Model-assisted interval designs such as the Keyboard design are transparent and easy to implement in phase I oncology trials. However, interim decisions based solely on data from the current dose may overlook informative signals from neighbouring doses, leading to unnecessary escalation or de-escalation. We propose the shared Keyboard design, a Bayesian model-assisted design that replaces the independent beta--binomial updating scheme at each dose with a posterior induced by a Beta kernel process using kernel-weighted pseudo-counts. The design preserves the decision structure of the Keyboard design while enabling controlled borrowing across nearby doses. To prioritise overdose control, we propose an asymmetric kernel that assigns greater weight to toxicities observed at higher doses during escalation. We further extend the proposed design to accommodate adaptive dose insertion when the initial dose grid is inadequate and time-to-event outcomes when late-onset toxicities are present. Extensive simulation studies demonstrate substantial improvements in both accuracy and safety for identifying the maximum tolerated dose. In settings involving dose insertion, the proposed design identifies inserted target doses more effectively than adaptive dose modification while maintaining a comparable modification rate.

MV Hondius, the Dutch cruise ship hit by a deadly hantavirus outbreak, has docked at its final destination in Rotterdam. Only the ship's crew were aboard for the last leg of the journey, as all passengers docked off the ship in the Canary Islands between 10 and 11 May. Rotterdam port harbour master René de Vries said 25 mobile homes kitted out with catering and satellite communications would be available for the crew to self-isolate in. Three people - a Dutch couple and a German woman - died after travelling on the ship, with two of them confirmed to have had the virus. The World Health Organization has so far reported 10 cases in total, eight confirmed and two suspected.

We consider the problem of testing properties of graphs underlying high-dimensional graphical models. We adopt the model of covariance queries introduced by Lugosi, Truszkowski, Velona, and Zwiernik (2021). We study the case when the underlying graph is a tree. The main results of the paper show that, while reconstructing the entire tree may be costly, certain global structural properties can be tested efficiently. In particular, we design randomized tests for global structural properties that use a sub-quadratic number of queries. We develop testing procedures for several fundamental properties, including the number of leaves, the maximum degree, the typical distance, and the diameter of the tree. For each property, we obtain explicit query complexity bounds that depend on the target threshold and tolerance parameters.

Bulgarian pop star Dara was met by a crowd of fans in Sofia airport on Sunday, celebrating her historic Eurovision win. The 27-year-old's tune Bangaranga won Bulgaria its first ever title in the song contest. Thank you for being here, she told fans as she arrived in the Bulgarian capital, Sofia, before adding I cannot wait to dip my toes in this atmosphere. Russia launched one of the biggest air strikes on Kyiv since the start of the war with several apartment blocks hit. Why is the Princess of Wales in Italy this week?

In this piece, we reflect on AIES 2025, and outline the conversations and presentations from a discussion session on LLMs in the context of clinical usage and human rights. This is a crosspost from the latest issue of AI Matters, published by the ACM SIAGI. This year's conference on artificial intelligence, ethics and society (AIES) took place in the north of Madrid within the 180m-high tower block that forms the vertical campus of IE University. The event kicked off with a welcome from the chairs and organising committee members, with this opening session also featuring the conference best paper awards. Topics covered during the three-day event included mitigating bias, integrating AI into the workplace, evaluating LLMs in clinical settings, power dynamics in AI ecosystems, and dataset creation.

Here's what you need to know, from why the cruise ship outbreak won't spark the next pandemic to how hantavirus spreads. Now that more than 100 passengers aboard a hantavirus -stricken luxury cruise ship have been evacuated, with 18 Americans in biocontainment units in Nebraska and Georgia, health officials around the world are working to monitor more than two dozen individuals who left the cruise and anyone with whom they might have come in close contact. So far, all of the 11 reported hantavirus cases are among passengers or crew on the ship, the World Health Organization's director-general Tedros Adhanom Ghebreyesus said at a press conference in Madrid on Tuesday. That includes three deaths resulting from the virus. Typically, hantaviruses are spread when contaminated rodent droppings and urine are stirred up in the air and breathed in.

Since 2023, Moderna and Korea University have been developing a new mRNA vaccine for hantavirus. The work has been promising so far, but a finished product isn't likely coming any time soon. US-based pharmaceutical company Moderna confirmed that it has been working on the development of hantavirus vaccines in collaboration with the Vaccine Innovation Center of Korea University College of Medicine (VIC-K). This comes after an outbreak of hantavirus occurred on a Dutch cruise ship that sailed from Argentina and disembarked its passengers and crew in the Canary Islands on May 10. At least three people aboard the MV died, and several cases were reported as serious.

Days before the cruise ship affected by a hantavirus outbreak is set to dock in southern Tenerife in the Canary Islands, locals are expressing a mix of concern and calm. According to Oceanwide Expeditions, there are currently no symptomatic individuals on board the ship. Iran's president says he has spoken to the country's Supreme Leader

Here's What You Need to Know About the Hantavirus While the outbreak aboard a cruise ship in the Atlantic is concerning, the virus isn't easily transmitted through casual contact. Cruises are so closely associated with illness that the highly contagious norovirus is commonly called the "cruise ship virus." But a ship headed for Spain's Canary Islands has attracted global attention due to a rare outbreak of hantavirus that's left three dead. While alarming, health officials and infectious disease experts say the risk to the general public right now is low because hantavirus is less contagious than other respiratory diseases like the coronavirus responsible for the Covid-19 pandemic . "This is not Covid, this is not influenza. It spreads very, very differently," Maria Van Kerkhove, director of epidemic and pandemic preparedness and prevention at the World Health Organization, said at a press conference on Thursday.

Despite theoretical advantages, causal methods for Gene Regulatory Network (GRN) inference from single-cell RNA-seq data consistently fail to match or outperform correlation-based baselines in many realistic benchmarks, a persistent puzzle which casts doubt on the value of causality for this task. We argue that existing benchmarks are insufficiently controlled to answer this question because they evaluate on real or semi-real data where multiple pathologies co-occur, confounding failure modes, and obscuring the specific conditions under which different inference methods excel or fail. To address this gap, we introduce a controlled diagnostic framework that isolates seven biologically motivated pathologies (dropout, latent confounders, cell-type mixing, feedback loops, network density, sample size, and pseudotime drift) and measure how six representative methods spanning three inference paradigms degrade as each pathology intensifies. Across 6,120 controlled experiments, we find that causal methods genuinely dominate in clean and structurally favorable regimes, but specific pathologies (notably dropout and latent confounders) selectively neutralize their advantages. We further introduce an errortype decomposition that reveals methods with similar aggregate accuracy commit qualitatively different errors. To probe whether single-pathology effects persist when multiple stressors co-occur, we perform an interaction sweep over the three most impactful pathologies and find that their joint effects are sub-additive, while also exposing density-conditional cross-overs invisible to single-dial analysis. Our findings offer a nuanced understanding of when and why different methods succeed or fail for GRN inference, providing actionable insights for method development and practical guidance for practitioners.3