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Medical Concept Representation Learning from Claims Data and Application to Health Plan Payment Risk Adjustment

arXiv.org Machine Learning

Risk adjustment has become an increasingly important tool in healthcare. It has been extensively applied to payment adjustment for health plans to reflect the expected cost of providing coverage for members. Risk adjustment models are typically estimated using linear regression, which does not fully exploit the information in claims data. Moreover, the development of such linear regression models requires substantial domain expert knowledge and computational effort for data preprocessing. In this paper, we propose a novel approach for risk adjustment that uses semantic embeddings to represent patient medical histories. Embeddings efficiently represent medical concepts learned from diagnostic, procedure, and prescription codes in patients' medical histories. This approach substantially reduces the need for feature engineering. Our results show that models using embeddings had better performance than a commercial risk adjustment model on the task of prospective risk score prediction.


Federated Reinforcement Distillation with Proxy Experience Memory

arXiv.org Machine Learning

In distributed reinforcement learning, it is common to exchange the experience memory of each agent and thereby collectively train their local models. The experience memory, however, contains all the preceding state observations and their corresponding policies of the host agent, which may violate the privacy of the agent. To avoid this problem, in this work, we propose a privacy-preserving distributed reinforcement learning (RL) framework, termed federated reinforcement distillation (FRD). The key idea is to exchange a proxy experience memory comprising a pre-arranged set of states and time-averaged policies, thereby preserving the privacy of actual experiences. Based on an advantage actor-critic RL architecture, we numerically evaluate the effectiveness of FRD and investigate how the performance of FRD is affected by the proxy memory structure and different memory exchanging rules.


Discriminative Active Learning

arXiv.org Machine Learning

We propose a new batch mode active learning algorithm designed for neural networks and large query batch sizes. The method, Discriminative Active Learning (DAL), poses active learning as a binary classification task, attempting to choose examples to label in such a way as to make the labeled set and the unlabeled pool indistinguishable. Experimenting on image classification tasks, we empirically show our method to be on par with state of the art methods in medium and large query batch sizes, while being simple to implement and also extend to other domains besides classification tasks. Our experiments also show that none of the state of the art methods of today are clearly better than uncertainty sampling when the batch size is relatively large, negating some of the reported results in the recent literature.


Deep Sequential Mosaicking of Fetoscopic Videos

arXiv.org Machine Learning

Twin-to-twin transfusion syndrome treatment requires fetoscopic laser photocoagulation of placental vascular anastomoses to regulate blood flow to both fetuses. Limited field-of-view (FoV) and low visual quality during fetoscopy make it challenging to identify all vascular connections. Mosaicking can align multiple overlapping images to generate an image with increased FoV, however, existing techniques apply poorly to fetoscopy due to the low visual quality, texture paucity, and hence fail in longer sequences due to the drift accumulated over time. Deep learning techniques can facilitate in overcoming these challenges. Therefore, we present a new generalized Deep Sequential Mosaicking (DSM) framework for fetoscopic videos captured from different settings such as simulation, phantom, and real environments. DSM extends an existing deep image-based homography model to sequential data by proposing controlled data augmentation and outlier rejection methods. Unlike existing methods, DSM can handle visual variations due to specular highlights and reflection across adjacent frames, hence reducing the accumulated drift. We perform experimental validation and comparison using 5 diverse fetoscopic videos to demonstrate the robustness of our framework.


What does it mean to understand a neural network?

arXiv.org Machine Learning

We can define a neural network that can learn to recognize objects in less than 100 lines of code. However, after training, it is characterized by millions of weights that contain the knowledge about many object types across visual scenes. Such networks are thus dramatically easier to understand in terms of the code that makes them than the resulting properties, such as tuning or connections. In analogy, we conjecture that rules for development and learning in brains may be far easier to understand than their resulting properties. The analogy suggests that neuroscience would benefit from a focus on learning and development.


Dynamical Systems as Temporal Feature Spaces

arXiv.org Machine Learning

Parameterized state space models in the form of recurrent networks are often used in machine learning to learn from data streams exhibiting temporal dependencies. To break the black box nature of such models it is important to understand the dynamical features of the input driving time series that are formed in the state space. We propose a framework for rigorous analysis of such state representations in vanishing memory state space models such as echo state networks (ESN). In particular, we consider the state space a temporal feature space and the readout mapping from the state space a kernel machine operating in that feature space. We show that: (1) The usual ESN strategy of randomly generating input-to-state, as well as state coupling leads to shallow memory time series representations, corresponding to cross-correlation operator with fast exponentially decaying coefficients; (2) Imposing symmetry on dynamic coupling yields a constrained dynamic kernel matching the input time series with straightforward exponentially decaying motifs or exponentially decaying motifs of the highest frequency; (3) Simple cycle high-dimensional reservoir topology specified only through two free parameters can implement deep memory dynamic kernels with a rich variety of matching motifs. We quantify richness of feature representations imposed by dynamic kernels and demonstrate that for dynamic kernel associated with cycle reservoir topology, the kernel richness undergoes a phase transition close to the edge of stability.


