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Evaluation of Popular XAI Applied to Clinical Prediction Models: Can They be Trusted?

arXiv.org Artificial Intelligence

The absence of transparency and explainability hinders the clinical adoption of Machine learning (ML) algorithms. Although various methods of explainable artificial intelligence (XAI) have been suggested, there is a lack of literature that delves into their practicality and assesses them based on criteria that could foster trust in clinical environments. To address this gap this study evaluates two popular XAI methods used for explaining predictive models in the healthcare context in terms of whether they (i) generate domain-appropriate representation, i.e. coherent with respect to the application task, (ii) impact clinical workflow and (iii) are consistent. To that end, explanations generated at the cohort and patient levels were analysed. The paper reports the first benchmarking of the XAI methods applied to risk prediction models obtained by evaluating the concordance between generated explanations and the trigger of a future clinical deterioration episode recorded by the data collection system. We carried out an analysis using two Electronic Medical Records (EMR) datasets sourced from Australian major hospitals. The findings underscore the limitations of state-of-the-art XAI methods in the clinical context and their potential benefits. We discuss these limitations and contribute to the theoretical development of trustworthy XAI solutions where clinical decision support guides the choice of intervention by suggesting the pattern or drivers for clinical deterioration in the future.


On Frequency-Wise Normalizations for Better Recording Device Generalization in Audio Spectrogram Transformers

arXiv.org Artificial Intelligence

Varying conditions between the data seen at training and at application time remain a major challenge for machine learning. We study this problem in the context of Acoustic Scene Classification (ASC) with mismatching recording devices. Previous works successfully employed frequency-wise normalization of inputs and hidden layer activations in convolutional neural networks to reduce the recording device discrepancy. The main objective of this work was to adopt frequency-wise normalization for Audio Spectrogram Transformers (ASTs), which have recently become the dominant model architecture in ASC. To this end, we first investigate how recording device characteristics are encoded in the hidden layer activations of ASTs. We find that recording device information is initially encoded in the frequency dimension; however, after the first self-attention block, it is largely transformed into the token dimension. Based on this observation, we conjecture that suppressing recording device characteristics in the input spectrogram is the most effective. We propose a frequency-centering operation for spectrograms that improves the ASC performance on unseen recording devices on average by up to 18.2 percentage points.


Advancing Biomedicine with Graph Representation Learning: Recent Progress, Challenges, and Future Directions

arXiv.org Artificial Intelligence

Objectives: Graph representation learning (GRL) has emerged as a pivotal field that has contributed significantly to breakthroughs in various fields, including biomedicine. The objective of this survey is to review the latest advancements in GRL methods and their applications in the biomedical field. We also highlight key challenges currently faced by GRL and outline potential directions for future research. Methods: We conducted a comprehensive search of multiple databases, including PubMed, Web of Science, IEEE Xplore, and Google Scholar, to collect relevant publications from the past two years (2021-2022). The studies selected for review were based on their relevance to the topic and the publication quality.


Survey of Malware Analysis through Control Flow Graph using Machine Learning

arXiv.org Artificial Intelligence

Malware is a significant threat to the security of computer systems and networks which requires sophisticated techniques to analyze the behavior and functionality for detection. Traditional signature-based malware detection methods have become ineffective in detecting new and unknown malware due to their rapid evolution. One of the most promising techniques that can overcome the limitations of signature-based detection is to use control flow graphs (CFGs). CFGs leverage the structural information of a program to represent the possible paths of execution as a graph, where nodes represent instructions and edges represent control flow dependencies. Machine learning (ML) algorithms are being used to extract these features from CFGs and classify them as malicious or benign. In this survey, we aim to review some state-of-the-art methods for malware detection through CFGs using ML, focusing on the different ways of extracting, representing, and classifying. Specifically, we present a comprehensive overview of different types of CFG features that have been used as well as different ML algorithms that have been applied to CFG-based malware detection. We provide an in-depth analysis of the challenges and limitations of these approaches, as well as suggest potential solutions to address some open problems and promising future directions for research in this field.


Harnessing the Power of Adversarial Prompting and Large Language Models for Robust Hypothesis Generation in Astronomy

arXiv.org Artificial Intelligence

This study investigates the application of Large Language Models (LLMs), specifically GPT-4, within Astronomy. We employ in-context prompting, supplying the model with up to 1000 papers from the NASA Astrophysics Data System, to explore the extent to which performance can be improved by immersing the model in domain-specific literature. Our findings point towards a substantial boost in hypothesis generation when using in-context prompting, a benefit that is further accentuated by adversarial prompting. We illustrate how adversarial prompting empowers GPT-4 to extract essential details from a vast knowledge base to produce meaningful hypotheses, signaling an innovative step towards employing LLMs for scientific research in Astronomy.


