Recent experimental data indicate that the strengthening or weakening of synaptic connections between neurons depends on the relative timing of pre-and postsynaptic action potentials. A Hebbian synaptic modification rule based on these data leads to a stable state in which the excitatory and inhibitory inputs to a neuron are balanced, producing an irregular pattern of firing. It has been proposed that neurons in vivo operate in such a mode.

We describe Maximum-Likelihood Continuity Mapping (MALCOM), an alternative to hidden Markov models (HMMs) for processing sequence data such as speech. While HMMs have a discrete "hidden" space constrained by a fixed finite-automaton architecture, MALCOM has a continuous hidden space-a continuity map-that is constrained only by a smoothness requirement on paths through the space. MALCOM fits into the same probabilistic framework for speech recognition as HMMs, but it represents a more realistic model of the speech production process. To evaluate the extent to which MALCOM captures speech production information, we generated continuous speech continuity maps for three speakers and used the paths through them to predict measured speech articulator data. The median correlation between the MALCOM paths obtained from only the speech acoustics and articulator measurements was 0.77 on an independent test set not used to train MALCOM or the predictor.

On the other hand, discriminative methods such as support vector machines enable us to construct flexible decision boundaries and often result in classification performance superior to that of the model based approaches. An ideal classifier should combine these two complementary approaches. In this paper, we develop a natural way of achieving this combination by deriving kernel functions for use in discriminative methods such as support vector machines from generative probability models.

Feature extraction is a typical example: The distance between a small pattern (i.e.

Event-related potentials (ERPs), are portions of electroencephalographic (EEG) recordings that are both time-and phase-locked to experimental events. ERPs are usually averaged to increase their signal/noise ratio relative to non-phase locked EEG activity, regardless of the fact that response activity in single epochs may vary widely in time course and scalp distribution. This study applies a linear decomposition tool, Independent Component Analysis (ICA) [1], to multichannel single-trial EEG records to derive spatial filters that decompose single-trial EEG epochs into a sum of temporally independent and spatially fixed components arising from distinct or overlapping brain or extra-brain networks. Our results on normal and autistic subjects show that ICA can separate artifactual, stimulus-locked, response-locked, and.

In robotics and other control applications it is commonplace to have a preexisting set of controllers for solving subtasks, perhaps handcrafted or previously learned or planned, and still face a difficult problem of how to choose and switch among the controllers to solve an overall task as well as possible. In this paper we present a framework based on Markov decision processes and semi-Markov decision processes for phrasing this problem, a basic theorem regarding the improvement in performance that can be obtained by switching flexibly between given controllers, and example applications of the theorem. In particular, we show how an agent can plan with these high-level controllers and then use the results of such planning to find an even better plan, by modifying the existing controllers, with negligible additional cost and no re-planning. In one of our examples, the complexity of the problem is reduced from 24 billion state-action pairs to less than a million state-controller pairs. In many applications, solutions to parts of a task are known, either because they were handcrafted by people or because they were previously learned or planned. For example, in robotics applications, there may exist controllers for moving joints to positions, picking up objects, controlling eye movements, or navigating along hallways. More generally, an intelligent system may have available to it several temporally extended courses of action to choose from. In such cases, a key challenge is to take full advantage of the existing temporally extended actions, to choose or switch among them effectively, and to plan at their level rather than at the level of individual actions.

Determining the relationship between the activity of a single nerve cell to that of an entire population is a fundamental question that bears on the basic neural computation paradigms. In this paper we apply an information theoretic approach to quantify the level of cooperative activity among cells in a behavioral context. It is possible to discriminate between synergetic activity of the cells vs. redundant activity, depending on the difference between the information they provide when measured jointly and the information they provide independently. We define a synergy value that is positive in the first case and negative in the second and show that the synergy value can be measured by detecting the behavioral mode of the animal from simultaneously recorded activity of the cells. We observe that among cortical cells positive synergy can be found, while cells from the basal ganglia, active during the same task, do not exhibit similar synergetic activity.

A directed generative model for binary data using a small number of hidden continuous units is investigated. The relationships between the correlations of the underlying continuous Gaussian variables and the binary output variables are utilized to learn the appropriate weights of the network. The advantages of this approach are illustrated on a translationally invariant binary distribution and on handwritten digit images. Introduction Principal Components Analysis (PCA) is a widely used statistical technique for representing data with a large number of variables [1]. It is based upon the assumption that although the data is embedded in a high dimensional vector space, most of the variability in the data is captured by a much lower climensional manifold.

A directed generative model for binary data using a small number of hidden continuous units is investigated. The relationships between the correlations of the underlying continuous Gaussian variables and the binary output variables are utilized to learn the appropriate weights of the network. The advantages of this approach are illustrated on a translationally invariant binary distribution and on handwritten digit images. Introduction Principal Components Analysis (PCA) is a widely used statistical technique for representing data with a large number of variables [1]. It is based upon the assumption that although the data is embedded in a high dimensional vector space, most of the variability in the data is captured by a much lower climensional manifold. In particular for PCA, this manifold is described by a linear hyperplane whose characteristic directions are given by the eigenvectors of the correlation matrix with the largest eigenvalues. The success of PCA and closely related techniques such as Factor Analysis (FA) and PCA mixtures clearly indicate that much real world data exhibit the low dimensional manifold structure assumed by these models [2, 3]. However, the linear manifold structure of PCA is not appropriate for data with binary valued variables.

These Ca2 signals are often organized in complex temporal and spatial patterns even under conditions of sustained stimulation.