Deep learning, an area of machine learning, is set to revolutionize patient care. But it is not yet part of standard of care, especially when it comes to individual patient care. In fact, it is unclear to what extent data-driven techniques are being used to support clinical decision making (CDS). Heretofore, there has not been a review of ways in which research in machine learning and other types of data-driven techniques can contribute effectively to clinical care and the types of support they can bring to clinicians. In this paper, we consider ways in which two data driven domains - machine learning and data visualizations - can contribute to the next generation of clinical decision support systems. We review the literature regarding the ways heuristic knowledge, machine learning, and visualization are - and can be - applied to three types of CDS. There has been substantial research into the use of predictive modeling for alerts, however current CDS systems are not utilizing these methods. Approaches that leverage interactive visualizations and machine-learning inferences to organize and review patient data are gaining popularity but are still at the prototype stage and are not yet in use. CDS systems that could benefit from prescriptive machine learning (e.g., treatment recommendations for specific patients) have not yet been developed. We discuss potential reasons for the lack of deployment of data-driven methods in CDS and directions for future research.

DNN pruning reduces memory footprint and computational work of DNN-based solutions to improve performance and energy-efficiency. An effective pruning scheme should be able to systematically remove connections and/or neurons that are unnecessary or redundant, reducing the DNN size without any loss in accuracy. In this paper we show that prior pruning schemes require an extremely time-consuming iterative process that requires retraining the DNN many times to tune the pruning hyperparameters. We propose a DNN pruning scheme based on Principal Component Analysis and relative importance of each neuron's connection that automatically finds the optimized DNN in one shot without requiring hand-tuning of multiple parameters.

The Maximum k-plex Problem is an important combinatorial optimization problem with increasingly wide applications. Due to its exponential time complexity, many heuristic methods have been proposed which can return a good-quality solution in a reasonable time. However, most of the heuristic algorithms are memoryless and unable to utilize the experience during the search. Inspired by the multi-armed bandit (MAB) problem in reinforcement learning (RL), we propose a novel perturbation mechanism named BLP, which can learn online to select a good vertex for perturbation when getting stuck in local optima. To our best of knowledge, this is the first attempt to combine local search with RL for the maximum $ k $-plex problem. Besides, we also propose a novel strategy, named Dynamic-threshold Configuration Checking (DTCC), which extends the original Configuration Checking (CC) strategy from two aspects. Based on the BLP and DTCC, we develop a local search algorithm named BDCC and improve it by a hyperheuristic strategy. The experimental result shows that our algorithms dominate on the standard DIMACS and BHOSLIB benchmarks and achieve state-of-the-art performance on massive graphs.

Variational autoencoders provide a principled framework for learning deep latent-variable models and corresponding inference models. In this work, we provide an introduction to variational autoencoders and some important extensions.

Self-supervised learning aims to learn representations from the data itself without explicit manual supervision. Existing efforts ignore a crucial aspect of self-supervised learning - the ability to scale to large amount of data because self-supervision requires no manual labels. In this work, we revisit this principle and scale two popular self-supervised approaches to 100 million images. We show that by scaling on various axes (including data size and problem 'hardness'), one can largely match or even exceed the performance of supervised pre-training on a variety of tasks such as object detection, surface normal estimation (3D) and visual navigation using reinforcement learning. Scaling these methods also provides many interesting insights into the limitations of current self-supervised techniques and evaluations. We conclude that current self-supervised methods are not 'hard' enough to take full advantage of large scale data and do not seem to learn effective high level semantic representations. We also introduce an extensive benchmark across 9 different datasets and tasks. We believe that such a benchmark along with comparable evaluation settings is necessary to make meaningful progress. Code is at: https://github.com/facebookresearch/fair_self_supervision_benchmark.

We introduce an off-policy evaluation procedure for highlighting episodes where applying a reinforcement learned (RL) policy is likely to have produced a substantially different outcome than the observed policy. In particular, we introduce a class of structural causal models (SCMs) for generating counterfactual trajectories in finite partially observable Markov Decision Processes (POMDPs). We see this as a useful procedure for off-policy "debugging" in high-risk settings (e.g., healthcare); by decomposing the expected difference in reward between the RL and observed policy into specific episodes, we can identify episodes where the counterfactual difference in reward is most dramatic. This in turn can be used to facilitate review of specific episodes by domain experts. We demonstrate the utility of this procedure with a synthetic environment of sepsis management.

Metric learning is the problem of learning a task-specific distance function given supervision. Classical linear methods for this problem (known as Mahalanobis metric learning approaches) are well-studied both theoretically and empirically, but are limited to Euclidean distances after learned linear transformations of the input space. In this paper, we consider learning a Bregman divergence, a rich and important class of divergences that includes Mahalanobis metrics as a special case but also includes the KL-divergence and others. We develop a formulation and algorithm for learning arbitrary Bregman divergences based on approximating their underlying convex generating function via a piecewise linear function. We show several theoretical results of our resulting model, including a PAC guarantee that the learned Bregman divergence approximates an arbitrary Bregman divergence with error O_p (m^(-1/(d+2))), where m is the number of training points and d is the dimension of the data. We provide empirical results on using the learned divergences for classification, semi-supervised clustering, and ranking problems.

Deep learning is increasingly used as a basic building block of security systems. Unfortunately, deep neural networks are hard to interpret, and their decision process is opaque to the practitioner. Recent work has started to address this problem by considering black-box explanations for deep learning in computer security (CCS'18). The underlying explanation methods, however, ignore the structure of neural networks and thus omit crucial information for analyzing the decision process. In this paper, we investigate white-box explanations and systematically compare them with current black-box approaches. In an extensive evaluation with learning-based systems for malware detection and vulnerability discovery, we demonstrate that white-box explanations are more concise, sparse, complete and efficient than black-box approaches. As a consequence, we generally recommend the use of white-box explanations if access to the employed neural network is available, which usually is the case for stand-alone systems for malware detection, binary analysis, and vulnerability discovery.

Neural network models for NLP are typically implemented without the explicit encoding of language rules and yet they are able to break one performance record after another. Despite much work, it is still unclear what the representations learned by these networks correspond to. We propose here a novel approach for interpreting neural networks that relies on the only processing system we have that does understand language: the human brain. We use brain imaging recordings of subjects reading complex natural text to interpret word and sequence embeddings from 4 recent NLP models - ELMo, USE, BERT and Transformer-XL. We study how their representations differ across layer depth, context length, and attention type. Our results reveal differences in the context-related representations across these models. Further, in the transformer models, we find an interaction between layer depth and context length, and between layer depth and attention type. We finally use the insights from the attention experiments to alter BERT: we remove the learned attention at shallow layers, and show that this manipulation improves performance on a wide range of syntactic tasks. Cognitive neuroscientists have already begun using NLP networks to study the brain, and this work closes the loop to allow the interaction between NLP and cognitive neuroscience to be a true cross-pollination.

Deep Reinforcement Learning (DRL) algorithms for continuous action spaces are known to be brittle toward hyperparameters as well as \cut{being}sample inefficient. Soft Actor Critic (SAC) proposes an off-policy deep actor critic algorithm within the maximum entropy RL framework which offers greater stability and empirical gains. The choice of policy distribution, a factored Gaussian, is motivated by \cut{chosen due}its easy re-parametrization rather than its modeling power. We introduce Normalizing Flow policies within the SAC framework that learn more expressive classes of policies than simple factored Gaussians. \cut{We also present a series of stabilization tricks that enable effective training of these policies in the RL setting.}We show empirically on continuous grid world tasks that our approach increases stability and is better suited to difficult exploration in sparse reward settings.