We describe a method that infers whether statistical dependences between two observed variables X and Y are due to a "direct" causal link or only due to a connecting causal path that contains an unobserved variable of low complexity, e.g., a binary variable. This problem is motivated by statistical genetics. Given a genetic marker that is correlated with a phenotype of interest, we want to detect whether this marker is causal or it only correlates with a causal one. Our method is based on the analysis of the location of the conditional distributions P(Y|x) in the simplex of all distributions of Y. We report encouraging results on semi-empirical data.

Latent force models (LFMs) are hybrid models combining mechanistic principles with non-parametric components. In this article, we shall show how LFMs can be equivalently formulated and solved using the state variable approach. We shall also show how the Gaussian process prior used in LFMs can be equivalently formulated as a linear statespace model driven by a white noise process and how inference on the resulting model can be efficiently implemented using Kalman filter and smoother. Then we shall show how the recently proposed switching LFM can be reformulated using the state variable approach, and how we can construct a probabilistic model for the switches by formulating a similar switching LFM as a switching linear dynamic system (SLDS). We illustrate the performance of the proposed methodology in simulated scenarios and apply it to inferring the switching points in GPS data collected from car movement data in urban environment.

The personalization of treatment via bio-markers and other risk categories has drawn increasing interest among clinical scientists. Personalized treatment strategies can be learned using data from clinical trials, but such trials are very costly to run. This paper explores the use of active learning techniques to design more efficient trials, addressing issues such as whom to recruit, at what point in the trial, and which treatment to assign, throughout the duration of the trial. We propose a minimax bandit model with two different optimization criteria, and discuss the computational challenges and issues pertaining to this approach. We evaluate our active learning policies using both simulated data, and data modeled after a clinical trial for treating depressed individuals, and contrast our methods with other plausible active learning policies.

The assignment of tasks to multiple resources becomes an interesting game theoretic problem, when both the task owner and the resources are strategic. In the classical, nonstrategic setting, where the states of the tasks and resources are observable by the controller, this problem is that of finding an optimal policy for a Markov decision process (MDP). When the states are held by strategic agents, the problem of an efficient task allocation extends beyond that of solving an MDP and becomes that of designing a mechanism. Motivated by this fact, we propose a general mechanism which decides on an allocation rule for the tasks and resources and a payment rule to incentivize agents' participation and truthful reports. In contrast to related dynamic strategic control problems studied in recent literature, the problem studied here has interdependent values: the benefit of an allocation to the task owner is not simply a function of the characteristics of the task itself and the allocation, but also of the state of the resources. We introduce a dynamic extension of Mezzetti's two phase mechanism for interdependent valuations. In this changed setting, the proposed dynamic mechanism is efficient, within period ex-post incentive compatible, and within period ex-post individually rational.

To deal with the prohibitive complexity of calculating policies in Decentralized MDPs, researchers have proposed models that exploit structured agent interactions. Settings where most agent actions are independent except for few actions that affect the transitions and/or rewards of other agents can be modeled using Event-Driven Interactions with Complex Rewards (EDI-CR). Finding the optimal joint policy can be formulated as an optimization problem. However, existing formulations are too verbose and/or lack optimality guarantees. We propose a compact Mixed Integer Linear Program formulation of EDI-CR instances. The key insight is that most action sequences of a group of agents have the same effect on a given agent. This allows us to treat these sequences similarly and use fewer variables. Experiments show that our formulation is more compact and leads to faster solution times and better solutions than existing formulations.

In this paper, we develop a qualitative theory of influence diagrams that can be used to model and solve sequential decision making tasks when only qualitative (or imprecise) information is available. Our approach is based on an order-of-magnitude approximation of both probabilities and utilities and allows for specifying partially ordered preferences via sets of utility values. We also propose a dedicated variable elimination algorithm that can be applied for solving order-of-magnitude influence diagrams.

Efficient Inference in Markov Control ProblemsThomas Furmston Computer Science Department University College London London, WC1E 6BT David Barber Computer Science Department University College London London, WC1E 6BT Abstract Markov control algorithms that perform smooth, non-greedy updates of the policy have been shown to be very general and versatile, with policy gradient and Expectation Maximisation algorithms being particularly popular. For these algorithms, marginal inference of the reward weighted trajectory distribution is required to perform policy updates. We discuss a new exact inference algorithm for these marginals in the finite horizon case that is more efficient than the standard approach based on classical forward-backward recursions. We also provide a principled extension to infinite horizon Markov Decision Problems that explicitly accounts for an infinite horizon. This extension provides a novel algorithm for both policy gradients and Expectation Maximisation in infinite horizon problems. The state and action spaces can be either discrete or continuous. For a discount factorγ the reward is defined as R t(s t,a t) γ t 1 R (s t,a t) for a stationary reward R (s t,a t), whereγ [0, 1).

Probabilistic logic programs are logic programs in which some of the facts are annotated with probabilities. Several classical probabilistic inference tasks (such as MAP and computing marginals) have not yet received a lot of attention for this formalism. The contribution of this paper is that we develop efficient inference algorithms for these tasks. This is based on a conversion of the probabilistic logic program and the query and evidence to a weighted CNF formula. This allows us to reduce the inference tasks to well-studied tasks such as weighted model counting. To solve such tasks, we employ state-of-the-art methods. We consider multiple methods for the conversion of the programs as well as for inference on the weighted CNF. The resulting approach is evaluated experimentally and shown to improve upon the state-of-the-art in probabilistic logic programming.

We present a novel approach to constraint-based causal discovery, that takes the form of straightforward logical inference, applied to a list of simple, logical statements about causal relations that are derived directly from observed (in)dependencies. It is both sound and complete, in the sense that all invariant features of the corresponding partial ancestral graph (PAG) are identified, even in the presence of latent variables and selection bias. The approach shows that every identifiable causal relation corresponds to one of just two fundamental forms. More importantly, as the basic building blocks of the method do not rely on the detailed (graphical) structure of the corresponding PAG, it opens up a range of new opportunities, including more robust inference, detailed accountability, and application to large models.

Hierarchical problem abstraction, when applicable, may offer exponential reductions in computational complexity. Previous work on coarse-to-fine dynamic programming (CFDP) has demonstrated this possibility using state abstraction to speed up the Viterbi algorithm. In this paper, we show how to apply temporal abstraction to the Viterbi problem. Our algorithm uses bounds derived from analysis of coarse timescales to prune large parts of the state trellis at finer timescales. We demonstrate improvements of several orders of magnitude over the standard Viterbi algorithm, as well as significant speedups over CFDP, for problems whose state variables evolve at widely differing rates.