Photoplethysmography (PPG) is the most widely used non-invasive technique for monitoring biosignals and cardiovascular health, with applications in both clinical settings and consumer health through wearable devices. Current machine learning models trained on PPG signals are mostly task-specific and lack generalizability. Previous works often used single-device datasets, did not explore out-of-domain generalization, or did not release their models, hindering reproducibility and further research. We introduce PaPaGei, the first open foundation model for PPG signals. PaPaGei is pre-trained on more than 57,000 hours of 20 million unlabeled segments of PPG signals using publicly available datasets exclusively. We evaluate against popular time-series foundation models and other benchmarks on 20 tasks of 10 diverse datasets spanning cardiovascular health, sleep disorders, pregnancy monitoring, and wellbeing assessment. Our architecture incorporates novel representation learning approaches that leverage differences in PPG signal morphology across individuals, enabling it to capture richer representations than traditional contrastive learning methods. Across 20 tasks, PaPaGei improves classification and regression performance by an average of 6.3% and 2.9%, respectively, compared to other competitive time-series foundation models in at least 14 tasks. PaPaGei is more data- and parameter-efficient than other foundation models or methods, as it outperforms 70x larger models. Beyond accuracy, we also investigate robustness against different skin tones, establishing a benchmark for bias evaluations of future models. Notably, PaPaGei can be used out of the box as both a feature extractor and an encoder for other multimodal models, opening up new opportunities for multimodal health monitoring

There have been key advancements to building universal approximators for multi-goal collections of reinforcement learning value functions -- key elements in estimating long-term returns of states in a parameterized manner. We extend this to hierarchical reinforcement learning, using the options framework, by introducing hierarchical universal value function approximators (H-UVFAs). This allows us to leverage the added benefits of scaling, planning, and generalization expected in temporal abstraction settings. We develop supervised and reinforcement learning methods for learning embeddings of the states, goals, options, and actions in the two hierarchical value functions: $Q(s, g, o; \theta)$ and $Q(s, g, o, a; \theta)$. Finally we demonstrate generalization of the HUVFAs and show they outperform corresponding UVFAs.

Regulatory frameworks for the use of AI are emerging. However, they trail behind the fast-evolving malicious AI technologies that can quickly cause lasting societal damage. In response, we introduce a pioneering Assistive AI framework designed to enhance human decision-making capabilities. This framework aims to establish a trust network across various fields, especially within legal contexts, serving as a proactive complement to ongoing regulatory efforts. Central to our framework are the principles of privacy, accountability, and credibility. In our methodology, the foundation of reliability of information and information sources is built upon the ability to uphold accountability, enhance security, and protect privacy. This approach supports, filters, and potentially guides communication, thereby empowering individuals and communities to make well-informed decisions based on cutting-edge advancements in AI. Our framework uses the concept of Boards as proxies to collectively ensure that AI-assisted decisions are reliable, accountable, and in alignment with societal values and legal standards. Through a detailed exploration of our framework, including its main components, operations, and sample use cases, the paper shows how AI can assist in the complex process of decision-making while maintaining human oversight. The proposed framework not only extends regulatory landscapes but also highlights the synergy between AI technology and human judgement, underscoring the potential of AI to serve as a vital instrument in discerning reality from fiction and thus enhancing the decision-making process. Furthermore, we provide domain-specific use cases to highlight the applicability of our framework.

Objective: This article offers a taxonomy of generative artificial intelligence (AI) for health economics and outcomes research (HEOR), explores its emerging applications, and outlines methods to enhance the accuracy and reliability of AI-generated outputs. Methods: The review defines foundational generative AI concepts and highlights current HEOR applications, including systematic literature reviews, health economic modeling, real-world evidence generation, and dossier development. Approaches such as prompt engineering (zero-shot, few-shot, chain-of-thought, persona pattern prompting), retrieval-augmented generation, model fine-tuning, and the use of domain-specific models are introduced to improve AI accuracy and reliability. Results: Generative AI shows significant potential in HEOR, enhancing efficiency, productivity, and offering novel solutions to complex challenges. Foundation models are promising in automating complex tasks, though challenges remain in scientific reliability, bias, interpretability, and workflow integration. The article discusses strategies to improve the accuracy of these AI tools. Conclusion: Generative AI could transform HEOR by increasing efficiency and accuracy across various applications. However, its full potential can only be realized by building HEOR expertise and addressing the limitations of current AI technologies. As AI evolves, ongoing research and innovation will shape its future role in the field.

Evaluating Large Language Models (LLMs) on reasoning benchmarks demonstrates their ability to solve compositional questions. However, little is known of whether these models engage in genuine logical reasoning or simply rely on implicit cues to generate answers. In this paper, we investigate the transitive reasoning capabilities of two distinct LLM architectures, LLaMA 2 and Flan-T5, by manipulating facts within two compositional datasets: QASC and Bamboogle. We controlled for potential cues that might influence the models' performance, including (a) word/phrase overlaps across sections of test input; (b) models' inherent knowledge during pre-training or fine-tuning; and (c) Named Entities. Our findings reveal that while both models leverage (a), Flan-T5 shows more resilience to experiments (b and c), having less variance than LLaMA 2. This suggests that models may develop an understanding of transitivity through fine-tuning on knowingly relevant datasets, a hypothesis we leave to future work.

