In clinical practice, decision-making relies heavily on established protocols, often formalised as rules. Concurrently, Machine Learning (ML) models, trained on clinical data, aspire to integrate into medical decision-making processes. However, despite the growing number of ML applications, their adoption into clinical practice remains limited. Two critical concerns arise, relevant to the notions of consistency and continuity of care: (a) accuracy - the ML model, albeit more accurate, might introduce errors that would not have occurred by applying the protocol; (b) interpretability - ML models operating as black boxes might make predictions based on relationships that contradict established clinical knowledge. In this context, the literature suggests using ML models integrating domain knowledge for improved accuracy and interpretability. However, there is a lack of appropriate metrics for comparing ML models with clinical rules in addressing these challenges. Accordingly, in this article, we first propose metrics to assess the accuracy of ML models with respect to the established protocol. Secondly, we propose an approach to measure the distance of explanations provided by two rule sets, with the goal of comparing the explanation similarity between clinical rule-based systems and rules extracted from ML models. The approach is validated on the Pima Indians Diabetes dataset by training two neural networks - one exclusively on data, and the other integrating a clinical protocol. Our findings demonstrate that the integrated ML model achieves comparable performance to that of a fully data-driven model while exhibiting superior accuracy relative to the clinical protocol, ensuring enhanced continuity of care. Furthermore, we show that our integrated model provides explanations for predictions that align more closely with the clinical protocol compared to the data-driven model.

Supervised machine learning often encounters concept drift, where the data distribution changes over time, degrading model performance. Existing drift detection methods focus on identifying these shifts but often overlook the challenge of acquiring labeled data for model retraining after a shift occurs. We present the Strategy for Drift Sampling (SUDS), a novel method that selects homogeneous samples for retraining using existing drift detection algorithms, thereby enhancing model adaptability to evolving data. SUDS seamlessly integrates with current drift detection techniques. We also introduce the Harmonized Annotated Data Accuracy Metric (HADAM), a metric that evaluates classifier performance in relation to the quantity of annotated data required to achieve the stated performance, thereby taking into account the difficulty of acquiring labeled data. Our contributions are twofold: SUDS combines drift detection with strategic sampling to improve the retraining process, and HADAM provides a metric that balances classifier performance with the amount of labeled data, ensuring efficient resource utilization. Empirical results demonstrate the efficacy of SUDS in optimizing labeled data use in dynamic environments, significantly improving the performance of machine learning applications in real-world scenarios. Our code is open source and available at https://github.com/cfellicious/SUDS/

For large groups, use the name of the group or consortium and include a full list of the authors and affiliations at the end of the main manuscript or in the Supplementary Materials. Abstract: How diverse are the outputs of large language models when diversity is desired? We examine the diversity of responses of various models to questions with multiple possible answers, comparing them with human responses. Our findings suggest that models' outputs are highly concentrated, reflecting a narrow, mainstream'worldview', in comparison to humans, whose responses exhibit a much longer-tail. We examine three ways to increase models' output diversity: 1) increasing generation randomness via temperature sampling; 2) prompting models to answer from diverse perspectives; 3) aggregating outputs from several models. A combination of these measures significantly increases models' output diversity, reaching that of humans. We discuss implications of these findings for AI policy that wishes to preserve cultural diversity, an essential building block of a democratic social fabric. Conversely, a lack of diversity can result in extremism and exclusion (e.g., 1, 2).

With the development of large language models (LLMs), the ability to handle longer contexts has become a key capability for Web applications such as cross-document understanding and LLM-powered search systems. However, this progress faces two major challenges: performance degradation due to sequence lengths out-of-distribution, and excessively long inference times caused by the quadratic computational complexity of attention. These issues hinder the application of LLMs in long-context scenarios. In this paper, we propose Dynamic Token-Level KV Cache Selection (TokenSelect), a model-agnostic, training-free method for efficient and accurate long-context inference. TokenSelect builds upon the observation of non-contiguous attention sparsity, using Query-Key dot products to measure per-head KV Cache criticality at token-level. By per-head soft voting mechanism, TokenSelect selectively involves a small number of critical KV cache tokens in the attention calculation without sacrificing accuracy. To further accelerate TokenSelect, we designed the Selection Cache based on observations of consecutive Query similarity and implemented efficient dot product kernel, significantly reducing the overhead of token selection. A comprehensive evaluation of TokenSelect demonstrates up to 23.84x speedup in attention computation and up to 2.28x acceleration in end-to-end latency, while providing superior performance compared to state-of-the-art long-context inference methods.

Accurate tissue segmentation in fetal brain MRI remains challenging due to the dynamically changing anatomical anatomy and contrast during fetal development. To enhance segmentation accuracy throughout gestation, we introduced AtlasSeg, a dual-U-shape convolution network incorporating gestational age (GA) specific information as guidance. By providing a publicly available fetal brain atlas with segmentation label at the corresponding GA, AtlasSeg effectively extracted the contextual features of age-specific patterns in atlas branch and generated tissue segmentation in segmentation branch. Multi-scale attentive atlas feature fusions were constructed in all stages during encoding and decoding, giving rise to a dual-U-shape network to assist feature flow and information interactions between two branches. AtlasSeg outperformed six well-known segmentation networks in both our internal fetal brain MRI dataset and the external FeTA dataset. Ablation experiments demonstrate the efficiency of atlas guidance and the attention mechanism. The proposed AtlasSeg demonstrated superior segmentation performance against other convolution networks with higher segmentation accuracy, and may facilitate fetal brain MRI analysis in large-scale fetal brain studies.

