and discusses the integration of multimodal data. We also propose a novel pipeline for treatment effect estimation from vEEG data using concept-based learning, offering a pathway for future research in this domain.
Foundation Models in Medical Image Analysis: A Systematic Review and Meta-Analysis
Rajendran, Praveenbalaji, Safari, Mojtaba, He, Wenfeng, Hu, Mingzhe, Wang, Shansong, Zhou, Jun, Yang, Xiaofeng
Recent advancements in artificial intelligence (AI), particularly foundation models (FMs), have revolutionized medical image analysis, demonstrating strong zero- and few-shot performance across diverse medical imaging tasks, from segmentation to report generation. Unlike traditional task-specific AI models, FMs leverage large corpora of labeled and unlabeled multimodal datasets to learn generalized representations that can be adapted to various downstream clinical applications with minimal fine-tuning. However, despite the rapid proliferation of FM research in medical imaging, the field remains fragmented, lacking a unified synthesis that systematically maps the evolution of architectures, training paradigms, and clinical applications across modalities. To address this gap, this review article provides a comprehensive and structured analysis of FMs in medical image analysis. We systematically categorize studies into vision-only and vision-language FMs based on their architectural foundations, training strategies, and downstream clinical tasks. Additionally, a quantitative meta-analysis of the studies was conducted to characterize temporal trends in dataset utilization and application domains. We also critically discuss persistent challenges, including domain adaptation, efficient fine-tuning, computational constraints, and interpretability along with emerging solutions such as federated learning, knowledge distillation, and advanced prompting. Finally, we identify key future research directions aimed at enhancing the robustness, explainability, and clinical integration of FMs, thereby accelerating their translation into real-world medical practice.
Mixed-Precision Quantization for Language Models: Techniques and Prospects
Rakka, Mariam, Fournarakis, Marios, Krestinskaya, Olga, Bazzi, Jinane, Salama, Khaled N., Kurdahi, Fadi, Eltawil, Ahmed M., Fouda, Mohammed E.
The rapid scaling of language models (LMs) has resulted in unprecedented computational, memory, and energy requirements, making their training and deployment increasingly unsustainable. Quantization has emerged as an essential compression technique to reduce model size, alleviate memory bottlenecks, and accelerate inference. However, while uniform low-bit quantization (e.g., INT8, INT4) provides significant efficiency gains, it can degrade accuracy in sensitive components of transformer-based LMs. Mixed-precision quantization offers a promising alternative by selectively allocating precision across layers or within tensors to balance efficiency and accuracy. This survey provides a comprehensive overview of Mixed-Precision quantization frameworks for LMs (MXPLMs). We first review quantization fundamentals, including uniform and non-uniform quantizers, quantization granularity, and methods widely used in post-training quantization. We then categorize and compare recent MXPLM frameworks according to their bit allocation strategies and precision configurations across weights, activations, and key-value caches. A comparative analysis highlights differences in perplexity, zero-shot task performance, and deployment trade-offs. Furthermore, we contrast MXPLMs with earlier mixed-precision quantization methods for deep neural networks, identifying strategies that transfer and those that face challenges in the LM setting. Finally, we summarize open issues and future directions, including hardware-aware design, activation quantization, and scalable optimization methods for billion-parameter models. By consolidating recent advances, this work serves as a reference for understanding the current landscape and research prospects of mixed-precision quantization for large-scale language models.
A Preliminary Exploration of the Differences and Conjunction of Traditional PNT and Brain-inspired PNT
He, Xu, Meng, Xiaolin, Yin, Wenxuan, Zhang, Youdong, Mo, Lingfei, An, Xiangdong, Yu, Fangwen, Pan, Shuguo, Liu, Yufeng, Liu, Jingnan, Zhang, Yujia, Gao, Wang
Developing universal Positioning, Navigation, and Timing (PNT) is our enduring goal. Today's complex environments demand PNT that is more resilient, energy - efficient and cognitively capable. This paper asks how we can endow unmanned systems with brain - inspired spatial cogniti on navigation while exploiting the h igh precision of machine PNT to advance universal PNT. We provide a new perspective and roadmap for shifting PNT from "tool - or iented " to "cogniti on - driven ". Contributions: (1) multi - level dissection of differences among traditional PNT, biological brain PN T and brain - inspired PNT; (2) a four - layer (observation - c apability - decision - hardware) fusion framework that unites numerical precision and brain - inspired intelligence; (3) forward - looking recommendations for future development of brain - inspired PNT . Keywords: Brain - inspired n avigation, PNT, Differences and Conjunction, Fusion F ramework 1. Introduction Unmanned system P ositioning, N avigation, and T iming (PNT) technologies have achieved numerous practical advance s. Particularly noteworthy is the rapid maturation of Global Navigation Satellite System (GNSS) - based PNT, which has not only expanded its application domains but also driven down operational costs. However, these technologies still face formidable challenges in highly uncertain and complex scenarios, such as deep s pace, the deep ocean, polar regions, and dense urban environments.