In this work, we introduce the Global Planar Convolution module as a building-block for fully-convolutional networks that aggregates global information and, therefore, enhances the context perception capabilities of segmentation networks in the context of brain tumor segmentation. We implement two baseline architectures (3D UNet and a residual version of 3D UNet, ResUNet) and present a novel architecture based on these two architectures, ContextNet, that includes the proposed Global Planar Convolution module. We show that the addition of such module eliminates the need of building networks with several representation levels, which tend to be over-parametrized and to showcase slow rates of convergence. Furthermore, we provide a visual demonstration of the behavior of GPC modules via visualization of intermediate representations. We finally participate in the 2018 edition of the BraTS challenge with our best performing models, that are based on ContextNet, and report the evaluation scores on the validation and the test sets of the challenge.

Image modality recognition is essential for efficient imaging workflows in current clinical environments, where multiple imaging modalities are used to better comprehend complex diseases. Emerging biomarkers from novel, rare modalities are being developed to aid in such understanding, however the availability of these images is often limited. This scenario raises the necessity of recognising new imaging modalities without them being collected and annotated in large amounts. In this work, we present a few-shot learning model for limited training examples based on Deep Triplet Networks. We show that the proposed model is more accurate in distinguishing different modalities than a traditional Convolutional Neural Network classifier when limited samples are available. Furthermore, we evaluate the performance of both classifiers when presented with noisy samples and provide an initial inspection of how the proposed model can incorporate measures of uncertainty to be more robust against out-of-sample examples.

We give a thorough overview of supervised learning and network design for learning membership on algebraic varieties via deep neural networks. We show how artificial neural networks can be trained to predict the entanglement type for quantum states. We give examples for detecting degenerate states, as well as border rank classification for up to 5 binary qubits and 3 qutrits (ternary qubits).

Accurate m odel selection is a fundamental requirement for statistical analysis (1 - 5) . In many real - world applications of graphical modelling, correct model structure ident ifica tion is the ultimate objective. S tandard model validation procedures such as information theoretic scores and cross validation have demonstr ated poor performance when . Specialised methods such as EBIC, StARS and RIC have been developed for the explicit purpose of high - dimensional Gaussian graphical model selection. We present a novel model score criterion, Graphical Neighbour Information. This method demonstrates oracle performance in high - dimensional model selection, outperforming the current state - of - the - a rt in our simulations. The Graphical Neighbour Information criterion has the additional advantage of efficient, closed - form computability, sparing the costly inference of multiple models on data subsamples. We provide a theoretic analysis of the method and benchmark simulations versus the current state of the art .

We present an end-to-end statistical framework for personalized, accurate, and minimally invasive modeling of female reproductive hormonal patterns. Reconstructing and forecasting the evolution of hormonal dynamics is a challenging task, but a critical one to improve general understanding of the menstrual cycle and personalized detection of potential health issues. Our goal is to infer and forecast individual hormone daily levels over time, while accommodating pragmatic and minimally invasive measurement settings. To that end, our approach combines the power of probabilistic generative models (i.e., multi-task Gaussian processes) with the flexibility of neural networks (i.e., a dilated convolutional architecture) to learn complex temporal mappings. To attain accurate hormone level reconstruction with as little data as possible, we propose a sampling mechanism for optimal reconstruction accuracy with limited sampling budget. Our results show the validity of our proposed hormonal dynamic modeling framework, as it provides accurate predictive performance across different realistic sampling budgets and outperforms baselines methods.

One of the most important challenges in the analysis of high-throughput genetic data is the development of efficient computational methods to identify statistically significant Single Nucleotide Polymorphisms (SNPs). Genome-wide association studies (GWAS) use single-locus analysis where each SNP is independently tested for association with phenotypes. The limitation with this approach, however, is its inability to explain genetic variation in complex diseases. Alternative approaches are required to model the intricate relationships between SNPs. Our proposed approach extends GWAS by combining deep learning stacked autoencoders (SAEs) and association rule mining (ARM) to identify epistatic interactions between SNPs. Following traditional GWAS quality control and association analysis, the most significant SNPs are selected and used in the subsequent analysis to investigate epistasis. SAERMA controls the classification results produced in the final fully connected multi-layer feedforward artificial neural network (MLP) by manipulating the interestingness measures, support and confidence, in the rule generation process. The best classification results were achieved with 204 SNPs compressed to 100 units (77% AUC, 77% SE, 68% SP, 53% Gini, logloss=0.58, and MSE=0.20), although it was possible to achieve 73% AUC (77% SE, 63% SP, 45% Gini, logloss=0.62, and MSE=0.21) with 50 hidden units - both supported by close model interpretation.