Reducing global poverty is a key objective of the Sustainable Development Goals (SDGs). Achieving this requires high-frequency, granular data to capture neighborhood-level changes, particularly in data scarce regions such as low- and middle-income countries. To fill in the data gaps, recent computer vision methods combining machine learning (ML) with earth observation (EO) data to improve poverty estimation. However, while much progress have been made, they often omit intra-annual variations, which are crucial for estimating poverty in agriculturally dependent countries. We explored the impact of integrating intra-annual NDVI information with annual multi-spectral data on model accuracy. To evaluate our method, we created a simulated dataset using Landsat imagery and nighttime light data to evaluate EO-ML methods that use intra-annual EO data. Additionally, we evaluated our method against the Demographic and Health Survey (DHS) dataset across Africa. Our results indicate that integrating specific NDVI-derived features with multi-spectral data provides valuable insights for poverty analysis, emphasizing the importance of retaining intra-annual information.

Large Language Models (LLMs) have achieved remarkable success in serving end-users with human-like intelligence. However, LLMs demand high computational resources, making it challenging to deploy them to satisfy various performance objectives, such as meeting the resource constraints on edge devices close to end-users or achieving high accuracy with ample resources. In this paper, we introduce CE-CoLLM, a novel cloud-edge collaboration framework that supports efficient and adaptive LLM inference for end-users at the edge with two modes, (1) low-latency edge standalone inference and (2) highly accurate cloud-edge collaborative inference. First, we show that the inherent high communication costs for transmitting LLM contextual information between the edge and cloud dominate the overall latency, making it inefficient and costly to deploy LLMs using cloud-edge collaboration. Second, we propose several critical techniques to address this challenge, including early-exit mechanism, cloud context manager, and quantization in cloud-edge collaboration to enable not only low-latency standalone edge inference but also efficient and adaptive cloud-edge collaborative inference for LLMs. Third, we perform comprehensive experimental analysis, which demonstrates that CE-CoLLM significantly reduces inference time by up to 13.81% and cloud computation costs by up to 84.55% compared to the popular cloud-based LLM deployment, while maintaining comparable model accuracy. The proposed approach effectively shifts the computational load to the edge, reduces the communication overhead, scales efficiently with multiple edge clients, and provides reliable LLM deployment using cloud-edge collaboration.

We demonstrate the efficacy of using intermediate representations from a single foundation model to enhance various music downstream tasks. We introduce SoniDo, a music foundation model (MFM) designed to extract hierarchical features from target music samples. By leveraging hierarchical intermediate features, SoniDo constrains the information granularity, leading to improved performance across various downstream tasks including both understanding and generative tasks. We specifically evaluated this approach on representative tasks such as music tagging, music transcription, music source separation, and music mixing. Our results reveal that the features extracted from foundation models provide valuable enhancements in training downstream task models. This highlights the capability of using features extracted from music foundation models as a booster for downstream tasks. Our approach not only benefits existing task-specific models but also supports music downstream tasks constrained by data scarcity. This paves the way for more effective and accessible music processing solutions. Figure 1: SoniDo extracts hierarchical features of target music samples, which are useful for solving music downstream tasks including understanding and generative tasks.

Large Language Models (LLMs) have revolutionized software engineering (SE), showcasing remarkable proficiency in various coding tasks. Despite recent advancements that have enabled the creation of autonomous software agents utilizing LLMs for end-to-end development tasks, these systems are typically designed for specific SE functions. We introduce HyperAgent, an innovative generalist multi-agent system designed to tackle a wide range of SE tasks across different programming languages by mimicking the workflows of human developers. HyperAgent features four specialized agents-Planner, Navigator, Code Editor, and Executor-capable of handling the entire lifecycle of SE tasks, from initial planning to final verification. HyperAgent sets new benchmarks in diverse SE tasks, including GitHub issue resolution on the renowned SWE-Bench benchmark, outperforming robust baselines. Furthermore, HyperAgent demonstrates exceptional performance in repository-level code generation (RepoExec) and fault localization and program repair (Defects4J), often surpassing state-of-the-art baselines.

The wreck was like a bug on the wall, a jumbly shape splayed on the abyssal plain. It was noticed by a team of autonomous-underwater-vehicle operators on board a subsea exploration vessel, working at an undisclosed location in the Atlantic Ocean, about a thousand miles from the nearest shore. The analysts belonged to a small private company that specializes in deep-sea search operations; I have been asked not to name it. They were looking for something else. In the past decade, the company has helped to transform the exploration of the seabed by deploying fleets of A.U.V.s--underwater drones--which cruise in formation, mapping large areas of the ocean floor with high-definition imagery.