We introduce a novel framework for simultaneous structure and parameter learning in hidden-variable conditional probability models, based on an en tropic prior and a solution for its maximum a posteriori (MAP) estimator. The MAP estimate minimizes uncertainty in all respects: cross-entropy between model and data; entropy of the model; entropy of the data's descriptive statistics. Iterative estimation extinguishes weakly supported parameters, compressing and sparsifying the model. Trimming operators accelerate this process by removing excess parameters and, unlike most pruning schemes, guarantee an increase in posterior probability. Entropic estimation takes a overcomplete random model and simplifies it, inducing the structure of relations between hidden and observed variables. Applied to hidden Markov models (HMMs), it finds a concise finite-state machine representing the hidden structure of a signal. We entropically model music, handwriting, and video time-series, and show that the resulting models are highly concise, structured, predictive, and interpretable: Surviving states tend to be highly correlated with meaningful partitions of the data, while surviving transitions provide a low-perplexity model of the signal dynamics.

Here we derive measures quantifying the information loss of a synaptic signal due to the presence of neuronal noise sources, as it electrotonically propagates along a weakly-active dendrite. We model the dendrite as an infinite linear cable, with noise sources distributed along its length. The noise sources we consider are thermal noise, channel noise arising from the stochastic nature of voltage-dependent ionic channels (K and Na) and synaptic noise due to spontaneous background activity. We assess the efficacy of information transfer using a signal detection paradigm where the objective is to detect the presence/absence of a presynaptic spike from the post-synaptic membrane voltage. This allows us to analytically assess the role of each of these noise sources in information transfer. For our choice of parameters, we find that the synaptic noise is the dominant noise source which limits the maximum length over which information be reliably transmitted. 1 Introduction This is a continuation of our efforts (Manwani and Koch, 1998) to understand the information capacity ofa neuronal link (in terms of the specific nature of neural "hardware") by a systematic study of information processing at different biophysical stages in a model of a single neuron. Here we investigate how the presence of neuronal noise sources influences the information transmission capabilities of a simplified model of a weakly-active dendrite. The noise sources we include are, thermal noise, channel noise arising from the stochastic nature of voltage-dependent channels (K and Na) and synaptic noise due to spontaneous background activity. We characterize the noise sources using analytical expressions of their current power spectral densities and compare their magnitudes for dendritic parameters reported in literature (Mainen and Sejnowski, 1998).

We present a new energy-minimization framework for the graph isomorphism problem which is based on an equivalent maximum clique formulation. The approach is centered around a fundamental result proved by Motzkin and Straus in the mid-1960s, and recently expanded in various ways, which allows us to formulate the maximum clique problem in terms of a standard quadratic program. To solve the program we use "replicator" equations, a class of simple continuous-and discrete-time dynamical systems developed in various branches of theoretical biology. We show how, despite their inability to escape from local solutions, they nevertheless provide experimental results which are competitive with those obtained using more elaborate mean-field annealing heuristics. 1 INTRODUCTION The graph isomorphism problem is one of those few combinatorial optimization problems which still resist any computational complexity characterization [6]. Despite decades of active research, no polynomial-time algorithm for it has yet been found.

Two developments of nonlinear latent variable models based on radial basis functions are discussed: in the first, the use of priors or constraints on allowable models is considered as a means of preserving data structure in low-dimensional representations for visualisation purposes. Also, a resampling approach is introduced which makes more effective use of the latent samples in evaluating the likelihood.

In supervised learning, we have a set of explicative variables x from which we wish to predict a response variable y.

In this paper we present a novel approach to multichannel blind that both mixingseparation/generalized deconvolution, assuming and demixing models are described by stable linear state-space systems. Based on the minimization of Kullback-Leibler Divergence, we develop a novel learning algorithm to train the matrices in the output equation. To estimate the state of the demixing model, we introduce a new concept, called to numerically implement the Kalman filter.hidden Referany priori knowledge of to review papers [lJ and [5J for the current state of theory and methods in the field. There are several reasons why as blind deconvolution models.

W is often taken to be diagonal, but if we allow W to be a general positive definite matrix which can be tuned on the basis of training data, then an eigen-analysis of W shows that we are effectively creating hidden features, where the dimensionality of the hidden-feature space is determined by the data. We demonstrate the superiority of predictions usi ng the general matrix over those based on a diagonal matrix on two test problems.

Based on a simple convexity lemma, we develop bounds for different typesof Bayesian prediction errors for regression with Gaussian processes. The basic bounds are formulated for a fixed training set. Simpler expressions are obtained for sampling from an input distribution whichequals the weight function of the covariance kernel, yielding asymptotically tight results. The results are compared with numerical experiments.

We present a new energy-minimization framework for the graph isomorphism problem which is based on an equivalent maximum clique formulation. The approach is centered around a fundamental result proved by Motzkin and Straus in the mid-1960s, and recently expanded in various ways, which allows us to formulate the maximum cliqueproblem in terms of a standard quadratic program. To solve the program we use "replicator" equations, a class of simple continuous-and discrete-time dynamical systems developed in various branchesof theoretical biology. We show how, despite their inability to escape from local solutions, they nevertheless provide experimental results which are competitive with those obtained using moreelaborate mean-field annealing heuristics. 1 INTRODUCTION The graph isomorphism problem is one of those few combinatorial optimization problems which still resist any computational complexity characterization [6]. Despite decadesof active research, no polynomial-time algorithm for it has yet been found.

In supervised learning, we have a set of explicative variables x from which we wish to predict aresponse variable y.