Deep neural networks (DNNs) are famous for their high prediction accuracy, but they are also known for their black-box nature and poor interpretability. We consider the problem of variable selection, that is, selecting the input variables that have significant predictive power on the output, in DNNs. We propose a backward elimination procedure called SurvNet, which is based on a new measure of variable importance that applies to a wide variety of networks. More importantly, SurvNet is able to estimate and control the false discovery rate of selected variables, while no existing methods provide such a quality control. Further, SurvNet adaptively determines how many variables to eliminate at each step in order to maximize the selection efficiency. To study its validity, SurvNet is applied to image data and gene expression data, as well as various simulation datasets.

-- Accurate volume segmentation from the Computed T omography (CT) scan is a common prerequisite for preoperative planning, intra-operative guidance and quantitative assessment of therapeutic outcomes in robot-assisted Minimally Invasive Surgery (MIS). The use of 3D Deep Convolutional Neural Network (DCNN) is a viable solution for this task but is memory intensive. The use of patch division can mitigate this issue in practice, but can cause discontinuities between the adjacent patches and severe class-imbalances within individual sub-volumes. This paper presents a new patch division approach - Patch-512 to tackle the class-imbalance issue by preserving a full field-of-view of the objects in the XY planes. T o achieve better segmentation results based on these asymmetric patches, a 3D DCNN architecture using asymmetrical separable convolutions is proposed. The proposed network, called Z-Net, can be seamlessly integrated into existing 3D DCNNs such as 3D U-Net and V-Net, for improved volume segmentation. Detailed validation of the method is provided for CT aortic, liver and lung segmentation, demonstrating the effectiveness and practical value of the method for intra-operative 3D navigation in robot-assisted MIS. Medical volume segmentation, which labels the class of each voxel in a 3D volume, is a fundamental task in medical image analysis.

Manifold learning now plays a very important role in machine learning and many relevant applications. Although its superior performance in dealing with nonlinear data distribution, data sparsity is always a thorny knot. There are few researches to well handle it in manifold learning. In this paper, we propose Hierarchic Neighbors Embedding (HNE), which enhance local connection by the hierarchic combination of neighbors. After further analyzing topological connection and reconstruction performance, three different versions of HNE are given. The experimental results show that our methods work well on both synthetic data and high-dimensional real-world tasks. HNE develops the outstanding advantages in dealing with general data. Furthermore, comparing with other popular manifold learning methods, the performance on sparse samples and weak-connected manifolds is better for HNE.

In this paper, we propose an AdaBoost - assisted extreme learning machine for efficient online sequential classification (AOS - ELM) . In order to achieve better accuracy in online sequential learning scenarios, we utilize the cost - sensitive algorithm - AdaBoost, which diversifying the weak classifiers, and addin g the forgetting mechanism, which stabilizing the performance during the training procedure . Hence, AOS - ELM adapt s bet ter to sequentially arrived data compared with other voting based methods. The experim ent results show AOS - ELM can achieve 9 4.41 % accuracy on MNIST dataset, which is the theoretical accuracy bound performed by original batch learning algorithm, AdaBoost - EL M. Moreover, with the forgetting mechanism, the standard deviation of accuracy during the online sequential learning process is reduced to 8.26x.

Reducing the incidence of surgical site infections (SSIs) is one of the objectives of the French nosocomial infection control program. Manual monitoring of SSIs is carried out each year by the hospital hygiene team and surgeons at the University Hospital of Bordeaux. Our goal was to develop an automatic detection algorithm based on hospital information system data. Three years (2015, 2016 and 2017) of manual spine surgery monitoring have been used as a gold standard to extract features and train machine learning algorithms. The dataset contained 22 SSIs out of 2133 spine surgeries. Two different approaches were compared. The first used several data sources and achieved the best performance but is difficult to generalize to other institutions. The second was based on free text only with semiautomatic extraction of discriminant terms. The algorithms managed to identify all the SSIs with 20 and 26 false positives respectively on the dataset. Another evaluation is underway. These results are encouraging for the development of semi-automated surveillance methods.