We implement a method for re-ranking top-10 results of a state-of-the-art question answering (QA) system. The goal of our re-ranking approach is to improve the answer selection given the user question and the top-10 candidates. We focus on improving deployed QA systems that do not allow re-training or re-training comes at a high cost. Our re-ranking approach learns a similarity function using n-gram based features using the query, the answer and the initial system confidence as input. Our contributions are: (1) we generate a QA training corpus starting from 877 answers from the customer care domain of T-Mobile Austria, (2) we implement a state-of-the-art QA pipeline using neural sentence embeddings that encode queries in the same space than the answer index, and (3) we evaluate the QA pipeline and our re-ranking approach using a separately provided test set. The test set can be considered to be available after deployment of the system, e.g., based on feedback of users. Our results show that the system performance, in terms of top-n accuracy and the mean reciprocal rank, benefits from re-ranking using gradient boosted regression trees. On average, the mean reciprocal rank improves by 9.15%.

This work describes and discusses an algorithm submitted to the Sound Event Localization and Detection Task of DCASE2019 Challenge. The proposed methodology relies on parametric spatial audio analysis for source localization and detection, combined with a deep learning-based monophonic event classifier. The evaluation of the proposed algorithm yields overall results comparable to the baseline system. The main highlight is a reduction of the localization error on the evaluation dataset by a factor of 2.6, compared with the baseline performance.

Heart disease is one of the most common diseases causing morbidity and mortality. Electrocardiogram (ECG) has been widely used for diagnosing heart diseases for its simplicity and non-invasive property. Automatic ECG analyzing technologies are expected to reduce human working load and increase diagnostic efficacy. However, there are still some challenges to be addressed for achieving this goal. In this study, we develop an algorithm to identify multiple abnormalities from 12-lead ECG recordings. In the algorithm pipeline, several preprocessing methods are firstly applied on the ECG data for denoising, augmentation and balancing recording numbers of variant classes. In consideration of efficiency and consistency of data length, the recordings are padded or truncated into a medium length, where the padding/truncating time windows are selected randomly to sup-press overfitting. Then, the ECGs are used to train deep neural network (DNN) models with a novel structure that combines a deep residual network with an attention mechanism. Finally, an ensemble model is built based on these trained models to make predictions on the test data set. Our method is evaluated based on the test set of the First China ECG Intelligent Competition dataset by using the F1 metric that is regarded as the harmonic mean between the precision and recall. The resultant overall F1 score of the algorithm is 0.875, showing a promising performance and potential for practical use.

We characterize the asymptotic performance of nonparametric one- and two-sample testing. The exponential decay rate or error exponent of the type-II error probability is used as the asymptotic performance metric, and an optimal test achieves the maximum rate subject to a constant level constraint on the type-I error probability. With Sanov's theorem, we derive a sufficient condition for one-sample tests to achieve the optimal error exponent in the universal setting, i.e., for any distribution defining the alternative hypothesis. We then show that two classes of Maximum Mean Discrepancy (MMD) based tests attain the optimal type-II error exponent on $\mathbb R^d$, while the quadratic-time Kernel Stein Discrepancy (KSD) based tests achieve this optimality with an asymptotic level constraint. For general two-sample testing, however, Sanov's theorem is insufficient to obtain a similar sufficient condition. We proceed to establish an extended version of Sanov's theorem and derive an exact error exponent for the quadratic-time MMD based two-sample tests. The obtained error exponent is further shown to be optimal among all two-sample tests satisfying a given level constraint. Our results not only solve a long-standing open problem in information theory and statistics, but also provide an achievability result for optimal nonparametric one- and two-sample testing. Application to off-line change detection and related issues are also discussed.