Data sharing is crucial for open science and reproducible research, but the legal sharing of clinical data requires the removal of protected health information from electronic health records. This process, known as de-identification, is often achieved through the use of machine learning algorithms by many commercial and open-source systems. While these systems have shown compelling results on average, the variation in their performance across different demographic groups has not been thoroughly examined. In this work, we investigate the bias of de-identification systems on names in clinical notes via a large-scale empirical analysis. To achieve this, we create 16 name sets that vary along four demographic dimensions: gender, race, name popularity, and the decade of popularity. We insert these names into 100 manually curated clinical templates and evaluate the performance of nine public and private de-identification methods. Our findings reveal that there are statistically significant performance gaps along a majority of the demographic dimensions in most methods. We further illustrate that de-identification quality is affected by polysemy in names, gender context, and clinical note characteristics. To mitigate the identified gaps, we propose a simple and method-agnostic solution by fine-tuning de-identification methods with clinical context and diverse names. Overall, it is imperative to address the bias in existing methods immediately so that downstream stakeholders can build high-quality systems to serve all demographic parties fairly.

Manual delineation of tumor regions from magnetic resonance (MR) images is time-consuming, requires an expert, and is prone to human error. In recent years, deep learning models have been the go-to approach for the segmentation of brain tumors. U-Net and its' variants for semantic segmentation of medical images have achieved good results in the literature. However, U-Net and its' variants tend to over-segment tumor regions and may not accurately segment the tumor edges. The edges of the tumor are as important as the tumor regions for accurate diagnosis, surgical precision, and treatment planning. In the proposed work, the authors aim to extract edges from the ground truth using a derivative-like filter followed by edge reconstruction to obtain an edge ground truth in addition to the brain tumor ground truth. Utilizing both ground truths, the author studies several U-Net and its' variant architectures with and without tumor edges ground truth as a target along with the tumor ground truth for brain tumor segmentation. The author used the BraTS2020 benchmark dataset to perform the study and the results are tabulated for the dice and Hausdorff95 metrics. The mean and median metrics are calculated for the whole tumor (WT), tumor core (TC), and enhancing tumor (ET) regions. Compared to the baseline U-Net and its variants, the models that learned edges along with the tumor regions performed well in core tumor regions in both training and validation datasets. The improved performance of edge-trained models trained on baseline models like U-Net and V-Net achieved performance similar to baseline state-of-the-art models like Swin U-Net and hybrid MR-U-Net. The edge-target trained models are capable of generating edge maps that can be useful for treatment planning. Additionally, for further explainability of the results, the activation map generated by the hybrid MR-U-Net has been studied.

Large language models (LLMs) have the potential to transform the practice of law, but this potential is threatened by the presence of legal hallucinations -- responses from these models that are not consistent with legal facts. We investigate the extent of these hallucinations using an original suite of legal queries, comparing LLMs' responses to structured legal metadata and examining their consistency. Our work makes four key contributions: (1) We develop a typology of legal hallucinations, providing a conceptual framework for future research in this area. (2) We find that legal hallucinations are alarmingly prevalent, occurring between 69% of the time with ChatGPT 3.5 and 88% with Llama 2, when these models are asked specific, verifiable questions about random federal court cases. (3) We illustrate that LLMs often fail to correct a user's incorrect legal assumptions in a contra-factual question setup. (4) We provide evidence that LLMs cannot always predict, or do not always know, when they are producing legal hallucinations. Taken together, these findings caution against the rapid and unsupervised integration of popular LLMs into legal tasks. Even experienced lawyers must remain wary of legal hallucinations, and the risks are highest for those who stand to benefit from LLMs the most -- pro se litigants or those without access to traditional legal resources.

The recent innovations and breakthroughs in diffusion models have significantly expanded the possibilities of generating high-quality videos for the given prompts. Most existing works tackle the single-scene scenario with only one video event occurring in a single background. Extending to generate multi-scene videos nevertheless is not trivial and necessitates to nicely manage the logic in between while preserving the consistent visual appearance of key content across video scenes. In this paper, we propose a novel framework, namely VideoDrafter, for content-consistent multi-scene video generation. Technically, VideoDrafter leverages Large Language Models (LLM) to convert the input prompt into comprehensive multi-scene script that benefits from the logical knowledge learnt by LLM. The script for each scene includes a prompt describing the event, the foreground/background entities, as well as camera movement. VideoDrafter identifies the common entities throughout the script and asks LLM to detail each entity. The resultant entity description is then fed into a text-to-image model to generate a reference image for each entity. Finally, VideoDrafter outputs a multi-scene video by generating each scene video via a diffusion process that takes the reference images, the descriptive prompt of the event and camera movement into account. The diffusion model incorporates the reference images as the condition and alignment to strengthen the content consistency of multi-scene videos. Extensive experiments demonstrate that VideoDrafter outperforms the SOTA video generation models in terms of visual quality, content consistency, and user preference.

