Artificial intelligence (AI) systems utilizing deep neural networks (DNNs) and machine learning (ML) algorithms are widely used for solving important problems in bioinformatics, biomedical informatics, and precision medicine. However, complex DNNs or ML models, which are often perceived as opaque and black-box, can make it difficult to understand the reasoning behind their decisions. This lack of transparency can be a challenge for both end-users and decision-makers, as well as AI developers. Additionally, in sensitive areas like healthcare, explainability and accountability are not only desirable but also legally required for AI systems that can have a significant impact on human lives. Fairness is another growing concern, as algorithmic decisions should not show bias or discrimination towards certain groups or individuals based on sensitive attributes. Explainable artificial intelligence (XAI) aims to overcome the opaqueness of black-box models and provide transparency in how AI systems make decisions. Interpretable ML models can explain how they make predictions and the factors that influence their outcomes. However, most state-of-the-art interpretable ML methods are domain-agnostic and evolved from fields like computer vision, automated reasoning, or statistics, making direct application to bioinformatics problems challenging without customization and domain-specific adaptation. In this paper, we discuss the importance of explainability in the context of bioinformatics, provide an overview of model-specific and model-agnostic interpretable ML methods and tools, and outline their potential caveats and drawbacks. Besides, we discuss how to customize existing interpretable ML methods for bioinformatics problems. Nevertheless, we demonstrate how XAI methods can improve transparency through case studies in bioimaging, cancer genomics, and text mining.

In sponsored search advertising (SSA), keywords serve as the basic unit of business model, linking three stakeholders: consumers, advertisers and search engines. This paper presents an overarching framework for keyword decisions that highlights the touchpoints in search advertising management, including four levels of keyword decisions, i.e., domain-specific keyword pool generation, keyword targeting, keyword assignment and grouping, and keyword adjustment. Using this framework, we review the state-of-the-art research literature on keyword decisions with respect to techniques, input features and evaluation metrics. Finally, we discuss evolving issues and identify potential gaps that exist in the literature and outline novel research perspectives for future exploration.

As an essential technology underpinning trusted computing, the trusted execution environment (TEE) allows one to launch computation tasks on both on- and off-premises data while assuring confidentiality and integrity. This article provides a systematic review and comparison of TEE-based secure computation protocols. We first propose a taxonomy that classifies secure computation protocols into three major categories, namely secure outsourced computation, secure distributed computation and secure multi-party computation. To enable a fair comparison of these protocols, we also present comprehensive assessment criteria with respect to four aspects: setting, methodology, security and performance. Based on these criteria, we review, discuss and compare the state-of-the-art TEE-based secure computation protocols for both general-purpose computation functions and special-purpose ones, such as privacy-preserving machine learning and encrypted database queries. To the best of our knowledge, this article is the first survey to review TEE-based secure computation protocols and the comprehensive comparison can serve as a guideline for selecting suitable protocols for deployment in practice. Finally, we also discuss several future research directions and challenges.

Over the past decade, domain adaptation has become a widely studied branch of transfer learning that aims to improve performance on target domains by leveraging knowledge from the source domain. Conventional domain adaptation methods often assume access to both source and target domain data simultaneously, which may not be feasible in real-world scenarios due to privacy and confidentiality concerns. As a result, the research of Source-Free Domain Adaptation (SFDA) has drawn growing attention in recent years, which only utilizes the source-trained model and unlabeled target data to adapt to the target domain. Despite the rapid explosion of SFDA work, yet there has no timely and comprehensive survey in the field. To fill this gap, we provide a comprehensive survey of recent advances in SFDA and organize them into a unified categorization scheme based on the framework of transfer learning. Instead of presenting each approach independently, we modularize several components of each method to more clearly illustrate their relationships and mechanics in light of the composite properties of each method. Furthermore, we compare the results of more than 30 representative SFDA methods on three popular classification benchmarks, namely Office-31, Office-home, and VisDA, to explore the effectiveness of various technical routes and the combination effects among them. Additionally, we briefly introduce the applications of SFDA and related fields. Drawing from our analysis of the challenges facing SFDA, we offer some insights into future research directions and potential settings.

