Digital assistants have become ubiquitous in e-commerce applications, following the recent advancements in Information Retrieval (IR), Natural Language Processing (NLP) and Generative Artificial Intelligence (AI). However, customers are often unsure or unaware of how to effectively converse with these assistants to meet their shopping needs. In this work, we emphasize the importance of providing customers a fast, easy to use, and natural way to interact with conversational shopping assistants. We propose a framework that employs Large Language Models (LLMs) to automatically generate contextual, useful, answerable, fluent and diverse questions about products, via in-context learning and supervised fine-tuning. Recommending these questions to customers as helpful suggestions or hints to both start and continue a conversation can result in a smoother and faster shopping experience with reduced conversation overhead and friction. We perform extensive offline evaluations, and discuss in detail about potential customer impact, and the type, length and latency of our generated product questions if incorporated into a real-world shopping assistant.

In the fast-evolving domain of artificial intelligence, large language models (LLMs) such as GPT-3 and GPT-4 are revolutionizing the landscapes of finance, healthcare, and law: domains characterized by their reliance on professional expertise, challenging data acquisition, high-stakes, and stringent regulatory compliance. This survey offers a detailed exploration of the methodologies, applications, challenges, and forward-looking opportunities of LLMs within these high-stakes sectors. We highlight the instrumental role of LLMs in enhancing diagnostic and treatment methodologies in healthcare, innovating financial analytics, and refining legal interpretation and compliance strategies. Moreover, we critically examine the ethics for LLM applications in these fields, pointing out the existing ethical concerns and the need for transparent, fair, and robust AI systems that respect regulatory norms. By presenting a thorough review of current literature and practical applications, we showcase the transformative impact of LLMs, and outline the imperative for interdisciplinary cooperation, methodological advancements, and ethical vigilance. Through this lens, we aim to spark dialogue and inspire future research dedicated to maximizing the benefits of LLMs while mitigating their risks in these precision-dependent sectors. To facilitate future research on LLMs in these critical societal domains, we also initiate a reading list that tracks the latest advancements under this topic, which will be continually updated.

Recent breakthroughs in generative modelling have led to a number of works proposing molecular generation models for drug discovery. While these models perform well at capturing drug-like motifs, they are known to often produce synthetically inaccessible molecules. This is because they are trained to compose atoms or fragments in a way that approximates the training distribution, but they are not explicitly aware of the synthesis constraints that come with making molecules in the lab. To address this issue, we introduce SynFlowNet, a GFlowNet model whose action space uses chemically validated reactions and reactants to sequentially build new molecules. We evaluate our approach using synthetic accessibility scores and an independent retrosynthesis tool. SynFlowNet consistently samples synthetically feasible molecules, while still being able to find diverse and high-utility candidates. Furthermore, we compare molecules designed with SynFlowNet to experimentally validated actives, and find that they show comparable properties of interest, such as molecular weight, SA score and predicted protein binding affinity.

The study of privacy-preserving Natural Language Processing (NLP) has gained rising attention in recent years. One promising avenue studies the integration of Differential Privacy in NLP, which has brought about innovative methods in a variety of application settings. Of particular note are $\textit{word-level Metric Local Differential Privacy (MLDP)}$ mechanisms, which work to obfuscate potentially sensitive input text by performing word-by-word $\textit{perturbations}$. Although these methods have shown promising results in empirical tests, there are two major drawbacks: (1) the inevitable loss of utility due to addition of noise, and (2) the computational expensiveness of running these mechanisms on high-dimensional word embeddings. In this work, we aim to address these challenges by proposing $\texttt{1-Diffractor}$, a new mechanism that boasts high speedups in comparison to previous mechanisms, while still demonstrating strong utility- and privacy-preserving capabilities. We evaluate $\texttt{1-Diffractor}$ for utility on several NLP tasks, for theoretical and task-based privacy, and for efficiency in terms of speed and memory. $\texttt{1-Diffractor}$ shows significant improvements in efficiency, while still maintaining competitive utility and privacy scores across all conducted comparative tests against previous MLDP mechanisms. Our code is made available at: https://github.com/sjmeis/Diffractor.

Machine learning systems require representations of the real world for training and testing - they require data, and lots of it. Collecting data at scale has logistical and ethical challenges, and synthetic data promises a solution to these challenges. Instead of needing to collect photos of real people's faces to train a facial recognition system, a model creator could create and use photo-realistic, synthetic faces. The comparative ease of generating this synthetic data rather than relying on collecting data has made it a common practice. We present two key risks of using synthetic data in model development. First, we detail the high risk of false confidence when using synthetic data to increase dataset diversity and representation. We base this in the examination of a real world use-case of synthetic data, where synthetic datasets were generated for an evaluation of facial recognition technology. Second, we examine how using synthetic data risks circumventing consent for data usage. We illustrate this by considering the importance of consent to the U.S. Federal Trade Commission's regulation of data collection and affected models. Finally, we discuss how these two risks exemplify how synthetic data complicates existing governance and ethical practice; by decoupling data from those it impacts, synthetic data is prone to consolidating power away those most impacted by algorithmically-mediated harm.

