Nancy Guthrie sheriff's appalling past revealed: Beat handcuffed suspect so badly he needed intensive care, used VILE language about woman and lied in sworn statement Vance grounded at White House as Iran peace talks in turmoil and Trump declares: 'I expect to be bombing' New'Hollywood dose' pill: A-listers hooked on'youth elixir' that dermatologists say is anti-ageing, shrinks pores, smooths wrinkles... and even banishes rosacea Days after we got engaged, the love of my life told me he'd killed a man and buried him in a bog. I reported him to police... but then I made this irreversible mistake Ark of the Covenant's final resting place pinpointed by archaeologists as fresh search begins Ritzy Bay Area town torn apart after teacher's daughter, 16, crashed car while speeding and killed four friends... then posted a TikTok video that poured fuel on the flames Jordon Hudson extends her control over Bill Belichick's empire with secret move that is set to leave his family and friends furious Two CIA officers killed in Mexico when their car skidded off ravine and exploded after meeting about bust of'largest ever drug lab' Life-threatening cantaloupe recall in four states upgraded to FDA's highest risk level... 'reasonable probability of death' AMANDA PLATELL: Why Sarah Ferguson - with the ghost of Princess Diana at her side - is ready to sensationally blow up the Royal Family. She knows ALL their secrets... Trump confronts Xi as US forces seize Chinese ship carrying mysterious'gift' to Iran Team USA Olympics star Noah Lyles slammed for'horrible' reaction to his wife's wedding dress reveal Humiliating moment runner celebrates winning marathon... only to be pipped at the line by rival in brutal finish In honour of the Queen's (purple!) reign: Kate mirrors late monarch's colourful wardrobe and wears her pearl earrings and necklace How to lose weight when perimenopause sabotages your metabolism: I'm a trainer but when I hit 46, I piled on the pounds overnight. The new'posh' drug that's easier to order than Uber Eats - and why all my middle-class friends have ditched booze and cocaine for it: JANA HOCKING Grieving mother says she went to LA school every day to complain daughter was being bullied... then tragedy struck when the lead tormentor, 12, hurled metal water bottle at victim's head Autistic woman, 24, worked hard to build independent life for herself... now she's PARALYZED thanks to selfishness of stranger Facial recognition on 21 popular devices can be easily spoofed with printed photos, tests reveal - so, is yours on the list? Facial recognition might seem like one of the safest ways to keep your phone secure, but experts say your device might be easy prey for hackers.

In online clustering problems, there is often a large amount of uncertainty over possible cluster assignments that cannot be resolved until more data are observed. This difficulty is compounded when clusters follow complex distributions, as is the case with text data. Sequential Monte Carlo (SMC) methods give a natural way of representing and updating this uncertainty over time, but have prohibitive memory requirements for large-scale problems. We propose a novel SMC algorithm that decomposes clustering problems into approximately independent subproblems, allowing a more compact representation of the algorithm state. Our approach is motivated by the knowledge base construction problem, and we show that our method is able to accurately and efficiently solve clustering problems in this setting and others where traditional SMC struggles.

To obtain more accurate model parameters and improve prediction accuracy, we proposed a regularized Kriging model that penalizes the hyperparameter theta in the Gaussian stochastic process, termed the Theta-regularized Kriging. We derived the optimization problem for this model from a maximum likelihood perspective. Additionally, we presented specific implementation details for the iterative process, including the regularized optimization algorithm and the geometric search cross-validation tuning algorithm. Three distinct penalty methods, Lasso, Ridge, and Elastic-net regularization, were meticulously considered. Meanwhile, the proposed Theta-regularized Kriging models were tested on nine common numerical functions and two practical engineering examples. The results demonstrate that, compared with other penalized Kriging models, the proposed model performs better in terms of accuracy and stability.

Vance grounded at White House as Iran peace talks in turmoil and Trump declares: 'I expect to be bombing' New'Hollywood dose' pill: A-listers hooked on'youth elixir' that dermatologists say is anti-ageing, shrinks pores, smooths wrinkles... and even banishes rosacea Days after we got engaged, the love of my life told me he'd killed a man and buried him in a bog. I reported him to police... but then I made this irreversible mistake Ark of the Covenant's final resting place pinpointed by archaeologists as fresh search begins Ritzy Bay Area town torn apart after teacher's daughter, 16, crashed car while speeding and killed four friends... then posted a TikTok video that poured fuel on the flames Jordon Hudson extends her control over Bill Belichick's empire with secret move that is set to leave his family and friends furious Two CIA officers killed in Mexico when their car skidded off ravine and exploded after meeting about bust of'largest ever drug lab' Life-threatening cantaloupe recall in four states upgraded to FDA's highest risk level... 'reasonable probability of death' AMANDA PLATELL: Why Sarah Ferguson - with the ghost of Princess Diana at her side - is ready to sensationally blow up the Royal Family. She knows ALL their secrets... Trump confronts Xi as US forces seize Chinese ship carrying mysterious'gift' to Iran Team USA Olympics star Noah Lyles slammed for'horrible' reaction to his wife's wedding dress reveal Humiliating moment runner celebrates winning marathon... only to be pipped at the line by rival in brutal finish Patriots coach Mike Vrabel reveals'difficult conversations' with his wife as he speaks out for the first time since Dianna Russini photo scandal How to lose weight when perimenopause sabotages your metabolism: I'm a trainer but when I hit 46, I piled on the pounds overnight. The new'posh' drug that's easier to order than Uber Eats - and why all my middle-class friends have ditched booze and cocaine for it: JANA HOCKING Grieving mother says she went to LA school every day to complain daughter was being bullied... then tragedy struck when the lead tormentor, 12, hurled metal water bottle at victim's head Autistic woman, 24, worked hard to build independent life for herself... now she's PARALYZED thanks to selfishness of stranger READ MORE: The five things you'll never see in a dream - including your phone It's never nice waking up and remembering a scary dream - but having night terrors might actually be a good thing, experts say. Researchers have found that feeling fear during your nighttime visions could indicate you're better at handling your emotions.