Users often interact with large language models through black-box inference APIs, both for closed- and open-weight models (e.g., Llama models are popularly accessed via Amazon Bedrock and Azure AI Studio). In order to cut costs or add functionality, API providers may quantize, watermark, or finetune the underlying model, changing the output distribution -- often without notifying users. We formalize detecting such distortions as Model Equality Testing, a two-sample testing problem, where the user collects samples from the API and a reference distribution and conducts a statistical test to see if the two distributions are the same. We find that tests based on the Maximum Mean Discrepancy between distributions are powerful for this task: a test built on a simple string kernel achieves a median of 77.4% power against a range of distortions, using an average of just 10 samples per prompt. We then apply this test to commercial inference APIs for four Llama models, finding that 11 out of 31 endpoints serve different distributions than reference weights released by Meta.

Advances in Large Language Models (LLMs) have spurred a wave of LLM library learning systems for mathematical reasoning. These systems aim to learn a reusable library of tools, such as formal Isabelle lemmas or Python programs that are tailored to a family of tasks. Many of these systems are inspired by the human structuring of knowledge into reusable and extendable concepts, but do current methods actually learn reusable libraries of tools? We study two library learning systems for mathematics which both reported increased accuracy: LEGO-Prover and TroVE. We find that function reuse is extremely infrequent on miniF2F and MATH. Our followup ablation experiments suggest that, rather than reuse, self-correction and self-consistency are the primary drivers of the observed performance gains. Our code and data are available at https://github.com/ikb-a/curious-case

This survey offers a comprehensive overview of Large Language Models (LLMs) designed for Arabic language and its dialects. It covers key architectures, including encoder-only, decoder-only, and encoder-decoder models, along with the datasets used for pre-training, spanning Classical Arabic, Modern Standard Arabic, and Dialectal Arabic. The study also explores monolingual, bilingual, and multilingual LLMs, analyzing their architectures and performance across downstream tasks, such as sentiment analysis, named entity recognition, and question answering. Furthermore, it assesses the openness of Arabic LLMs based on factors, such as source code availability, training data, model weights, and documentation. The survey highlights the need for more diverse dialectal datasets and attributes the importance of openness for research reproducibility and transparency. It concludes by identifying key challenges and opportunities for future research and stressing the need for more inclusive and representative models.

During the early stages of respiratory virus outbreaks, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the efficient utilize of limited nasopharyngeal swabs for rapid and accurate screening is crucial for public health. In this study, we present a methodology that integrates attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) with the adaptive iteratively reweighted penalized least squares (airPLS) preprocessing algorithm and a channel-wise attention-based partial least squares one-dimensional convolutional neural network (PLS-1D-CNN) model, enabling accurate screening of infected individuals within 10 minutes. Two cohorts of nasopharyngeal swab samples, comprising 126 and 112 samples from suspected SARS-CoV-2 Omicron variant cases, were collected at Beijing You'an Hospital for verification. Given that ATR-FTIR spectra are highly sensitive to variations in experimental conditions, which can affect their quality, we propose a biomolecular importance (BMI) evaluation method to assess signal quality across different conditions, validated by comparing BMI with PLS-GBM and PLS-RF results. For the ATR-FTIR signals in cohort 2, which exhibited a higher BMI, airPLS was utilized for signal preprocessing, followed by the application of the channel-wise attention-based PLS-1D-CNN model for screening. The experimental results demonstrate that our model outperforms recently reported methods in the field of respiratory virus spectrum detection, achieving a recognition screening accuracy of 96.48%, a sensitivity of 96.24%, a specificity of 97.14%, an F1-score of 96.12%, and an AUC of 0.99. It meets the World Health Organization (WHO) recommended criteria for an acceptable product: sensitivity of 95.00% or greater and specificity of 97.00% or greater for testing prior SARS-CoV-2 infection in moderate to high volume scenarios.

In this work, we present FRTree planner, a novel robot navigation framework that leverages a tree structure of free regions, specifically designed for navigation in cluttered and unknown environments with narrow passages. The framework continuously incorporates real-time perceptive information to identify distinct navigation options and dynamically expands the tree toward explorable and traversable directions. This dynamically constructed tree incrementally encodes the geometric and topological information of the collision-free space, enabling efficient selection of the intermediate goals, navigating around dead-end situations, and avoidance of dynamic obstacles without a prior map. Crucially, our method performs a comprehensive analysis of the geometric relationship between free regions and the robot during online replanning. In particular, the planner assesses the accessibility of candidate passages based on the robot's geometries, facilitating the effective selection of the most viable intermediate goals through accessible narrow passages while minimizing unnecessary detours. By combining the free region information with a bi-level trajectory optimization tailored for robots with specific geometries, our approach generates robust and adaptable obstacle avoidance strategies in confined spaces. Through extensive simulations and real-world experiments, FRTree demonstrates its superiority over benchmark methods in generating safe, efficient motion plans through highly cluttered and unknown terrains with narrow gaps.