Skin lesions are classified in benign or malignant. Among the malignant, melanoma is a very aggressive cancer and the major cause of deaths. So, early diagnosis of skin cancer is very desired. In the last few years, there is a growing interest in computer aided diagnostic (CAD) using most image and clinical data of the lesion. These sources of information present limitations due to their inability to provide information of the molecular structure of the lesion. NIR spectroscopy may provide an alternative source of information to automated CAD of skin lesions. The most commonly used techniques and classification algorithms used in spectroscopy are Principal Component Analysis (PCA), Partial Least Squares - Discriminant Analysis (PLS-DA), and Support Vector Machines (SVM). Nonetheless, there is a growing interest in applying the modern techniques of machine and deep learning (MDL) to spectroscopy. One of the main limitations to apply MDL to spectroscopy is the lack of public datasets. Since there is no public dataset of NIR spectral data to skin lesions, as far as we know, an effort has been made and a new dataset named NIR-SC-UFES, has been collected, annotated and analyzed generating the gold-standard for classification of NIR spectral data to skin cancer. Next, the machine learning algorithms XGBoost, CatBoost, LightGBM, 1D-convolutional neural network (1D-CNN) were investigated to classify cancer and non-cancer skin lesions. Experimental results indicate the best performance obtained by LightGBM with pre-processing using standard normal variate (SNV), feature extraction providing values of 0.839 for balanced accuracy, 0.851 for recall, 0.852 for precision, and 0.850 for F-score. The obtained results indicate the first steps in CAD of skin lesions aiming the automated triage of patients with skin lesions in vivo using NIR spectral data.

Misinformation poses a variety of risks, such as undermining public trust and distorting factual discourse. Large Language Models (LLMs) like GPT-4 have been shown effective in mitigating misinformation, particularly in handling statements where enough context is provided. However, they struggle to assess ambiguous or context-deficient statements accurately. This work introduces a new method to resolve uncertainty in such statements. We propose a framework to categorize missing information and publish category labels for the LIAR-New dataset, which is adaptable to cross-domain content with missing information. We then leverage this framework to generate effective user queries for missing context. Compared to baselines, our method improves the rate at which generated questions are answerable by the user by 38 percentage points and classification performance by over 10 percentage points macro F1. Thus, this approach may provide a valuable component for future misinformation mitigation pipelines.

We describe a new general method for segmentation in MRI scans using Topological Data Analysis (TDA), offering several advantages over traditional machine learning approaches. It works in three steps, first identifying the whole object to segment via automatic thresholding, then detecting a distinctive subset whose topology is known in advance, and finally deducing the various components of the segmentation. Although convoking classical ideas of TDA, such an algorithm has never been proposed separately from deep learning methods. To achieve this, our approach takes into account, in addition to the homology of the image, the localization of representative cycles, a piece of information that seems never to have been exploited in this context. In particular, it offers the ability to perform segmentation without the need for large annotated data sets. TDA also provides a more interpretable and stable framework for segmentation by explicitly mapping topological features to segmentation components. By adapting the geometric object to be detected, the algorithm can be adjusted to a wide range of data segmentation challenges. We carefully study the examples of glioblastoma segmentation in brain MRI, where a sphere is to be detected, as well as myocardium in cardiac MRI, involving a cylinder, and cortical plate detection in fetal brain MRI, whose 2D slices are circles. We compare our method to state-of-the-art algorithms.

Marker code is an effective coding scheme to protect data from insertions and deletions. It has potential applications in future storage systems, such as DNA storage and racetrack memory. When decoding marker codes, perfect channel state information (CSI), i.e., insertion and deletion probabilities, are required to detect insertion and deletion errors. Sometimes, the perfect CSI is not easy to obtain or the accurate channel model is unknown. Therefore, it is deserved to develop detecting algorithms for marker code without the knowledge of perfect CSI. In this paper, we propose two CSI-agnostic detecting algorithms for marker code based on deep learning. The first one is a model-driven deep learning method, which deep unfolds the original iterative detecting algorithm of marker code. In this method, CSI become weights in neural networks and these weights can be learned from training data. The second one is a data-driven method which is an end-to-end system based on the deep bidirectional gated recurrent unit network. Simulation results show that error performances of the proposed methods are significantly better than that of the original detection algorithm with CSI uncertainty. Furthermore, the proposed data-driven method exhibits better error performances than other methods for unknown channel models.

This paper presents the development of a specialized chatbot for materials science, leveraging the Llama-2 language model, and continuing pre-training on the expansive research articles in the materials science domain from the S2ORC dataset. The methodology involves an initial pretraining phase on over one million domain-specific papers, followed by an instruction-tuning process to refine the chatbot's capabilities. The chatbot is designed to assist researchers, educators, and students by providing instant, context-aware responses to queries in the field of materials science.

AI alignment aims to make AI systems behave in line with human intentions and values. As AI systems grow more capable, so do risks from misalignment. To provide a comprehensive and up-to-date overview of the alignment field, in this survey, we delve into the core concepts, methodology, and practice of alignment. First, we identify four principles as the key objectives of AI alignment: Robustness, Interpretability, Controllability, and Ethicality (RICE). Guided by these four principles, we outline the landscape of current alignment research and decompose them into two key components: forward alignment and backward alignment. The former aims to make AI systems aligned via alignment training, while the latter aims to gain evidence about the systems' alignment and govern them appropriately to avoid exacerbating misalignment risks. On forward alignment, we discuss techniques for learning from feedback and learning under distribution shift. On backward alignment, we discuss assurance techniques and governance practices. We also release and continually update the website (www.alignmentsurvey.com) which features tutorials, collections of papers, blog posts, and other resources.