CT scans help a museum examine mummified remains that were sitting in its collections for half a century. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Multiple mummy specimens have been stored in the museum since it opened in 1965. Breakthroughs, discoveries, and DIY tips sent six days a week. Not every mummy is treated equally.

Antibody lead optimization is inherently a multi-objective challenge in drug discovery. Achieving a balance between different drug-like properties is crucial for the development of viable candidates, and this search becomes exponentially challenging as desired properties grow. The ever-growing zoo of sophisticated in silico tools for predicting antibody properties calls for an efficient joint optimization procedure to overcome resource-intensive sequential filtering pipelines. We present BOAT, a versatile Bayesian optimization framework for multi-property antibody engineering. Our `plug-and-play' framework couples uncertainty-aware surrogate modeling with a genetic algorithm to jointly optimize various predicted antibody traits while enabling efficient exploration of sequence space. Through systematic benchmarking against genetic algorithms and newer generative learning approaches, we demonstrate competitive performance with state-of-the-art methods for multi-objective protein optimization. We identify clear regimes where surrogate-driven optimization outperforms expensive generative approaches and establish practical limits imposed by sequence dimensionality and oracle costs.

The robust low-rank tensor completion problem addresses the challenge of recovering corrupted high-dimensional tensor data with missing entries, outliers, and sparse noise commonly found in real-world applications. Existing methodologies have encountered fundamental limitations due to their reliance on uniform regularization schemes, particularly the tensor nuclear norm and $\ell_1$ norm regularization approaches, which indiscriminately apply equal shrinkage to all singular values and sparse components, thereby compromising the preservation of critical tensor structures. The proposed tensor weighted correlated total variation (TWCTV) regularizer addresses these shortcomings through an $M$-product framework that combines a weighted Schatten-$p$ norm on gradient tensors for low-rankness with smoothness enforcement and weighted sparse components for noise suppression. The proposed weighting scheme adaptively reduces the thresholding level to preserve both dominant singular values and sparse components, thus improving the reconstruction of critical structural elements and nuanced details in the recovered signal. Through a systematic algorithmic approach, we introduce an enhanced alternating direction method of multipliers (ADMM) that offers both computational efficiency and theoretical substantiation, with convergence properties comprehensively analyzed within the $M$-product framework.Comprehensive numerical evaluations across image completion, denoising, and background subtraction tasks validate the superior performance of this approach relative to established benchmark methods.

Causal representation learning (CRL) aims to identify the underlying latent variables from high-dimensional observations, even when variables are dependent with each other. We study this problem for latent variables that follow a potentially degenerate Gaussian mixture distribution and that are only observed through the transformation via a piecewise affine mixing function. We provide a series of progressively stronger identifiability results for this challenging setting in which the probability density functions are ill-defined because of the potential degeneracy. For identifiability up to permutation and scaling, we leverage a sparsity regularization on the learned representation. Based on our theoretical results, we propose a two-stage method to estimate the latent variables by enforcing sparsity and Gaussianity in the learned representations. Experiments on synthetic and image data highlight our method's effectiveness in recovering the ground-truth latent variables.

Surprising study reveals peaceful succession is possible. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Naked mole-rats are among the only eusocial mammals. Breakthroughs, discoveries, and DIY tips sent six days a week. Queen bees may get most of the glory, but there is another queen of the animal kingdom who is the linchpin of her entire society.

We decompose the Kullback--Leibler generalization error (GE) -- the expected KL divergence from the data distribution to the trained model -- of unsupervised learning into three non-negative components: model error, data bias, and variance. The decomposition is exact for any e-flat model class and follows from two identities of information geometry: the generalized Pythagorean theorem and a dual e-mixture variance identity. As an analytically tractable demonstration, we apply the framework to $ε$-PCA, a regularized principal component analysis in which the empirical covariance is truncated at rank $N_K$ and discarded directions are pinned at a fixed noise floor $ε$. Although rank-constrained $ε$-PCA is not itself e-flat, it admits a technical reformulation with the same total GE on isotropic Gaussian data, under which each component of the decomposition takes closed form. The optimal rank emerges as the cutoff $λ_{\mathrm{cut}}^{*} = ε$ -- the model retains exactly those empirical eigenvalues exceeding the noise floor -- with the cutoff reflecting a marginal-rate balance between model-error gain and data-bias cost. A boundary comparison further yields a three-regime phase diagram -- retain-all, interior, and collapse -- separated by the lower Marchenko--Pastur edge and an analytically computable collapse threshold $ε_{*}(α)$, where $α$ is the dimension-to-sample-size ratio. All claims are verified numerically.