The test-negative design (TND) is a resource-efficient observational study design that can assess vaccine effectiveness and exposure-proximal immune correlates of disease. The TND enrolls symptomatic individuals seeking diagnostic testing and compares case status by an exposure variable, such as vaccination status or immune marker level, that is measured at testing. While the TND reduces confounding by healthcare-seeking behavior, other sources of confounding may remain. TND studies may also have missing data in the exposure variable due to incomplete records or two-phase sampling designs. We present a targeted maximum likelihood estimation approach involving a semiparametric logistic regression model that targets a causal conditional risk ratio of symptomatic disease in the healthcare-seeking population. Under causal and missing at random assumptions, our method produces an efficient, asymptotically linear estimator that provides flexible, data-driven confounding control and valid causal inference when analyzing TND studies with missing exposure variable data. We evaluate our method's finite sample properties using plasmode simulations of a two-phase TND immune correlates study. We also apply our method to assess COVID-19 vaccine effectiveness and antibody marker correlates of COVID-19 from TND study cohorts derived from the Moderna Coronavirus Efficacy phase 3 trial.

Date Posted: Sept. 16, 2022 Domestic relocation as well as Visa sponsorship is available. Required qualifications: Minimum of a Bachelor's degree with five plus years of experience or Masters degree with two plus years' experience or PhD; Educational preparation or applied experience in at least one of the following areas: Machine Learning, Computational Biology, Applied Mathematics, Bioinformatics, Genomics, Computer Science, Statistics, Biostatistics, or other related quantitative discipline; Demonstrate proficiency applying deep learning, machine learning algorithms, concepts to image classification, object detection, and object segmentation; Skilled in computational skills and level of experience building models using Python and building analysis pipelines; Understanding of software development best practices (version control, code documentation & review, cloud-based sequence analysis, database management); Intermediate proficiency in predictive modeling including comprehension of theory, identification strategies, limitations, and pitfalls; Experience in successful delivery of valuable analysis through application of domain knowledge; Possess strong business acumen; Strong communication competencies to include presentations and delivery of complex quantitative analyses in a clear, concise and actionable manner. Entirely remote jobs that could be performed in Colorado: employees can expect to be paid a salary of approximately $120,000 (or between $110,000 to $135,000). Additional compensation may include a bonus or commission (if relevant). Additional benefits include health care, vision, dental, retirement, PTO, sick leave, etc..

Single Australians looking for sex or love will soon stand out from the competition if they've been vaccinated against Covid-19. Dating app Bumble announced it will roll out a new feature this week enabling users in Australia and New Zealand to add a "vaccination badge" to their profile if they've received a Covid-19 jab. Competitor Tinder says it looks forward to "making [vaccine] badges available soon" in Australia too. A Bumble representative says it will not independently verify the vaccination status of those who claim the badge, meaning the system will rely on user honesty. The dating app says it decided to launch the feature after a recent survey revealed a "45% increase in users asking potential dates if they had the vaccine or have Covid symptoms". It's not just in Australia that dating apps are encouraging users to boast about their vaccination status.

The White House is pushing a new reason to swipe right: vaccination badges and "super swipes" for people who've gotten their coronavirus shots. The Biden administration said Friday it's teaming up with dating apps to showcase the benefits of getting a shot. Apps like Hinge, Tinder, Match and Bumble are offering special incentives to people who roll up their sleeves, including badges showing vaccination status and free access to premium content. BLK and Chispa will boost profiles of those who are vaccinated, to make them more visible to potential matches. And OKCupid will even let users filter out potential partners based on whether they've gotten a vaccine.

Singles looking for love now have the option to declare their vaccination status. San Francisco-based dating app Coffee Meets Bagel is adding a Vaccine Status to its dating profile this week allowing singles to declare if they've received the COVID-19 vaccination, the company announced Thursday. Coffee Meets Bagel has a new vaccination feature on its app that lets users declare where they are in the process. Daters will be able to select from one of five responses to add to their dating profile: fully vaccinated, waiting on an additional dose, planning to get vaccinated, not getting vaccinated or prefer not to say, the company said. Users can edit responses at any time depending on their status.