A long standing goal in neuroscience has been to elucidate the functional organization of the brain.

We apply brain dissection across the visual cortex to uncover functional differences between regions.

Encoding models have been used to assess how the human brain represents concepts in language and vision.

During natural evolution, the primary visual cortex (V1) of lower mammals typically forms salt-and-pepper organizations, while higher mammals and primates develop pinwheel structures with distinct topological properties. Despite the general belief that V1 neurons primarily serve as edge detectors, the functional advantages of pinwheel structures over salt-and-peppers are not well recognized. To this end, we propose a two-dimensional self-evolving spiking neural network that integrates Hebbian-like plasticity and empirical morphological data.

A long standing goal in neuroscience has been to elucidate the functional organization of the brain. Within higher visual cortex, functional accounts have remained relatively coarse, focusing on regions of interest (ROIs) and taking the form of selectivity for broad categories such as faces, places, bodies, food, or words. Because the identification of such ROIs has typically relied on manually assembled stimulus sets consisting of isolated objects in non-ecological contexts, exploring functional organization without robust a priori hypotheses has been challenging. To overcome these limitations, we introduce a data-driven approach in which we synthesize images predicted to activate a given brain region using paired natural images and fMRI recordings, bypassing the need for category-specific stimuli. Our approach -- Brain Diffusion for Visual Exploration (BrainDiVE) -- builds on recent generative methods by combining large-scale diffusion models with brain-guided image synthesis. Validating our method, we demonstrate the ability to synthesize preferred images with appropriate semantic specificity for well-characterized category-selective ROIs. We then show that BrainDiVE can characterize differences between ROIs selective for the same high-level category. Finally we identify novel functional subdivisions within these ROIs, validated with behavioral data. These results advance our understanding of the fine-grained functional organization of human visual cortex, and provide well-specified constraints for further examination of cortical organization using hypothesis-driven methods.

The alignment between deep neural network (DNN) features and cortical responses currently provides the most accurate quantitative explanation for higher visual areas. At the same time, these model features have been critiqued as uninterpretable explanations, trading one black box (the human brain) for another (a neural network). In this paper, we train networks to directly predict, from scratch, brain responses to images from a large-scale dataset of natural scenes (Allen et.

Numerous neurophysiological studies have revealed that a large number of the primary visual cortex neurons operate in a regime called surround modulation. Surround modulation has a substantial effect on various perceptual tasks, and it also plays a crucial role in the efficient neural coding of the visual cortex. Inspired by the notion of surround modulation, we designed new excitatory-inhibitory connections between a unit and its surrounding units in the convolutional neural network (CNN) to achieve a more biologically plausible network. Our experiments show that this simple mechanism can considerably improve both the performance and training speed of traditional CNNs in visual tasks. We further explore additional outcomes of the proposed structure. We first evaluate the model under several visual challenges, such as the presence of clutter or change in lighting conditions and show its superior generalization capability in handling these challenging situations. We then study possible changes in the statistics of neural activities such as sparsity and decorrelation and provide further insight into the underlying efficiencies of surround modulation. Experimental results show that importing surround modulation into the convolutional layers ensues various effects analogous to those derived by surround modulation in the visual cortex.