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Multi-LLM Collaboration for Medication Recommendation
Sanchez, Huascar, Hitaj, Briland, Bergmann, Jules, Briesemeister, Linda
As healthcare increasingly turns to AI for scalable and trustworthy clinical decision support, ensuring reliability in model reasoning remains a critical challenge. Individual large language models (LLMs) are susceptible to hallucinations and inconsistency, whereas naive ensembles of models often fail to deliver stable and credible recommendations. Building on our previous work on LLM Chemistry, which quantifies the collaborative compatibility among LLMs, we apply this framework to improve the reliability in medication recommendation from brief clinical vignettes. Our approach leverages multi-LLM collaboration guided by Chemistry-inspired interaction modeling, enabling ensembles that are effective (exploiting complementary strengths), stable (producing consistent quality), and calibrated (minimizing interference and error amplification). We evaluate our Chemistry-based Multi-LLM collaboration strategy on real-world clinical scenarios to investigate whether such interaction-aware ensembles can generate credible, patient-specific medication recommendations. Preliminary results are encouraging, suggesting that LLM Chemistry-guided collaboration may offer a promising path toward reliable and trustworthy AI assistants in clinical practice.
Meta-Learning for Quantum Optimization via Quantum Sequence Model
Lin, Yu-Cheng, Hsu, Yu-Chao, Chen, Samuel Yen-Chi
The Quantum Approximate Optimization Algorithm (QAOA) is a leading approach for solving combinatorial optimization problems on near-term quantum processors. However, finding good variational parameters remains a significant challenge due to the non-convex energy landscape, often resulting in slow convergence and poor solution quality. In this work, we propose a quantum meta-learning framework that trains advanced quantum sequence models to generate effective parameter initialization policies. We investigate four classical or quantum sequence models, including the Quantum Kernel-based Long Short-Term Memory (QK-LSTM), as learned optimizers in a "learning to learn" paradigm. Our numerical experiments on the Max-Cut problem demonstrate that the QK-LSTM optimizer achieves superior performance, obtaining the highest approximation ratios and exhibiting the fastest convergence rate across all tested problem sizes (n=10 to 13). Crucially, the QK-LSTM model achieves perfect parameter transferability by synthesizing a single, fixed set of near-optimal parameters, leading to a remarkable sustained acceleration of convergence even when generalizing to larger problems. This capability, enabled by the compact and expressive power of the quantum kernel architecture, underscores its effectiveness. The QK-LSTM, with only 43 trainable parameters, substantially outperforms the classical LSTM (56 parameters) and other quantum sequence models, establishing a robust pathway toward highly efficient parameter initialization for variational quantum algorithms in the NISQ era.
QKAN-LSTM: Quantum-inspired Kolmogorov-Arnold Long Short-term Memory
Hsu, Yu-Chao, Jiang, Jiun-Cheng, Lin, Chun-Hua, Peng, Kuo-Chung, Chen, Nan-Yow, Chen, Samuel Yen-Chi, Kuo, En-Jui, Goan, Hsi-Sheng
Long short-term memory (LSTM) models are a particular type of recurrent neural networks (RNNs) that are central to sequential modeling tasks in domains such as urban telecommunication forecasting, where temporal correlations and nonlinear dependencies dominate. However, conventional LSTMs suffer from high parameter redundancy and limited nonlinear expressivity. In this work, we propose the Quantum-inspired Kolmogorov-Arnold Long Short-Term Memory (QKAN-LSTM), which integrates Data Re-Uploading Activation (DARUAN) modules into the gating structure of LSTMs. Each DARUAN acts as a quantum variational activation function (QVAF), enhancing frequency adaptability and enabling an exponentially enriched spectral representation without multi-qubit entanglement. The resulting architecture preserves quantum-level expressivity while remaining fully executable on classical hardware. Empirical evaluations on three datasets, Damped Simple Harmonic Motion, Bessel Function, and Urban Telecommunication, demonstrate that QKAN-LSTM achieves superior predictive accuracy and generalization with a 79% reduction in trainable parameters compared to classical LSTMs. We extend the framework to the Jiang-Huang-Chen-Goan Network (JHCG Net), which generalizes KAN to encoder-decoder structures, and then further use QKAN to realize the latent KAN, thereby creating a Hybrid QKAN (HQKAN) for hierarchical representation learning. The proposed HQKAN-LSTM thus provides a scalable and interpretable pathway toward quantum-inspired sequential modeling in real-world data environments.
