Our aim in this paper is to outline how the design space for the ontologization process is richer than current practice would suggest. We point out that engineering processes as well as products need to be designed - and identify some components of the design. We investigate the possibility of designing a range of radically new practices, providing examples of the new practices from our work over the last three decades with an outlier methodology, bCLEARer. We also suggest that setting an evolutionary context for ontologization helps one to better understand the nature of these new practices and provides the conceptual scaffolding that shapes fertile processes. Where this evolutionary perspective positions digitalization (the evolutionary emergence of computing technologies) as the latest step in a long evolutionary trail of information transitions. This reframes ontologization as a strategic tool for leveraging the emerging opportunities offered by digitalization.

Parkinson's disease (PD) is a neurological disorder requiring early and accurate diagnosis for effective management. Machine learning (ML) has emerged as a powerful tool to enhance PD classification and diagnostic accuracy, particularly by leveraging wearable sensor data. This survey comprehensively reviews current ML methodologies used in classifying Parkinsonian tremors, evaluating various tremor data acquisition methodologies, signal preprocessing techniques, and feature selection methods across time and frequency domains, highlighting practical approaches for tremor classification. The survey explores ML models utilized in existing studies, ranging from traditional methods such as Support Vector Machines (SVM) and Random Forests to advanced deep learning architectures like Convolutional Neural Networks (CNN) and Long Short-Term Memory networks (LSTM). We assess the efficacy of these models in classifying tremor patterns associated with PD, considering their strengths and limitations. Furthermore, we discuss challenges and discrepancies in current research and broader challenges in applying ML to PD diagnosis using wearable sensor data. We also outline future research directions to advance ML applications in PD diagnostics, providing insights for researchers and practitioners.

We introduce MedXpertQA, a highly challenging and comprehensive benchmark to evaluate expert-level medical knowledge and advanced reasoning. MedXpertQA includes 4,460 questions spanning 17 specialties and 11 body systems. It includes two subsets, Text for text evaluation and MM for multimodal evaluation. Notably, MM introduces expert-level exam questions with diverse images and rich clinical information, including patient records and examination results, setting it apart from traditional medical multimodal benchmarks with simple QA pairs generated from image captions. MedXpertQA applies rigorous filtering and augmentation to address the insufficient difficulty of existing benchmarks like MedQA, and incorporates specialty board questions to improve clinical relevance and comprehensiveness. We perform data synthesis to mitigate data leakage risk and conduct multiple rounds of expert reviews to ensure accuracy and reliability. We evaluate 16 leading models on MedXpertQA. Moreover, medicine is deeply connected to real-world decision-making, providing a rich and representative setting for assessing reasoning abilities beyond mathematics and code. To this end, we develop a reasoning-oriented subset to facilitate the assessment of o1-like models.

Large Language Models (LLMs) demand significant computational resources, making it essential to enhance their capabilities without retraining from scratch. A key challenge in this domain is \textit{catastrophic forgetting} (CF), which hampers performance during Continuous Pre-training (CPT) and Continuous Supervised Fine-Tuning (CSFT). We propose \textbf{Control LLM}, a novel approach that leverages parallel pre-trained and expanded transformer blocks, aligning their hidden-states through interpolation strategies This method effectively preserves performance on existing tasks while seamlessly integrating new knowledge. Extensive experiments demonstrate the effectiveness of Control LLM in both CPT and CSFT. On Llama3.1-8B-Instruct, it achieves significant improvements in mathematical reasoning ($+14.4\%$ on Math-Hard) and coding performance ($+10\%$ on MBPP-PLUS). On Llama3.1-8B, it enhances multilingual capabilities ($+10.6\%$ on C-Eval, $+6.8\%$ on CMMLU, and $+30.2\%$ on CMMLU-0shot-CoT). It surpasses existing methods and achieves SOTA among open-source models tuned from the same base model, using substantially less data and compute. Crucially, these gains are realized while preserving strong original capabilities, with minimal degradation ($<4.3\% \text{on MMLU}$) compared to $>35\%$ in open-source Math and Coding models. This approach has been successfully deployed in LinkedIn's GenAI-powered job seeker and Ads unit products. To support further research, we release the training and evaluation code (https://github.com/linkedin/ControlLLM) along with models trained on public datasets (https://huggingface.co/ControlLLM) to the community.

I am honoured to present the International AI Safety Report. It is the work of 96 international AI experts who collaborated in an unprecedented effort to establish an internationally shared scientific understanding of risks from advanced AI and methods for managing them. We embarked on this journey just over a year ago, shortly after the countries present at the Bletchley Park AI Safety Summit agreed to support the creation of this report. Since then, we published an Interim Report in May 2024, which was presented at the AI Seoul Summit. We are now pleased to publish the present, full report ahead of the AI Action Summit in Paris in February 2025. Since the Bletchley Summit, the capabilities of general-purpose AI, the type of AI this report focuses on, have increased further. For example, new models have shown markedly better performance at tests of Professor Yoshua Bengio programming and scientific reasoning.