In recent years, multi object tracking (MOT) problem has drawn attention to it and has been studied in various research areas. However, some of the challenging problems including time dependent cardinality, unordered measurement set, and object labeling remain unclear. In this paper, we propose robust nonparametric methods to model the state prior for MOT problem. These models are shown to be more flexible and robust compared to existing methods. In particular, the overall approach estimates time dependent object cardinality, provides object labeling, and identifies object associated measurements. Moreover, our proposed framework dynamically contends with the birth/death and survival of the objects through dependent nonparametric processes. We present Inference algorithms that demonstrate the utility of the dependent nonparametric models for tracking. We employ Monte Carlo sampling methods to demonstrate the proposed algorithms efficiently learn the trajectory of objects from noisy measurements. The computational results display the performance of the proposed algorithms and comparison not only between one another, but also between proposed algorithms and labeled multi Bernoulli tracker.

Imagining Affordances Using Simulations of an Articulated Human Body Hongtao Wu, Student Member, IEEE, Deven Misra, and Gregory S. Chirikjian, Fellow, IEEE Abstract --For robots to exhibit a high level of intelligence in the real world, they must be able to assess objects for which they have no prior knowledge. Therefore, it is crucial for robots to perceive object affordances by reasoning about physical interactions with the object. In this paper, we propose a novel method to provide robots with an imagination of object affordances using physical simulations. The class of chair is chosen here as an initial category of objects to illustrate a more general paradigm. In our method, the robot "imagines" the affordance of an arbitrarily oriented object as a chair by simulating a physical "sitting" interaction between an articulated human body and the object. This object affordance reasoning is used as a cue for object classification (chair vs non-chair). Moreover, if an object is classified as a chair, the affordance reasoning can also predict the upright pose of the object which allows the sitting interaction to take place. We call this type of poses the functional pose . We demonstrate our method in chair classification on synthetic 3D CAD models. Although our method uses only 20 models for training, it outperforms appearance-based deep learning methods, which require a large amount of training data, when the upright orientation is not assumed to be known as a priori. In addition, we showcase that the functional pose predictions of our method on both synthetic models and real objects scanned by a depth camera align well with human judgments.

As intelligent systems are increasingly capable of performing their tasks without the n eed for continuous human input, direction, or supervision, new human - machine interaction concepts are needed. A promising approac h to this end is human - agent teaming, which envisions a novel interaction form where humans and machines behave as equal team partners . This paper presents an overview of the current state of the art in human - agent teaming, including the analysis of human - agent teams on five dimensions; a framework describing important teaming functionalities; a technical architecture, called SAIL, supporting social human - agent teaming through the modular implementation of the human - agent teaming functionalities; a technica l implementation of the architecture; and a proof - of - concept prototype created with the framework and architecture. We conclude this paper with a reflection on where we stand and a glance into the future showing the way forward .

Skin cancer is one of the most common types of cancer around the world. For this reason, over the past years, different approaches have been proposed to assist detect it. Nonetheless, most of them are based only on dermoscopy images and do not take into account the patient clinical information. In this work, first, we present a new dataset that contains clinical images, acquired from smartphones, and patient clinical information of the skin lesions. Next, we introduce a straightforward approach to combine the clinical data and the images using different well-known deep learning models. These models are applied to the presented dataset using only the images and combining them with the patient clinical information. We present a comprehensive study to show the impact of the clinical data on the final predictions. The results obtained by combining both sets of information show a general improvement of around 7% in the balanced accuracy for all models. In addition, the statistical test indicates significant differences between the models with and without considering both data. The improvement achieved shows the potential of using patient clinical information in skin cancer detection and indicates that this piece of information is important to leverage skin cancer detection systems.

-- 3D shape instantiation which reconstructs the 3D shape of a target from limited 2D images or projections is an emerging technique for surgical intervention. It improves the currently less-informative and insufficient 2D navigation schemes for robot-assisted Minimally Invasive Surgery (MIS) to 3D navigation. Previously, a general and registration-free framework was proposed for 3D shape instantiation based on Kernel Partial Least Square Regression (KPLSR), requiring manually segmented anatomical structures as the prerequisite. Two hyper-parameters including the Gaussian width and component number also need to be carefully adjusted. Deep Convolutional Neural Network (DCNN) based framework has also been proposed to reconstruct a 3D point cloud from a single 2D image, with end-to-end and fully automatic learning. In this paper, an Instantiation-Net is proposed to reconstruct the 3D mesh of a target from its a single 2D image, by using DCNN to extract features from the 2D image and Graph Convolutional Network (GCN) to reconstruct the 3D mesh, and using Fully Connected (FC) layers to connect the DCNN to GCN. Detailed validation was performed to demonstrate the practical strength of the method and its potential clinical use.