We characterized the generalization capabilities of deep neural network encoding models when predicting neuronal responses from the visual cortex to flashed images. We collected MacaqueITBench, a large-scale dataset of neuronal population responses from the macaque inferior temporal (IT) cortex to over 300,000 images, comprising 8,233 unique natural images presented to seven monkeys over 109 sessions. Using MacaqueITBench, we investigated the impact of distribution shifts on models predicting neuronal activity by dividing the images into Out-Of-Distribution (OOD) train and test splits. The OOD splits included variations in image contrast, hue, intensity, temperature, and saturation. Compared to the performance on in-distribution test images---the conventional way in which these models have been evaluated---models performed worse at predicting neuronal responses to out-of-distribution images, retaining as little as 20\\% of the performance on in-distribution test images.