Freezing of gait (FOG) is a debilitating feature of Parkinson's disease (PD), which is a cause of injurious falls among PD patients. Recent advances in wearable-based human activity recognition (HAR) technology have enabled the detection of FOG subtypes across benchmark datasets. Since FOG manifestation is heterogeneous, developing models that quantify FOG consistently across patients with varying demographics, FOG types, and PD conditions is important. Bias and fairness in FOG models remain understudied in HAR, with research focused mainly on FOG detection using single benchmark datasets. We evaluated the bias and fairness of HAR models for wearable-based FOG detection across demographics and PD conditions using multiple datasets and the effectiveness of transfer learning as a potential bias mitigation approach. Our evaluation using demographic parity ratio (DPR) and equalized odds ratio (EOR) showed model bias (DPR & EOR < 0.8) for all stratified demographic variables, including age, sex, and disease duration. Our experiments demonstrated that transfer learning from multi-site datasets and generic human activity representations significantly improved fairness (average change in DPR +0.027, +0.039, respectively) and performance (average change in F1-score +0.026, +0.018, respectively) across attributes, supporting the hypothesis that generic human activity representations learn fairer representations applicable to health analytics.

The constant engagement with extensive written materials is fundamental and immensely time-consuming [104]. Legal professionals often spend hours, if not days, combing through documents to find precedents or relevant cases that could be pivotal to their current cases. This laborious process is a significant part of the workload of legal professionals like lawyers and judges, taking up lots of time that could be invested otherwise. Automatic summarization tools could help to condense lengthy legal documents into concise summaries, helping to save both time and costs. Moreover, integrating advanced Natural Language Processing (NLP) techniques into legal research holds significant promise for democratizing access to legal information. Figure 1 shows the general pipeline for legal summarization. Compared to other domains, legal texts present unique challenges that distinguish them from other document types. Legal documents tend to be longer and more detailed than those from other domains.

The search for symbolic regression models with genetic programming (GP) has a tendency of revisiting expressions in their original or equivalent forms. Repeatedly evaluating equivalent expressions is inefficient, as it does not immediately lead to better solutions. However, evolutionary algorithms require diversity and should allow the accumulation of inactive building blocks that can play an important role at a later point. The equality graph is a data structure capable of compactly storing expressions and their equivalent forms allowing an efficient verification of whether an expression has been visited in any of their stored equivalent forms. We exploit the e-graph to adapt the subtree operators to reduce the chances of revisiting expressions. Our adaptation, called eggp, stores every visited expression in the e-graph, allowing us to filter out from the available selection of subtrees all the combinations that would create already visited expressions. Results show that, for small expressions, this approach improves the performance of a simple GP algorithm to compete with PySR and Operon without increasing computational cost. As a highlight, eggp was capable of reliably delivering short and at the same time accurate models for a selected set of benchmarks from SRBench and a set of real-world datasets.

Recent advances in healthcare technologies have led to the availability of large amounts of biological samples across several techniques and applications. In particular, in the last few years, Raman spectroscopy analysis of biological samples has been successfully applied for early-stage diagnosis. However, spectra' inherent complexity and variability make the manual analysis challenging, even for domain experts. For the same reason, the use of traditional Statistical and Machine Learning (ML) techniques could not guarantee for accurate and reliable results. ML models, combined with robust optimization techniques, offer the possibility to improve the classification accuracy and enhance the resilience of predictive models. In this paper, we investigate the performance of a novel robust formulation for Support Vector Machine (SVM) in classifying COVID-19 samples obtained from Raman Spectroscopy. Given the noisy and perturbed nature of biological samples, we protect the classification process against uncertainty through the application of robust optimization techniques. Specifically, we derive robust counterpart models of deterministic formulations using bounded-by-norm uncertainty sets around each observation. We explore the cases of both linear and kernel-induced classifiers to address binary and multiclass classification tasks. The effectiveness of our approach is validated on real-world COVID-19 datasets provided by Italian hospitals by comparing the results of our simulations with a state-of-the-art classifier.

Sparse autoencoders (SAEs) are an increasingly popular technique for interpreting the internal representations of transformers. In this paper, we apply SAEs to 'interpret' random transformers, i.e., transformers where the parameters are sampled IID from a Gaussian rather than trained on text data. We find that random and trained transformers produce similarly interpretable SAE latents, and we confirm this finding quantitatively using an open-source auto-interpretability pipeline. Further, we find that SAE quality metrics are broadly similar for random and trained transformers. We find that these results hold across model sizes and layers. We discuss a number of number interesting questions that this work raises for the use of SAEs and auto-interpretability in the context of mechanistic interpretability.