In recent years, large strides have been taken in developing machine learning methods for dermatological applications, supported in part by the success of deep learning (DL). To date, diagnosing diseases from images is one of the most explored applications of DL within dermatology. Convolutional neural networks (ConvNets) are the most common (DL) method in medical imaging due to their training efficiency and accuracy, although they are often described as black boxes because of their limited explainability. One popular way to obtain insight into a ConvNet's decision mechanism is gradient class activation maps (Grad-CAM). A quantitative evaluation of the Grad-CAM explainability has been recently made possible by the release of DermXDB, a skin disease diagnosis explainability dataset which enables explainability benchmarking of ConvNet architectures. In this paper, we perform a literature review to identify the most common ConvNet architectures used for this task, and compare their Grad-CAM explanations with the explanation maps provided by DermXDB. We identified 11 architectures: DenseNet121, EfficientNet-B0, InceptionV3, InceptionResNetV2, MobileNet, MobileNetV2, NASNetMobile, ResNet50, ResNet50V2, VGG16, and Xception. We pre-trained all architectures on an clinical skin disease dataset, and fine-tuned them on a DermXDB subset. Validation results on the DermXDB holdout subset show an explainability F1 score of between 0.35-0.46, with Xception displaying the highest explainability performance. NASNetMobile reports the highest characteristic-level explainability sensitivity, despite it's mediocre diagnosis performance. These results highlight the importance of choosing the right architecture for the desired application and target market, underline need for additional explainability datasets, and further confirm the need for explainability benchmarking that relies on quantitative analyses.

In this paper, we summarize the current state of the field of NLP & Law with a specific focus on recent technical and substantive developments. To support our analysis, we construct and analyze a nearly complete corpus of more than six hundred NLP & Law related papers published over the past decade. Our analysis highlights several major trends. Namely, we document an increasing number of papers written, tasks undertaken, and languages covered over the course of the past decade. We observe an increase in the sophistication of the methods which researchers deployed in this applied context. Slowly but surely, Legal NLP is beginning to match not only the methodological sophistication of general NLP but also the professional standards of data availability and code reproducibility observed within the broader scientific community. We believe all of these trends bode well for the future of the field, but many questions in both the academic and commercial sphere still remain open.

Agent-based computational economics is a field with a rich academic history, yet one which has struggled to enter mainstream policy design toolboxes--plagued by the challenges associated with representing a complex and dynamic reality. The field of Reinforcement Learning (RL), too, has a rich history, and has recently been at the centre of several exponential developments. Modern RL implementations have been able to achieve unprecedented levels of sophistication, handling previously unthinkable degrees of complexity. This review surveys the historical barriers of classical agent-based techniques in economic modelling, and contemplates whether recent developments in RL can overcome any of them.

Like many other revolutionary technologies of the modern day, machine learning was once science fiction. However, its applications in real world industries are only limited by our imagination. In 2022, recent innovations in machine learning have made a great deal of tasks more feasible, efficient, and precise than ever before. Powered by data science, machine learning makes our lives easier. When properly trained, they can complete tasks more efficiently than a human. Understanding the possibilities and recent innovations of ML technology is important for businesses so that they can plot a course for the most efficient ways of conducting their business.

The symposium consisted of four keynote speakers with varying engagement with the idea of a distributed teaching collaborative. The symposium began with a keynote by Chad Jenkins, a professor of robotics at the University of Michigan. In his talk, he laid out the symposium's goal and the intent of the distributed teaching collaborative. He highlighted efforts to offer distributed classes between the University of Michigan and Barea College, Howard University, and Morehouse College. The second keynote was Dr. Talitha Washington the current director of the AUC data science initiative.

Much of named entity recognition (NER) research focuses on developing dataset-specific models based on data from the domain of interest, and a limited set of related entity types. This is frustrating as each new dataset requires a new model to be trained and stored. In this work, we present a ``versatile'' model -- the Prompting-based Unified NER system (PUnifiedNER) -- that works with data from different domains and can recognise up to 37 entity types simultaneously, and theoretically it could be as many as possible. By using prompt learning, PUnifiedNER is a novel approach that is able to jointly train across multiple corpora, implementing intelligent on-demand entity recognition. Experimental results show that PUnifiedNER leads to significant prediction benefits compared to dataset-specific models with impressively reduced model deployment costs. Furthermore, the performance of PUnifiedNER can achieve competitive or even better performance than state-of-the-art domain-specific methods for some datasets. We also perform comprehensive pilot and ablation studies to support in-depth analysis of each component in PUnifiedNER.