SuperActivators: Only the Tail of the Distribution Contains Reliable Concept Signals
Goldberg, Cassandra, Kim, Chaehyeon, Stein, Adam, Wong, Eric
Concept vectors aim to enhance model interpretability by linking internal representations with human-understandable semantics, but their utility is often limited by noisy and inconsistent activations. In this work, we uncover a clear pattern within the noise, which we term the SuperActivator Mechanism: while in-concept and out-of-concept activations overlap considerably, the token activations in the extreme high tail of the in-concept distribution provide a reliable signal of concept presence. We demonstrate the generality of this mechanism by showing that SuperActivator tokens consistently outperform standard vector-based and prompting concept detection approaches, achieving up to a 14% higher F1 score across image and text modalities, model architectures, model layers, and concept extraction techniques. Finally, we leverage SuperActivator tokens to improve feature attributions for concepts.
Dual-Path Region-Guided Attention Network for Ground Reaction Force and Moment Regression
Accurate estimation of three-dimensional ground reaction forces and moments (GRFs/GRMs) is crucial for both biomechanics research and clinical rehabilitation evaluation. In this study, we focus on insole-based GRF/GRM estimation and further validate our approach on a public walking dataset. We propose a Dual-Path Region-Guided Attention Network that integrates anatomy-inspired spatial priors and temporal priors into a region-level attention mechanism, while a complementary path captures context from the full sensor field. The two paths are trained jointly and their outputs are combined to produce the final GRF/GRM predictions. Conclusions: Our model outperforms strong baseline models, including CNN and CNN-LSTM architectures on two datasets, achieving the lowest six-component average NRMSE of 5.78% on the insole dataset and 1.42% for the vertical ground reaction force on the public dataset. This demonstrates robust performance for ground reaction force and moment estimation.
HTR-ConvText: Leveraging Convolution and Textual Information for Handwritten Text Recognition
Truc, Pham Thach Thanh, Nam, Dang Hoai, Khoa, Huynh Tong Dang, Duy, Vo Nguyen Le
Handwritten Text Recognition remains challenging due to the limited data, high writing style variance, and scripts with complex diacritics. Existing approaches, though partially address these issues, often struggle to generalize without massive synthetic data. To address these challenges, we propose HTR-ConvText, a model designed to capture fine-grained, stroke-level local features while preserving global contextual dependencies. In the feature extraction stage, we integrate a residual Convolutional Neural Network backbone with a MobileViT with Positional Encoding block. This enables the model to both capture structural patterns and learn subtle writing details. We then introduce the ConvText encoder, a hybrid architecture combining global context and local features within a hierarchical structure that reduces sequence length for improved efficiency. Additionally, an auxiliary module injects textual context to mitigate the weakness of Connectionist Temporal Classification. Evaluations on IAM, READ2016, LAM and HANDS-VNOnDB demonstrate that our approach achieves improved performance and better generalization compared to existing methods, especially in scenarios with limited training samples and high handwriting diversity.
