Oceania
Symbolic Neural Generation with Applications to Lead Discovery in Drug Design
Srinivasan, Ashwin, Baskar, A, Dash, Tirtharaj, Bain, Michael, Dey, Sanjay Kumar, Banerjee, Mainak
We investigate a relatively underexplored class of hybrid neurosymbolic models integrating symbolic learning with neural reasoning to construct data generators meeting formal correctness criteria. In \textit{Symbolic Neural Generators} (SNGs), symbolic learners examine logical specifications of feasible data from a small set of instances -- sometimes just one. Each specification in turn constrains the conditional information supplied to a neural-based generator, which rejects any instance violating the symbolic specification. Like other neurosymbolic approaches, SNG exploits the complementary strengths of symbolic and neural methods. The outcome of an SNG is a triple $(H, X, W)$, where $H$ is a symbolic description of feasible instances constructed from data, $X$ a set of generated new instances that satisfy the description, and $W$ an associated weight. We introduce a semantics for such systems, based on the construction of appropriate \textit{base} and \textit{fibre} partially-ordered sets combined into an overall partial order, and outline a probabilistic extension relevant to practical applications. In this extension, SNGs result from searching over a weighted partial ordering. We implement an SNG combining a restricted form of Inductive Logic Programming (ILP) with a large language model (LLM) and evaluate it on early-stage drug design. Our main interest is the description and the set of potential inhibitor molecules generated by the SNG. On benchmark problems -- where drug targets are well understood -- SNG performance is statistically comparable to state-of-the-art methods. On exploratory problems with poorly understood targets, generated molecules exhibit binding affinities on par with leading clinical candidates. Experts further find the symbolic specifications useful as preliminary filters, with several generated molecules identified as viable for synthesis and wet-lab testing.
Treble10: A high-quality dataset for far-field speech recognition, dereverberation, and enhancement
Mullins, Sarabeth S., Gรถtz, Georg, Bezzam, Eric, Zheng, Steven, Nielsen, Daniel Gert
Accurate far-field speech datasets are critical for tasks such as automatic speech recognition (ASR), dereverberation, speech enhancement, and source separation. However, current datasets are limited by the trade-off between acoustic realism and scalability. Measured corpora provide faithful physics but are expensive, low-coverage, and rarely include paired clean and reverberant data. In contrast, most simulation-based datasets rely on simplified geometrical acoustics, thus failing to reproduce key physical phenomena like diffraction, scattering, and interference that govern sound propagation in complex environments. We introduce Treble10, a large-scale, physically accurate room-acoustic dataset. Treble10 contains over 3000 broadband room impulse responses (RIRs) simulated in 10 fully furnished real-world rooms, using a hybrid simulation paradigm implemented in the Treble SDK that combines a wave-based and geometrical acoustics solver. The dataset provides six complementary subsets, spanning mono, 8th-order Ambisonics, and 6-channel device RIRs, as well as pre-convolved reverberant speech scenes paired with LibriSpeech utterances. All signals are simulated at 32 kHz, accurately modelling low-frequency wave effects and high-frequency reflections. Treble10 bridges the realism gap between measurement and simulation, enabling reproducible, physically grounded evaluation and large-scale data augmentation for far-field speech tasks. The dataset is openly available via the Hugging Face Hub, and is intended as both a benchmark and a template for next-generation simulation-driven audio research.
LangLingual: A Personalised, Exercise-oriented English Language Learning Tool Leveraging Large Language Models
Gupta, Sammriddh, Singh, Sonit, Joshi, Aditya, Kim, Mira
Language educators strive to create a rich experience for learners, while they may be restricted in the extend of feedback and practice they can provide. We present the design and development of LangLingual, a conversational agent built using the LangChain framework and powered by Large Language Models. The system is specifically designed to provide real-time, grammar-focused feedback, generate context-aware language exercises and track learner proficiency over time. The paper discusses the architecture, implementation and evaluation of LangLingual in detail. The results indicate strong usability, positive learning outcomes and encouraging learner engagement.
