Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

The tradeoff between time and frequency resolution is viewed as the fundamental difference between conventional spectrographic analysis and cochlear signal processing for broadband, rapid-changing signals. The model's response exhibits a wavelet-like analysis in the scale domain that preserves good temporal resolution; the frequency of each spectral component in a broadband signal can be accurately determined from the interpeak intervals in the instantaneous firing rates of auditory fibers. Such properties of the cochlear model are demonstrated with natural speech and synthetic complex signals. 1 Introduction As a nonparametric tool, spectrogram, or short-term Fourier transform, is widely used in analyzing non-stationary signals, such speech. Usually a window is applied to the running signal and then the Fourier transform is performed. The specific window applied determines the tradeoff between temporal and spectral resolutions of the analysis, as indicated by the uncertainty principle [1].

Channel equalization problem is an important problem in high-speed communications. The sequences of symbols transmitted are distorted by neighboring symbols. Traditionally, the channel equalization problem is considered as a channel-inversion operation. One problem of this approach is that there is no direct correspondence between error probability and residual error produced by the channel inversion operation. In this paper, the optimal equalizer design is formulated as a classification problem. The optimal classifier can be constructed by Bayes decision rule. In general it is nonlinear. An efficient hybrid linear/nonlinear equalizer approach has been proposed to train the equalizer. The error probability of new linear/nonlinear equalizer has been shown to be better than a linear equalizer in an experimental channel. 1 INTRODUCTION

IR is typically a sigmoidal function such as (1.2) but other choices than (1.2) are possible and of interest.

We compare activation functions in terms of the approximation power of their feedforward nets. We consider the case of analog as well as boolean input. 1 Introduction

The invariance of an objects' identity as it transformed over time provides a powerful cue for perceptual learning. We present an unsupervised learning procedure which maximizes the mutual information between the representations adopted by a feed-forward network at consecutive time steps. We demonstrate that the network can learn, entirely unsupervised, to classify an ensemble of several patterns by observing pattern trajectories, even though there are abrupt transitions from one object to another between trajectories. The same learning procedure should be widely applicable to a variety of perceptual learning tasks. 1 INTRODUCTION A promising approach to understanding human perception is to try to model its developmental stages. There is ample evidence that much of perception is learned.

Basic connectionist principles imply that grammars should take the form of systems of parallel soft constraints defining an optimization problem the solutions to which are the well-formed structures in the language. Such Harmonic Grammars have been successfully applied to a number of problems in the theory of natural languages. Here it is shown that formal languages too can be specified by Harmonic Grammars, rather than by conventional serial rewrite rule systems. 1 HARMONIC GRAMMARS In collaboration with Geraldine Legendre, Yoshiro Miyata, and Alan Prince, I have been studying how symbolic computation in human cognition can arise naturally as a higher-level virtual machine realized in appropriately designed lower-level connectionist networks. The basic computational principles of the approach are these: (1) a. \Vhell analyzed at the lower level, mental representations are distributed patterns of connectionist activity; when analyzed at a higher level, these same representations constitute symbolic structures.

Our efforts proceed in the context of a problem suggested by the operational needs of a particular electric utility to make daily forecasts of short-term load or demand. Forecasts are made at midday (1 p.m.) on a weekday t ( Monday - Thursday), for the next evening peak e(t) (occuring usually about 8 p.m. in the winter), the daily minimum d(t

We present a theory of cortico-hippocampal interaction in discrimination learning. The hippocampal region is presumed to form new stimulus representations which facilitate learning by enhancing the discriminability of predictive stimuli and compressing stimulus-stimulus redundancies. The cortical and cerebellar regions, which are the sites of long-term memory.

Connectionist Rpeech recognition systems are often handicapped by an inconsistency between training and testing criteria. This problem is addressed by the Multi-State Time Delay Neural Network (MS-TDNN), a hierarchical phonf'mp and word classifier which uses DTW to modulate its connectivit.y