Detecting Perspective Shifts in Multi-agent Systems
Bridgeford, Eric, Helm, Hayden
Generative models augmented with external tools and update mechanisms (or \textit{agents}) have demonstrated capabilities beyond intelligent prompting of base models. As agent use proliferates, dynamic multi-agent systems have naturally emerged. Recent work has investigated the theoretical and empirical properties of low-dimensional representations of agents based on query responses at a single time point. This paper introduces the Temporal Data Kernel Perspective Space (TDKPS), which jointly embeds agents across time, and proposes several novel hypothesis tests for detecting behavioral change at the agent- and group-level in black-box multi-agent systems. We characterize the empirical properties of our proposed tests, including their sensitivity to key hyperparameters, in simulations motivated by a multi-agent system of evolving digital personas. Finally, we demonstrate via natural experiment that our proposed tests detect changes that correlate sensitively, specifically, and significantly with a real exogenous event. As far as we are aware, TDKPS is the first principled framework for monitoring behavioral dynamics in black-box multi-agent systems -- a critical capability as generative agent deployment continues to scale.
Factuality and Transparency Are All RAG Needs! Self-Explaining Contrastive Evidence Re-ranking
Vargas, Francielle, Pedronette, Daniel
This extended abstract introduces Self-Explaining Contrastive Evidence Re-Ranking (CER), a novel method that restructures retrieval around factual evidence by fine-tuning embeddings with contrastive learning and generating token-level attribution rationales for each retrieved passage. Hard negatives are automatically selected using a subjectivity-based criterion, forcing the model to pull factual rationales closer while pushing subjective or misleading explanations apart. As a result, the method creates an embedding space explicitly aligned with evidential reasoning. We evaluated our method on clinical trial reports, and initial experimental results show that CER improves retrieval accuracy, mitigates the potential for hallucinations in RAG systems, and provides transparent, evidence-based retrieval that enhances reliability, especially in safety-critical domains.
Introducing V-Soft Pro: a Modular Platform for a Transhumeral Prosthesis with Controllable Stiffness
Milazzo, Giuseppe, Grioli, Giorgio, Bicchi, Antonio, Catalano, Manuel G.
Current upper limb prostheses aim to enhance user independence in daily activities by incorporating basic motor functions. However, they fall short of replicating the natural movement and interaction capabilities of the human arm. In contrast, human limbs leverage intrinsic compliance and actively modulate joint stiffness, enabling adaptive responses to varying tasks, impact absorption, and efficient energy transfer during dynamic actions. Inspired by this adaptability, we developed a transhumeral prosthesis with Variable Stiffness Actuators (VSAs) to replicate the controllable compliance found in biological joints. The proposed prosthesis features a modular design, allowing customization for different residual limb shapes and accommodating a range of independent control signals derived from users' biological cues. Integrated elastic elements passively support more natural movements, facilitate safe interactions with the environment, and adapt to diverse task requirements. This paper presents a comprehensive overview of the platform and its functionalities, highlighting its potential applications in the field of prosthetics.
Environment-Aware Channel Inference via Cross-Modal Flow: From Multimodal Sensing to Wireless Channels
Liang, Guangming, Yang, Mingjie, Liu, Dongzhu, Henderson, Paul, Hanzo, Lajos
Accurate channel state information (CSI) underpins reliable and efficient wireless communication. However, acquiring CSI via pilot estimation incurs substantial overhead, especially in massive multiple-input multiple-output (MIMO) systems operating in high-Doppler environments. By leveraging the growing availability of environmental sensing data, this treatise investigates pilot-free channel inference that estimates complete CSI directly from multimodal observations, including camera images, LiDAR point clouds, and GPS coordinates. In contrast to prior studies that rely on predefined channel models, we develop a data-driven framework that formulates the sensing-to-channel mapping as a cross-modal flow matching problem. The framework fuses multimodal features into a latent distribution within the channel domain, and learns a velocity field that continuously transforms the latent distribution toward the channel distribution. To make this formulation tractable and efficient, we reformulate the problem as an equivalent conditional flow matching objective and incorporate a modality alignment loss, while adopting low-latency inference mechanisms to enable real-time CSI estimation. In experiments, we build a procedural data generator based on Sionna and Blender to support realistic modeling of sensing scenes and wireless propagation. System-level evaluations demonstrate significant improvements over pilot- and sensing-based benchmarks in both channel estimation accuracy and spectral efficiency for the downstream beamforming task.