FAME: Fairness-aware Attention-modulated Video Editing
Wu, Zhangkai, Fan, Xuhui, Xie, Zhongyuan, Shi, Kaize, Li, Zhidong, Cao, Longbing
Training-free video editing (VE) models tend to fall back on gender stereotypes when rendering profession-related prompts. We propose \textbf{FAME} for \textit{Fairness-aware Attention-modulated Video Editing} that mitigates profession-related gender biases while preserving prompt alignment and temporal consistency for coherent VE. We derive fairness embeddings from existing minority representations by softly injecting debiasing tokens into the text encoder. Simultaneously, FAME integrates fairness modulation into both temporal self attention and prompt-to-region cross attention to mitigate the motion corruption and temporal inconsistency caused by directly introducing fairness cues. For temporal self attention, FAME introduces a region constrained attention mask combined with time decay weighting, which enhances intra-region coherence while suppressing irrelevant inter-region interactions. For cross attention, it reweights tokens to region matching scores by incorporating fairness sensitive similarity masks derived from debiasing prompt embeddings. Together, these modulations keep fairness-sensitive semantics tied to the right visual regions and prevent temporal drift across frames. Extensive experiments on new VE fairness-oriented benchmark \textit{FairVE} demonstrate that FAME achieves stronger fairness alignment and semantic fidelity, surpassing existing VE baselines.
Transforming volcanic monitoring: A dataset and benchmark for onboard volcano activity detection
Priyasad, Darshana, Fernando, Tharindu, Haghighat, Maryam, Gammulle, Harshala, Fookes, Clinton
Natural disasters, such as volcanic eruptions, pose significant challenges to daily life and incur considerable global economic losses. The emergence of next-generation small-satellites, capable of constellation-based operations, offers unparalleled opportunities for near-real-time monitoring and onboard processing of such events. However, a major bottleneck remains the lack of extensive annotated datasets capturing volcanic activity, which hinders the development of robust detection systems. This paper introduces a novel dataset explicitly designed for volcanic activity and eruption detection, encompassing diverse volcanoes worldwide. The dataset provides binary annotations to identify volcanic anomalies or non-anomalies, covering phenomena such as temperature anomalies, eruptions, and volcanic ash emissions. These annotations offer a foundational resource for developing and evaluating detection models, addressing a critical gap in volcanic monitoring research. Additionally, we present comprehensive benchmarks using state-of-the-art models to establish baselines for future studies. Furthermore, we explore the potential for deploying these models onboard next-generation satellites. Using the Intel Movidius Myriad X VPU as a testbed, we demonstrate the feasibility of volcanic activity detection directly onboard. This capability significantly reduces latency and enhances response times, paving the way for advanced early warning systems. This paves the way for innovative solutions in volcanic disaster management, encouraging further exploration and refinement of onboard monitoring technologies.
Limits of Generative Pre-Training in Structured EMR Trajectories with Irregular Sampling
Kuo, Nicholas I-Hsien, Gallego, Blanca, Jorm, Louisa
Foundation models refer to architectures trained on vast datasets using autoregressive pre-training from natural language processing to capture intricate patterns and motifs. They were originally developed to transfer such learned knowledge to downstream predictive tasks. Recently, however, some studies repurpose these learned representations for phenotype discovery without rigorous validation, risking superficially realistic but clinically incoherent embeddings. To test this mismatch, we trained two autoregressive models -- a sequence-to-sequence LSTM and a reduced Transformer -- on longitudinal ART for HIV and Acute Hypotension datasets. Controlled irregularity was added during training via random inter-visit gaps, while test sequences stayed complete. Patient-trajectory synthesis evaluated distributional and correlational fidelity. Both reproduced feature distributions but failed to preserve cross-feature structure -- showing that generative pre-training yields local realism but limited clinical coherence. These results highlight the need for domain-specific evaluation and support trajectory synthesis as a practical probe before fine-tuning or deployment.