Unsupervised Fault Detection in Varying Operating Conditions

arXiv.org Machine Learning

Training data-driven approaches for complex industrial system health monitoring is challenging. When data on faulty conditions are rare or not available, the training has to be performed in a unsupervised manner. In addition, when the observation period, used for training, is kept short, to be able to monitor the system in its early life, the training data might not be representative of all the system normal operating conditions. In this paper, we propose five approaches to perform fault detection in such context. Two approaches rely on the data from the unit to be monitored only: the baseline is trained on the early life of the unit. An incremental learning procedure tries to learn new operating conditions as they arise. Three other approaches take advantage of data from other similar units within a fleet. In two cases, units are directly compared to each other with similarity measures, and the data from similar units are combined in the training set. We propose, in the third case, a new deep-learning methodology to perform, first, a feature alignment of different units with an Unsupervised Feature Alignment Network (UFAN). Then, features of both units are combined in the training set of the fault detection neural network. The approaches are tested on a fleet comprising 112 units, observed over one year of data. All approaches proposed here are an improvement to the baseline, trained with two months of data only. As units in the fleet are found to be very dissimilar, the new architecture UFAN, that aligns units in the feature space, is outperforming others.


A Model-based Approach for Sample-efficient Multi-task Reinforcement Learning

arXiv.org Artificial Intelligence

The aim of multi-task reinforcement learning is two-fold: (1) efficiently learn by training against multiple tasks and (2) quickly adapt, using limited samples, to a variety of new tasks. In this work, the tasks correspond to reward functions for environments with the same (or similar) dynamical models. We propose to learn a dynamical model during the training process and use this model to perform sample-efficient adaptation to new tasks at test time. We use significantly fewer samples by performing policy optimization only in a "virtual" environment whose transitions are given by our learned dynamical model. Our algorithm sequentially trains against several tasks. Upon encountering a new task, we first warm-up a policy on our learned dynamical model, which requires no new samples from the environment. We then adapt the dynamical model with samples from this policy in the real environment. We evaluate our approach on several continuous control benchmarks and demonstrate its efficacy over MAML, a state-of-the-art meta-learning algorithm, on these tasks.


Cataloging Accreted Stars within Gaia DR2 using Deep Learning

arXiv.org Machine Learning

The goal of this paper is to develop a machine learning based approach that utilizes phase space alone to separate the Gaia DR2 stars into two categories: those accreted onto the Milky Way from in situ stars that were born within the Galaxy. Traditional selection methods that have been used to identify accreted stars typically rely on full 3D velocity and/or metallicity information, which significantly reduces the number of classifiable stars. The approach advocated here is applicable to a much larger fraction of Gaia DR2. A method known as transfer learning is shown to be effective through extensive testing on a set of mock Gaia catalogs that are based on the FIRE cosmological zoom-in hydrodynamic simulations of Milky Way-mass galaxies. The machine is first trained on simulated data using only 5D kinematics as inputs, and is then further trained on a cross-matched Gaia/RAVE data set, which improves sensitivity to properties of the real Milky Way. The result is a catalog that identifies ~650,000 accreted stars within Gaia DR2. This catalog can yield empirical insights into the merger history of the Milky Way, and could be used to infer properties of the dark matter distribution.


Subspace Determination through Local Intrinsic Dimensional Decomposition: Theory and Experimentation

arXiv.org Machine Learning

In data mining, machine learning, and other areas of AI, we are often faced with datasets that contain many more attributes than needed, or that can even be helpful for tasks such as clustering or classification. Problems associated with such high dimensional data are for example the concentration effect of distances [13, 20] or irrelevant features [25, 49]. For clustering [31] and outlier detection [49], researchers have made use of various techniques to identify relevant subspaces, as defined by subsets of features that are informative for a particular task. Examples of how relevant subspaces can be determined for individual clusters or outliers include local density estimation in a systematic search through candidate subspaces (often following the Apriori principle [7] in various adaptations to the subspace search problem [48]), or the adaptation of distance measures based on the distribution within local neighborhoods (using some analysis of variance or even covariance -- typically based on PCA -- to allow also for an adaptation to correlated features). For sufficiently tight local neighborhoods, the underlying local data manifold can be regarded as approaching a linear form [40], an assumption that further justifies the determination of locally relevant features for subspace determination.