SeFNet: Bridging Tabular Datasets with Semantic Feature Nets

arXiv.org Artificial Intelligence

Machine learning applications cover a wide range of predictive tasks in which tabular datasets play a significant role. However, although they often address similar problems, tabular datasets are typically treated as standalone tasks. The possibilities of using previously solved problems are limited due to the lack of structured contextual information about their features and the lack of understanding of the relations between them. To overcome this limitation, we propose a new approach called Semantic Feature Net (SeFNet), capturing the semantic meaning of the analyzed tabular features. By leveraging existing ontologies and domain knowledge, SeFNet opens up new opportunities for sharing insights between diverse predictive tasks. One such opportunity is the Dataset Ontology-based Semantic Similarity (DOSS) measure, which quantifies the similarity between datasets using relations across their features. In this paper, we present an example of SeFNet prepared for a collection of predictive tasks in healthcare, with the features' relations derived from the SNOMED-CT ontology. The proposed SeFNet framework and the accompanying DOSS measure address the issue of limited contextual information in tabular datasets. By incorporating domain knowledge and establishing semantic relations between features, we enhance the potential for meta-learning and enable valuable insights to be shared across different predictive tasks.


The Ecological Fallacy in Annotation: Modelling Human Label Variation goes beyond Sociodemographics

arXiv.org Artificial Intelligence

Many NLP tasks exhibit human label variation, where different annotators give different labels to the same texts. This variation is known to depend, at least in part, on the sociodemographics of annotators. Recent research aims to model individual annotator behaviour rather than predicting aggregated labels, and we would expect that sociodemographic information is useful for these models. On the other hand, the ecological fallacy states that aggregate group behaviour, such as the behaviour of the average female annotator, does not necessarily explain individual behaviour. To account for sociodemographics in models of individual annotator behaviour, we introduce group-specific layers to multi-annotator models. In a series of experiments for toxic content detection, we find that explicitly accounting for sociodemographic attributes in this way does not significantly improve model performance. This result shows that individual annotation behaviour depends on much more than just sociodemographics.


Hallucination is the last thing you need

arXiv.org Artificial Intelligence

The legal profession necessitates a multidimensional approach that involves synthesizing an in-depth comprehension of a legal issue with insightful commentary based on personal experience, combined with a comprehensive understanding of pertinent legislation, regulation, and case law, in order to deliver an informed legal solution. The present offering with generative AI presents major obstacles in replicating this, as current models struggle to integrate and navigate such a complex interplay of understanding, experience, and fact-checking procedures. It is noteworthy that where generative AI outputs understanding and experience, which reflect the aggregate of various subjective views on similar topics, this often deflects the model's attention from the crucial legal facts, thereby resulting in hallucination. Hence, this paper delves into the feasibility of three independent LLMs, each focused on understanding, experience, and facts, synthesising as one single ensemble model to effectively counteract the current challenges posed by the existing monolithic generative AI models. We introduce an idea of mutli-length tokenisation to protect key information assets like common law judgements, and finally we interrogate the most advanced publicly available models for legal hallucination, with some interesting results.


CATS: A Pragmatic Chinese Answer-to-Sequence Dataset with Large Scale and High Quality

arXiv.org Artificial Intelligence

There are three problems existing in the popular data-to-text datasets. First, the large-scale datasets either contain noise or lack real application scenarios. Second, the datasets close to real applications are relatively small in size. Last, current datasets bias in the English language while leaving other languages underexplored. To alleviate these limitations, in this paper, we present CATS, a pragmatic Chinese answer-to-sequence dataset with large scale and high quality. The dataset aims to generate textual descriptions for the answer in the practical TableQA system. Further, to bridge the structural gap between the input SQL and table and establish better semantic alignments, we propose a Unified Graph Transformation approach to establish a joint encoding space for the two hybrid knowledge resources and convert this task to a graph-to-text problem. The experiment results demonstrate the effectiveness of our proposed method. Further analysis on CATS attests to both the high quality and challenges of the dataset.


Safe, Efficient, Comfort, and Energy-saving Automated Driving through Roundabout Based on Deep Reinforcement Learning

arXiv.org Artificial Intelligence

Traffic scenarios in roundabouts pose substantial complexity for automated driving. Manually mapping all possible scenarios into a state space is labor-intensive and challenging. Deep reinforcement learning (DRL) with its ability to learn from interacting with the environment emerges as a promising solution for training such automated driving models. This study explores, employs, and implements various DRL algorithms, namely Deep Deterministic Policy Gradient (DDPG), Proximal Policy Optimization (PPO), and Trust Region Policy Optimization (TRPO) to instruct automated vehicles' driving through roundabouts. The driving state space, action space, and reward function are designed. The reward function considers safety, efficiency, comfort, and energy consumption to align with real-world requirements. All three tested DRL algorithms succeed in enabling automated vehicles to drive through the roundabout. To holistically evaluate the performance of these algorithms, this study establishes an evaluation methodology considering multiple indicators such as safety, efficiency, and comfort level. A method employing the Analytic Hierarchy Process is also developed to weigh these evaluation indicators. Experimental results on various testing scenarios reveal that the TRPO algorithm outperforms DDPG and PPO in terms of safety and efficiency, and PPO performs best in terms of comfort level. Lastly, to verify the model's adaptability and robustness regarding other driving scenarios, this study also deploys the model trained by TRPO to a range of different testing scenarios, e.g., highway driving and merging. Experimental results demonstrate that the TRPO model trained on only roundabout driving scenarios exhibits a certain degree of proficiency in highway driving and merging scenarios. This study provides a foundation for the application of automated driving with DRL in real traffic environments.