Cancer is a complex disease characterized by uncontrolled cell growth and proliferation. T cell receptors (TCRs) are essential proteins for the adaptive immune system, and their specific recognition of antigens plays a crucial role in the immune response against diseases, including cancer. The diversity and specificity of TCRs make them ideal for targeting cancer cells, and recent advancements in sequencing technologies have enabled the comprehensive profiling of TCR repertoires. This has led to the discovery of TCRs with potent anti-cancer activity and the development of TCR-based immunotherapies. In this study, we investigate the use of sparse coding for the multi-class classification of TCR protein sequences with cancer categories as target labels. Sparse coding is a popular technique in machine learning that enables the representation of data with a set of informative features and can capture complex relationships between amino acids and identify subtle patterns in the sequence that might be missed by low-dimensional methods. We first compute the k-mers from the TCR sequences and then apply sparse coding to capture the essential features of the data. To improve the predictive performance of the final embeddings, we integrate domain knowledge regarding different types of cancer properties. We then train different machine learning (linear and non-linear) classifiers on the embeddings of TCR sequences for the purpose of supervised analysis. Our proposed embedding method on a benchmark dataset of TCR sequences significantly outperforms the baselines in terms of predictive performance, achieving an accuracy of 99.8\%. Our study highlights the potential of sparse coding for the analysis of TCR protein sequences in cancer research and other related fields.

Due to the complexity of modern computer systems, novel and unexpected behaviors frequently occur. Such deviations are either normal occurrences, such as software updates and new user activities, or abnormalities, such as misconfigurations, latency issues, intrusions, and software bugs. Regardless, novel behaviors are of great interest to developers, and there is a genuine need for efficient and effective methods to detect them. Nowadays, researchers consider system calls to be the most fine-grained and accurate source of information to investigate the behavior of computer systems. Accordingly, this paper introduces a novelty detection methodology that relies on a probability distribution over sequences of system calls, which can be seen as a language model. Language models estimate the likelihood of sequences, and since novelties deviate from previously observed behaviors by definition, they would be unlikely under the model. Following the success of neural networks for language models, three architectures are evaluated in this work: the widespread LSTM, the state-of-the-art Transformer, and the lower-complexity Longformer. However, large neural networks typically require an enormous amount of data to be trained effectively, and to the best of our knowledge, no massive modern datasets of kernel traces are publicly available. This paper addresses this limitation by introducing a new open-source dataset of kernel traces comprising over 2 million web requests with seven distinct behaviors. The proposed methodology requires minimal expert hand-crafting and achieves an F-score and AuROC greater than 95% on most novelties while being data- and task-agnostic. The source code and trained models are publicly available on GitHub while the datasets are available on Zenodo.

Real-time traffic light recognition is essential for autonomous driving. Yet, a cohesive overview of the underlying model architectures for this task is currently missing. In this work, we conduct a comprehensive survey and analysis of traffic light recognition methods that use convolutional neural networks (CNNs). We focus on two essential aspects: datasets and CNN architectures. Based on an underlying architecture, we cluster methods into three major groups: (1) modifications of generic object detectors which compensate for specific task characteristics, (2) multi-stage approaches involving both rule-based and CNN components, and (3) task-specific single-stage methods. We describe the most important works in each cluster, discuss the usage of the datasets, and identify research gaps.

Multimodal emotion recognition (MER) aims to detect the emotional status of a given expression by combining the speech and text information. Intuitively, label information should be capable of helping the model locate the salient tokens/frames relevant to the specific emotion, which finally facilitates the MER task. Inspired by this, we propose a novel approach for MER by leveraging label information. Specifically, we first obtain the representative label embeddings for both text and speech modalities, then learn the label-enhanced text/speech representations for each utterance via label-token and label-frame interactions. Finally, we devise a novel label-guided attentive fusion module to fuse the label-aware text and speech representations for emotion classification. Extensive experiments were conducted on the public IEMOCAP dataset, and experimental results demonstrate that our proposed approach outperforms existing baselines and achieves new state-of-the-art performance.

Causal probabilistic graph-based models have gained widespread utility, enabling the modeling of cause-and-effect relationships across diverse domains. With their rising adoption in new areas, such as automotive system safety and machine learning, the need for an integrated lifecycle framework akin to DevOps and MLOps has emerged. Currently, a process reference for organizations interested in employing causal engineering is missing. To address this gap and foster widespread industrial adoption, we propose CausalOps, a novel lifecycle framework for causal model development and application. By defining key entities, dependencies, and intermediate artifacts generated during causal engineering, we establish a consistent vocabulary and workflow model. This work contextualizes causal model usage across different stages and stakeholders, outlining a holistic view of creating and maintaining them. CausalOps' aim is to drive the adoption of causal methods in practical applications within interested organizations and the causality community.