We introduce Chronos, a simple yet effective framework for pretrained probabilistic time series models. Chronos tokenizes time series values using scaling and quantization into a fixed vocabulary and trains existing transformer-based language model architectures on these tokenized time series via the cross-entropy loss. We pretrained Chronos models based on the T5 family (ranging from 20M to 710M parameters) on a large collection of publicly available datasets, complemented by a synthetic dataset that we generated via Gaussian processes to improve generalization. In a comprehensive benchmark consisting of 42 datasets, and comprising both classical local models and deep learning methods, we show that Chronos models: (a) significantly outperform other methods on datasets that were part of the training corpus; and (b) have comparable and occasionally superior zero-shot performance on new datasets, relative to methods that were trained specifically on them. Our results demonstrate that Chronos models can leverage time series data from diverse domains to improve zero-shot accuracy on unseen forecasting tasks, positioning pretrained models as a viable tool to greatly simplify forecasting pipelines.

AI Foundation models are gaining traction in various applications, including medical fields like radiology. However, medical foundation models are often tested on limited tasks, leaving their generalisability and biases unexplored. We present RayDINO, a large visual encoder trained by self-supervision on 873k chest X-rays. We compare RayDINO to previous state-of-the-art models across nine radiology tasks, from classification and dense segmentation to text generation, and provide an in depth analysis of population, age and sex biases of our model. Our findings suggest that self-supervision allows patient-centric AI proving useful in clinical workflows and interpreting X-rays holistically. With RayDINO and small task-specific adapters, we reach state-of-the-art results and improve generalization to unseen populations while mitigating bias, illustrating the true promise of foundation models: versatility and robustness.

Image and multimodal machine learning tasks are very challenging to solve in the case of poorly distributed data. In particular, data availability and privacy restrictions exacerbate these hurdles in the medical domain. The state of the art in image generation quality is held by Latent Diffusion models, making them prime candidates for tackling this problem. However, a few key issues still need to be solved, such as the difficulty in generating data from under-represented classes and a slow inference process. To mitigate these issues, we propose a new method for image augmentation in long-tailed data based on leveraging the rich latent space of pre-trained Stable Diffusion Models. We create a modified separable latent space to mix head and tail class examples. We build this space via Iterated Learning of underlying sparsified embeddings, which we apply to task-specific saliency maps via a K-NN approach. Code is available at https://github.com/SugarFreeManatee/Feature-Space-Augmentation-and-Iterated-Learning

An accurate detection and tracking of devices such as guiding catheters in live X-ray image acquisitions is an essential prerequisite for endovascular cardiac interventions. This information is leveraged for procedural guidance, e.g., directing stent placements. To ensure procedural safety and efficacy, there is a need for high robustness no failures during tracking. To achieve that, one needs to efficiently tackle challenges, such as: device obscuration by contrast agent or other external devices or wires, changes in field-of-view or acquisition angle, as well as the continuous movement due to cardiac and respiratory motion. To overcome the aforementioned challenges, we propose a novel approach to learn spatio-temporal features from a very large data cohort of over 16 million interventional X-ray frames using self-supervision for image sequence data. Our approach is based on a masked image modeling technique that leverages frame interpolation based reconstruction to learn fine inter-frame temporal correspondences. The features encoded in the resulting model are fine-tuned downstream. Our approach achieves state-of-the-art performance and in particular robustness compared to ultra optimized reference solutions (that use multi-stage feature fusion, multi-task and flow regularization). The experiments show that our method achieves 66.31% reduction in maximum tracking error against reference solutions (23.20% when flow regularization is used); achieving a success score of 97.95% at a 3x faster inference speed of 42 frames-per-second (on GPU). The results encourage the use of our approach in various other tasks within interventional image analytics that require effective understanding of spatio-temporal semantics.

This paper explores the use of Hybrid CTC/Attention encoder-decoder models trained with Intermediate CTC (InterCTC) for Irish (Gaelic) low-resource speech recognition (ASR) and dialect identification (DID). Results are compared to the current best performing models trained for ASR (TDNN-HMM) and DID (ECAPA-TDNN). An optimal InterCTC setting is initially established using a Conformer encoder. This setting is then used to train a model with an E-branchformer encoder and the performance of both architectures are compared. A multi-task fine-tuning approach is adopted for language model (LM) shallow fusion. The experiments yielded an improvement in DID accuracy of 10.8% relative to a baseline ECAPA-TDNN, and WER performance approaching the TDNN-HMM model. This multi-task approach emerges as a promising strategy for Irish low-resource ASR and DID.