Drug-Drug Interactions (DDIs) may hamper the functionalities of drugs, and in the worst scenario, they may lead to adverse drug reactions (ADRs). Predicting all DDIs is a challenging and critical problem. Most existing computational models integrate drug-centric information from different sources and leverage them as features in machine learning classifiers to predict DDIs. However, these models have a high chance of failure, especially for the new drugs when all the information is not available. This paper proposes a novel Hypergraph Neural Network (HyGNN) model based on only the SMILES string of drugs, available for any drug, for the DDI prediction problem. To capture the drug similarities, we create a hypergraph from drugs' chemical substructures extracted from the SMILES strings. Then, we develop HyGNN consisting of a novel attention-based hypergraph edge encoder to get the representation of drugs as hyperedges and a decoder to predict the interactions between drug pairs. Furthermore, we conduct extensive experiments to evaluate our model and compare it with several state-of-the-art methods. Experimental results demonstrate that our proposed HyGNN model effectively predicts DDIs and impressively outperforms the baselines with a maximum ROC-AUC and PR-AUC of 97.9% and 98.1%, respectively.

Modern data science applications often involve complex relational data with dynamic structures. An abrupt change in such dynamic relational data is typically observed in systems that undergo regime changes due to interventions. In such a case, we consider a factorized fusion shrinkage model in which all decomposed factors are dynamically shrunk towards group-wise fusion structures, where the shrinkage is obtained by applying global-local shrinkage priors to the successive differences of the row vectors of the factorized matrices. The proposed priors enjoy many favorable properties in comparison and clustering of the estimated dynamic latent factors. Comparing estimated latent factors involves both adjacent and long-term comparisons, with the time range of comparison considered as a variable. Under certain conditions, we demonstrate that the posterior distribution attains the minimax optimal rate up to logarithmic factors. In terms of computation, we present a structured mean-field variational inference framework that balances optimal posterior inference with computational scalability, exploiting both the dependence among components and across time. The framework can accommodate a wide variety of models, including dynamic matrix factorization, latent space models for networks and low-rank tensors. The effectiveness of our methodology is demonstrated through extensive simulations and real-world data analysis.

In this paper, we fill in an existing gap in resources available to the Hebrew NLP community by providing it with the largest so far pre-train dataset HeDC4, a state-of-the-art pre-trained language model HeRo for standard length inputs and an efficient transformer LongHeRo for long input sequences. The HeRo model was evaluated on the sentiment analysis, the named entity recognition, and the question answering tasks while the LongHeRo model was evaluated on the document classification task with a dataset composed of long documents. Both HeRo and LongHeRo presented state-of-the-art performance. The dataset and model checkpoints used in this work are publicly available.

AI in Manufacturing to surpass USD 42.5 billion by 2031 from USD 1.7 billion in 2021 at a CAGR of 37.6% in the coming years, i.e., 2021-31. Artificial Intelligence technology is widely being adopted in manufacturing industries to analyze complex sets of data, changes in consumer behavior, and demand for detecting anomalies and improving supply chains and distribution networks. Further, AI can improve decision making by using advanced software to gain more insights and visibility in the operation process, which is driving the market growth of AI in Manufacturing. Based on Offering, the AI in Manufacturing Market is divided into Hardware, Software, and Services, of which the Software segment is expected to lead. Specific programs can be run by software alone without the need for additional hardware.

Access to highly detailed models of heterogeneous forests from the near surface to above the tree canopy at varying scales is of increasing demand as it enables more advanced computational tools for analysis, planning, and ecosystem management. LiDAR sensors available through different scanning platforms including terrestrial, mobile and aerial have become established as one of the primary technologies for forest mapping due to their inherited capability to collect direct, precise and rapid 3D information of a scene. However, their scalability to large forest areas is highly dependent upon use of effective and efficient methods of co-registration of multiple scan sources. Surprisingly, work in forestry in GPS denied areas has mostly resorted to methods of co-registration that use reference based targets (e.g., reflective, marked trees), a process far from scalable in practice. In this work, we propose an effective, targetless and fully automatic method based on an incremental co-registration strategy matching and grouping points according to levels of structural complexity. Empirical evidence shows the method's effectiveness in aligning both TLS-to-TLS and TLS-to-ALS scans under a variety of ecosystem conditions including pre/post fire treatment effects, of interest to forest inventory surveyors.

