Inner-product operators, often referred to as kernels in statistical learning, define amapping from some input space into a feature space. The focus of this paper is the construction of biologically-motivated kernels for cortical activities. Thekernels we derive, termed Spikernels, map spike count sequences into an abstract vector space in which we can perform various prediction tasks. We discuss in detail the derivation of Spikernels and describe an efficient algorithm forcomputing their value on any two sequences of neural population spike counts. We demonstrate the merits of our modeling approach using the Spikernel and various standard kernels for the task of predicting hand movement velocitiesfrom cortical recordings. In all of our experiments all the kernels we tested outperform the standard scalar product used in regression with the Spikernel consistently achieving the best performance.

We discuss the problem of ranking k instances with the use of a "large margin" principle. We introduce two main approaches: the first is the "fixed margin" policy in which the margin of the closest neighboring classes is being maximized - which turns out to be a direct generalization ofSVM to ranking learning. The second approach allows for k - 1 different margins where the sum of margins is maximized. This approach is shown to reduce to lI-SVM when the number of classes k 2. Both approaches are optimal in size of 21 where I is the total number of training examples. Experiments performed on visual classification and "collaborative filtering"show that both approaches outperform existing ordinal regression algorithms applied for ranking and multi-class SVM applied to general multi-class classification. 1 Introduction In this paper we investigate the problem of inductive learning from the point of view of predicting variables of ordinal scale [3, 7,5], a setting referred to as ranking learning or ordinal regression. We consider the problem of applying the large margin principle used in Support Vector methods [12, 1] to the ordinal regression problem while maintaining an (optimal) problem size linear in the number of training examples.

We show the existence of critical points as lines for the likelihood function of mixture-type models.

We used two large clusters .

AdaBoost [3] minimizes an upper error bound which is an exponential function of the margin on the training set [14]. However, the ultimate goal in applications of pattern classification is always minimum error rate. On the other hand, AdaBoost needs an effective procedure for learning weak classifiers, which by itself is difficult especially for high dimensional data. In this paper, we present a novel procedure, called FloatBoost, for learning a better boosted classifier. FloatBoost uses a backtrack mechanism after each iteration of AdaBoost to remove weak classifiers which cause higher error rates. The resulting float-boosted classifier consists of fewer weak classifiers yet achieves lower error rates than AdaBoost in both training and test. We also propose a statistical model for learning weak classifiers, based on a stagewise approximation of the posterior using an overcomplete set of scalar features. Experimental comparisonsof FloatBoost and AdaBoost are provided through a difficult classification problem, face detection, where the goal is to learn from training examples a highly nonlinear classifier to differentiate between faceand nonface patterns in a high dimensional space. The results clearly demonstrate the promises made by FloatBoost over AdaBoost.

We propose probabilistic generative models, called parametric mixture models(PMMs), for multiclass, multi-labeled text categorization problem.Conventionally, the binary classification approach has been employed, in which whether or not text belongs to a category isjudged by the binary classifier for every category. In contrast, our approach can simultaneously detect multiple categories of text using PMMs. We derive efficient learning and prediction algorithms forPMMs. We also empirically show that our method could significantly outperform the conventional binary methods when applied tomulti-labeled text categorization using real World Wide Web pages.

The problem of extracting the relevant aspects of data, in face of multiple conflicting structures, is inherent to modeling of complex data. Extracting structurein one random variable that is relevant for another variable has been principally addressed recently via the information bottleneck method [15]. However, such auxiliary variables often contain more information thanis actually required due to structures that are irrelevant for the task. In many other cases it is in fact easier to specify what is irrelevant than what is, for the task at hand. Identifying the relevant structures, however, can thus be considerably improved by also minimizing theinformation about another, irrelevant, variable. In this paper we give a general formulation of this problem and derive its formal, as well as algorithmic, solution. Its operation is demonstrated in a synthetic example and in two real world problems in the context of text categorization andface images. While the original information bottleneck problem is related to rate distortion theory, with the distortion measure replaced by the relevant information, extracting relevant features while removing irrelevant ones is related to rate distortion with side information.

A lot of learning machines with hidden variables used in information sciencehave singularities in their parameter spaces. At singularities, the Fisher information matrix becomes degenerate, resulting that the learning theory of regular statistical models does not hold. Recently, it was proven that, if the true parameter is contained in singularities, then the coefficient of the Bayes generalization erroris equal to the pole of the zeta function of the Kullback information.

We introduce efficient learning equilibrium (ELE), a normative approach tolearning in non cooperative settings. In ELE, the learning algorithms themselves are required to be in equilibrium. In addition, the learning algorithms arrive at a desired value after polynomial time, and deviations from a prescribed ELE become irrational afterpolynomial time. We prove the existence of an ELE in the perfect monitoring setting, where the desired value is the expected payoff in a Nash equilibrium. We also show that an ELE does not always exist in the imperfect monitoring case.

We present an algorithm to extract features from high-dimensional gene expression profiles, based on the knowledge of a graph which links together genesknown to participate to successive reactions in metabolic pathways. Motivated by the intuition that biologically relevant features are likely to exhibit smoothness with respect to the graph topology, the algorithm involves encoding the graph and the set of expression profiles intokernel functions, and performing a generalized form of canonical correlation analysis in the corresponding reproducible kernel Hilbert spaces. Functionprediction experiments for the genes of the yeast S. Cerevisiae validate this approach by showing a consistent increase in performance when a state-of-the-art classifier uses the vector of features instead of the original expression profile to predict the functional class of a gene.