A new distance measure between probability density functions (pdfs) is introduced, which we refer to as the Laplacian pdf distance. The Laplacian pdf distance exhibits a remarkable connection to Mercer kernel based learning theory via the Parzen window technique for density estimation. In a kernel feature space defined by the eigenspectrum of the Laplacian data matrix, this pdf distance is shown to measure the cosine of the angle between cluster mean vectors. The Laplacian data matrix, and hence its eigenspec-trum, can be obtained automatically based on the data at hand, by optimal Parzen window selection. We show that the Laplacian pdf distance has an interesting interpretation as a risk function connected to the probability of error.

In this paper we present a framework for using multi-layer perceptron (MLP) networks in nonlinear generative models trained by variational Bayesian learning. The nonlinearity is handled by linearizing it using a Gauss-Hermite quadrature at the hidden neurons.

We present a biophysically constrained cerebellar model of classical conditioning, implemented using a neuromorphic analog VLSI (aVLSI) chip. Like its biological counterpart, our cerebellar model is able to control adaptive behavior by predicting the precise timing of events. Here we describe the functionality of the chip and present its learning performance, as evaluated in simulated conditioning experiments at the circuit level and in behavioral experiments using a mobile robot. We show that this aVLSI model supports the acquisition and extinction of adaptively timed conditioned responses under real-world conditions with ultra-low power consumption.

Motivated by the particular problems involved in communicating with "locked-in" paralysed patients, we aim to develop a braincomputer interface that uses auditory stimuli. We describe a paradigm that allows a user to make a binary decision by focusing attention on one of two concurrent auditory stimulus sequences. Using Support Vector Machine classification and Recursive Channel Elimination on the independent components of averaged eventrelated potentials, we show that an untrained user's EEG data can be classified with an encouragingly high level of accuracy. This suggests that it is possible for users to modulate EEG signals in a single trial by the conscious direction of attention, well enough to be useful in BCI.

The NIPS 2003 workshops included a feature selection competition organized by the authors. We provided participants with five datasets from different application domains and called for classification results using a minimal number of features. The competition took place over a period of 13 weeks and attracted 78 research groups. Participants were asked to make online submissions on the validation and test sets, with performance on the validation set being presented immediately to the participant and performance on the test set presented to the participants at the workshop. In total 1863 entries were made on the validation sets during the development period and 135 entries on all test sets for the final competition. The winners used a combination of Bayesian neural networks with ARD priors and Dirichlet diffusion trees. Other top entries used a variety of methods for feature selection, which combined filters and/or wrapper or embedded methods using Random Forests, kernel methods, or neural networks as a classification engine. The results of the benchmark (including the predictions made by the participants and the features they selected) and the scoring software are publicly available. The benchmark is available at www.nipsfsc.ecs.soton.ac.uk for post-challenge submissions to stimulate further research.

We describe an algorithm for support vector machines (SVM) that can be parallelized efficiently and scales to very large problems with hundreds of thousands of training vectors. Instead of analyzing the whole training set in one optimization step, the data are split into subsets and optimized separately with multiple SVMs. The partial results are combined and filtered again in a'Cascade' of SVMs, until the global optimum is reached. The Cascade SVM can be spread over multiple processors with minimal communication overhead and requires far less memory, since the kernel matrices are much smaller than for a regular SVM. Convergence to the global optimum is guaranteed with multiple passes th rough the Cascade, but already a single pass provides good generalization. A single pass is 5x - 10x faster than a regular SVM for problems of 100,000 vectors when implemented on a single processor. Parallel implementations on a cluster of 16 processors were tested with over 1 million vectors (2-class problems), converging in a day or two, while a regular SVM never converged in over a week.

High retrieval precision in content-based image retrieval can be attained by adopting relevance feedback mechanisms. These mechanisms require that the user judges the quality of the results of the query by marking all the retrieved images as being either relevant or not. Then, the search engine exploits this information to adapt the search to better meet user's needs. At present, the vast majority of proposed relevance feedback mechanisms are formulated in terms of search model that has to be optimized. Such an optimization involves the modification of some search parameters so that the nearest neighbor of the query vector contains the largest number of relevant images.

Saliency mechanisms play an important role when visual recognition must be performed in cluttered scenes. We propose a computational definition of saliency that deviates from existing models by equating saliency to discrimination. In particular, the salient attributes of a given visual class are defined as the features that enable best discrimination between that class and all other classes of recognition interest. It is shown that this definition leads to saliency algorithms of low complexity, that are scalable to large recognition problems, and is compatible with existing models of early biological vision. Experimental results demonstrating success in the context of challenging recognition problems are also presented.

The computation of classical higher-order statistics such as higher-order moments or spectra is difficult for images due to the huge number of terms to be estimated and interpreted. We propose an alternative approach in which multiplicative pixel interactions are described by a series of Wiener functionals. Since the functionals are estimated implicitly via polynomial kernels, the combinatorial explosion associated with the classical higher-order statistics is avoided. First results show that image structures such as lines or corners can be predicted correctly, and that pixel interactions up to the order of five play an important role in natural images. Most of the interesting structure in a natural image is characterized by its higher-order statistics.

De novo Sequencing of peptides is a challenging task in proteome research. While there exist reliable DNAsequencing methods, the highthroughput de novo sequencing of proteins by mass spectrometry is still an open problem. Current approaches suffer from a lack in precision to detect mass peaks in the spectrograms. In this paper we present a novel method for de novo peptide sequencing based on a hidden Markov model. Experiments effectively demonstrate that this new method significantly outperforms standard approaches in matching quality.