Recommender systems are widely used to help people find items that are tailored to their interests. These interests are often influenced by social networks, making it important to use social network information effectively in recommender systems. This is especially true for demographic groups with interests that differ from the majority. This paper introduces STUDY, a Socially-aware Temporally caUsal Decoder recommender sYstem. STUDY introduces a new socially-aware recommender system architecture that is significantly more efficient to learn and train than existing methods. STUDY performs joint inference over socially connected groups in a single forward pass of a modified transformer decoder network. We demonstrate the benefits of STUDY in the recommendation of books for students who are dyslexic, or struggling readers. Dyslexic students often have difficulty engaging with reading material, making it critical to recommend books that are tailored to their interests. We worked with our non-profit partner Learning Ally to evaluate STUDY on a dataset of struggling readers. STUDY was able to generate recommendations that more accurately predicted student engagement, when compared with existing methods.

In recent years, the development of robotics and artificial intelligence (AI) systems has been nothing short of remarkable. As these systems continue to evolve, they are being utilized in increasingly complex and unstructured environments, such as autonomous driving, aerial robotics, and natural language processing. As a consequence, programming their behaviors manually or defining their behavior through reward functions (as done in reinforcement learning (RL)) has become exceedingly difficult. This is because such environments require a high degree of flexibility and adaptability, making it challenging to specify an optimal set of rules or reward signals that can account for all possible situations. In such environments, learning from an expert's behavior through imitation is often more appealing. This is where imitation learning (IL) comes into play - a process where desired behavior is learned by imitating an expert's behavior, which is provided through demonstrations. This paper aims to provide an introduction to IL and an overview of its underlying assumptions and approaches. It also offers a detailed description of recent advances and emerging areas of research in the field. Additionally, the paper discusses how researchers have addressed common challenges associated with IL and provides potential directions for future research. Overall, the goal of the paper is to provide a comprehensive guide to the growing field of IL in robotics and AI.

Artificial Intelligence (AI) is currently spearheaded by machine learning (ML) methods such as deep learning (DL) which have accelerated progress on many tasks thought to be out of reach of AI. These ML methods can often be compute hungry, energy intensive, and result in significant carbon emissions, a known driver of anthropogenic climate change. Additionally, the platforms on which ML systems run are associated with environmental impacts including and beyond carbon emissions. The solution lionized by both industry and the ML community to improve the environmental sustainability of ML is to increase the efficiency with which ML systems operate in terms of both compute and energy consumption. In this perspective, we argue that efficiency alone is not enough to make ML as a technology environmentally sustainable. We do so by presenting three high level discrepancies between the effect of efficiency on the environmental sustainability of ML when considering the many variables which it interacts with. In doing so, we comprehensively demonstrate, at multiple levels of granularity both technical and non-technical reasons, why efficiency is not enough to fully remedy the environmental impacts of ML. Based on this, we present and argue for systems thinking as a viable path towards improving the environmental sustainability of ML holistically.

We introduce a class of manifold neural networks (MNNs) that we call Manifold Filter-Combine Networks (MFCNs), which aims to further our understanding of MNNs, analogous to how the aggregate-combine framework helps with the understanding of graph neural networks (GNNs). This class includes a wide variety of subclasses that can be thought of as the manifold analog of various popular GNNs. We then consider a method, based on building a data-driven graph, for implementing such networks when one does not have global knowledge of the manifold, but merely has access to finitely many points sampled from some probability distribution on the manifold. We provide sufficient conditions for the network to provably converge to its continuum limit as the number of sample points tends to infinity. Unlike previous work (which focused on specific graph constructions and assumed that the data was drawn from the uniform distribution), our rate of convergence does not directly depend on the number of filters used. Moreover, it exhibits linear dependence on the depth of the network rather than the exponential dependence obtained previously. Additionally, we provide several examples of interesting subclasses of MFCNs and of the rates of convergence that are obtained under specific graph constructions.

A central problem in unsupervised deep learning is how to find useful representations of high-dimensional data, sometimes called "disentanglement". Most approaches are heuristic and lack a proper theoretical foundation. In linear representation learning, independent component analysis (ICA) has been successful in many applications areas, and it is principled, i.e., based on a well-defined probabilistic model. However, extension of ICA to the nonlinear case has been problematic due to the lack of identifiability, i.e., uniqueness of the representation. Recently, nonlinear extensions that utilize temporal structure or some auxiliary information have been proposed. Such models are in fact identifiable, and consequently, an increasing number of algorithms have been developed. In particular, some self-supervised algorithms can be shown to estimate nonlinear ICA, even though they have initially been proposed from heuristic perspectives. This paper reviews the state-of-the-art of nonlinear ICA theory and algorithms.