Labeling is the cornerstone of supervised machine learning, which has been exploited in a plethora of various applications, with sign language recognition being one of them. However, such algorithms must be fed with a huge amount of consistently labeled data during the training process to elaborate a well-generalizing model. In addition, there is a great need for an automated solution that works with any nationally diversified sign language. Although there are language-agnostic transcription systems, such as the Hamburg Sign Language Notation System (HamNoSys) that describe the signer's initial position and body movement instead of the glosses' meanings, there are still issues with providing accurate and reliable labels for every real-world use case. In this context, the industry relies heavily on manual attribution and labeling of the available video data. In this work, we tackle this issue and thoroughly analyze the HamNoSys labels provided by various maintainers of open sign language corpora in five sign languages, in order to examine the challenges encountered in labeling video data. We also investigate the consistency and objectivity of HamNoSys-based labels for the purpose of training machine learning models. Our findings provide valuable insights into the limitations of the current labeling methods and pave the way for future research on developing more accurate and efficient solutions for sign language recognition.

The integration of Artificial Intelligence (AI) into the field of drug discovery has been a growing area of interdisciplinary scientific research. However, conventional AI models are heavily limited in handling complex biomedical structures (such as 2D or 3D protein and molecule structures) and providing interpretations for outputs, which hinders their practical application. As of late, Graph Machine Learning (GML) has gained considerable attention for its exceptional ability to model graph-structured biomedical data and investigate their properties and functional relationships. Despite extensive efforts, GML methods still suffer from several deficiencies, such as the limited ability to handle supervision sparsity and provide interpretability in learning and inference processes, and their ineffectiveness in utilising relevant domain knowledge. In response, recent studies have proposed integrating external biomedical knowledge into the GML pipeline to realise more precise and interpretable drug discovery with limited training instances. However, a systematic definition for this burgeoning research direction is yet to be established. This survey presents a comprehensive overview of long-standing drug discovery principles, provides the foundational concepts and cutting-edge techniques for graph-structured data and knowledge databases, and formally summarises Knowledge-augmented Graph Machine Learning (KaGML) for drug discovery. we propose a thorough review of related KaGML works, collected following a carefully designed search methodology, and organise them into four categories following a novel-defined taxonomy. To facilitate research in this promptly emerging field, we also share collected practical resources that are valuable for intelligent drug discovery and provide an in-depth discussion of the potential avenues for future advancements.

Recently, ChatGPT, along with DALL-E-2 and Codex,has been gaining significant attention from society. As a result, many individuals have become interested in related resources and are seeking to uncover the background and secrets behind its impressive performance. In fact, ChatGPT and other Generative AI (GAI) techniques belong to the category of Artificial Intelligence Generated Content (AIGC), which involves the creation of digital content, such as images, music, and natural language, through AI models. The goal of AIGC is to make the content creation process more efficient and accessible, allowing for the production of high-quality content at a faster pace. AIGC is achieved by extracting and understanding intent information from instructions provided by human, and generating the content according to its knowledge and the intent information. In recent years, large-scale models have become increasingly important in AIGC as they provide better intent extraction and thus, improved generation results. With the growth of data and the size of the models, the distribution that the model can learn becomes more comprehensive and closer to reality, leading to more realistic and high-quality content generation. This survey provides a comprehensive review on the history of generative models, and basic components, recent advances in AIGC from unimodal interaction and multimodal interaction. From the perspective of unimodality, we introduce the generation tasks and relative models of text and image. From the perspective of multimodality, we introduce the cross-application between the modalities mentioned above. Finally, we discuss the existing open problems and future challenges in AIGC.

Tasks such as weather simulation, medical diagnosis, business optimisation and automation like autonomous cars have benefited from these new Artificial Intelligence (AI) methods. Some of these ML models are used in ways that their predictions can affect people's safety or commercial success. These models must be considered trustworthy with errors detected and dealt with before they can affect the success or safety of the process being controlled. Neural Networks (NNs), and in particular Deep Neural Networks (DNNs), represent one such class of ML algorithm. Due to the nature of DNNs, the decisions they produce can seem arbitrary. These DNNs are comprised of thousands of nodes that perform mathematical operations, creating a "black-box like" system, in which one is unable to judge the decisions being made by simple inspection.

Distributed learning is one of the most critical components in the ML stack of modern tech companies: by parallelizing over a large number of machines, one can train bigger models on more data faster, unlocking higher-quality production models with more rapid iteration cycles. But don't just take my word for it. Using customized distributed training […] allows us to iterate faster and train models on more and fresher data. Our experiments show that our new large-scale training methods can use a cluster of machines to train even modestly sized deep networks significantly faster than a GPU, and without the GPU's limitation on the maximum size of the model. We sought out to implement a large-scale Neural Network training system that leveraged both the advantages of GPUs and the AWS cloud.

