Mental-illness stigma is a persistent social problem, hampering both treatment-seeking and recovery. Accordingly, there is a pressing need to understand it more clearly, but analyzing the relevant data is highly labor-intensive. Therefore, we designed a chatbot to engage participants in conversations; coded those conversations qualitatively with AI assistance; and, based on those coding results, built causal knowledge graphs to decode stigma. The results we obtained from 1,002 participants demonstrate that conversation with our chatbot can elicit rich information about people's attitudes toward depression, while our AI-assisted coding was strongly consistent with human-expert coding. Our novel approach combining large language models (LLMs) and causal knowledge graphs uncovered patterns in individual responses and illustrated the interrelationships of psychological constructs in the dataset as a whole. The paper also discusses these findings' implications for HCI researchers in developing digital interventions, decomposing human psychological constructs, and fostering inclusive attitudes.

Understanding disease progression at the molecular pathway level usually requires capturing both structural dependencies between pathways and the temporal dynamics of disease evolution. In this work, we solve the former challenge by developing a biologically informed graph-forming method to efficiently construct pathway graphs for subjects from our newly curated JR5558 mouse transcriptomics dataset. We then develop Graph-level Pseudotime Analysis (GPA) to infer graph-level trajectories that reveal how disease progresses at the population level, rather than in individual subjects. Based on the trajectories estimated by GPA, we identify the most sensitive pathways that drive disease stage transitions. In addition, we measure changes in pathway features using neural stochastic differential equations (SDEs), which enables us to formally define and compute pathway stability and disease bifurcation points (points of no return), two fundamental problems in disease progression research. We further extend our theory to the case when pathways can interact with each other, enabling a more comprehensive and multi-faceted characterization of disease phenotypes. The comprehensive experimental results demonstrate the effectiveness of our framework in reconstructing the dynamics of the pathway, identifying critical transitions, and providing novel insights into the mechanistic understanding of disease evolution.

We introduce a model where the rate of an inhomogeneous Poisson process is modified by a Chinese restaurant process. Applying a MCMC sampler to this model allows us to do posterior Bayesian inference about the number of states in Poisson-like data. Our sampler is shown to get accurate results for synthetic data and we apply it to V1 neuron spike data to find discrete firing rate states depending on the orientation of a stimulus.

The flaw in practice is that it can take a large and/or unknown amount of time to converge to the stationary distribution. This paper gives sufficient conditions to guarantee that univariate Gibbs sampling on Markov Random Fields (MRFs) will be fast mixing, in a precise sense. Further, an algorithm is given to project onto this set of fast-mixing parameters in the Euclidean norm. Following recent work, we give an example use of this to project in various divergence measures, comparingunivariatemarginals obtained by sampling after projection to common variational methodsandGibbs sampling on the original parameters.

Deriving from the gradient vector of a generative model of local features, Fisher vector coding (FVC) has been identified as an effective coding method for image classification. Most, if not all, FVC implementations employ the Gaussian mixture model (GMM) to characterize the generation process of local features. This choice has shown to be sufficient for traditional low dimensional local features, e.g., SIFT; and typically, good performance can be achieved with only a few hundred Gaussian distributions. However, the same number of Gaussians is insufficient to model the feature space spanned by higher dimensional local features, which have become popular recently. In order to improve the modeling capacity for high dimensional features, it turns out to be inefficient and computationally impractical to simply increase the number of Gaussians.

A central challenge to many fields of science and engineering involves minimizing non-convex error functions over continuous, high dimensional spaces. Gradient descent or quasi-Newton methods are almost ubiquitously used to perform such minimizations, and it is often thought that a main source of difficulty for these local methods to find the global minimum is the proliferation of local minima with much higher error than the global minimum. Here we argue, based on results from statistical physics, random matrix theory, neural network theory, and empirical evidence, that a deeper and more profound difficulty originates from the proliferation of saddle points, not local minima, especially in high dimensional problems of practical interest. Such saddle points are surrounded by high error plateaus that can dramatically slow down learning, and give the illusory impression of the existence of a local minimum. Motivated by these arguments, we propose a new approach to second-order optimization, the saddle-free Newton method, that can rapidly escape high dimensional saddle points, unlike gradient descent and quasi-Newton methods. We apply this algorithm to deep or recurrent neural network training, and provide numerical evidence for its superior optimization performance.

Stephen Ma has every right to claim bragging rights for helping to hatch the world's most popular online mapping platform. Instead, for the past two decades Ma, one of the four co-founders of Google Maps, has buried himself in a big black hole of anonymity. But not because of any shame or regret – it's just that he isn't one to blow his own trumpet. "I tend to be a very private person," Ma says in a rare interview. "I find the limelight uncomfortable."

Bennett's tree kangaroos, one of Australia's most mysterious marsupials, have long eluded researchers. Our new study, published in Australian Mammalogy today, has achieved a breakthrough: using thermal drones to detect these rare animals with unprecedented efficiency. Tree kangaroos are found only in the tropical rainforests of Australia and New Guinea. Unlike their ground-dwelling relatives, they spend their lives in treetops, feeding on leaves and vines. Their dependence on rainforest trees makes them vulnerable to deforestation and climate change.

Accurate greenhouse gas (GHG) emission reporting is critical for governments, businesses, and investors. However, adoption remains limited particularly among small and medium enterprises due to high implementation costs, fragmented emission factor databases, and a lack of robust sector classification methods. To address these challenges, we introduce Group Reasoning Emission Estimation Networks (GREEN), an AI-driven carbon accounting framework that standardizes enterprise-level emission estimation, constructs a large-scale benchmark dataset, and leverages a novel reasoning approach with large language models (LLMs). Specifically, we compile textual descriptions for 20,850 companies with validated North American Industry Classification System (NAICS) labels and align these with an economic model of carbon intensity factors. By reframing sector classification as an information retrieval task, we fine-tune Sentence-BERT models using a contrastive learning loss. To overcome the limitations of single-stage models in handling thousands of hierarchical categories, we propose a Group Reasoning method that ensembles LLM classifiers based on the natural NAICS ontology, decomposing the task into multiple sub-classification steps. We theoretically prove that this approach reduces classification uncertainty and computational complexity. Experiments on 1,114 NAICS categories yield state-of-the-art performance (83.68% Top-1, 91.47% Top-10 accuracy), and case studies on 20 companies report a mean absolute percentage error (MAPE) of 45.88%. The project is available at: https://huggingface.co/datasets/Yvnminc/ExioNAICS.

Retrieval-Augmented Generation (RAG) is an advanced technique designed to address the challenges of Artificial Intelligence-Generated Content (AIGC). By integrating context retrieval into content generation, RAG provides reliable and up-to-date external knowledge, reduces hallucinations, and ensures relevant context across a wide range of tasks. However, despite RAG's success and potential, recent studies have shown that the RAG paradigm also introduces new risks, including robustness issues, privacy concerns, adversarial attacks, and accountability issues. Addressing these risks is critical for future applications of RAG systems, as they directly impact their trustworthiness. Although various methods have been developed to improve the trustworthiness of RAG methods, there is a lack of a unified perspective and framework for research in this topic. Thus, in this paper, we aim to address this gap by providing a comprehensive roadmap for developing trustworthy RAG systems. We place our discussion around five key perspectives: reliability, privacy, safety, fairness, explainability, and accountability. For each perspective, we present a general framework and taxonomy, offering a structured approach to understanding the current challenges, evaluating existing solutions, and identifying promising future research directions. To encourage broader adoption and innovation, we also highlight the downstream applications where trustworthy RAG systems have a significant impact.