GateFuseNet: An Adaptive 3D Multimodal Neuroimaging Fusion Network for Parkinson's Disease Diagnosis
Jin, Rui, Chen, Chen, Liu, Yin, Sun, Hongfu, Zeng, Min, Li, Min, Gao, Yang
Accurate diagnosis of Parkinson's disease (PD) from MRI remains challenging due to symptom variability and pathological heterogeneity. Most existing methods rely on conventional magnitude-based MRI modalities, such as T1-weighted images (T1w), which are less sensitive to PD pathology than Quantitative Susceptibility Mapping (QSM), a phase-based MRI technique that quantifies iron deposition in deep gray matter nuclei. In this study, we propose GateFuseNet, an adaptive 3D multimodal fusion network that integrates QSM and T1w images for PD diagnosis. The core innovation lies in a gated fusion module that learns modality-specific attention weights and channel-wise gating vectors for selective feature modulation. This hierarchical gating mechanism enhances ROI-aware features while suppressing irrelevant signals. Experimental results show that our method outperforms three existing state-of-the-art approaches, achieving 85.00% accuracy and 92.06% AUC. Ablation studies further validate the contributions of ROI guidance, multimodal integration, and fusion positioning. Grad-CAM visualizations confirm the model's focus on clinically relevant pathological regions. The source codes and pretrained models can be found at https://github.com/YangGaoUQ/GateFuseNet
A Physics-Informed Neural Network Approach for UAV Path Planning in Dynamic Environments
Unmanned aerial vehicles (UAVs) operating in dynamic wind fields must generate safe and energy-efficient trajectories under physical and environmental constraints. Traditional planners, such as A* and kinodynamic RRT*, often yield suboptimal or non-smooth paths due to discretization and sampling limitations. This paper presents a physics-informed neural network (PINN) framework that embeds UAV dynamics, wind disturbances, and obstacle avoidance directly into the learning process. Without requiring supervised data, the PINN learns dynamically feasible and collision-free trajectories by minimizing physical residuals and risk-aware objectives. Comparative simulations show that the proposed method outperforms A* and Kino-RRT* in control energy, smoothness, and safety margin, while maintaining similar flight efficiency. The results highlight the potential of physics-informed learning to unify model-based and data-driven planning, providing a scalable and physically consistent framework for UAV trajectory optimization.
HRM-Agent: Training a recurrent reasoning model in dynamic environments using reinforcement learning
Dang, Long H, Rawlinson, David
The Hierarchical Reasoning Model (HRM) has impressive reasoning abilities given its small size, but has only been applied to supervised, static, fully-observable problems. One of HRM's strengths is its ability to adapt its computational effort to the difficulty of the problem. However, in its current form it cannot integrate and reuse computation from previous time-steps if the problem is dynamic, uncertain or partially observable, or be applied where the correct action is undefined, characteristics of many real-world problems. This paper presents HRM-Agent, a variant of HRM trained using only reinforcement learning. We show that HRM can learn to navigate to goals in dynamic and uncertain maze environments. Recent work suggests that HRM's reasoning abilities stem from its recurrent inference process. We explore the dynamics of the recurrent inference process and find evidence that it is successfully reusing computation from earlier environment time-steps.
ChatGPT shares data on how many users exhibit psychosis or suicidal thoughts
OpenAI has released new estimates of the number of ChatGPT users who exhibit possible signs of mental health emergencies, including mania, psychosis or suicidal thoughts. The company said that around 0.07% of ChatGPT users active in a given week exhibited such signs, adding that its artificial intelligence (AI) chatbot recognizes and responds to these sensitive conversations. While OpenAI maintains these cases are extremely rare, critics said even a small percentage may amount to hundreds of thousands of people, as ChatGPT recently reached 800 million weekly active users, per boss Sam Altman. As scrutiny mounts, the company said it built a network of experts around the world to advise it. Those experts include more than 170 psychiatrists, psychologists, and primary care physicians who have practiced in 60 countries, the company said. They have devised a series of responses in ChatGPT to encourage users to seek help in the real world, according to OpenAI.