Recent advances of data-driven machine learning have revolutionized fields like computer vision, reinforcement learning, and many scientific and engineering domains. In many real-world and scientific problems, systems that generate data are governed by physical laws. Recent work shows that it provides potential benefits for machine learning models by incorporating the physical prior and collected data, which makes the intersection of machine learning and physics become a prevailing paradigm. By integrating the data and mathematical physics models seamlessly, it can guide the machine learning model towards solutions that are physically plausible, improving accuracy and efficiency even in uncertain and high-dimensional contexts. In this survey, we present this learning paradigm called Physics-Informed Machine Learning (PIML) which is to build a model that leverages empirical data and available physical prior knowledge to improve performance on a set of tasks that involve a physical mechanism. We systematically review the recent development of physics-informed machine learning from three perspectives of machine learning tasks, representation of physical prior, and methods for incorporating physical prior. We also propose several important open research problems based on the current trends in the field. We argue that encoding different forms of physical prior into model architectures, optimizers, inference algorithms, and significant domain-specific applications like inverse engineering design and robotic control is far from being fully explored in the field of physics-informed machine learning. We believe that the interdisciplinary research of physics-informed machine learning will significantly propel research progress, foster the creation of more effective machine learning models, and also offer invaluable assistance in addressing long-standing problems in related disciplines.

Developing explainability methods for Natural Language Processing (NLP) models is a challenging task, for two main reasons. First, the high dimensionality of the data (large number of tokens) results in low coverage and in turn small contributions for the top tokens, compared to the overall model performance. Second, owing to their textual nature, the input variables, after appropriate transformations, are effectively binary (presence or absence of a token in an observation), making the input-output relationship difficult to understand. Common NLP interpretation techniques do not have flexibility in resolution, because they usually operate at word-level and provide fully local (message level) or fully global (over all messages) summaries. The goal of this paper is to create more flexible model explainability summaries by segments of observation or clusters of words that are semantically related to each other. In addition, we introduce a root cause analysis method for NLP models, by analyzing representative False Positive and False Negative examples from different segments. At the end, we illustrate, using a Yelp review data set with three segments (Restaurant, Hotel, and Beauty), that exploiting group/cluster structures in words and/or messages can aid in the interpretation of decisions made by NLP models and can be utilized to assess the model's sensitivity or bias towards gender, syntax, and word meanings.

Autism Spectrum Disorder (autism) is a neurodevelopmental delay which affects at least 1 in 44 children. Like many neurological disorder phenotypes, the diagnostic features are observable, can be tracked over time, and can be managed or even eliminated through proper therapy and treatments. Yet, there are major bottlenecks in the diagnostic, therapeutic, and longitudinal tracking pipelines for autism and related delays, creating an opportunity for novel data science solutions to augment and transform existing workflows and provide access to services for more affected families. Several prior efforts conducted by a multitude of research labs have spawned great progress towards improved digital diagnostics and digital therapies for children with autism. We review the literature of digital health methods for autism behavior quantification using data science. We describe both case-control studies and classification systems for digital phenotyping. We then discuss digital diagnostics and therapeutics which integrate machine learning models of autism-related behaviors, including the factors which must be addressed for translational use. Finally, we describe ongoing challenges and potent opportunities for the field of autism data science. Given the heterogeneous nature of autism and the complexities of the relevant behaviors, this review contains insights which are relevant to neurological behavior analysis and digital psychiatry more broadly.

A data marketplace is an online venue that brings data owners, data brokers, and data consumers together and facilitates commoditisation of data amongst them. Data pricing, as a key function of a data marketplace, demands quantifying the monetary value of data. A considerable number of studies on data pricing can be found in literature. This paper attempts to comprehensively review the state-of-the-art on existing data pricing studies to provide a general understanding of this emerging research area. Our key contribution lies in a new taxonomy of data pricing studies that unifies different attributes determining data prices. The basis of our framework categorises these studies by the kind of market structure, be it sell-side, buy-side, or two-sided. Then in a sell-side market, the studies are further divided by query type, which defines the way a data consumer accesses data, while in a buy-side market, the studies are divided according to privacy notion, which defines the way to quantify privacy of data owners. In a two-sided market, both privacy notion and query type are used as criteria. We systematically examine the studies falling into each category in our taxonomy. Lastly, we discuss gaps within the existing research and define future research directions.

This paper presents a novel approach to vehicle positioning that operates without reliance on the global navigation satellite system (GNSS). Traditional GNSS approaches are vulnerable to interference in certain environments, rendering them unreliable in situations such as urban canyons, under flyovers, or in low reception areas. This study proposes a vehicle positioning method based on learning the road signature from accelerometer and gyroscope measurements obtained by an inertial measurement unit (IMU) sensor. In our approach, the route is divided into segments, each with a distinct signature that the IMU can detect through the vibrations of a vehicle in response to subtle changes in the road surface. The study presents two different data-driven methods for learning the road segment from IMU measurements. One method is based on convolutional neural networks and the other on ensemble random forest applied to handcrafted features. Additionally, the authors present an algorithm to deduce the position of a vehicle in real-time using the learned road segment. The approach was applied in two positioning tasks: (i) a car along a 6[km] route in a dense urban area; (ii) an e-scooter on a 1[km] route that combined road and pavement surfaces. The mean error between the proposed method's position and the ground truth was approximately 50[m] for the car and 30[m] for the e-scooter. Compared to a solution based on time integration of the IMU measurements, the proposed approach has a mean error of more than 5 times better for e-scooters and 20 times better for cars.