Federated learning allows for the training of machine learning models on multiple decentralized local datasets without requiring explicit data exchange. However, data pre-processing, including strategies for handling missing data, remains a major bottleneck in real-world federated learning deployment, and is typically performed locally. This approach may be biased, since the subpopulations locally observed at each center may not be representative of the overall one. To address this issue, this paper first proposes a more consistent approach to data standardization through a federated model. Additionally, we propose Fed-MIWAE, a federated version of the state-of-the-art imputation method MIWAE, a deep latent variable model for missing data imputation based on variational autoencoders. MIWAE has the great advantage of being easily trainable with classical federated aggregators. Furthermore, it is able to deal with MAR (Missing At Random) data, a more challenging missing-data mechanism than MCAR (Missing Completely At Random), where the missingness of a variable can depend on the observed ones. We evaluate our method on multi-modal medical imaging data and clinical scores from a simulated federated scenario with the ADNI dataset. We compare Fed-MIWAE with respect to classical imputation methods, either performed locally or in a centralized fashion. Fed-MIWAE allows to achieve imputation accuracy comparable with the best centralized method, even when local data distributions are highly heterogeneous. In addition, thanks to the variational nature of Fed-MIWAE, our method is designed to perform multiple imputation, allowing for the quantification of the imputation uncertainty in the federated scenario.

Fine-tuning language models on tasks with instructions has demonstrated potential in facilitating zero-shot generalization to unseen tasks. In this paper, we introduce a straightforward yet effective method for enhancing instruction tuning by employing symbolic tasks. Compared to crowdsourced human tasks or modelgenerated tasks, symbolic tasks present a unique advantage as they can be easily generated in vast quantities, theoretically providing an infinite supply of highquality training instances. To explore the potential of symbolic tasks, we carry out an extensive case study on the representative symbolic task of SQL execution. Empirical results on various benchmarks validate that the integration of SQL execution leads to significant improvements in zero-shot scenarios, particularly in table reasoning. Furthermore, experimental results on BBH (27 tasks) and MMLU (57 tasks) reveal that language models can be enhanced through symbolic tasks without compromising their generality. We hope that our paper serves as a catalyst, inspiring increased efforts to incorporate symbolic tasks in instruction tuning. In recent years, the development of large language models (LM) has been one of the most significant advances in natural language processing (NLP) (Devlin et al., 2019; Raffel et al., 2020; Brown et al., 2020).

With the surging inclination towards carrying out tasks on computational devices and digital mediums, any method that converts a task that was previously carried out manually, to a digitized version, is always welcome. Irrespective of the various documentation tasks that can be done online today, there are still many applications and domains where handwritten text is inevitable, which makes the digitization of handwritten documents a very essential task. Over the past decades, there has been extensive research on offline handwritten text recognition. In the recent past, most of these attempts have shifted to Machine learning and Deep learning based approaches. In order to design more complex and deeper networks, and ensure stellar performances, it is essential to have larger quantities of annotated data. Most of the databases present for offline handwritten text recognition today, have either been manually annotated or semi automatically annotated with a lot of manual involvement. These processes are very time consuming and prone to human errors. To tackle this problem, we present an innovative, complete end-to-end pipeline, that annotates offline handwritten manuscripts written in both print and cursive English, using Deep Learning and User Interaction techniques. This novel method, which involves an architectural combination of a detection system built upon a state-of-the-art text detection model, and a custom made Deep Learning model for the recognition system, is combined with an easy-to-use interactive interface, aiming to improve the accuracy of the detection, segmentation, serialization and recognition phases, in order to ensure high quality annotated data with minimal human interaction.

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer's disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image classification. However, it often leads to negative transfer due to the discrepancy between the non-medical source and target medical domains. To address this, we present evidence-empowered transfer learning for AD diagnosis. Unlike conventional approaches, we leverage an AD-relevant auxiliary task, namely morphological change prediction, without requiring additional MRI data. In this auxiliary task, the diagnosis model learns the evidential and transferable knowledge from morphological features in MRI scans. Experimental results demonstrate that our framework is not only effective in improving detection performance regardless of model capacity, but also more data-efficient and faithful.

In active source seeking, a robot takes repeated measurements in order to locate a signal source in a cluttered and unknown environment. A key component of an active source seeking robot planner is a model that can produce estimates of the signal at unknown locations with uncertainty quantification. This model allows the robot to plan for future measurements in the environment. Traditionally, this model has been in the form of a Gaussian process, which has difficulty scaling and cannot represent obstacles. %In this work, We propose a global and local factor graph model for active source seeking, which allows the model to scale to a large number of measurements and represent unknown obstacles in the environment. We combine this model with extensions to a highly scalable planner to form a system for large-scale active source seeking. We demonstrate that our approach outperforms baseline methods in both simulated and real robot experiments.